ACR Meeting Abstracts

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  • Abstract Number: 935 • 2014 ACR/ARHP Annual Meeting

    Targeting Glycolysis in Rheumatoid Arthritis

    Monica Guma1, Alessia Lodi2, Ajit Divakaruni3, Anne Murphy3, Stefano Tiziani4 and Gary S. Firestein5, 1Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 2nutritional Sciences, University of Texas at Austin, Austin, TX, 3Pharmacology, University of California, San Diego, La Jolla, CA, 4Nutritional Sciences, University of Texas at Austin, Austin, TX, 5Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA

    Background/Purpose: Many of the signaling pathways activated in inflammation have a profound effect on cell metabolism. However, little is known about metabolome in rheumatoid arthritis…
  • Abstract Number: 934 • 2014 ACR/ARHP Annual Meeting

    Amelioration of Inflammatory Arthritis By Anti-TNF Therapy Is Associated with Restoration of Lymphatic Contraction

    Echoe M. Bouta1, Igor Kuzin2, Karen de Mesy-Bentley1, Ronald Wood3, Homaira Rahimi4, Rui-Cheng Ji5, Christopher T. Ritchlin6, Andrea Bottaro2, Lianping Xing7 and Edward M. Schwarz8, 1University of Rochester, Rochester, NY, 2Cooper Medical School, Camden, NJ, 3Department of Urology, University of Rochester Medical Center, Rochester, NY, 4Rheumatology, University of Rochester/Golisano Children's Hospit, Rochester, NY, 5Department of Anatomy, Biology and Medicine, Oita University, Oita, Japan, 6Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 7Pathology & Lab Medicine, University of Rochester, Rochester, NY, 8Center for Musculoskeletal Research, University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with episodic flares. In tumor necrosis factor transgenic (TNF-Tg) mice, a model of inflammatory-erosive arthritis,…
  • Abstract Number: 933 • 2014 ACR/ARHP Annual Meeting

    A Multi-Center, Double-Blind, Randomized-Withdrawal Trial of Subcutaneous Golimumab in Pediatric Patients with Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy: Week 48 Results

    Hermine I. Brunner1, Nicolino Ruperto2, N Tzaribachev3, Gerd Horneff4, Carine Wouters5, Violeta Vladislava Panaviene6, Vyacheslav Chasnyk7, Carlos Abud-Mendoza8, Ruben Cuttica9, Andreas Reiff10, M Maldonado-Velázquez1, Nadina Rubio-Pérez11, Rik Joos12, V Keltsev13, Evgeny Nasonov14, Daniel Kingsbury15, M Bandeira16, Earl Silverman17, F Weller-Heinemann11, A van Royen-Kerkhof18, Alan M. Mendelsohn19, Lilianne Kim20, Daniel Lovell21 and A Martini22, 1PRCSG, Cincinnati, OH, 2Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, 3PRINTO & PRCSG, Bramstedt, Germany, 4Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, 5Pediatric Rheumatology, University Hosp Gasthuisberg, Leuven, Belgium, 6Istituto Giannina Gaslini, Genoa, Italy, 7Litovskaya Str., 2, Novartis Pharma, Saint-Peterburg, Russia, 8Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, 9Tilcara 3023, Hospital de Ninos Pedro de Elizalde, Capital Federal, Argentina, 10Children’s Hospital of Los Angeles, Los Angeles, CA, 11PRINTO, Genoa, Italy, 12UZ Gent, Gent, Belgium, 13Paediatric Rheumatology International Trials Organisation–IRCCS [PRINTO], Genoa, Italy, 14State Institute of Rheumatology of RAMS, Moscow, Russia, 15Pediatric Rheumatology, Randall Children's Hospital at Legacy Emanuel, Portland, OR, 16Pediatrics, Hospital Infantil Pequeno Príncipe, Curitiba, Brazil, 17Division of Rheumatology, Hosp for Sick Children, Toronto, ON, Canada, 18Department of Pediatric Immunology & Rheumatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, Netherlands, 19Immunology, Janssen Research & Development, LLC., Spring House, PA, 20Janssen Research & Development, LLC., Spring House, PA, 21Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, 22Istituto Gaslini-PRINTO, Genova, Italy

    Background/Purpose:   To assess efficacy and safety of SC golimumab (GLM) in polyarticular pediatric juvenile idiopathic arthritis pts (aged 2 to
  • Abstract Number: 932 • 2014 ACR/ARHP Annual Meeting

    MRP8/14 Serum Level As Predictor of Response to Starting and Stopping Anti-TNF Treatment in Non-Systemic Juvenile Idiopathic Arthritis

    Janneke Anink1, Marieke H. Otten1, Lisette W.A. van Suijlekom-Smit1, Marion A.J. Van Rossum2, Koert M. Dolman3, Esther P.A. Hoppenreijs4, Rebecca ten Cate5, Simona Ursu6, Lucy R Wedderburn7, Gerd Horneff8, Thomas Vogl9,10, Dirk Föll10,11, Johannes Roth9,12 and Dirk Holzinger10,13, 1Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, 2Pediatric Rheumatology, Emma Kinderziekenhuis Academic Medical Center, Amsterdam, Netherlands, 3Pediatric Rheumatology, St. Lucas Andreas Hospital and Reade Institute, Amsterdam, Netherlands, 4Pediatric Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 5Pediatric Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, 7Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 8Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, 9Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 10Interdisciplinary Centre for Clinical Research IZKF, University Hospital Muenster, Muenster, Germany, 11Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany, 12University Hospital Muenster, Muenster, Germany, 13Pediatric Rheumatology and Immunology, University Children’s Hospital Muenster, Muenster, Germany

    Background/Purpose: Biological therapy has dramatically improved the treatment of patients with JIA. However, there is still a group of patients that shows a lack of…
  • Abstract Number: 931 • 2014 ACR/ARHP Annual Meeting

    Response to Canakinumab Treatment Is Maintained in Systemic Juvenile Idiopathic Arthritis Patients

    N.M. Wulffraat1,2, N. Ruperto2, H.I. Brunner3, S. Oliveira2, Y. Uziel2, K. Nistala2, R. Cimaz2, M. Ferrandiz2, B. Flato2, M.L. Gamir2, I. Koné-Paut2, C. Gaillez4, K. Lheritier4, K. Abrams5, A. Martini2 and D.J. Lovell3, 1Pediatric Rheumatology, UMC Utrecht, Utrecht, Netherlands, 2PRINTO-Istituto Gaslini, Genova, Italy, 3PRCSG, Cincinnati, OH, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Canakinumab, a selective, human, anti-interleukin (IL) -1β monoclonal antibody, is approved for the treatment of systemic juvenile idiopathic arthritis (SJIA) patients (≥ 2 years…
  • Abstract Number: 930 • 2014 ACR/ARHP Annual Meeting

    An Exploratory Analysis of Predictors of Response from 12-Weeks of Canakinumab Therapy in Patients with Active Systemic Juvenile Idiopathic Arthritis

    Hermine I. Brunner1, Nicola Ruperto2, Isabelle Koné-Paut2, Bo Magnusson2, Seza Ozen2, Flavio Sztajnbok2, Jordi Anton2, Judith Barash2, Reinhard Berner2, Fabrizia Corona2, Karine Lheritier3, Corine Gaillez3, Alberto Martini2 and Daniel Lovell1, 1PRCSG, Cincinnati, OH, 2PRINTO-Istituto Gaslini, Genova, Italy, 3Novartis Pharma AG, Basel, Switzerland

    Background/Purpose Systemic juvenile idiopathic arthritis (SJIA), an interleukin-1β (IL-1β)-mediated autoinflammatory disease, is characterized by recurrent flares of active disease. Canakinumab (CAN), a selective, human, anti-…
  • Abstract Number: 929 • 2014 ACR/ARHP Annual Meeting

    Antibiotic Exposure and the Development of Juvenile Idiopathic Arthritis: A Population-Based Case-Control Study

    Daniel B. Horton1,2, Frank I. Scott IV1,3, Kevin Haynes1, Mary E. Putt1, Carlos D. Rose2, James D. Lewis1,3 and Brian L. Strom1,4, 1Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Pediatrics, Division of Rheumatology, Nemours A.I. duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE, 3Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, 4Rutgers Biomedical and Health Sciences, Newark, NJ

    Background/Purpose: Dysregulation of the human microbiome has been implicated in the development of several autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). Moreover,…
  • Abstract Number: 928 • 2014 ACR/ARHP Annual Meeting

    A Multinational Study of the Epidemiology, Treatment and Outcome of Childhood Arthritis: Preliminary Data from 6,940 Patients

    Alessandro Consolaro1, Amita Aggarwal2, Troels Herlin3, Olga Vougiouka4, Rubén Burgos-Vargas5, Ilonka Orban6, Nahid Shafaie7, Maria Trachana8, Lidia Rutkowska-Sak9, Ingrida Rumba-Rozenfelde10, Dimitrina Mihaylova11, Alberto Martini12,13 and Angelo Ravelli1,14, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 3Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, 4P. A. Kyriakou Childrens Hospital of Athens University, Athens, Greece, 5Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, 6National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 7Rheumatology Research Centre, Tehran University of Medical Sciences, Tehran, Iran, 8Aristotle University, Thessaloniki, Greece, 9Institute of Rheumatology, Warsaw, Poland, 10University of Latvia, Riga, Latvia, 11University Children Hospital, Sofia, Bulgaria, 12Istituto Giannina Gaslini, Genova, Italy, 13University of Genova, Genova, Italy, 14Istituto Giannina Gaslini and University of Genova, Genova, Italy

    Background/Purpose The epidemiology of juvenile idiopathic arthritis (JIA) is known to be variable worldwide and the therapeutic approach to JIA is not standardized. Moreover, the…
  • Abstract Number: 912 • 2014 ACR/ARHP Annual Meeting

    A Consensus Hybrid Definition Using a Conjoint Analysis Is the Proposed As Response Criteria for Minimal and Moderate Improvement for Adult Polymyositis and Dermatomyositis Clincal Trials

    Rohit Aggarwal1, Lisa G. Rider2, Nicolino Ruperto3, Nastaran Bayat2, Brian Erman4, Brian M. Feldman5, Adam M. Huber6, Chester V. Oddis7, Ingrid E. Lundberg8, Anthony A. Amato, MD9,10, Robert G. Cooper, MD, FRCP11, Hector Chinoy12, Maryam Dastmalchi13, David Fiorentino14, David Isenberg15, James D. Katz16, Andrew L. Mammen17, Marianne de Visser18, Steven R. Ytterberg19, Katalin Danko20, Luca Villa21, Mariangela Rinaldi21, Howard Rockette22, Peter A. Lachenbruch2, Frederick W. Miller2 and Jiri Vencovsky, MD, DSc23, 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 3Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, 4Social and Scientific Systems, Inc., Durham, NC, 5Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 6IWK Health Centre, Halifax, NS, Canada, 7Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 9Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 11MRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, 12Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 13Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, 14Dermatology, Stanford University, Redwood City, CA, 15Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 16NIAMS, NIH, Bethesda, MD, 17Neurology and Medicine, Johns Hopkins University, Baltimore, MD, 18Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands, 19Rheumatology Division, Mayo Clinic, Rochester, MN, 20Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, 21Pediatria II, Reumatologia, PRINTO, IRCCS Istituto G. Gaslini, Genova, Italy, 22University of Pittsburgh, Pittsburgh, PA, 23Institute of Rheumatology, Charles University, Prague, Czech Republic

    Background/Purpose: To develop consensus on definitions of improvement (DOIs) for minimal and moderate improvement (and draft preliminary criteria for major improvement) in adult dermatomyositis (DM)…
  • Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting

    Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation

    Nicholas A. Young1, Lai-Chu Wu1, Michael Bruss2, Wael N. Jarjour3 and Dana P. Ascherman4, 1Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 2Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, 3Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 4Rheumatology, Miami VAMC, Miami, FL

    Background/Purpose:  The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
  • Abstract Number: 910 • 2014 ACR/ARHP Annual Meeting

    The Selective Sphingosine-1- Phosphate Receptor 1/5 Modulator Siponimod (BAF312) Shows Beneficial Effects in Patients with Active, Treatment Refractory Polymyositis and Dermatomyositis: A Phase IIa Proof-of-Concept, Double-Blind, Randomized Trial

    Katalin Danko1, Jiri Vencovsky2, Ingrid E. Lundberg3, Anthony A Amato4, Chester V. Oddis5, Maria Molnar6, Antonette Mallari Moher7, Laurence Colin8, Florian Muellershausen9, David Lee10 and Peter Gergely9, 1Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, 2Institute of Rheumatology, Charles University, Prague, Czech Republic, 3Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary, 7Translational Medicine, Novartis Institutes for Biomedical Research (former emplyee), Basel, Switzerland, 8Novartis Pharma, Basel, Switzerland, 9Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, 10Novartis Pharmaceuticals Corporation, Basel, Switzerland

    Background/Purpose Polymyositis and dermatomyositis (PM/DM) comprise a heterogeneous group of chronic inflammatory muscle diseases where infiltration of lymphocytes in the skeletal muscle plays a key…
  • Abstract Number: 909 • 2014 ACR/ARHP Annual Meeting

    A Diagnostic Protocol for Giant Cell Arteritis (GCA) Using Ultrasound Assessment

    Jennifer Piper1, Ana Sofia Serafim1, Cristina Ponte1, Surjeet Singh2, Bhaskar Dasgupta3, Wolfgang A. Schmidt4, Eugene McNally5, Andreas P. Diamantopoulos6, Andrew Hutchings7 and Raashid Luqmani8, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2University of Oxford, Sciences, Oxford, England, 3Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, 4Rheumatology, Immanuel Krankenhaus, Berlin, Germany, 5Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom, 6Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 7Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, 8Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom

    Background/Purpose Ultrasound (US) has not yet superseded temporal artery biopsy as a diagnostic test. This may reflect poor consistency of the scanning technique, due to…
  • Abstract Number: 908 • 2014 ACR/ARHP Annual Meeting

    Ultrasound-Detected Tenosynovitis Independently Associates with Flare in Patients with Rheumatoid Arthritis in Clinical Remission

    Emanuela Bellis1, Greta Carrara2, Carlo Alberto Scirè2, Alessandra Bortoluzzi3, Alberto Batticciotto4, Antonella Adinolfi5, Giovanni Cagnotto6, Marta Caprioli7, Marco Canzoni8, Francesco Cavatorta9, Fulvia Ceccarelli10, Orazio De Lucia11, Valentina Di Sabatino12, Antonella Draghessi13, Georgios Filippou12, Ilaria Farina3, Maria Cristina Focherini14, Paola Frallonardo15, Alessandra Gabba16, Angelica Gattamelata10, Marwin Gutierrez13, Luca Idolazzi17, Filippo Luccioli18, Pierluigi Macchioni19, Marco Massarotti20, Claudio Mastaglio21, Luana Menza21, Giulia Mirabelli18, Maurizio Muratore22, Simone Parisi23, Valentina Picerno12, Matteo Piga24, Roberta Ramonda25, Bernd Raffeiner26, Daniela Rossi27, Paola Rossini28, Garifallia Sakellariou29,30, Crescenzio Scioscia31, Carlo Venditti32, Annamaria Iagnocco10 and Marco Matucci-Cerinic33, 1Rheumatology, Ospedale Mauriziano, Turin, Italy, 2Italian Society for Rheumatology, Milan, Italy, 3A.O.U. S.Anna di Cona, Ferrara, Italy, 4L.Sacco University Hospital, Milan, Italy, 5Policlinico le Scotte, Siena, Italy, 6IRCCS Policlinico San Matteo, Pavia, Italy, 7Istituto di Cura Città di Pavia, Pavia, Italy, 8A.O. Sant'Andrea, Rome, Italy, 9A.O.U.P. Santa Chiara, Trento, Italy, 10Sapienza University of Rome, Rome, Italy, 11Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, 12University of Siena, Siena, Italy, 13Università Politecnica delle Marche, Jesi, Italy, 14Ospedale Infermi, Rimini, Italy, 15Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, 16A.O.U. di Cagliari, Cagliari, Italy, 17Ospedale Civile Maggiore, Verona, Italy, 18University of Perugia, Perugia, Italy, 19Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 20Istituto Clinico Humanitas, Rozzano, Italy, 21Moriggia-Pelascini, Gravedona, Italy, 22Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy, 23A.O. Città della Salute e della Scienza di Torino, Turin, Italy, 24Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, 25Rheumatology Unit, Department of Medicine, University of Padua, Padova, Italy, 26Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, 27University of Turin, Turin, Italy, 28P.O. “Destra Secchia”, Pieve di Coriano, Italy, 29Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, 30Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, 31University of Bari, Bari, Italy, 32A.O. Rummo, Benevento, Italy, 33Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Background/Purpose Clinical remission is now an achievable goal in patients with rheumatoid arthritis (RA). Much has been done in order to better understand and define…
  • Abstract Number: 907 • 2014 ACR/ARHP Annual Meeting

    Ultrasonographic Tenosynovitis Score Is Responsive to Biologic Treatment in Patients with Rheumatoid Arthritis

    Hilde B. Hammer1 and Tore K. Kvien2, 1Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Ultrasound (US) is sensitive for detecting tenosynovitis in patients with rheumatoid arthritis (RA), where the synovitis can be assessed by grey scale (GS) and…
  • Abstract Number: 906 • 2014 ACR/ARHP Annual Meeting

    How Long Does Sonographic Joint Activity Continue in Clinically Remittive Joints of Patients with Rheumatoid Arthritis?

    Miriam Gärtner1, Farideh Alasthi2, Gabriela Supp1, Peter Mandl2, Josef Smolen1 and Daniel Aletaha1, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine III, Devision of Rheumatology, Medical University of Vienna, Vienna, Austria

    How long does sonographic joint activity continue in clinically remittive joints of patients with rheumatoid arthritis? M. Gärtner, F. Alasthi, G. Supp, P. Mandl, JS…
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