Abstracts Archive - Page 1976 of 2425 - ACR Meeting Abstracts

Abstract Number: 1136 • 2014 ACR/ARHP Annual Meeting
Transcriptional Heterogeneity of the SLC2A9 Gene Encoding the GLUT9 Urate Transporter
David B. Mount^1,2, Tony R. Merriman³, Eli A. Stahl⁴, Hyon K. Choi⁵ and Asim Mandal¹, ¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Renal Division, VA Boston Healthcare System, Boston, MA, ³Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Variation in SLC2A9, which encodes the urate transporter GLUT9, is the major single genetic determinant of serum uric acid (SUA); however, the causal variant(s)…
Abstract Number: 1135 • 2014 ACR/ARHP Annual Meeting
Genes Involved in Cartilage Synthesis and Risk to Knee Osteoarthritis
Abhishek Mishra Sr., Rajeshwar Srivastava II, Divya Sanghi III, Ajai Singh IV and Devendra Parmar V, Deptt of Orthopaedic Surgery, King George's Medical University,, Lucknow, India
Background/Purpose Osteoarthritis (OA), characterized by gradual loss of articular cartilage in the joint, is a leading cause of disability among the elderly people. Though the…
Abstract Number: 1134 • 2014 ACR/ARHP Annual Meeting
Role of NOD2 Pathway in Sarcoidosis Cases with Characteristics of Blau Syndrome
Gerard Dumancas¹, Indra Adrianto², Albert M. Levin³, Michael C. Iannuzzi⁴, Benjamin A. Rybicki³ and Courtney Montgomery⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²825 Ne 13th St. Ms 57, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, ⁴Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Blau syndrome (BS) is a rare autosomal dominant, autoinflammatory syndrome characterized by the clinical triad symptoms of symmetric arthritis, dermatitis, and granulomatous recurrent uveitis,…
Abstract Number: 1133 • 2014 ACR/ARHP Annual Meeting
Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans with Rheumatoid Arthritis
Rector Arya¹, del Rincon Inmaculada², Vidya S Farook³, Jose Felix Restrepo⁴, Deidre A Winnier⁵, Marcel J Fourcaudot², Daniel Battafarano⁶, Satish Kumar⁷, Marcio AA de Almeida³, Joanne E Curran⁷, Christopher P Jenkinson⁵, John Blangero³, Ravindranath Duggirala⁷ and Agustin Escalante^4,8,9, ¹Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, ³Genetics, Texas Biomedical Research Institute, San Antonio, TX, ⁴Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁵University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁶Rheumatology, San Antonio Military Medical Center, JBSA - Ft Sam Houston, TX, ⁷Texas Biomedical Research Institute, San Antonio, TX, ⁸Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁹Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Joint damage in rheumatoid arthritis (RA) has been shown to be heritable, but knowledge on specific genetic determinants of joint damage in RA is…
Abstract Number: 1132 • 2014 ACR/ARHP Annual Meeting
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Jun Li¹, Keith Giles², Parastoo Azadi³, Mayumi Ishihara³, PingAr Yang¹, Qi Wu¹, Bao Luo¹, David M. Spalding⁴, James A Mobley⁵, S. Louis Bridges Jr.^6,7, Hui-Chen Hsu¹ and John D. Mountz^1,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Stem cell Institute, Birmingham, AL, ³University of Georgia, Complex Carbohydrate Research Center, Athens, GA, ⁴University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁵University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…
Abstract Number: 1131 • 2014 ACR/ARHP Annual Meeting
Identification of Genetic Variants Associated with Response to Adalimumab Plus Methotrexate in Patients with Early Rheumatoid Arthritis
Alla Skapenko¹, Hendrik Schulze-Koops¹, Viswanath Devanarayan², Kenneth Idler³, Feng Hong⁴, Josef Smolen⁵, Arthur Kavanaugh⁶, Hartmut Kupper⁷ and Jeffrey F. Waring³, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²AbbVie Bioresearch Center, Worcester, MA, ³AbbVie Inc., North Chicago, IL, ⁴AbbVie Bioresearch Center, Worchester, MA, ⁵Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁶University of California San Diego, La Jolla, CA, ⁷AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: For patients with rheumatoid arthritis (RA) who fail to attain remission or low disease activity after 6 months of methotrexate (MTX) treatment, TNF inhibitors…
Abstract Number: 1130 • 2014 ACR/ARHP Annual Meeting
IRF8 Gene Contributes to Disease Susceptibility and Interacts with NF-KB By Modulating Interferon Signature in Patients with Systemic Sclerosis
Maria Arismendi^1,2, Matthieu Giraud¹, Nadira Ruzehaji¹, Philippe Dieude³, Eugénie Koumakis⁴, Barbara Ruiz⁵, Paolo Airo⁶, Daniele Cusi⁷, Marco Matucci-Cerinic⁸, Erika Salvi⁹, Giovanna Cuomo¹⁰, Eric Hachulla¹¹, Elizabeth Diot¹², Paola Caramaschi¹³, Valeria Riccieri¹⁴, Jerome Avouac¹⁵, Cristiane Kayser¹⁶ and Yannick Allanore¹⁷, ¹INSERM U1016, Paris Descartes University, Paris, France, ²Department of Rheumatology, Federal University of São Paulo, São Paulo, Brazil, ³Rhumatologie, Hopital Bichat Claude Bernard, Paris, France, ⁴Rheumatology A department, Cochin Hospital, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁵Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ⁶Rheumatology and Clinical Immunology, Spedali Civili, AO Spedali Civili, Brescia, Italy, ⁷Department of Medicine, Surgery and Dentistry San Paolo & Genomics and Bioinformatics Platform, Fondazione Filarete, University of Milano, Milano, Italy, ⁸RAID working group for EULAR, Zurich, Switzerland, ⁹Department of Medicine, Surgery and Dentistry San Paolo & Genomics and Bioinformatics Platform, Fondazione Filarete, University of Milano, Milan, Italy, ¹⁰Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ¹¹Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, ¹²Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, ¹³Rheumatology Unit, Department of Medicine, Verona, Italy, ¹⁴Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy, ¹⁵Cochin Hospital, Paris, France, ¹⁶Rheumatology Division, Universidade Federal de São Paulo, São Paulo - SP, Brazil, ¹⁷Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France
Background/Purpose . Systemic Sclerosis (SSc) is a polygenic autoimmune disease (AID) characterized by fibroblast dysregulation. It shares some genetic bases with other AIDs, as evidenced…
Abstract Number: 1129 • 2014 ACR/ARHP Annual Meeting
FCGR2A Polymorphism and Response to Anti-TNF Treatment in Rheumatoid Arthritis
G. Avila¹, Jesús Tornero², Antonio Fernandez Nebro³, Francisco Blanco⁴, Isidoro Gonzalez-Alvaro⁵, Juan D. Cañete⁶, Joan Maymo⁷, Javier Ballina⁸, Benjamin Fernandez Gutierrez⁹, Alejandro Olivé¹⁰, Hector Corominas¹¹, Alba Erra¹², Raül Tortosa¹, María América López-Lasanta¹, Adrìa Aterido¹, Antonio Julia¹ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁴Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁵Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, ⁶Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁷Rheumatology, Hospital del Mar, Barcelona, Spain, ⁸Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain, ⁹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁰Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ¹¹Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, ¹²Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain
Background/Purpose TNF-α inhibitors have significantly improved the prognosis of patients with Rheumatoid Arthritis (RA). Despite this, approximately 30% of patients fail to achieve a satisfactory…
Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting
Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis
Lenka Pleštilová¹, Niharika Gaur¹, Mária Filková², Borbala Aradi-Vegh¹, Ladislav Senolt³, Adrian Ciurea¹, Renate E. Gay⁴, Jiri Vencovsky³, Michel Neidhart⁵, Steffen Gay⁵ and Astrid Juengel¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…
Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage
Beatriz Rocha¹, Berta Cillero-Pastor², Gert Eijkel², Valentina Calamia¹, Lucia Lourido¹, Carolina Fernández-Costa¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Cristina Ruiz-Romero^1,3, Ron MA Heeren² and Francisco J. Blanco Garcia¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²1Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, ³CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
Abstract Number: 1125 • 2014 ACR/ARHP Annual Meeting
The Mitochondrial Genome Influences the Risk of Incident Knee OA. DATA from the Osteoarthritis Initiative
Angel Soto-Hermida¹, Ignacio Rego-Pérez¹, Juan Fernández-Tajes¹, Mercedes Fernandez Moreno¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sonia Pértega-Díaz², Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹ and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose Previous studies by our group showed a significant influence of the mtDNA haplogroups on both radiographic progression and cartilage integrity of knee OA patients…
Abstract Number: 1126 • 2014 ACR/ARHP Annual Meeting
Quantitative Proteomics (iTRAQ) Reveals Putative Biomarkers in Pre-Radiological Osteoarthritis
Jesús Mateos¹, Alejandra Pintor-Iglesias¹, Patricia Fernandez-Puente², Sara Relaño³, Ignacio Rego-Perez⁴, Carlos Fernández-López⁵, Natividad Oreiro⁶, Cristina Ruiz-Romero⁷ and Francisco J. Blanco Garcia⁴, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, Spain, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, Spain, A Coruna, Spain, ³Grupo de Genomica. RIER/ISCIII; Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, Spain., A Coruña, Spain, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁵INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ⁶Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain, ⁷Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: In this study we have identified proteins differentially abundant in the serum of Osteoarthritis (OA) patients comparing four different progressive pathological grades using mass…
Abstract Number: 1124 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Profiling of DNA from Cartilage Reveals Regions Differently Methylated in Osteoarthritis Patients
Guangju Zhai¹, Ming Liu², Yuhua Zhang¹, Patricia E. Harper¹, Erfan Aref-Eshghi², Glynn Martin³, Andrew Furey³, Roger Green¹, Guang Sun⁴ and Proton Rahman⁵, ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Memorial University, St. John's, NF, Canada, ³Department of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and has substantial clinical and economic impact. Evidence supports that DNA methylation plays a significant…
Abstract Number: 1123 • 2014 ACR/ARHP Annual Meeting
Impact of Genes Modulating Serum Low-Density Lipoprotein Cholesterol Levels on Progression of Joint Destruction in Japanese Patients with Rheumatoid Arthritis
Shinji Yoshida¹, Katsunori Ikari¹, Koichiro Yano¹, Yoshiaki Toyama², Atsuo Taniguchi³, Hisashi Yamanaka¹ and Shigeki Momohara³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Patients with rheumatoid arthritis (RA) have a higher prevalence of dyslipidemia than healthy individuals. Since RA is a chronic inflammatory disease, an inflammatory response…
Abstract Number: 1122 • 2014 ACR/ARHP Annual Meeting
Transmitocondrial Cybrids: A Tool to Study the Role of mtDNA Haplogroups in OA Pathogenesis
Mercedes Fernandez Moreno¹, Tamara Hermida-Gómez², Angel Soto-Hermida¹, Juan Fernández-Tajes¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernandez¹, Natividad Oreiro-Villar¹, Carlos Fernandez-Lopez¹, Esther Gallardo-Perez³, Rafael Garesse³, Ignacio Rego-Perez¹ and Francisco J. Blanco Garcia¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain, ³Laboratorio de Enfermedades Mitocondriales, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Departamento de Bioquímica, Instituto de Investigaciones Biomédicas, Madrid, Spain
Background/Purpose Mitochondria play an important role in the OA pathogenesis. mtDNA haplogroup J is significantly associated with a lower risk of OA in northwest Spanish…

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