ACR Meeting Abstracts

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  • Abstract Number: 1152 • 2014 ACR/ARHP Annual Meeting

    Euroqol-5-Dimensions Utility Gain in Rheumatoid Arthritis, Treated with Abatacept, Rituximab, Tocilizumab or Tumor Necrosis Factor Inhibitors

    Anders Gülfe1, Johan A. Karlsson2 and Lars-Erik Kristensen3, 1Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden, 2Dept of Clinical Sciences, Section for Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden, 3Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Malmö, Sweden

    Background/Purpose: We have earlier demonstrated that EuroQoL-5-Dimensions (EQ-5D) utility improves rapidly after commencement of tumor necrosis factor inhibition (TNFi) in rheumatoid arthritis (RA) and other…
  • Abstract Number: 1151 • 2014 ACR/ARHP Annual Meeting

    Barriers and Facilitators of a Career in Research Among Rheumatologists in the United States

    Alexis Ogdie1, Sheila Angeles-Han2, Una Makris3,  Amanda Nelson4, Ami Shah5, Yihui Jiang6, J. Michelle Kahlenberg7, Eyal Muscal8, Flavia V. Castelino9, Amit Golding10 and Alfred Kim11, 1Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, 2Pediatrics, Emory University School of Medicine, Atlanta, GA, 3Rheumatology, Dallas VA Medical Ctr, Dallas, TX, 45) Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Division of Rheumatology, John Hopkins University, Baltimore, MD, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 7Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 8Rheumatology, Texas Children's Hospital, Houston, TX, 9Rheumatology, Massachusetts General Hospital, Boston, MA, 10Medicine/Rheumatology and Clinical Immunology, Baltimore VA and University of Maryland School of Medicine, Baltimore, MD, 11Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO

    Background/Purpose: Development of young rheumatology investigators is critical to the future of rheumatology.  Beyond funding, the specific barriers to maintaining a career in rheumatology research…
  • Abstract Number: 1150 • 2014 ACR/ARHP Annual Meeting

    Marked Differences in Euro-Qol-5-Dimensions Preference Sets Based on Hypothetical or Experience Based Valuation

    Anna Cooper1, Johan A. Karlsson2 and Anders Gülfe1, 1Dept of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden, 2Dept of Clinical Sciences, Section for Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden

    Background/Purpose: Health related quality of life (HRQoL) can be expressed as utility, a value anchored at 0 (death) and 1 (perfect health, forming the basis…
  • Abstract Number: 1149 • 2014 ACR/ARHP Annual Meeting

    Novel Adherence Measures for Infusible Therapeutic Agents in Rheumatoid Arthritis

    Roxanne Meyer1, Michael Ingham2, Joseph Tkacz3, Brenna Brady3 and Charles Ruetsch4, 1Janssen Scientific Affairs, Horsham, PA, 2850 Ridgeview Drive, Janssen Services, LLC, Horsham, PA, 3Health Analytics, LLC, Columbia, MD, 4Health Analytics LLC, Columbia, MD

    Background/Purpose: Adherence is under consideration for quality reporting in a number of disease states. Published data on adherence of biologics reveal a wide range of…
  • Abstract Number: 1148 • 2014 ACR/ARHP Annual Meeting

    Evaluation of a Methodological Approach to Determine Timing of Rheumatoid Arthritis Disease Onset Using Administrative Claims Data

    Jie Zhang1, Fenglong Xie2, Lang Chen3, Jeffrey D. Greenberg4 and Jeffrey R. Curtis5, 1Ryals Soph Bldg., Rm. 517b, Univ. of Alabama at Birmingham, Birmingham, AL, 2Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Rheumatology, New York University School of Medicine, New York, NY, 5University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The identification of patients with recent-onset rheumatoid arthritis (RA) is often desirable to create inception cohorts of patients.  We evaluated an approach to identify…
  • Abstract Number: 1147 • 2014 ACR/ARHP Annual Meeting

    Economic Implications of Flares Among Patients with Early Rheumatoid Arthritis (RA)

    James Signorovitch1, Keith Betts1, Vishvas Garg2 and Yanjun Bao2, 1Analysis Group, Inc., Boston, MA, 2AbbVie Inc., North Chicago, IL

    Background/Purpose: Government mandated dose tapering and withdrawal of biologic treatments for RA after achievement of sustained disease control is currently observed in Taiwan, the Netherlands,…
  • Abstract Number: 1146 • 2014 ACR/ARHP Annual Meeting

    Cost-Effectiveness of Adalimumab for Rheumatoid Arthritis in Germany

    Christian Gissel1, Georg Götz2, Holger Repp3 and Uwe Lange4, 1Rheumatology, Justus-Liebig-University Giessen, Giessen, Germany, 2Department of Economics and Business, Justus-Liebig-University Giessen, Giessen, Germany, 3Department of Medicine, Justus-Liebig-University Giessen, Giessen, Germany, 4Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Clinic, Bad Nauheim, Germany

    Background/Purpose: In Germany, Rheumatoid Arthritis (RA) can be treated with TNF-α inhibitors after the failure of conventional disease-modifying antirheumatic drugs like Methotrexate. The clinical use…
  • Abstract Number: 1145 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Biologic Treatment Patterns, Clinical Outcomes, and Healthcare Resource Utilization Post-Tumor Necrosis Factor Inhibitor Discontinuation in Rheumatoid Arthritis

    J. Harnett1, D. Wiederkehr1, R. Gerber2, D. Gruben2, A. Koenig3 and J. Bourret3, 1Pfizer Inc, New York, NY, 2Pfizer Inc, Groton, CT, 3Pfizer Inc, Collegeville, PA

    Background/Purpose: For rheumatoid arthritis (RA) patients (pts) with inadequate response to a TNF inhibitor (TNFi), limited evidence exists from observational studies and indirect comparisons of…
  • Abstract Number: 1144 • 2014 ACR/ARHP Annual Meeting

    Economic Implications for Policies Regarding Triple Therapy Use in Patients with Rheumatoid Arthritis

    Nick Bansback1, Diane V. Lacaille2, Daphne Guh3, Kamran Shojania4 and Aslam H. Anis3, 1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, 2Rheumatology, Arthritis Research Centre of Canada/University of British Columbia, Richmond, BC, Canada, 3St. Paul's Hospital, Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada, 4Rheumatology, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Recent randomized controlled trials in rheumatoid arthritis (RA) patients have determined that a strategy of first adding the two Disease Modifying Anti-Rheumatic Drugs (DMARDs)…
  • Abstract Number: 1143 • 2014 ACR/ARHP Annual Meeting

    Preferences of Biologic Treatment Characteristics Among Rheumatoid Arthritis Patients Who Are Current Biologic Therapy Users

    David M. Kern1, Angela E. Williams2, Ozgur Tunceli1, Bingcao Wu1, Judy Stephenson1, Laura Horne3 and Alfred Sackeyfio4, 1HealthCore, Inc., Wilmington, DE, 2MedImmune, LLC, Cambridge, United Kingdom, 3AstraZeneca, Wilmington, DE, 4AstraZeneca, Manchester, United Kingdom

    Background/Purpose: To identify the most and least important characteristics of rheumatoid arthritis (RA) treatment according to patients currently on biologic therapy. Methods: From the HealthCore…
  • Abstract Number: 1142 • 2014 ACR/ARHP Annual Meeting

    Healthcare Costs Associated with Serious Infections Among Biologic-Naïve Rheumatoid Arthritis Patients Initiating First-Line Biologic Treatment

    S Johnston1, S Kelly2, A Nadkarni2, K Wilson1, B Limone1 and M Hochberg3, 1Truven Health Analytics, Bethesda, MD, 2Bristol-Myers Squibb, Plainsboro, NJ, 3Medicine, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: The risk of serious infections can vary across biologics. For example, in the 2-year AMPLE trial, serious infections occurred in 3.8% of SC abatacept-treated…
  • Abstract Number: 1141 • 2014 ACR/ARHP Annual Meeting

    Comparisons of Quality of Life, Resource Use and Physical Functioning in RA Patients Classified As High, Moderate or Low Risk for Rapid Radiographic Progression

    E Alemao1, S Joo2, P Allison3, M Al4, M Rutten-van Molken4, S Banerjee1, C Iannaccone5, M Frits5, N Shadick5, M Weinblatt5 and Katherine Liao6, 1Bristol-Myers Squibb, Princeton, NJ, 2Bristol-Myers Squibb, Hopewell, NJ, 3University of Pennsylvania, Philadelphia, PA, 4Erasmus University, Rotterdam, Netherlands, 5Brigham and Women's Hospital, Boston, MA, 6Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: We developed and validated a prognostic model to identify subjects with elevated risk of rapid radiographic progression (RRP). The objective of this study was…
  • Abstract Number: 1160 • 2014 ACR/ARHP Annual Meeting

    Annual Real-Practice Costs of Biologics for 200 Cases with Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Treated By Tight Control and Treat to Target Strategy Permitting Dose Reduction

    Bernd Raffeiner1, Costantino Botsios2, Michele Ragazzi3 and Ernesto De Menis4, 1Department of Medicine, Rheumatology - General Hospital Bolzano, Bolzano, Italy, 2Department of Medicine, Rheumatology - Hospital San Valentino Montebelluna, Montebelluna, Italy, 3Pharmacy - Hospital San Valentino Montebelluna, Montebelluna, Italy, 4Department of Medicine, Internal Medicine - Hospital San Valentino Montebelluna, Montebelluna, Italy

    Background/Purpose To investigate annually real-practice costs of biologic therapy for rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) cohort treated by tight control…
  • Abstract Number: 1138 • 2014 ACR/ARHP Annual Meeting

    Vasoactive Intestinal Peptide (VIP) Genetic Variants Determine VIP Serum Levels and Could be Used As a Prognosis Biomarker

    Amalia Lamana1, Iria Valino-Seoane2, Luis Rodriguez-Rodriguez3, Javier Leceta2, Yasmina Juarranz2, Ana M. Ortiz Garcia1, Carmen Martinez-Mora4, Benjamín Fernández-Gutiérrez3, Isidoro González-Alvaro5, Rosa P Gomariz2 and Rosario Garcia-Vicuña5, 1Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, 2Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, 3Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 4Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, 5Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain

    Background/Purpose: VIP has shown immunoregulatory properties in assays performed with human or murine cells. VIP has demonstrated a therapeutic effect in a murine model of…
  • Abstract Number: 1137 • 2014 ACR/ARHP Annual Meeting

    Multiway Transcriptomic Analysis of Monocyte-Derived Dendritic Cells Discriminates Effects of Disease and of HLA-B27 in Spondyloarthritis

    Emmanuel Chaplais1, Alice Talpin2, Félicie Costantino1, Clémence Desjardin1, Nelly Bonilla2, Ariane Leboime3, Roula Said Nahal4, Franck Letourneur2, Jacques Sébastien2, Gilles Chiocchia5, Maxime Breban1 and Henri-Jean Garchon1, 1INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, 2INSERM U1016, Cochin Institute, Paris, France, 3Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, 4Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, 5Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France

    Background/Purpose Spondyloarthritis (SpA) etiology is largely multifactorial with a genetic component dominated by the long-known strong association with the HLA-B27 allele. This allele, however, is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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