Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Cardiovascular diseases are important contributors to the excess of overall morbidity and mortality in patients with rheumatoid arthritis (RA). The aim of this study is to investigate the effects of RA on cardiac remodeling in patients with acute coronary syndrome (ACS)
Methods: Sixty-one patients with ACS complicated with RA and 55 age- and sex-matched patients with ACS having no RA (controls) were enrolled; General parameters and cardiovascular risk factors were compared in 2 groups. Echocardiogram measurements were used to determine the changes of cardiac morphology and function.
Results: Mean value of BMI in patients of ACS+RA group (27.50±3.53) was significantly higher than that of the controls (24.84±2.36) (P<0.05). No difference was observed in the levels of serum TG, TC and LDL-C, but HDL levels were significantly lower in ACS+RA patients (0.91±0.20 mmol/L) than that in controls(1.10±0.23mmol/L) (P<0.05). Serum HCY (17.27±4.71 mmol/L) ,CRP levels(9.84±5.50 mg/L) and ESR (28.35±15.87 mm/1h) were significantly higher in patients in the ACS+RA group than controls (13.16±4.23 mmol/L,P<0.05), (4.21±3.25 mg/L, P<0.01), (9.33±3.88 mm/1h, P<0.01) respectively. The BNP levels in patients of ACS+RA group (386.31±225.88 pg/ml) was significantly higher than the control group (258.43±136.97 pg/ml),(P<0.05). Rate of left ventricular (LV)hypertrophy (50.8%), and LV diastolic dysfunction (E/A<1) (96.7%) were significantly higher in the ACS+RA group(29.1%, P<0.05), (61.6%),(P<0.01). While the LV ejection fraction % were significantly lower (54.86±12.12% Vs 63.83±5.61%), (P<0.05). Incidence of tricuspid regurgitation (45.9%) and pulmonary valve regurgitation (9.8%) were significantly higher in ACS patients complicated with RA than that in control (12.7%, P<0.01) (0%P<0.05). Comparison of aortic and mitral regurgitation between the two groups had no statistical significance.
Conclusion: with ACS complicated with RA are more likely to be afflicted with left ventricular remodeling, reduction of systolic and diastolic functions, and cardiac valve impairment.
To cite this abstract in AMA style:Pan LL, Wang T. Cardiac Morphology and Function in Patients with Acute Coronary Syndrome Complicated with Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/cardiac-morphology-and-function-in-patients-with-acute-coronary-syndrome-complicated-with-rheumatoid-arthritis/. Accessed April 9, 2020.
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