ACR Meeting Abstracts

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  • Abstract Number: 1674 • 2014 ACR/ARHP Annual Meeting

    Long-Term Efficacy of Rituximab in Systemic Sclerosis

    Javier Narváez1, Juan Jose Alegre Sancho2, Ivan Castellvi3, Susana Herrera4, Maria Molina Molina5, Diego Castillo6, Isabel de la Morena Barrio2, Montserrat Robustillo Villarino2, Angels Martínez Ferrer2, Desamparados Ybañez García2, Elia Valls Pascual2, Josep Maria LLobet3, Francisca Gil Latorre4 and Joan Miquel Nolla7, 1Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 2Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, 3Rheumatology, Hospital de Sant Pau, Barcelona, Spain, 4Hospital Universitario Dr Peset, Valencia, Spain, 5Pneumology, Hospital Universitario de Bellvitge, Barcelona, Spain, 6Pneumology, Hospital de Sant Pau, Barcelona, Spain, 7Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: It has been proved in several studies with a small number of patients that Rituximab (RTX) can prevent worsening of interstitial lung disease (ILD)…
  • Abstract Number: 1673 • 2014 ACR/ARHP Annual Meeting

    Disease Specific Quality of Life in Patients with Lupus Nephritis

    Chi Chiu Mok1, Sergio Toloza2, Berna Goker3, Ann E. Clarke4, S. Navarra5, Daniel J. Wallace6, Michael H. Weisman7 and Meenakshi Jolly8, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Hospital San Juan Bautista, San Fernando del Valle de Catamarca, Argentina, 3Department of Internal Medicine- Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 4Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 5University of Santo Tomas Hospital, Manila, Philippines, 6Rheumatology, Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, 7Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 8Rheumatology, Rush University Medical Center, Chicago, IL

      ACR-LN     Active LN       No Yes P value No Yes P value Age (yrs) 42.8 (13.6) 40.3 (13.1) 0.002 41.1…
  • Abstract Number: 1672 • 2014 ACR/ARHP Annual Meeting

    Facilitating the Medication Decision-Making process—What Do Patients with Lupus Nephritis Say?

    Ricahrd Shewchuk1, Haiyan Qu2, W. Winn Chatham2, Jinoos Yazdany3, Maria Dall'era4 and Jasvinder A. Singh5, 1University fo Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of California, San Francisco, San Francisco, CA, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5University of Alabama and VA Medical Center, Birmingham, AL

    Background/Purpose: Low medication adherence in lupus nephritis puts patients at risk for poor outcomes, but to our knowledge, relatively little is known about what patients…
  • Abstract Number: 1671 • 2014 ACR/ARHP Annual Meeting

    Renal Relapses Are Common in Lupus Nephritis

    Angela Pakozdi1, Ravindra Rajakariar2, Michael Sheaff3 and Dev Pyne1, 1Rheumatology, Barts Health NHS Trust, London, United Kingdom, 2Renal Medicine, Barts Health NHS Trust, London, United Kingdom, 3Histopathology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose Renal relapses are part of the natural history of lupus nephritis (LN) and represent a significant challenge not only because they are associated with…
  • Abstract Number: 1670 • 2014 ACR/ARHP Annual Meeting

    Characterization of Patients with Lupus Nephritis Included in a Large Cohort from the Spanish Society of Rheumatology Registry of Patients with Systemic Lupus Erythematosus

    María Galindo Izquierdo1, Esther Rodriguez-Almaraz1, Sabina Perez2, José M. Pego-Reigosa3, Jaime Calvo-Alen4, Francisco Javier López-Longo5, Iñigo Rúa-Figueroa6, Alejandro Olivé7, Víctor Martínez Taboada8, Paloma Vela Casasempere9, Mercedes Freire10, Javier Narváez11, Antonio Fernandez Nebro12, Jose Rosas13, Monica Ibanez Barcelo14, Esther Uriarte15, Eva Tomero16, Antonio Zea17, Maria Loreto Horcada18, Vicente Torrente19, Ivan Castellvi20, Joan Calvet21, Raúl Menor Almagro22, Mª Angeles Aguirre23, Enrique Raya24, Elvira Diez Alvarez25, Tomás Vázquez Rodríguez26, Paloma García de la Peña27, Atusa Movasat28, José Luis Andreu29, Patricia Richi30, Carlos Marras Fernandez-Cid31, Carlos Alberto Montilla Morales32, Blanca Hernández-Cruz33, José Luis Marenco de la Fuente34, Marian Gantes35, Eduardo Ucar36, Juan J. Alegre37, Javier Manero38, Jesús Ibañez Ruán39, Manuel Rodríguez-Gómez40, Victor Quevedo41, José Hernández Beiraín42 and Lucía Silva Fernández43, 1Department of Rheumatology. Hospital Universitario 12 de Octubre, Madrid, Spain, 2Sociedad Española de Reumatología, Research Unit,, Madrid, Spain, 3Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain, 4Rheumatology Division, Sierrallana Hospital, Torrelavega, Spain, 5Rheumatology, Hospital Gregorio Marañon, Rheumatology, Hospital Gregorio Marañon, Madrid, Spain, 6Rheumatology, Hospital Doctor Negrin, Las Palmas de Gran Canaria, Spain, 7Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 8Rheumatology, Marqués de Valdecilla, Santander, Spain, 9Hospital General de Alicante, Alicante, Spain, 10Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain, 11Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, 12Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, 13Rheumatology, Hospital Marina Baixa. Villajoyosa, Villajoyosa, Spain, 14H. Son Llatzer, Palma de Mallorca, Spain, 15Rheumatology, Hospital de Donosti, San Sebastian, Spain, 16Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 17Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, 18Rheumatology, Complejo Hospitalario de Navarra, Pamplona, Spain, 19Rheumatology, Hospital Moisès Broggi, Barcelona, Spain, 20Unitat de Reumatologia., Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 21Hospital Parc Taulí, Barcelona, Spain, 22Rheumatology, Hospital de Jerez, Jerez de la Frontera, Spain, 23Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, 24Rheumatology, University Hospital San Cecilio, Granada, Spain, 25Rheumatology, Leon Hospital, Leon, Spain, 26Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 27Rheumatology, Hospital Norte Sanchinarro, Madrid, Spain, 28Hospital Príncipe de Asturias, Immune System Diseases/Rheumatology department, Alcalá de Henares, Madrid, Spain, 29Rheumatology, Hospital Puerta de Hierro, Madrid, Spain, 30Hospital Infanta Sofía, Madrid, Spain, 31C/ Salvia 11, H. Arrixaca, Alicante, Spain, 32Rheumatology Department, Hospital Virgen de la Vega, Salamanca, Spain, 33Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, 34Hospital de Valme. Sevilla, Sevilla, Spain, 35Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, 36Hospital de Basurto, Rheumatology, Bilbao, Spain, 37Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, 38Ophthalmology and Rheumatology. Hospital Miguel Servet Zaragoza, Spain, Zaragoza, Spain, 39POVISA, Rheumatology, Vigo, Spain, 40Rheumatology, Complejo Hospitalario Universitario de Ourense, Ourense, Spain, 41Rheumatology, Hospital de Monforte, Lugo, Spain, 42Rheumatology, Hospital Insular de Gran Canaria, Las palmas Gran Canarias, Spain, 43Rheumatology, Hospital Universitario de Guadalajara, Guadalajara, Spain

    Background/Purpose To describe the profile of patients included in RELESSER with histologically confirmed lupus nephritis (LN). Methods RELESSER is a multicentre cross-sectional study, with information…
  • Abstract Number: 1669 • 2014 ACR/ARHP Annual Meeting

    Validation of a Machine Learning Lupus Nephritis Decision Support Tool to Predict Complete Response to Therapy

    Bethany Wolf1, John Christian Spainhour1, John Arthur2, Michael Janech2, Michelle Petri3, Adnan Kiani4 and Jim Oates5,6, 1Public Health Sciences, Medical University of South Carolina, Charleston, SC, 2Medicine, Medical University of South Carolina, Charleston, SC, 3Johns Hopkins University School of Medicine, Baltimore, MD, 41830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, 5Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 6Medical Service, Ralph H. Johnson VAMC, Charleston, SC

    Background/Purpose .The American College of Rheumatology treatment guidelines for lupus nephritis (LN) recommend that induction therapy be changed when response to therapy has not occurred…
  • Abstract Number: 1668 • 2014 ACR/ARHP Annual Meeting

    Identifying Patient Perceptions of Medication Decision Making Barriers in Minorities with Lupus Nephritis

    Jasvinder A. Singh1, Haiyan Qu2, Jinoos Yazdany3, W. Winn Chatham2, Maria Dall'era4 and Ricahrd Shewchuk5, 1University of Alabama and VA Medical Center, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Medicine, University of California, San Francisco, San Francisco, CA, 4Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5University fo Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Studies suggest that adherence to medications for lupus nephritis is low.  However, there are limited data available on the barriers that patients with lupus…
  • Abstract Number: 1667 • 2014 ACR/ARHP Annual Meeting

    Probability of 3 and 6 Month Complete Response in Lupus Nephritis

    Homa Timlin1, Michelle Petri1 and Laurence S Magder2, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Lupus nephritis is a major cause of morbidity and mortality. The complete response rate is the most sensitive in detecting differences among therapeutic regimens.…
  • Abstract Number: 1666 • 2014 ACR/ARHP Annual Meeting

    The Relevance of Urinary Podocyte Number and Urinary Podocalyxin Level with Response to Treatment and 1 Year Renal Prognosis in Systemic Lupus Erythematosus

    Hiroshi Kajiyama1, Keiju Hiromura2, Daisuke Ikuma1, Hidekazu Ikeuchi2, Hiroyuki Kurosawa3, Yoshiaki Hirayama3, Fumio Gondaira3, Masanori Hara4, Yoshihisa Nojima2 and Toshihide Mimura5, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 2Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, 3Department of reagent research and development, Denka Seiken Co. Ltd., Niigata, Japan, 4Department of Pediatrics, Yoshida Hospital, Niigata, Japan, 5Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose Podocytes are glomerular visceral epithelial cells, whose number decrease due to death and/or detachment from capillary wall leads to severe proteinuria and end stage…
  • Abstract Number: 1665 • 2014 ACR/ARHP Annual Meeting

    Efficacy Versus Safety of Prednisone in Lupus Nephritis Since 1988

    Tanmayee Bichile1, Laurence S Magder2 and Michelle Petri3, 1Rehumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose Morbidity and damage due to prednisone use in the treatment of SLE is recognized, but prednisone has been a requisite of lupus nephritis induction…
  • Abstract Number: 1664 • 2014 ACR/ARHP Annual Meeting

    Novel Risk Factors for Systemic Lupus Erythematosus (SLE) Flares in Patients with End-Stage Renal Disease: Is SLE in Patients with End-Stage Renal Disease a “sleeping beauty”?

    Jorge Alcocer-Varela1, Mariana Quintanar2, Javier Merayo-Chalico3, Ana Barrera-Vargas1 and Diana Gómez-Martín1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose Renal involvement in systemic lupus erythematosus (SLE) is frequent, and a high percentage of patients (~15%) develop end-stage renal disease (ESRD) even with optimal…
  • Abstract Number: 1663 • 2014 ACR/ARHP Annual Meeting

    Influence of Ethnicity on Efficacy of Current Immunosuppressive Protocols in Proliferative Lupus Nephritis

    Angela Pakozdi1, Ravindra Rajakariar2, Michael Sheaff3 and Dev Pyne1, 1Rheumatology, Barts Health NHS Trust, London, United Kingdom, 2Renal Medicine, Barts Health NHS Trust, London, United Kingdom, 3Histopathology, Barts Health NHS Trust, London, United Kingdom

    Background/Purpose  Lupus nephritis (LN) is a major complication of systemic lupus erythematous (SLE) and prevalence is estimated to be 50-60%. Recently, variable responses to induction…
  • Abstract Number: 1682 • 2014 ACR/ARHP Annual Meeting

    Mycophenolate Mofetil Versus Azathioprine in Scleroderma-Associated Interstitial Lung Disease: Results from the Australian Scleroderma Cohort Study

    Claire Owen1, Gene Ngian2, Kathleen Elford2, Owen Moore3, Mandy Nikpour3, Wendy Stevens3, Susanna Proudman4, Janet Roddy5, Jane Zochling6, Catherine Hill7, Peter Nash8, Allan Sturgess9 and Joanne Sahhar2, 1Rheumatology, Monash Health, Melbourne, Australia, 2Monash Health, Melbourne, Australia, 3St Vincent's Hospital, Melbourne, Australia, 4Royal Adelaide Hospital, Adelaide, Australia, 5Royal Perth Hospital, Perth, Australia, 6Department of Rheumatology, Menzies Research Institute Tasmania, Hobart, TAS, Australia, 7Queen Elizabeth Hospital, Adelaide, Australia, 8Sunshine Coast Rheumatology, Maroochydore, Australia, 9The St George Hospital, Sydney, Australia

    Background/Purpose: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is common and when progressive, associated with significant morbidity and mortality. Cyclophosphamide is frequently used as first line…
  • Abstract Number: 1681 • 2014 ACR/ARHP Annual Meeting

    Heart Transplantation in 6 Patients with Systemic Sclerosis and a Primary Cardiac Involvement

    Alena Ikic1, Emmanuel Chatelus2, Eric Epailly3, Hélène Kremer3, Jean Sibilia2, Jacques Gottenberg4, Sabine Pattier5, Erwan Flecher6, Céline Goeminne7 and Thierry Martin1, 1Strasbourg University Hospital, Strasbourg, France, 2Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 3Cardiology, Strasbourg University Hospital, Strasbourg, France, 4Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Cardiology, Nantes University Hospital, Nantes, France, 6Cardiac Surgey, Rennes University Hospital, Rennes, France, 7Cardiology, Lille University Hospital, Lille, France

    Background/Purpose: There is no specific treatment for primary cardiac involvement in SSc. Even if heart transplantation is an option, only 1 case have been reported1.…
  • Abstract Number: 1680 • 2014 ACR/ARHP Annual Meeting

    an Indirect Comparisons Analysis of Medications Used for Treatment of Raynaud’s Phenomenon

    Sampath Manickam1, Elie Donath2, Sandeep Dayanand3 and Jonathan Greer4, 1University of Miami Palm Beach Internal Medicine, West Palm Beach, FL, 2Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, FL, 3University of Miami Palm Beach Internal medicine, West palm beach, FL, 4Arthritis & Rheumatology Associates, Boynton Beach, FL

    An Indirect Comparisons Analysis of Medications used for treatment of Raynaud’s phenomenonBackground/Purpose: There are several pharmacological treatments used for treatment of Raynaud’s phenomenon: calcium channel…
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