ACR Meeting Abstracts

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  • Abstract Number: 1699 • 2014 ACR/ARHP Annual Meeting

    Endothelial and Platelet Microparticles As Potential Novel Biomarkers of Peripheral Microvascular Dysfunction in Systemic Sclerosis and Primary Raynaud’s Phenomenon

    John D. Pauling1,2, Daniel Moreno-Martinez3, Fiona Wilkinson4, Ben Parker5,6, Jacqueline A. Shipley1, Darren Hart1, Neil J McHugh1,2 and Yvonne Alexander3, 1Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 3Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 4School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, 5Institute of Inflammation and Repair School of Translation Medicine The University of Manchester, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 6Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). MPs form during cell activation…
  • Abstract Number: 1700 • 2014 ACR/ARHP Annual Meeting

    Laser Speckle Contrast Analysis in the Follow-up of Digital Ulcers in Systemic Sclerosis Patients

    Barbara Ruaro, Alberto Sulli, Teresa Cannavale, Marco Amedeo Cimmino, Carmen Pizzorni, Sabrina Paolino and Maurizio Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy

    Background/Purpose .  Typical clinical aspects of systemic sclerosis (SSc) include microvascular damage and reduction of peripheral blood perfusion, resulting in increased incidence of digital ulcers…
  • Abstract Number: 1701 • 2014 ACR/ARHP Annual Meeting

    Short-Term Effects of Iloprost on Micro-Vessels Hemodynamics in Systemic Sclerosis Patients Evaluated By Laser Doppler Flowmetry

    Florenzo Iannone, Cinzia Rotondo, Mariangela Nivuori, Emanuela Praino, Laura Coladonato, Michele Covelli and Giovanni Lapadula, DIM, Rheumatology Unit, Bari, Italy

    Background/Purpose Iloprost is a milestone in the treatment of Raynaud’s Phenomenon (RP). However, it has transient hemodynamic effects due to a very short half-time, thereby…
  • Abstract Number: 1702 • 2014 ACR/ARHP Annual Meeting

    Antiphospholipid Antibodies in Systemic Sclerosis: Prevalence and Clinical Significance?

    Anjali Shetty1, Suncica Volkov1, Claudia Vergara2 and William Swedler3, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Rheumatology, University of Illinois Chicago, Chicago, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by collagen deposition and vascular changes of the skin and internal organs, leading ultimately to fibrosis.  …
  • Abstract Number: 1698 • 2014 ACR/ARHP Annual Meeting

    Peripheral Blood Eosinophil Counts Increase in Patients with Systemic Sclerosis and Associated with Its Disease Severity

    Tamao Nakashita1, Shinji Motojima2, Katsutoshi Ando3 and Akira Dibatake4, 1Department of Rheumatology and Allergy, Kameda Medical Center, Kamogawa City, Japan, 2[email protected], Kameda Medical Center, Kamogawa City, Japan, 3Depertment of Respiratoly Medicine, Juntendo university, tokyo, Japan, 4Rheumatology and Allergy, Kameda Medical Center, Kamogawa city, Japan

    Background/Purpose : Increased levels of serum pro-fibrotic cytokines such as IL-4 and IL-13 and plasma CXCL4 have been previously reported in patients with systemic sclerosis…
  • Abstract Number: 1697 • 2014 ACR/ARHP Annual Meeting

    High Frequency Skin Ultrasound Detects Subclinical Diffuse Dermal Involvement in Patients with Limited Cutaneous Systemic Sclerosis

    Alberto Sulli, Barbara Ruaro, Carmen Pizzorni, Giorgia Ferrari, Elena Bernero, Sabrina Paolino and Maurizio Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy

    Background/Purpose .  The modified Rodnan’s skin score (mRSS) is the validated method to detect both severity and extension of skin involvement, and high frequency skin…
  • Abstract Number: 1696 • 2014 ACR/ARHP Annual Meeting

    Left Atrial Area Measurement Is Useful for Evaluating Left Ventricular Diastolic Dysfunction Coexisting with Pulmonary Arterial Hypertension Associated with Systemic Sclerosis

    Sumiaki Tanaka1, Nobuhiro Sho2, Tatsuo Nagai3, Yoshiyuki Arinuma2 and Shunsei Hirohata1, 1Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, 2Kitasato University School of Medicine, Sagamihara, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a crucial organ involvement affecting survival of patients with connective tissue disease (CTDs), such as systemic sclerosis (SSc), systemic…
  • Abstract Number: 1695 • 2014 ACR/ARHP Annual Meeting

    Validation of Vesmeter As a Diagnostic Tool of Scleroderma

    Yoshihiro Hishitani1,2, Yoshihito Shima1, Toshio Tanaka1 and Atsushi Kumanogoh1, 1Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Japan, 2Internal Medicine, Kinki Central Hospital, Itami, Japan

    Background/Purpose: Objective method to evaluate the skin involvement in the patients with scleroderma has not been definitely established. We have developed Vesmeter, a computer-linked device…
  • Abstract Number: 1694 • 2014 ACR/ARHP Annual Meeting

    a Feasibility Study of Subjective and Objective Assessment of Sublingual Abnormalities in Systemic Sclerosis

    Tracy M. Frech1, John Pauling2, Maureen Murtaugh3, Lee S. Shapiro4, Bernard Choi5, Ryan Farraro5 and Robyn T. Domsic6, 1Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, 2Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom, 3Internal Medicine-Division of Epidemiology, University of Utah School of Medicine, SLC, UT, 4The Center for Rheumatology, Albany, NY, 5University of Irvine, Irvine, CA, 6Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Sublingual frenulum abnormalities are reported in systemic sclerosis (SSc), but the exact nature and clinical relevance of such abnormalities is unknown.  Laser speckle contrast…
  • Abstract Number: 1693 • 2014 ACR/ARHP Annual Meeting

    Progressive Disease in Systemic Sclerosis after One Year of Follow-up;  Results of a Standardized Multidisciplinary Health Care Program

    Jessica Meijs1, Anne Schouffoer2, Nina Ajmone Marsan3, Lucia Kroft4, Maarten K. Ninaber5, T.W.J. Huizinga1 and Jeska K. De Vries-Bouwstra1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Cardiology, Leiden University Medical Center, Leiden, Netherlands, 4Deparment of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Pulmonology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The aim of this study is to evaluate disease course of systemic sclerosis (SSc) patients participating in a single centre multidisciplinary health-care program over…
  • Abstract Number: 1692 • 2014 ACR/ARHP Annual Meeting

    The Additive Value of Nailfold Videocapillaroscopy Patterns to Disease-Specific Autoantibodies in Discrimination of Patients with Systemic Sclerosis at Risk for Severe Organ Involvement

    I.M. Markusse1, J. Meijs2, B. de Boer2, A. a. Schouffoer1, N. Ajmone Marsan3, L. J. M. Kroft4, M. K. Ninaber5, T. W. J. Huizinga2 and J.K. de Vries-Bouwstra6, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Cardiology, Leiden University Medical Center, Leiden, Netherlands, 4Deparment of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5Pulmonology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Severe nailfold videocapillaroscopy (NVC) patterns in patients with systemic sclerosis (SSc) are associated with a high risk of organ involvement. SSc-specific autoantibodies seem to…
  • Abstract Number: 1691 • 2014 ACR/ARHP Annual Meeting

    Systemic Sclerosis Patients with Pulmonary Hypertension Have a Lower Change in End Tidal Carbon Dioxide Following Three Minutes of Step Exercise Than Systemic Sclerosis Patients without Pulmonary Hypertension: A Cross-Sectional Study

    Elana J. Bernstein1, Jessica K. Gordon2, Robert F. Spiera2, Wei-Ti Huang3, Evelyn M. Horn4 and Lisa A. Mandl2, 1Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Biostatistics, Hospital for Special Surgery, New York, NY, 4Cardiology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY

    Background/Purpose: Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc).  Transthoracic echocardiogram and pulmonary function testing are standard noninvasive…
  • Abstract Number: 1689 • 2014 ACR/ARHP Annual Meeting

    Microhaemorrages and Giant Capillaries in Nailfold  Videocapillariscopies Are Able to Accurately Predict Disease Activity Level in Systemic Sclerosis

    Domenico Sambataro1, Nicoletta Del Papa1, Gianluca Sambataro2, Wanda Maglione2, Eleonora Zaccara2 and Claudio Vitali3, 1Rheumatology Unit, Istituto G.Pini, Milan, Italy, 2U.O.C. Day Hospital Reumatologia, Osp. G. Pini, Milano, Italy, 3Sezione Reumatologia, Istituto San Giuseppe, Lecco, Italy

    Background/Purpose Systemic Sclerosis (SSc) is a connective tissue disease characterized by Raynaud’s phenomenon, skin fibrosis and involvement of internal organs such as lung, heart, bowel,…
  • Abstract Number: 1676 • 2014 ACR/ARHP Annual Meeting

    Physical Therapy for Systemic Sclerosis: Systematic Review and Meta-Analysis

    Madhavi Peddi1, Maria A. Lopez-Olivo2, Prashanth Peddi1, Gisela Espinosa Cuervo3 and Maria E. Suarez-Almazor4, 1Good Shepherd Medical Center, The University of Tyler Texas, Tyler, TX, 2Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Instituto Mexicano del Seguro Social, Mexico City, Mexico, 4The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose Physical therapy and rehabilitation are often recommended to improve function in patients with systemic sclerosis (SSc), but a systematic review of the evidence supporting…
  • Abstract Number: 1675 • 2014 ACR/ARHP Annual Meeting

    Regional Implantation of Adipose Tissue-Derived Cells Induces a Prompt Healing of Long-Lasting Indolent Digital Ulcers in Patients with Systemic Sclerosis

    Nicoletta Del Papa1, Gabriele Di Luca2, Domenico Sambataro1,3, Eleonora Zaccara4, Wanda Maglione4, Armando Gabrielli5, Paolo Fraticelli6, Gianluca Moroncini5, Lorenzo Beretta7,8, Alessandro Santaniello9 and Claudio Vitali10, 1Rheumatology Unit, Istituto G.Pini, Milan, Italy, 2UOS Chirurgia Vascolare,, Osp. G. Pini, Milano, Italy, 3UOC Day Hospital Reumatologia,, G. Pini Hospital, Milano, Italy, 4U.O.C. Day Hospital Reumatologia, Osp. G. Pini, Milano, Italy, 5Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, 6Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, 7Via Francesco Sforza 28, Ospedale Maggiore Policlinico, Milano, Italy, 8Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 9Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 10Sezione Reumatologia, Istituto San Giuseppe, Lecco, Italy

    Background/Purpose Fingertip digital ulcers (DUs) are a rather frequent and invalidating complication in the course of systemic sclerosis (SSc), often showing a very slow or…
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