ACR Meeting Abstracts

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  • Abstract Number: 1703 • 2014 ACR/ARHP Annual Meeting

    An Association of Anti-PM/Scl Antibody Reactivity with Risk of Malignancy in Scleroderma

    Cosimo Bruni1, Ana Lages2, Hitesh Patel3, Jennifer Harvey3, Voon H. Ong4, Marco Matucci-Cerinic1, Emma C. Derrett-Smith5 and Christopher P Denton6, 1Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 2Affiliation servicio de Medicina Interna, Hospital De Braga, Braga, Portugal, 3Department of Clinical Immunology, Royal Free Hospital, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, 6Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom

    Association of anti-PM/Scl antibody with risk of malignancy in scleroderma. C. Bruni¹, A. Lages², H. Patel3, J. Harvey3, V. Ong4, M. Matucci-Cerinic¹, E. Derrett-Smith4, C.P.…
  • Abstract Number: 1704 • 2014 ACR/ARHP Annual Meeting

    CXCL4 Promotes Fibrosis By Increasing Expression of Extracellular Matrix Modifying Factors and By Facilitating Epithelial/Endothelial Mesenchymal Transition

    W. Marut1, A.J. Affandi1, A. Limpers1 and T.R.D.J. Radstake2, 1Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose Systemic sclerosis (SSc) is a degenerative disorder, characterized by vascular abnormalities and immunological disturbances followed by excessive fibrosis in multiple organ systems. In a…
  • Abstract Number: 1723 • 2014 ACR/ARHP Annual Meeting

    Identification of the Microbiome As a Potential Trigger of Systemic Sclerosis By Metagenomic RNA-Sequencing of Skin Biopsies

    Michael Johnson1, Zhenghui Li1, Michelle Dimon2, Tammara A. Wood1, Robert Lafyatis3, Sarah Arron2 and Michael Whitfield4, 1Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Dermatology, University of California, San Francisco, San Francisco, CA, 3Arthritis Center, Boston University, Boston, MA, 4Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose:    Systemic sclerosis (SSc) is a rare and poorly understood systemic autoimmune disease that results in skin fibrosis and severe internal organ involvement. There…
  • Abstract Number: 1722 • 2014 ACR/ARHP Annual Meeting

    TLR4 and TLR7 Are Required for Gadolinium Based Contrast Agent Induction of Dermal and Pulmonary Fibrosis in an Adenine-Induced Model of Chronic Renal Failure

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose : Nephrogenic Systemic Fibrosis (NSF) is a generalized progressive fibrotic disorder that occurs in some patients with renal insufficiency exposed to various gadolinium based…
  • Abstract Number: 1721 • 2014 ACR/ARHP Annual Meeting

    Investigating the SCF/c-Kit Pathway in Scleroderma Fibrosis

    Bahja Ahmed Abdi1, Oseme Etomi2, Xu Shiwen1, David Abraham3, Christopher Denton3 and Richard J. Stratton1, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Rheumatology, UCL Medical School, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom

    Background/Purpose: Stem cell factor (SCF) is a potential driving factor in the development of systemic sclerosis (SSc) and a possible therapeutic target. SCF is a…
  • Abstract Number: 1720 • 2014 ACR/ARHP Annual Meeting

    GATA6 Deficiency Activates UPR Pathways in Endothelial Cells during the Development of Pulmonary Arterial Hypertension

    Rong Han1, Rosanne Van Deuren2, Stefania Lenna1, Izabela Chrobak1, Timothy Radstake3, Carol Feghali-Bostwick4 and Maria Trojanowska1, 1Arthritis Center, Boston University, Boston, MA, 2Rheumatology Department, University Medical Center Nijmegen, Nijmegen, Netherlands, 3University Medical Center Utrecht, Utrecht, Netherlands, 4Medical University of South Carolina, Charleston, SC

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a severe lung complication of systemic sclerosis (SSc), and accounts for a large proportion of SSc-related deaths. As a…
  • Abstract Number: 1719 • 2014 ACR/ARHP Annual Meeting

    Periostin May Promote Productin of Extracellular Matrix By Modulating TGF-β Signaling in Human Skin Fibroblasts

    Yukie Yamaguchi1, Noriko Koumitsu1, Kazuhiko Arima2, Kenji Izuhara2 and Michiko Aihara3, 1Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, 3Department of Environmental-immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Systemic sclerosis (SSc) results in significant morbidity and mortality due to organ fibrosis characterized by increased deposition of extracellular matrix (ECM). Periostin is one…
  • Abstract Number: 1718 • 2014 ACR/ARHP Annual Meeting

    B Cell Subsets Homeostasis and Functional Properties Are Altered in a Murine Model of Systemic Sclerosis

    Sébastien Sanges1,2,3, Niloufar Kavian4, Carine Hauspie1,3,5, Carole Nicco4, Thomas Guerrier1,3, Virginie Dutoit-Lefèvre1,3, Guillaume Lefèvre1,2,5,6, Alexandra Forestier1,2,3, Vincent Sobanski1,2,6, Christelle Faveeuw7, Myriam Labalette1,3,5, Frédéric Batteux4, David Launay1,2,3 and Sylvain Dubucquoi1,3,5, 1Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, 2Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, 3EA 2686, Lille, Lille, France, 4Université Paris Descartes, EA 1833, Hôpital Cochin, AP-HP, Paris, Paris, France, 5Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, 6EA 2686, Lille, LILLE, France, 7Institut National de la Santé et de la Recherche Médicale Unité 547, Institut Pasteur de Lille, Institut Fédératif de Recherche 142, Université de Lille Nord de France, Lille, France

    Background/Purpose Systemic sclerosis (SSc) is a multi-organ fibrotic disease associated with auto-immune abnormalities. Several clinical and experimental observations suggest that B cells are involved in…
  • Abstract Number: 1690 • 2014 ACR/ARHP Annual Meeting

    Improvement of Digital Ulcerative Disease in Patients with Systemic Sclerosis Is Associated with Better Functional Prognosis

    Patrick Carpentier1, Catherine Lok-Charles2, Pierre Clerson3, Virginie Gressin4, Eric Hachulla5, Alice Berezne6, Elizabeth Diot7, Aurelie Khau VAN Kien8, Patrick Jego9, Christian Agard10, Anne Bénédicte Duval Modeste11, Agnès Sparsa12, Eve Puzenat13, Marie-Aleth Richard14 and Luc Mouthon15, 1Vascular Medicine, La Tronche Hospital, Grenoble, France, 2Amiens University Hospital, Amiens, France, 3Orgametrie, Roubaix, France, 4Actelion France, Actelion France, Paris, France, 5Internal Medicine, National Scleroderma Centre, Lille CEDEX, France, 6Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, 7Department of Internal Medicine, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, Tours, France, Tours, France, 8Montpelier University Hospital, Department of Internal Medicine, Montpelier, France, 9Department of Internal Medicine, Rennes University Hospital, Rennes, France, 10Internal Medicine Department, Nantes University Hospital, Nantes, France, 11Rouen University Hospital - Clinical Dermatology, Rouen, France, 12Dupuytren Regional University Hospital-, Limoges, France, 13Besançon University Hospital, Besançon, France, 14Dermatology, Marseille, Paris, France, 15National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France

    Background/Purpose Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc) leading to hand disability. We investigated the impact of controlling the ulcerative…
  • Abstract Number: 1688 • 2014 ACR/ARHP Annual Meeting

    Early Detection of Left Ventricular Morphological, Functional Abnormalities and Myocardial Characteristics in Systemic Sclerosis without Cardiac Symptoms Using Cardiac Magnetic Resonance Imaging: A Preliminary Report

    Kaita Sugiyama1, Hitomi Kobayashi2, Yasuyuki Kobayashi3, Yosuke Nagasawa4, Natsumi Ikumi2, Takamasa Nozaki4, Hirotake Inomata2, Hidetaka Shiraiwa2, Hiromi Karasawa2, Noboru Kitamura4, Mitsuhiro Iwata4, Yoshihiro Matsukawa2 and Masami Takei4, 1Nihon University School of Medicine, Tokyo, Japan, 2Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 3Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, 4Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan

    Background/Purpose Systemic sclerosis (SSc) is associated with an increased prevalence of cardiac involvement despite often being clinically silent. Cardiac involvement is a major factor in…
  • Abstract Number: 1687 • 2014 ACR/ARHP Annual Meeting

    Key Role of Cardiac Biomarkers in the Assessment of Systemic Sclerosis: Contribution of High Sensitivity Cardiac Troponin

    Jerome Avouac1, Christophe Meune2, Camille Gobeaux3, Didier Borderie3, Guillaume Lefevre4, Andre Kahan5 and Yannick Allanore1, 1Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, 2Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, 3Paris Descartes University, Biochemistry A department, Cochin Hospital, Paris, France, 4Clinical Chemistry and Hormonology Department, Tenon Hospital, paris, France, 5Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France

    Background/Purpose: Microangiopathy is a cardinal feature of systemic sclerosis (SSc), which plays a critical role in the development of primary myocardial involvement and pulmonary hypertension,…
  • Abstract Number: 1686 • 2014 ACR/ARHP Annual Meeting

    DUAL Energy Computed Tomography for the Evaluation of Calcinosis in Systemic Sclerosis

    Vivien Hsu1, Mark Bramwit2 and Naomi Schlesinger3, 1Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, 2Radiology, Robert Wood Johnson University Hospital, New Brunswick, NJ, 3Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ

    Background/Purpose: To better characterize the soft tissue details of systemic sclerosis--related (SSc) calcinosis of the hands using dual-energy computer tomography (DECT). DECT is an imaging…
  • Abstract Number: 1685 • 2014 ACR/ARHP Annual Meeting

    Effects of Mycophenolate Mofetil on Pulmonary Lung Function in Interstitial Lung Disease of Systemic Sclerosis

    Michael Pham1 and W Leroy Griffing2, 1Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ, 2Division of Rheumatology, Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose:  Interstitial lung disease remains a primary driver of morbidity and mortality in patients suffering from systemic sclerosis.  Cyclophosphamide currently is the treatment with the…
  • Abstract Number: 1684 • 2014 ACR/ARHP Annual Meeting

    Treatment of Scleroderma Associated Lung Disease with Mycophenolate Mofetil: A Community-Based Study

    Audrey Bearden1, Kent Kwasind Huston2 and Judy Foxworth3, 1Internal Medicine, University of Missouri-Kansas City, Kansas City, MO, 2Rheumatology, The Center for Rheumatic Disease, Kansas City, MO, 3Associate Program Director & Director of Research, The University of Missouri-Kansas City, Kansas City, MO

    Background/Purpose:  Interstitial lung disease occurs in over 80% of patients with scleroderma. Cyclophosphamide is the only treatment proven to benefit scleroderma lung disease in a…
  • Abstract Number: 1683 • 2014 ACR/ARHP Annual Meeting

    Botulinum Toxin-a for the Treatment of Severe Raynaud Phenomenon

    Lucía Ruiz Gutiérrez1, Ana Pérez Gómez1, Nuria Valdeolivas Casillas2, Henry Moruno Cruz1, Eduardo Cuende Quintana1, Ana Sánchez Atrio1, Ana Turrión Nieves1, Atusa Movasat1, Cristina Bohórquez Heras1, Fernando Albarrán Hernández1, Maria Liz Romero Bogado1, Susana Medina Montalvo2 and Melchor Álvarez de Mon1, 1Hospital Príncipe de Asturias, Immune System Diseases/Rheumatology department, Alcalá de Henares, Madrid, Spain, 2Hospital Príncipe de Asturias, Dermatology department, Alcalá de Henares, Madrid, Spain

    Background/Purpose Raynaud's phenomenon (RP) is characterized by transient episodes of vasoconstriction of the arteries and arterioles of the extremities in response to cold or emotional…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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