Abstracts Archive - Page 1936 of 2607 - ACR Meeting Abstracts

Abstract Number: 974 • 2015 ACR/ARHP Annual Meeting
Secukinumab Significantly Improves Signs and Symptoms of Active Ankylosing Spondylitis: 52-Week Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial with Subcutaneous Loading and Maintenance Dosing
Juergen Braun¹, Atul A. Deodhar², Joachim Sieper³, Maxime Dougados⁴, Brian Porter⁵, Mats Andersson⁶ and Hanno Richards⁶, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Novartis Pharma AG, Basel, Switzerland
Background/Purpose: In MEASURE 2 (NCT01649375), subcutaneous (s.c.) secukinumab, an anti–interleukin-17A antibody, improved the signs and symptoms of ankylosing spondylitis (AS) through 16 weeks (wks) of…
Abstract Number: 975 • 2015 ACR/ARHP Annual Meeting
The Effect of TNF Inhibition on Radiographic Progression in Ankylosing Spondylitis: An Observational Cohort Study of 374 Patients
Walter Maksymowych¹, Yufei Zheng², Stephanie Wichuk¹, Sasha Bernatsky³, Praveena Chiowchanwisawakit⁴ and Robert G Lambert⁵, ¹Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ²Alberta Institute of Health Economics, Edmonton, AB, Canada, ³Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ⁴Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁵Radiology, Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: An analysis of radiographic progression in an observational cohort has suggested that anti-TNF therapy lessens radiographic progression, especially when treatment is introduced within 5…
Abstract Number: 976 • 2015 ACR/ARHP Annual Meeting
The Reason of Discontinuation of a First TNF Inhibitor Affects Drug Retention of a Second Anti-TNF Agent in Axial Spondyloarthritis
Adrian Ciurea¹, Pascale Exer², Ulrich Weber^3,4, Giorgio Tamborrini⁵, Beate Steininger¹, Rudolf O. Kissling⁶, Jürg Bernhard⁷ and Almut Scherer⁸, ¹Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Private rheumatology practice, Basel, Switzerland, ³Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁴Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ⁵Department of Rheumatology, University Hospital, Zurich, Switzerland, ⁶Division of Rheumatology, Balgrist University Hospital, Zurich, Switzerland, ⁷Rheumatology and Rehabilitation, Bürgerspital Solothurn, Solothurn, Switzerland, ⁸SCQM Foundation, Zurich, Switzerland
Background/Purpose: Conflicting results have been demonstrated in axial spondyloarthritis (axSpA) with regard to whether effectiveness of a second (2°) TNFi depends on the reason of…
Abstract Number: 977 • 2015 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Active- and Placebo-Controlled Phase 3 Study of Efficacy and Safety of Ixekizumab, Adalimumab, and Placebo Therapy in Patients Naïve to Biologic Disease Modifying Anti-Rheumatic Drugs with Active Psoriatic Arthritis
Philip J. Mease¹, Désirée van der Heijde², Christopher T. Ritchlin³, Raquel Cuchacovich^4,5, Catherine L. Shuler⁵, Chin H. Lee⁵, Suvajit Samanta⁵, Chen-Yen Lin⁵, Dafna D. Gladman⁶ and Harald Vangerow⁵, ¹Department of Rheumatology, Swedish Medical Center and University of Washington, Seattle, WA, ²Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴School of Medicine, Rheumatology Division, Indiana University, Indianapolis, IN, ⁵Eli Lilly and Company, Indianapolis, IN, ⁶Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease associated with psoriasis which includes peripheral arthritis, enthesitis, dactylitis, and spondylitis manifestations. Ixekizumab, under investigation…
Abstract Number: 978 • 2015 ACR/ARHP Annual Meeting
Continuous Versus on Demand Treatment of Ankylosing Spondylitis with Diclofenac over 2 Years Does Not Prevent Radiographic Progression of the Spine: Results from a Randomized Prospective Multi-Center Trial
Joachim Sieper¹, Joachim Listing², Denis Poddubnyy¹, In-Ho Song^1,3, Kay-Geert Hermann¹, Johanna Callhoff², Jürgen Braun⁴ and Martin Rudwaleit^1,5, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Abbvie, Chicago, IL, ⁴Rheumazentrum Ruhrgebiet, Herne, Germany, ⁵Klinikum Bielefeld, Bielefeld, Germany
Background/Purpose: Previously it was shown that non-steroidal antiinflammatory drugs (NSAIDs) given continuously reduce radiographic progression compared to an on demand therapy over 2 years in…
Abstract Number: 979 • 2015 ACR/ARHP Annual Meeting
HLA Class I Genes As Susceptibility Markers of Psoriatic Arthritis in Patients with Psoriasis – a Meta-Analysis
Lihi Eder¹, Fatima Abji², Cheryl Rosen³, Muhammad Haroon⁴, Vinod Chandran¹, Rubén Queiro⁵, Shelley Bull⁶, Richard J. Cook⁷, Proton Rahman⁸, Robert Winchester⁹, Oliver FitzGerald¹⁰ and Dafna D. Gladman¹, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Kerry General Hospital, Tralee, Ireland, ⁵Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁶School of Public Health, Mount Sinai Hospital, Toronto, ON, Canada, ⁷Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁸Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ⁹Columbia University, New York, NY, ¹⁰Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Genes that differentiate patients with psoriatic arthritis (PsA) from those with psoriasis alone may serve as markers for the development of PsA in psoriasis…
Abstract Number: 980 • 2015 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and ß1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung-Cheol Shim¹, In-Seol Yoo², Su-Jin Yoo¹, Young Kim¹, Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴ and Jinhyun Kim⁵, ¹Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Medicine, Eulji University Hospital, Daejeon, South Korea, ⁴Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁵Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 981 • 2015 ACR/ARHP Annual Meeting
Anti-IL-17A Treatment Blocks Inflammation, Destruction and New Bone Formation in Experimental Spondyloarthritis in HLA-B27 Transgenic Rats
Melissa van Tok^1,2, Leonie van Duivenvoorde^1,3, Ina Kramer⁴, Peter Ingold⁴, Joel Taurog⁵, Frank Kolbinger⁴ and Dominique Baeten^1,2, ¹Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ²Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Novartis Institutes for Biomedical Research, Basel, Switzerland, ⁵Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: The IL-17 axis has been identified as a crucial pathophysiological pathway in spondyloarthritis (SpA). Targeting the IL-17 axis significantly suppressed inflammation and halted bone…
Abstract Number: 982 • 2015 ACR/ARHP Annual Meeting
CD4+CD146+ T Cells: The Primed IL-17 Secreting Cells in the Pathogenesis of Psoriatic Arthritis
Siba Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Med/Rheumatology, Univ California Davis/VA Sacramento, Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: CD146, also called melanoma cell adhesion molecule (MCAM), is a cell surface adhesion molecule. A small minority of the T cell population also express…
Abstract Number: 983 • 2015 ACR/ARHP Annual Meeting
ERAP1 Deficiency Protects HLA-B27 Transgenic Rats from Arthritis
Tri M. Tran¹, Sohee Hong², Tejpal Gill¹, Joshua Bennett¹, Keith Sikora¹ and Robert A. Colbert³, ¹NIAMS/NIH, Bethesda, MD, ²Bldg 10 Crc 10 Center Dr, NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27 (B27) confers a strong predisposition to spondyloarthritis (SpA), but accounts for < 25% of overall heritability of ankylosing spondylitis. Rats transgenic for HLA-B27…
Abstract Number: 984 • 2015 ACR/ARHP Annual Meeting
Tofacitinib Inhibits Inflammation and New Bone Formation in Murine Spondyloarthritis but Does Not Adversely Inhibit Normal Human MSC Function
Rik Lories¹, Katelijne De Wilde², Kerri Heritage¹, Richard Cuthbert³, Elena Jones³, Karlijn Debusschere⁴, Dennis McGonagle³ and Dirk Elewaut⁵, ¹Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ²Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology,, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ⁵Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium
Background/Purpose: Inflammation and new bone formation at entheseal sites are hallmarks of spondyloarthritis (SpA). As TNF inhibition has only limited impact on new bone formation,…
Abstract Number: 985 • 2015 ACR/ARHP Annual Meeting
Improved Survival in Systemic Lupus Erythematosus: A Population-Based Study
Kateryna Vostretsova¹, Sharan K. Rai², Eric C. Sayre³, Hyon K. Choi⁴, JM Esdaile⁵ and J Antonio Avina-Zubieta⁶, ¹Rheumatology, Arthritis Research Centre, Vancouver, BC, Canada, ²Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁶Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) is associated with an increased risk of mortality. However, recent mortality trends of SLE are unknown, particularly at the general…
Abstract Number: 986 • 2015 ACR/ARHP Annual Meeting
Application of New EULAR Definitions of Remission in SLE: Durable 1-Year Remission Is Rare
Theresa Fischer¹, Laurence S Magder² and Michelle Petri³, ¹Charité-Universitätsmedizin, Berlin, Germany, ²University of Maryland School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University Hospital, Baltimore, MD
Background/Purpose: Developing definition(s) of remission in SLE is one of the primary recommendations on the research agenda of the treat-to-taget international task force. Definitions of…
Abstract Number: 987 • 2015 ACR/ARHP Annual Meeting
Pre-Emptive Renal Transplantation Among End Stage Renal Disease Patients with and without SLE
Anna R. Broder¹, Wenzhu Mowrey², Ladan Golestaneh³, Mimi Kim⁴, Karen H. Costenbader⁵ and Chaim Putterman⁶, ¹Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ²Department of Epidemiology and Population Health/Division of Biostatistics, Albert Einstein College of Medicine, Bronx, NY, ³Medicine/Nephrology, Albert Einstein College of Medicine, Bronx, NY, ⁴Biostatistics and Research Design Resource, Albert Einstein Coll Med, Bronx, NY, ⁵Rheumatology, Brigham & Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Lack of evidence-based recommendations about pre-emptive renal transplantation in systemic lupus erythematosus (SLE) patients with end stage renal disease (ESRD) may be unnecessarily delaying…
Abstract Number: 988 • 2015 ACR/ARHP Annual Meeting
Factors Associated with Renal Remission, Relapse and Long-Term Renal Function Decline in Lupus Nephritis Treated with Combined Prednisolone and Mycophenolate Mofetil (MMF) or Tacrolimus (Tac)
Chi Chiu Mok¹, Ling Yin Ho², Chi Hung To³ and Kar Li Chan¹, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong, ³Medicine, Pok Oi Hospital, Hong Kong, Hong Kong
Background/Purpose: To study the factors associated with renal remission, relapse and renal function decline in patients with lupus nephritis treated with combined steroid and MMF or…

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