ACR Meeting Abstracts

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  • Abstract Number: 1741 • 2014 ACR/ARHP Annual Meeting

    Anti-TNFα Treatment Increases IL-17A+ and IL-22+ T Cells in Spondyloarthritis Regardless of Concomittant Gut Inflammation

    Thomas Andersen1, René Østgård1,2, Bent Deleuran1,2, Malene Hvid3 and Henning Glerup4, 1Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, 2Dept. of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4Dept. of Gastroenterology, Regional Hospital of Silkeborg, Silkeborg, Denmark

    Background/Purpose The pro-inflammatory Th17 associated cytokines IL-17A and IL-22 have been proposed as important mediators of the inflammation seen in spondyloarthritis (SpA) and inflammatory bowel…
  • Abstract Number: 1740 • 2014 ACR/ARHP Annual Meeting

    Predicting the Evolution of Inflammatory Arthritis in ACPA-Positive Individuals: Can T-Cell Subsets Model Help?

    Laura Hunt1, Agata Burska2, Elizabeth M.A. Hensor1, Jackie L. Nam1, Frederique Ponchel1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom

    Background/Purpose: ACPA+ individuals with non-specific musculoskeletal symptoms are at high risk of developing rheumatoid arthritis (RA). We previously demonstrated dys-regulation of T-cell subsets with loss…
  • Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting

    Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells

    Alicia Usategui1, Manuel J. Del Rey1, Regina Faré1, Gabriel Criado2, Vanessa Miranda1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…
  • Abstract Number: 1738 • 2014 ACR/ARHP Annual Meeting

    Prominent Role of CCR6+ T Helper Cells in the Pathogenesis of ACPA+ Patients with Early RA

    Sandra M.J. Paulissen1, Jan Piet van Hamburg2, Nadine Davelaar2, Heleen Vroman3, Johanna MW Hazes4, P.H.P. de Jong5 and Erik Lubberts2, 1Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, 2Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology and Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, 5Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: Presence of serum anti-citrullinated protein antibodies (ACPAs) in patients with rheumatoid arthritis (RA) predicts worse disease course and a more erosive disease. In the…
  • Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting

    Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis

    Johannes Fessler1, Chrsitine Schwarz1, Anja C. Ficjan1, Rusmir Husic2, Evelyne Höller3, Angelika Lackner1, Winfried B. Graninger4 and Christian Dejaco1,5, 1Rheumatology and Immunology, Medical University Graz, Graz, Austria, 2Rheumatology, Medical University Graz, Graz, Austria, 3Endocrinology, Medical University Graz, Graz, Austria, 4Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, 5Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria

    Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells  is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…
  • Abstract Number: 1736 • 2014 ACR/ARHP Annual Meeting

    Immune Related Adverse Events Associated with Anti-CTLA-4 Antibodies: Systematic Review and Meta-Analysis

    Anne Bertrand, Marie Kostine, Thomas Barnetche and Thierry Schaeverbeke, Rheumatology, Bordeaux University Hospital, Bordeaux, France

    Background/Purpose CTLA-4 is a costimulatory molecule that downregulates T-cell activation and promotes an immunotolerance, well known by rheumatologist since the use of Abatacept. Targeting CTLA-4…
  • Abstract Number: 1735 • 2014 ACR/ARHP Annual Meeting

    T–cell Tolerance Induction By the Glycosylated Type II Collagen Peptide-Based Vaccination in Murine Arthritis

    Vilma Urbonaviciute1, Changrong Ge1, Bingze Xu1, Susanne van den Berg1, Balik Dzhambazov2, Johan Bäcklund1 and Rikard Holmdahl1, 1Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 2Department of Developmental Biology, Plovdiv University, Plovdiv, Bulgaria

    Background/Purpose: Type II collagen (CII) has been suggested as a possible autoantigen in RA, since autoimmunity to CII is commonly detected in patients with RA.…
  • Abstract Number: 1734 • 2014 ACR/ARHP Annual Meeting

    IL-22 Plays a Significant Role in the Initiation and Augmentation of Th17-Dependent Experimental Arthritis

    Debbie M. Roeleveld1, Renoud Marijnissen2, Rebecca Rogier3, Birgitte Walgreen1, Monique M. Helsen3, Liduine van den Bersselaar3, Shahla Abdollahi-Roodsaz4, Wim B. van den Berg3 and Marije I. Koenders3, 1Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that leads to progressive destruction of cartilage and bone. IL-22 and IL-22-producing T helper cells…
  • Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting

    Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis

    Rebecca Rogier1, Tom Ederveen2, Anita Hartog3, Birgitte Walgreen4, Liduine van den Bersselaar1, Monique M. Helsen1, Paul Vos3, Johan Garssen3,5, Linette Willemsen5, Wim B. van den Berg1, Marije I. Koenders1 and Shahla Abdollahi-Roodsaz6, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, 3Danone Nutricia Research, Utrecht, Netherlands, 4Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 5Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, 6Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…
  • Abstract Number: 1732 • 2014 ACR/ARHP Annual Meeting

    Attenuation of Sclerodermatous Graft Versus Host Disease (sclGVHD) in IL4RA Receptor-Deficient Mice

    Katia Urso1, Kelly Tsang2, Robert Lafyatis3 and Antonios O. Aliprantis2, 1Rheumatology, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Rheumatology, Boston University School of Medicine, Boston, MA

    Background/Purpose Scleroderma is a rare autoimmune disease characterized by the accumulation of fibrotic tissue in multiple organs including the skin, gut and lungs. To date,…
  • Abstract Number: 1731 • 2014 ACR/ARHP Annual Meeting

    Translocation of IGFBP-5 to the Nucleus and Its Interaction with Nucleolin Do Not Dictate Its Fibrotic Effects

    Yunyun Su1 and Carol Feghali-Bostwick2, 1Medicine, Medical University of South Carolina, Charleston, SC, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose:  Insulin-like growth factor binding protein (IGFBP)-5 is one of six IGFBPs. IGFBP-5 is the most conserved member of the family. IGFBP-5 levels are increased…
  • Abstract Number: 1730 • 2014 ACR/ARHP Annual Meeting

    Identification of Novel Scleroderma –associated Antigens and Development of an Autoantibody Assay Panel Enabling Their Subsequent Validation

    Hans-Dieter Zucht1, Petra Budde1, Peter Schulz-Knappe1, Nicolas Hunzelmann2, Karsten Conrad3 and Prof. Dr. Matthias Schneider4, 1Protagen AG, Dortmund, Germany, 2Department of Dermatology, University of Cologne, Cologne, Germany, 3Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, 4Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Scleroderma (systemic sclerosis or SSc) has a highly variable clinical presentation and course resulting in difficulties for disease management. When SSc is suspected, autoantibodies…
  • Abstract Number: 1729 • 2014 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor (A2AR) Promotes Collagen Type 3 Expression Via β-Catenin Activation

    Miguel Perez-Aso1 and Bruce N. Cronstein2, 1545 1st Ave., New York University, New York City, NY, 2NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose A2AR stimulation promotes collagen 1 and 3 (Col1 and Col3) synthesis, principal mediators of fibrosis and scarring. We have recently demonstrated that the A2AR…
  • Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting

    Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice

    Sarah Trinder1, Mary Tarriela2, Adrian Gilbane1, Robert Good3, Xu Shi-Wen4, David Abraham5 and Alan M. Holmes6, 1Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, 4Centre for Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, 5Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 6Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I.  The…
  • Abstract Number: 1727 • 2014 ACR/ARHP Annual Meeting

    Poly(ADP-ribose) Polymerase-1 (PARP-1) Suppresses the Profibrotic Effects of Transforming Growth Factor â in Systemic Sclerosis

    Yun Zhang, University Hospital Of Erlangen, Erlangen, Germany

    Background/Purpose The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units from the donor β-NAD onto various substrate proteins either as mono- or oligomeric moieties…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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