Abstracts Archive - Page 1935 of 2425 - ACR Meeting Abstracts

Abstract Number: 1753 • 2014 ACR/ARHP Annual Meeting
Human T-Cells Express RANKL in Response to Combination of ZAP-70, Calcineurin and Voltage-Gated K+-Channel Signaling Following Co-Ligation of the Adhesion Molecule CD2 and the T-Cell Receptor Complex
Bohdan P. Harvey and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose Human T lymphocytes promote osteolysis in rheumatic diseases through the production of the osteoclastogenic cytokine RANKL. We have previously demonstrated that RANKL secretion is…
Abstract Number: 1752 • 2014 ACR/ARHP Annual Meeting
CD30 As a Target of Aptamers and Delivery Portal for Aptamer-shRNA to Block Th17 Cells
Cong-Qiu Chu¹, Pingfang Song², Yuan K. Chou³ and Shao Tao², ¹Rheumatology, Oregon Health & Science Univ, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose Aptamers are single-stranded 20 –100 nucleotides (RNA or DNA) that bind to molecular targets with high affinity and specificity due to their stable three…
Abstract Number: 1751 • 2014 ACR/ARHP Annual Meeting
CD4 Aptamer-RORγt shRNA Chimera Inhibits IL-17 Synthesis By Human CD4⁺ T cells
Cong-Qiu Chu¹, Pingfang Song², Yuan K. Chou³, Xiaowei Zhang², Roberto Meza-Romero², Kentaro Yomogida³ and Gil Benedek², ¹Rheumatology, Oregon Health & Science Univ, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose RNA interfering (RNAi)-mediated gene silencing holds great promise for manipulating T cells to study basic T cell biology and for developing potential T cell…
Abstract Number: 1750 • 2014 ACR/ARHP Annual Meeting
The Effect of a Pro-Inflammatory Milieu on Tregalizumab (BT-061)-Induced Regulatory T-Cell Activity
Jan Kubach¹, Faiza Rharbaoui², Martin Koenig², Jörg Schüttrumpf², Silke Aigner², Benjamin Dälken² and Helmut Jonuleit¹, ¹Department of Dermatology, University of Mainz Medical Center, Mainz, Germany, ²Biotest AG, Dreieich, Germany
Background/Purpose Regulatory T cells (Tregs) are essential for maintaining normal immune homeostasis. We have previously reported that tregalizumab is a humanized, non-depleting, CD4 agonistic antibody…
Abstract Number: 1749 • 2014 ACR/ARHP Annual Meeting
Molecular Mechanisms Underlying 1,25(OH)₂D₃-Mediated Suppression of Th17 Cell Activity
Wendy Dankers^1,2, Jan Piet van Hamburg^2,3, Wida Razawy^1,2, Nadine Davelaar^1,2, Anne-Marie Mus^1,2, Patrick Asmawidjaja^1,2, Johannes van Leeuwen⁴, Edgar Colin⁵ and Erik Lubberts^1,2, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, Th17 cells play a crucial role in the…
Abstract Number: 1748 • 2014 ACR/ARHP Annual Meeting
CCR6⁺CD4⁺ Cells Are Counterparts of Follicular T-Cells Supporting Autoantibody Production in Rheumatoid Arthritis
Karin ME Andersson¹, Dan Hu², Ron Cialic², Nicola Cavallini³, Vijay K. Kuchroo⁴, Malin Erlandsson¹, Howard Lee Weiner² and Maria Bokarewa⁵, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Department of Neurology, Brigham and Women's Hospital, Boston, MA, ⁵Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose CCR6 has been associated with rheumatoid arthritis (RA) in genome-wide association studies. CCR6 expression characterises Th17 cells recruited to inflamed joints of RA patients.…
Abstract Number: 1746 • 2014 ACR/ARHP Annual Meeting
Involvement of IL-17-Producing MAIT Cells in the Pathogenesis of Rheumatoid Arthritis
Eri Hayashi¹, Asako Chiba², Mie Kitagaichi³, Kurisu Tada³, Ken Yamaji⁴, Naoto Tamura¹, Yoshinari Takasaki³ and Sachiko Miyake², ¹Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Immunology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express a semi-invariant TCRα…
Abstract Number: 1745 • 2014 ACR/ARHP Annual Meeting
Memory Stem T Cells Are Selectively Enriched in Patients with Rheumatoid Arthritis, Contract upon Anti-TNF Treatment, and May Provide a Long-Term Reservoir of Arthritogenic Lymphocytes
Nicoletta Cieri¹, Giacomo Oliveira¹, Raffaella Greco², Mattia Baldini³, Elena Baldissera⁴, Fabio Ciceri² and Chiara Bonini¹, ¹Division of Immunology, Infectious Diseases and Transplants, Experimental Hematology Unit, San Raffaele Scientific Institute, Milan, Italy, ²Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy, ³Division of Immunology, Infectious Diseases and Transplants, Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy, ⁴Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy
Background/Purpose: the T-cell memory compartment is multi-faceted and encompasses multiple subsets with divergent properties. In addition to central memory (TCM) and effector memory (TEM) cells,…
Abstract Number: 1764 • 2014 ACR/ARHP Annual Meeting
Clinical and Other Differences Observed Between Cocaine Induced and Non-Cocaine Induced Anti-Neutrophil Cytoplasmic Antibody Positive Vasculitis
Santhi Penmetsa¹, N. Suzanne Emil², Joshua Duchesne¹, Wilmer Sibbitt Jr.³, Arthur Bankhurst⁴ and Roderick Fields⁵, ¹Rheumatology, University of New Mexico Health sciences center, Albuquerque, NM, ²Rheumatology, Presbyterian Medical Group, Rio Rancho, NM, ³Rheumatology, University of New mexico health sciences center, Albuquerque, NM, ⁴Rheum/ MSC 105550, University of NM Med Ctr, Albuquerque, NM, ⁵Division of Rheumatology, University of New Mexico health Sciences center, Albuquerque, NM
Background/Purpose Objective: To compare various factors including clinical manifestations, laboratory data and mortality in between two groups of patients with anti-neutrophil cytoplasmic antibody (ANCA) positive…
Abstract Number: 1763 • 2014 ACR/ARHP Annual Meeting
Tobacco Differentially Affects the Clinical-Biological Phenotype of ANCA-Associated Vasculitides at Diagnosis
Lucas Benarous¹, Benjamin Terrier², Bertrand Dunogué³, Pascal Cohen⁴, Xavier Puéchal⁴, Claire Le Jeunne⁴, Luc Mouthon⁴ and Loïc Guillevin for the French Vasculitis Study Group⁴, ¹Cochin Hospital, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ³Internal Medicine, Hôpital Cochin, Paris, France, ⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Occupational and non-occupational exposures may play a role in the occurrence of ANCA-associated vasculitides (AAV) and affect their initial clinical-biological phenotype. Among these potential…
Abstract Number: 1762 • 2014 ACR/ARHP Annual Meeting
The Muscle Biopsy Is a Useful and Noninvasive Procedure in Diagnosing Systemic Vasculitis Affecting Small-to-Medium-Sized Vessels: A Prospective Evaluation
Takahiro Nunokawa¹, Takayasu Kise¹, Naoto Yokogawa², Kota Shimada¹ and Shoji Sugii², ¹Department of Rheumatic diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Histopathological confirmation is required for the diagnosis of systemic vasculitis. However, patients suspected of vasculitis often only have lesions with a low diagnostic yield…
Abstract Number: 1761 • 2014 ACR/ARHP Annual Meeting
Standardisation of Disease Assesment in Systemic Vasculitis: Use of a Novel Web-Based Software Training Application
Jan Sznajd^1,2, Joe Rosa¹, David Gray³, Jennifer O'Donoghue¹, Joanna Robson¹, Surjeet Singh¹, Richard Philipson⁴, Judith Brown⁴, Thor Ostenfeld⁴ and Raashid Luqmani⁵, ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Jagiellonian University Medical College, Krakow, Poland, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁴GlaxoSmithKline R&D, Brentford, United Kingdom, ⁵Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom
Background/Purpose The Birmingham Vasculitis Activity Score (BVAS) and Vasculitis Damage Index (VDI) are validated clinical assessment tools for the systemic vasculitides. However use of BVAS…
Abstract Number: 1744 • 2014 ACR/ARHP Annual Meeting
CD4+ T Cell Subpopulations in Blood and Synovial Fluid Defined By Differential Expression of Integrins
Deepak A. Rao¹, Adam Chicoine², Peter A. Nigrovic³, Soumya Raychaudhuri⁴, Michael B. Brenner⁵ and ACR Authors 2014, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁴Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁵Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose CD4+ T cells are important mediators of inflammation in rheumatoid arthritis; however, the specific CD4+ T cell populations most important in driving disease pathology…
Abstract Number: 1743 • 2014 ACR/ARHP Annual Meeting
Antigen-Specificity Regulates Peripheral Homeostasis of Regulatory T Cells
Laura Su¹ and Mark Davis², ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Microbiology, Stanford, Stanford, CA
Background/Purpose One key mechanism of peripheral tolerance involves regulatory T cells (Tregs). Tregs are best known for the expression of the transcription factor Foxp3 that…
Abstract Number: 1742 • 2014 ACR/ARHP Annual Meeting
Depletion of Reactive Oxygen Species Biases T Cells to Proinflammatory Cytokine Production in Rheumatoid Arthritis
Zhen Yang¹, Eric L. Matteson², Jorg J. Goronzy¹ and Cornelia M. Weyand³, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, genetically associated with polymorphisms in HLA class II molecules. CD4 cells produce proinflammatory cytokines and orchestrate…

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