Abstracts Archive - Page 1932 of 2425 - ACR Meeting Abstracts

Abstract Number: 1789 • 2014 ACR/ARHP Annual Meeting
Are EULAR/Printo/PRES Classification Criteria Appropriate for Classification of IgA Vasculitis in Adults?
Alojzija Hočevar¹, Ziga Rotar², Vesna Jurcic³, Joze Pizem³, Sasa Cucnik², Alenka Vizjak³ and Matija Tomsic⁴, ¹Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, ⁴Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia
Background/Purpose In 2010 EULAR/PRINTO/PRES proposed new classification criteria for pediatric IgA vasculitis (IgAV). In pediatric population these criteria have a higher diagnostic sensitivity than the…
Abstract Number: 1788 • 2014 ACR/ARHP Annual Meeting
Association of HLA-B*41 with Henoch-Schönlein Purpura in Spanish Individuals Irrespective of the HLA-DRB1 Status
Fernanda Genre¹, Raquel López-Mejías¹, Belén Sevilla Pérez², Santos Castañeda³, Norberto Ortego-Centeno², Javier Llorca⁴, Begoña Ubilla¹, Trinitario Pina Murcia¹, Vanesa Calvo-Río⁵, Ana Márquez⁶, Luis Sala-Icardo⁷, Jose A. Miranda-Filloy⁸, Marta Conde-Jaldón⁹, Lourdes Ortiz-Fernández⁹, Juan María Blanco-Madrigal¹⁰, Eva Galindez-Agirregoikoa¹⁰, Francisca González Escribano⁹, Javier Martin¹¹, Ricardo Blanco¹² and MA González-Gay¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ³Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁵Av. Cardenal Herrera Oria s/n - Lab. 201, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ⁶Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁹Immunology department, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹⁰Rheumatology Department. Basurto University Hospital, Bilbao, Spain, ¹¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ¹²Hospital Marques de Valdecilla, Santander, Spain
Background/Purpose: Henoch-Schönlein purpura (HSP), the most common type of primary small-sized blood vessel leukocytoclastic vasculitis, is characterized by infiltration of the small blood vessels with…
Abstract Number: 1787 • 2014 ACR/ARHP Annual Meeting
HLA-DRB1*01 Is Associated with Henoch- Schönlein Purpura in the Spanish Population
Raquel López-Mejías¹, Fernanda Genre¹, Belén Sevilla Pérez², Santos Castañeda³, Norberto Ortego-Centeno², Javier Llorca⁴, Begoña Ubilla¹, Trinitario Pina Murcia¹, Vanesa Calvo-Rio¹, Ana Márquez⁵, Luis Sala-Icardo⁶, Jose A. Miranda-Filloy⁷, Marta Conde-Jaldón⁸, Lourdes Ortiz-Fernández⁸, Juan María Blanco-Madrigal⁹, Eva Galindez-Agirregoikoa⁹, Francisca González Escribano⁸, Javier Martin¹⁰, Ricardo Blanco¹¹ and MA González-Gay¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ³Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁵Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Immunology department, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ⁹Rheumatology Department. Basurto University Hospital, Bilbao, Spain, ¹⁰Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ¹¹Hospital Marques de Valdecilla, Santander, Spain
Background/Purpose: Henoch-Schönlein purpura (HSP) is essentially a childhood disease, being the most common type of vasculitis in children and an infrequent condition in adults. An…
Abstract Number: 1786 • 2014 ACR/ARHP Annual Meeting
Vasculitis As Underlying Cause of Death in the United States: 1999 – 2010
Alicia Rodriguez-Pla¹, Paul A. Monach² and Jose Rossello-Urgell³, ¹Rheumatology, Boston University, Boston, MA, ²Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ³Baylor Research Institut, Baylor Institute for Immunology Research, Dallas, TX
Background/Purpose Current data on mortality rates of primary vasculitis, which were tradionally associated with a dreadful prognosis, are limited. Therefore, we aimed to estimate the mortality rates…
Abstract Number: 1785 • 2014 ACR/ARHP Annual Meeting
Survival of Microscopic Polyangiitis (MPA) Patients with and without Pulmonary Fibrosis (PF)
Lina María Saldarriaga Rivera, Natllely Ruiz and Luis F. Flores-Suarez, Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
Background/Purpose:Pulmonary fibrosis (PF) occurs in up to 30% of patients with microscopic polyangiitis (MPA). Data suggest PF implies a higher mortality. We examined the survival…
Abstract Number: 1803 • 2014 ACR/ARHP Annual Meeting
Knee Osteoarthritis and All-Cause Mortality: The Wuchuan Osteoarthritis Study
Qiang Liu¹, Xu Tang Sr.², Jingbo Niu³, Xu Wu⁴, Yan Ke⁵, Jian Huang⁶, Rujun Li⁵, Hu Li⁵, Xin Zhi⁵, Kai Wang⁵, Zhengming Cao¹ and Jianhao Lin², ¹Arthritis Institute, People’s Hospital, Peking University, Beijing, China, ²Peking University Health Science Center, Beijing, China, ³Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ⁴Peking University People's Hospital Arthritis Clinic & Research Center, Peking University Health Science Center, Beijing, China, ⁵Peking University People’s Hospital, Beijing, China, ⁶Orthopeadics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Background/Purpose Several studies published recently found that knee osteoarthritis (OA) is associated with an increased mortality in Caucasians. While prevalence of knee OA is higher…
Abstract Number: 1802 • 2014 ACR/ARHP Annual Meeting
Are Outcomes after Total Knee Arthroplasty Worsening over Time? a Time-Trends Study of Activity Limitation and Pain Outcomes
Jasvinder A. Singh¹ and David Lewallen², ¹University of Alabama and VA Medical Center, Birmingham, AL, ²Orthopedics, Mayo Clinic college of medicine, Rochester, MN
Background/Purpose: To examine whether function and pain outcomes of patients undergoing primary total knee arthroplasty (TKA) are changing over time.Methods: The Mayo Clinic Total Joint…
Abstract Number: 1801 • 2014 ACR/ARHP Annual Meeting
The Association of Knee Shape with Sex: The Osteoarthritis Initiative
Barton L. Wise¹, Lisa Kritikos², Felix Liu³, Neeta Parimi³, John A. Lynch⁴, Yuqing Zhang⁵ and Nancy E. Lane¹, ¹Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ²Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ³University of California at San Francisco, San Francisco, CA, ⁴Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Incidence of knee osteoarthritis (OA) is much higher in women than in men. Previous studies have shown that bone shape is a risk factor…
Abstract Number: 1799 • 2014 ACR/ARHP Annual Meeting
Elevated Indoleamine-2,3-Dioxygenase (IDO) Activity and Kynurinene-3-Monooxygenase (KMO) Expression in Interferon Positive Primary Sjogrens Syndrome Patients Is Associated with Increased CD25^hiFoxP3⁺regulatory Tcells: A Skew Towards Neurotoxicity or an Attempt to Rescue?
Naomi I Maria¹, Cornelia G. van Helden-Meeuwsen¹, Zana Brkic¹, Sandra M.J. Paulissen^1,2, Virgil A. Dalm¹, Paul L. van Daele¹, P. Martin van Hagen¹, Sinead M. Gibney^1,3, Andrew Harkin³, Hemmo A. Drexhage¹, Erik Lubberts^1,2 and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands, ³Trinity College Institute of Neuroscience, Neuropsychopharmacology, Dublin, Ireland
Background/Purpose: A role for indoleamine-2,3-dioxygenase (IDO) in suppression of effector T-cell function and promotion of regulatory T-cell (Treg) differentiation has been described. IDO - the…
Abstract Number: 1798 • 2014 ACR/ARHP Annual Meeting
Interaction Between Innate Immunity and Anti-Ro52 Antibodies is Critical for the Induction of Sjogren’s Syndrome-like Disease in Mice
Paulina Kaplonek¹, Barbara Szczerba², Nina Wolska¹, Paulina Rybakowska¹, Arkadiusz Klopocki¹, Paromita Dey³, Astrid Rasmussen⁴, Kimberly Hefner⁵, Stephen Young⁶, Donald U. Stone⁷, David M. Lewis⁶, Lida Radfar⁸, R. Hal Scofield⁴, Kathy Moser Sivils⁹, Harini Bagavant⁹ and Umesh Deshmukh⁹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Virginia, Charlottesville, VA, ³Department of Medicine, University of Virginia, Charlottesville, VA, ⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁶College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose . Autoantibodies reactive with Ro52 are present in almost 70% of Sjögren’s syndrome (SS) patients. This study was undertaken to investigate the role of…
Abstract Number: 1797 • 2014 ACR/ARHP Annual Meeting
One-Year Survival of Adults with Systemic Sclerosis Following Lung Transplantation: A Nationwide Cohort Study
Elana J. Bernstein¹, Eric R. Peterson², Joan M. Bathon² and David J. Lederer², ¹Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Medicine, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Lung transplantation is a potentially life-saving treatment for patients with systemic sclerosis (SSc) who have developed end-stage lung disease due to interstitial lung disease…
Abstract Number: 1796 • 2014 ACR/ARHP Annual Meeting
Autotaxin Is Highly Expressed in Systemic Sclerosis (SSc) Skin, Mediates Dermal Fibrosis Via IL-6, and Is a Target for SSc Therapy
Flavia V. Castelino^1,2, Leaya M. George³, Gretchen Bain⁴, Lance Goulet⁵, Robert Lafyatis⁶ and Andrew M. Tager^3,7, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Pulmonary Unit, Massachusetts General Hospital, Boston, MA, ⁴Biology, PharmAkea Pharmaceuticals, San Diego, CA, ⁵PharmAkea Pharmaceuticals, San Diego, CA, ⁶Rheumatology, Boston University School of Medicine, Boston, MA, ⁷Massachusetts General Hospital, Boston, MA
Background/Purpose Autotaxin (ATX) is an enzyme present in biological fluids that is responsible for the production of the lipid mediator, lysophosphatidic acid (LPA). We previously…
Abstract Number: 1795 • 2014 ACR/ARHP Annual Meeting
Denosumab Restores Cortical Bone Loss at the Distal Radius Associated with Aging and Reduces Wrist Fracture Risk: Analyses from the Cross-over Group in the Extension of the Denosumab Pivotal Fracture Trial
JP Bilezikian¹, CL Benhamou², CJF Lin³, JP Brown⁴, NS Daizadeh³, PR Ebeling⁵, A Fahrleitner-Pammer⁶, E Franek⁷, N Gilchrist⁸, PD Miller⁹, JA Simon¹⁰, I Valter¹¹, CAF Zerbini¹² and C Libanati³, ¹College of Physicians and Surgeons, Columbia University, New York, NY, ²CHR d'Orléans, Orléans, France, ³Amgen Inc., Thousand Oaks, CA, ⁴CHU de Québec Research Centre and Laval University, Quebec City, QC, Canada, ⁵Monash University, Clayton, Australia, ⁶Medical University, Graz, Austria, ⁷Medical Research Center, Polish Academy of Sciences, Warsaw, Poland, ⁸The Princess Margaret Hospital, Christchurch, New Zealand, ⁹Colorado Center for Bone Research, Lakewood, CO, ¹⁰George Washington University, Washington, DC, ¹¹Center for Clinical and Basic Research, Tallinn, Estonia, ¹²Centro Paulista de Investigação Clinica, São Paulo, Brazil
Background/Purpose: Cortical bone loss is a major determinant of increased fracture risk. Denosumab (DMAb) has been shown to increase BMD at sites of cortical bone,…
Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Rebecca Baum¹, Jason M. Organ², David B. Burr³, Ann Marshak-Rothstein⁴, Katherine A. Fitzgerald⁵ and Ellen M. Gravallese⁶, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, ³Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, ⁴Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…
Abstract Number: 1793 • 2014 ACR/ARHP Annual Meeting
Efficacy and Safety of IFN-Alpha in Induction and Maintenance of Remission in Patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA). Single Center Observational Study
Benjamin Seeliger¹, Martin Foerster¹, Anne Moeser¹, Janett Happe¹, Claus Kroegel¹ and Thomas Neumann², ¹Jena University Hospital, Internal Medicine I, Jena, Germany, ²Jena University Hospital, Internal Medicine III, Jena, Germany
Background/Purpose: To evaluate the efficiency and safety of IFN-alpha in induction and maintenance of remission in patients with EGPA and to describe its effects on…

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