Abstracts Archive - Page 1931 of 2425 - ACR Meeting Abstracts

Abstract Number: 1816 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor 4-Induced Interleukin-1 Defines the Intestinal Microbiome and Mucosal Immune Response in Arthritis-Prone IL-1 Receptor Antagonist Deficient Mice
Tom Ederveen¹, Rebecca Rogier², Jos Boekhorst¹, Harm Wopereis³, Johan Garssen³, Sacha van Hijum¹, Fons A.J. van de Loo², Marije I. Koenders², Wim B. van den Berg² and Shahla Abdollahi-Roodsaz⁴, ¹Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands, ⁴Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Interleukin-1 (IL-1) plays a pivotal role in inflammation and autoimmunity. Mice deficient in the IL-1 receptor antagonist (IL-1Ra-/-) spontaneously develop a T cell-driven autoimmune…
Abstract Number: 1815 • 2014 ACR/ARHP Annual Meeting
STAT3-Mediated Regulation of Mitochondrial Membrane Potential Is Critical for NLRP3 Inflammasome Activation
Jehad H. Edwan¹, Raphaela Goldbach-Mansky² and Robert A. Colbert³, ¹NIAMS NIH, Bethesda, MD, ²NIAMS, NIH Building 10 Room 6D47B, Bethesda, MD, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: Self-activating mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS). NLRP3 is a key component of a multiprotein…
Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting
RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa
Christian Lood¹, Xizhang Sun², Lena Tanaka², Andrew Oberst³, Jeffrey Ledbetter² and Keith B. Elkon², ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Department of Immunology, University of Washington, Seattle, WA
Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…
Abstract Number: 1813 • 2014 ACR/ARHP Annual Meeting
DNA Sensors Regulate Inflammation in a Model of Autoimmune Arthritis
Rebecca Baum¹, Shruti Sharma², Sudesh Pawaria³, Susan Carpenter⁴, Katherine A. Fitzgerald⁵, Ann Marshak-Rothstein⁶ and Ellen M. Gravallese⁷, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine - Infectious Diseases Division, University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴University of California, San Francisco, San Francisco, CA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Innate immune sensors such as cytosolic DNA sensors and toll-like receptors (TLRs) detect viral or bacterial DNA, resulting in production of proinflammatory cytokines and…
Abstract Number: 1812 • 2014 ACR/ARHP Annual Meeting
Investigation of the Sting/Interferon Pathway Activation in a Novel Vasculopathy and Pulmonary Syndrome
Yin Liu¹, Adriana Almeida de Jesus^2,3, Bernadette Marrero⁴, Dan Yang⁵, Gina A. Montealegre Sanchez⁶, Steve Brooks⁷, Zuoming Deng⁸, Amy Paller⁹, Manfred Boehm⁵ and Raphaela Goldbach-Mansky⁶, ¹Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ³Translational Autoinflammatory Diseases Section, NIAMS/NIH, Bethesda, MD, ⁴Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ⁵Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁶Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁷NIAMS/NIH, Bethesda, MD, ⁸Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁹Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have recently studied a group of patients with a prominent interferon (IFN) signature in the blood, distinct from IL-1 mediated autoinflammatory diseases. Six…
Abstract Number: 1811 • 2014 ACR/ARHP Annual Meeting
The Burden of Depression on Healthcare Utilization in a Population-Based Cohort of Patients with Systemic Lupus Erythematosus
Alfredo Aguirre¹, Gaobin Bao², S. Sam Lim³ and Cristina Drenkard⁴, ¹Department of Rheumatology, Emory University, Atlanta, GA, ²Medicine, Emory University, Atlanta, GA, ³Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, ⁴Medicine, Div Rheumatology, Emory University, Atlanta, GA
Background/Purpose . Systemic lupus erythematosus (SLE) is a chronic disease that disproportionately strikes black women. Depression is a potentially debilitating co-morbidity that affects 15-75% of…
Abstract Number: 1810 • 2014 ACR/ARHP Annual Meeting
Improper Use of Antinuclear Antibody (ANA) Test Can Result in Misdiagnosis, Increased Patient Anxiety, and Wasted Health Care Resources
Sahar Eivaz Mohammadi¹, Imam H Shaik¹, Parag Chevli¹, Fernando Gonzalez-Ibarra¹, Sohini Sarkar¹, Saurav Acharya¹, Prerna Dogra¹, Hesam Hekmatjou², Maushmi Savjani², Waheed Abdul² and Valentin Marian³, ¹Internal Medicine, Jersey City Medical Center-Barnabas Health, Jersey City, NJ, ²Internal Medicine, St. George's University SOM, St. George's, Grenada, ³Rheumatology, Jersey City Medical Center-Barnabas Health, Jersey City, NJ
Background/Purpose: Results of serologic tests for autoantibodies, including tests for Antinuclear antibodies (ANAs) and antibodies to specific nuclear antigens such as double-stranded DNA (dsDNA), play…
Abstract Number: 1809 • 2014 ACR/ARHP Annual Meeting
Is Team Care Better? a Comparison of Rheumatoid Arthritis Disease Activity Among Patients Cared for in Practices with Nurse Practitioners and Physicians Assistants Versus Rheumatologist Only
DH Solomon^1,2, Liana Fraenkel³, Bing Lu¹, Erika Brown¹, Peter Hsun Tsao⁴, Elena Losina⁵, Jeffrey N. Katz⁶ and Asaf Bitton⁷, ¹Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ⁶Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ⁷Medicine, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The Affordable Care Act proposes more widespread use of mid-level providers (MLPs), such as nurse practitioners and physician assistants, but little is known about…
Abstract Number: 1808 • 2014 ACR/ARHP Annual Meeting
Role of HLA-B*5801 Genetic Testing and a Safety Programme When Initiating Allopurinol Therapy for Chronic Gout Management: A Cost-Effectiveness Analysis
Di Dong¹, Wei Chuen Tan-Koi^2,3, Gim Gee Teng^4,5, Eric Finkelstein⁶ and Cynthia Sung^7,8, ¹Health Services and Systems Research Program, Duke-NUS Graduate Medical School, Singapore, Singapore, ²Vigilance & Compliance Branch, Health Sciences Authority, Singapore, Singapore, Singapore, ³Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, ⁴Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ⁵Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, ⁶Health Services and Systems Research Program, Duke-NUS Graduate Medical School, Singapore., Singapore, Singapore, ⁷Vigilance & Compliance Branch, Health Products Regulation Group, Health Sciences Authority, Singapore, Singapore, Singapore, ⁸Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School, Singapore., Singapore, Singapore
Background/Purpose To conduct a cost-effectiveness analysis from a health system perspective of various strategies in managing chronic gout to mitigate risk of allopurinol-induced Stevens-Johnson Syndrome…
Abstract Number: 1807 • 2014 ACR/ARHP Annual Meeting
Problems with Fee for Service Payments for Academic Rheumatology Practices: A Need for Payment Reform:
Allen P. Anandarajah¹ and Christopher T. Ritchlin², ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: The current fee-for-service model rewards providers for the volume of services. The model is designed to deliver higher compensation for care of more complex cases. Rheumatologists…
Abstract Number: 1805 • 2014 ACR/ARHP Annual Meeting
Prevalence and Associating Factors with Atypical Femoral Fractures: An Asian Single Center Based Case-Control Study
Dam Kim¹, Yoon-Kyoung Sung^2,3, Soo-Kyung Cho^1,3, Minkyung Han¹ and Yee-Suk Kim⁴, ¹Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Department of Orthopedic Surgery, Hanyang University Hospital, Seoul, South Korea
Background/Purpose Although the use of bisphosphonates has been shown to reduce vertebral and proximal femur fracture risk in patients with osteoporosis, current evidence suggests that…
Abstract Number: 1826 • 2014 ACR/ARHP Annual Meeting
A Renal Activity Index May Predict Histological Activity in Lupus Nephritis in Children
Khalid Abulaban¹, Michael Bennett², Marisa Klein-Gitelman³, Stacy P. Ardoin⁴, Kelly A. Rouster-Stevens⁵, Lori B. Tucker⁶, Kasha Wiley⁷, Shannen Nelson⁸, Karen Onel⁹, Nora G. Singer¹⁰, Kathleen M. O'Neil¹¹, Elizabeth Brooks¹², B Anne Eberhard¹³, Lawrence K. Jung¹⁴, Lisa F. Imundo¹⁵, Tracey Wright¹⁶, David Witte¹⁷, Jun Ying¹⁸, Prasad Devarajan² and Hermine I. Brunner¹⁹, ¹Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Anne & Robert H Lurie Childrens Hospital of Chicago, Chicago, IL, ⁴Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH, ⁵Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁶Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ⁷Rheumatology, Cincinnati Children's Hospital Medical Center, c, OH, ⁸Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, ¹⁰Medicine, Division of Rhuematology, Division of Rheumatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, ¹¹Division of Pediatric Rheumatology, Riley Hospital for Children, Indianapolis, IN, ¹²Rheumatology, Univ Hospitals of Cleveland, Cleveland, OH, ¹³Pediatrics/Rheumatology, Cohen Children's Medical Center, Lake Success, NY, ¹⁴Pediatric Rheumatology, Children's National Medical Center, Washington, DC, ¹⁵Assoociate Professor of Pediatrics in Medicine - Rheumatoology, Columbia University Medical Center, New York, NY, ¹⁶Pediatrics/Rheumatology, UT Southwestern Medical Center, Dallas, TX, ¹⁷Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ¹⁸University of Cincinnati, Cincinnati, OH, ¹⁹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose Lupus Nephritis (LN) occurs in up to 80% of childhood-onset Systemic Lupus Erythematosus (cSLE) and it has a worse prognosis than adults. The current…
Abstract Number: 1825 • 2014 ACR/ARHP Annual Meeting
Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus Erythematosus
Patricia Vega-Fernandez¹, Shana Vanderburgh², Deborah M. Levy³, Frank A. Zelko⁴, Eyal Muscal⁵, Natasha M. Ruth⁶, Adam M. Huber⁷, Marisa S. Klein-Gitelman⁸, Kasha Wiley⁹, Wenjie Zheng¹⁰, Lori B. Tucker¹¹, Tresa Roebuck-Spencer¹², Jun Ying¹³ and Hermine Brunner¹⁴, ¹Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Texas Children's Hospital, Houston, TX, ⁶Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ⁷IWK Health Centre, Halifax, NS, Canada, ⁸Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ¹²Cognitive Science Research Center, University of Oklahoma, Norman, OK, ¹³Medicine-Internal Medicine-General Medicine, University of Cincinnati, Cincinnati, OH, ¹⁴PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Patients with childhood-onset SLE (cSLE) may experience neuropsychiatric SLE (NPSLE) manifested as neurocognitive dysfunction (NCD). Formal neurocognitive testing (FNCT) is the most accepted method…
Abstract Number: 1791 • 2014 ACR/ARHP Annual Meeting
Applicability of the 2006 European League Against Rheumatism (EULAR) Criteria for the Classification of Henoch-Schönlein Purpura. an Analysis Based on 766 Patients with Cutaneous Vasculitis
Montserrat Santos-Gómez¹, Francisco Ortiz Sanjuan¹, Jose L. Hernández², Marcos A. González-López³, Ricardo Blanco¹, Javier Loricera¹, Vanesa Calvo-Río¹, Trinitario Pina Murcia⁴, Carmen Gonzalez-Vela⁵, Marina Lacalle³, Javier Rueda-Gotor¹, Lino Álvarez⁶, Leyre Riancho-Zarrabeitia¹ and Miguel A. González-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ²Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Dermatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ⁵Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁶Pediatrics, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose The European League Against Rheumatism (EULAR) proposed in 2006 a new classification criteria for Henoch-Schönlein Purpura (HSP). We aimed to establish the applicability of…
Abstract Number: 1790 • 2014 ACR/ARHP Annual Meeting
Follow up of an Unselected IgA Vasculitis (Henoch-Schönlein Purpura) Population at Single Rheumatology Center
Alojzija Hočevar¹, Ziga Rotar², Jaka Ostrovrsnik² and Matija Tomsic³, ¹Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Department of Rheumatology, BioRx.si, University Medical Centre Ljubjana, Ljubljana, Slovenia
Background/Purpose In our population IgA vasculitis (IgAV) has an annual incidence rate of 5.1 cases per 105 adults increasing with patients’ age which makes it…

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