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  • Abstract Number: 1926 • 2014 ACR/ARHP Annual Meeting

    Nailfold Videocapillaroscopy Patterns Associated with Calcinosis and Acro-Osteolysis in Systemic Sclerosis

    Jerome Avouac1, Laetitia Morardet2, Maya Sammour3, Andre Kahan2, Antoine Feydy3 and Yannick Allanore1, 1Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, 2Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 3Paris Descartes University, Radiology B department, Cochin Hospital, Paris, France

    Background/Purpose: Calcinosis and acro-osteolysis are frequent in systemic sclerosis (SSc). They may be related to digital vasculopathy, which can be assessed by nailfold videocapillaroscopy (NVC).…
  • Abstract Number: 1925 • 2014 ACR/ARHP Annual Meeting

    Determinants of Blood Hydroxychloroquine Concentration Variations in Systemic Lupus Erythematosus Patients

    Moez Jallouli1, Lionel Galicier2, Olivier Aumaître3, Camille Francès4, Véronique Le-Guern5, F. Lioté6, Amar Smail7, Nicolas Limal8, L. Perard9, H. Desmurs-Clavel10, Du Boutin11, B. Asli12, Jean Emmanuel Kahn13, Jacques Pourrat14, Laurent Sailler15, F. Ackermann1,13, T. Papo16, Karim Sacre17, O. Fain18, J. Stirnemann18, Patrice Cacoub19, Gaëlle Leroux20, Judith Cohen-Bittan21, Js Hulot22, Zahir Amoura23, Jean-Charles Piette24 and Nathalie Costedoat-Chalumeau25, 1Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, 2Internal Medicine, Hopital St Louis, AP-HP, Paris, France, 3Division of internal Medicine, Centre Hospitalier Universitaire, Hôpital Gabriel Montpied, Clermont–Ferrand, Clermont–Ferrand, France, 4service de dermatologie allergologie, Hôpital Tenon, Paris Cedex 20, France, 5service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 6service de rhumatologie, Hôpital Lariboisière, Université Paris-Diderot, Sorbonne Paris-Cité, Paris, France, 7Internal Medicine Department, CHU Amiens Nord, Amiens, France, 8Department of Internal Medicine, Hôpital Henri Mondor, APHP, Creteil, France, 9service de médecine interne, Hospices Civils de Lyon, groupement Hospitalier Edouard Herriot, Lyon, France, 10service de médecine interne, Hospice civils de Lyon, Lyon, France, 11Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 12Departement of clinical immunology, Hopital Saint Louis, Université Paris Diderot, Sorbonne Paris Cité, Paris, France, 13internal medicine, Hopital Foch, Suresnes, France, 14nephrolohy, CHU Toulouse, Hopital Rangueil, University of Paul Sabatier, Toulouse, France, 15Service de Médecine Interne, S, CHU Toulouse, Hopital Purpan, University of Paul Sabatier, Toulouse, France, 16Internal Medicine, Hopital Bichat Claude Bernard, University of Paris Diderot, Sorbonne Paris cité, Paris, FL, France, 17Internal Medicine, University Paris-7, INSERM U699, APHP, Bichat Hospital, Paris, France, 18Internal Medicine, Hopital Jean Verdier, University Paris Nord, Sorbonne Paris Cité, Paris, France, 19Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France, 20Department of Internal Medicine 1, CHU Pitié-Salpêtrière, Paris, France, 21Service de medecine gériatrique, CHU Pitié-Salpêtrière, Paris, France, 22Pharmacology, CHU Pitié-Salpêtrière, UPMC, University Paris 6, Paris, France, 23Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, 24Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, 25Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Hydroxychloroquine (HCQ) is now recognized as an important treatment of systemic lupus erythematosus (SLE). Blood HCQ levels ([HCQ]) can be quantified by high performance…
  • Abstract Number: 1924 • 2014 ACR/ARHP Annual Meeting

    Cell Bound Complement Activation Products Have Higher Sensitivity Than Serum C3 and C4 Levels in Systemic Lupus Erythematosus

    Rosalind Ramsey-Goldman1, Richard Furie2, Chaim Putterman3, Anka Askanase4, Jill P. Buyon5, Kenneth Kalunian6, W. Winn Chatham7, E Massarotti8, Kyriakos A. Kirou9, A. Weinstein10, Puja Chitkara11, Susan Manzi12, Joe Ahearn13, Leilani Wolover14, John Conklin15, Tyler O'Malley14, Claudia Ibarra15, Derren Barken16 and Thierry Dervieux17, 1FSM-300, Northwestern University, Chicago, IL, 2Division of Rheumatology, North Shore-LIJ Health System, Great Neck, NY, 3The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 4Department of Medicine Rhemuatology, Colombia University, New York, NY, 5Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 6UCSD School of Medicine, La Jolla, CA, 7University of Alabama at Birmingham, Birmingham, AL, 8Brigham and Women's Hospital, Boston, MA, 9Hospital for Special Surgery, New York, NY, 10Washington Hospital Center, Washington, DC, 11Internal Medicine, Sharp Memorial Hospital, San Diego, CA, 12Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 13Internal Medicine, West Penn Allegheny Health System, Pittsburgh, PA, 14Research and Development, Exagen Diagnostics, Inc., Vista, CA, 151261 Liberty Way Suite C, Exagen Diagnostics, Inc., Vista, CA, 16Exagen Diagnostics, Inc., Vista, CA, 17rd, Exagen Diagnostics, Inc., Vista, CA

    Background/Purpose: Elevated levels of cell bound complement activation products (CBCAPS) have been established as valuable biomarkers in the diagnosis of Systemic Lupus Erythematosus (SLE). In…
  • Abstract Number: 1896 • 2014 ACR/ARHP Annual Meeting

    Validation of a Novel IFN-Regulated Gene Score As Biomarker in Chronic Atypical Neutrophilic Dermatosis with Lipdoystrophy and Elevated Temperature (CANDLE) Patients on Baricitinib, a Janus Kinase 1 /2 Inhibitor, a Proof of Concept

    Hanna Kim1, Steve Brooks2, Yin Liu1, Adriana Almeida de Jesus3, Gina A. Montealegre Sanchez1, Dawn C. Chapelle1, Nicole Plass1, Yan Huang1 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD, 3Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose CANDLE syndrome is a novel autoinflammatory disease with strong IFN response signature.  We hypothesize that IFN dysregulation may drive clinical manifestations in CANDLE and…
  • Abstract Number: 1895 • 2014 ACR/ARHP Annual Meeting

    Sacroiliitis at Diagnosis in Children with Juvenile Spondyloarthritis

    Pamela Weiss1, Rui Xiao2,3 and Nancy Chauvin4, 1Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Pediatrics, Division of Biostatistics, Children's Hospital of Philadelphia, Philadelphia, PA, 3Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 4Radiology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose The prevalence of sacroiliitis in children with juvenile spondyloarthritis (JSpA) at diagnosis is unknown. We aimed to evaluate: 1) the prevalence of sacroiliitis at…
  • Abstract Number: 1894 • 2014 ACR/ARHP Annual Meeting

    Is It Worth It to Include MRI of the Spine in the ASAS Classification Criteria for Axial Spondyloarthritis?

    Manouk de Hooge1, Jean-Baptiste Pialat2, Antoine Feydy3, Monique Reijnierse1, Pascal Claudepierre4, Alain Saraux5, Maxime Dougados3 and Désirée van der Heijde1, 1Leiden University Medical Center, Leiden, Netherlands, 2Hôpital Edouard Herriot, Lyon, France, 3Descartes University, Cochin Hospital, Paris, France, 4Henri Mondor Teaching Hospital, Creteil, France, 5CHU de la Cavale Blanche, Brest Cedex, France

    Background/Purpose: Spinal MRI lesions suggestive of axial Spondyloarthritis (axSpA) are not included in the ASAS definition of a positive MRI, but do occur in the…
  • Abstract Number: 1893 • 2014 ACR/ARHP Annual Meeting

    Substantial Structural Lesions on MRI in the Sacroiliac Joints of Patients with Non-Radiographic Axial Spondyloarthritis Even in the Absence of MRI Inflammation

    Walter P. Maksymowych1, S Wichuk1, H Jones2, A Szumski3, L Marshall4, J Bukowski5 and RG Lambert6, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Inflammation & Immunology, Pfizer Inc., Collegeville, PA, 3Specialty Care, Pfizer Inc., Collegeville, PA, 4Inflammation Immunology Disease Group, Pfizer Inc., Collegeville, PA, 5Pfizer Inc., Collegeville, PA, 6Radiology, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Treatment of axial SpA is increasingly aimed at intervention early in the disease course before radiographic sacroiliitis has appeared and when response to treatment…
  • Abstract Number: 1892 • 2014 ACR/ARHP Annual Meeting

    In Vivo Visualization of Cortical Microchannels in Metacarpal Bones in Patients with Cutaneous Psoriasis By High Resolution Peripheral Computed tomography – Detecting Cortical Pathologies before the Clinical Onset of Psoriatic-Arthritis

    David Simon1, Francesca Faustini1, Arnd Kleyer1, Judith Haschka1, David Werner1, Axel J. Hueber1, Michael Sticherling2, Georg Schett1 and Juergen Rech1, 1Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose Normal bones present cortical micro-channels (CMC), which carry micro-vessels and ensure communication between the bone marrow and the synovial compartment. Only recently these structures…
  • Abstract Number: 1891 • 2014 ACR/ARHP Annual Meeting

    Early MRI Endpoints Provide a Valid Measure of Structural Damage While Reducing Study Duration and Participant Numbers in Rheumatoid Arthritis Clinical Trials

    Joshua Baker1, Philip G. Conaghan2, Paul Emery3, Daniel Baker4 and Mikkel Østergaard5, 1Medicine/Rheumatology, Philadelphia VA Medical Center, Philadelphia, PA, 2University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Janseen R&D, Spring House, PA, 5Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark

    Background/Purpose We used data from a large randomized controlled clinical trial of an effective biologic (golimumab, GO-BEFORE study) to compare the associations of disease activity…
  • Abstract Number: 1890 • 2014 ACR/ARHP Annual Meeting

    Consistent Inhibition of Bone Destruction By Denosumab in Important Subgroups of Japanese Patients with Rheumatoid Arthritis

    Naoki Ishiguro1, Yoshiya Tanaka2, Hisashi Yamanaka3, Toshiyuki Yoneda4, Takeshi Ohira5, Naoki Okubo6, Harry K. Genant7, Desiree van der Heijde8 and Tsutomu Takeuchi9, 1Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, 4Indiana University School of Medicine, Indianapolis, IN, 5Daiich Sankyo Co. Ltd, Tokyo, Japan, 61-2-58, Hiromachi, Daiichi Sankyo Co. Ltd, Tokyo, Japan, 7University of California, San Francisco, CCBR-Synarc, Newark, Tiburon, CA, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose Denosumab is a fully human monoclonal antibody (IgG2 subclass) that binds specifically to RANKL, inhibits osteoclast-induced bone resorption by preventing the binding of RANKL…
  • Abstract Number: 1889 • 2014 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA)-Associated Risk Allele LBH Alters the Function of a Differentially Methylated LBH Enhancer

    Deepa Hammaker1, Gary S. Firestein2, Wei Wang3, John W. Whitaker4 and Anna-Karin Ekwall5, 1Medicine, University of California San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, 3Chemistry, UCSD, La Jolla, CA, 4860 island ave, UCSD, San Diego, CA, 5Medicine, UC San Diego, La Jolla, CA

    Background/Purpose Recent data suggest that epigenetics, including DNA methylation, contributes to imprinting RA fibroblast-like synoviocytes (FLS) and alters their behavior. To understand how RA-associated risk…
  • Abstract Number: 1888 • 2014 ACR/ARHP Annual Meeting

    PU.1, Mitf, and Their Novel Co-Partner, Eomes, Set up a Transcription Factor Network That Is Critical for Osteoclast Differentiation

    Heather Carey1, Sankha Ghosh1, Eason Hildreth III2, Jennifer Cabrera1, Dias Kurmashev1, Wael N. Jarjour3, Ramiro Toribio2, Sudarshana Sharma1 and Michael Ostrowski1, 1Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, 2Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, 3Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose Osteoclasts are bone resorbing cells which differentiate from myeloid precursors. The crosstalk between osteoblasts and osteoclasts tightly regulates the dynamic and continuous process of…
  • Abstract Number: 1907 • 2014 ACR/ARHP Annual Meeting

    Clinical Evaluation of Anti-Aminoacyl tRNA Synthase Antibodies in Rheumatoid Arthritis Patients

    Masakazu Matsushita1, Ken Yamaji1, Naoto Tamura2 and Yoshinari Takasaki3, 1Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Anti-Jo-1 is an autoantibody that is specifically detected in the blood sera of patients with polymyositis/dermatomyositis (PM/DM). The corresponding antigen is known to be…
  • Abstract Number: 1906 • 2014 ACR/ARHP Annual Meeting

    IL-6 Blockade Reduces Circulating N-Terminal Pro-Brain Natriuretic Peptide Levels in Patients with Active Rheumatoid Arthritis

    Atsuma Nishiwaki1, Hitomi Kobayashi2, Yasuyuki Kobayashi3, Isamu Yokoe1, Noboru Kitamura2, Hidetake Shiraiwa1, Takamasa Nozaki1, Hirotake Inomata2, Natsumi Ikumi4, Kaita Sugiyama1, Yousuke Nagasawa1 and Masami Takei5, 1Nihon University School of Medicine, Tokyo, Japan, 2Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 3Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, 4Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 5Dept of Med Rheumatology, Nihon University School of Medicine, Itabashi Tokyo, Japan

    Background/Purpose Patients with rheumatoid arthritis (RA) have a 1.5–2.0 fold higher risk of developing congestive heart failure (CHF) than the general population. Small increases in…
  • Abstract Number: 1905 • 2014 ACR/ARHP Annual Meeting

    Within-Day Variation and Influence of Physical Exercise on Circulating Galectin-3 in Patients with Rheumatoid Arthritis and Healthy Individuals

    Saida Farah Issa1, Anne Friesgaard Christensen2, Tine Lottenburger2, Kirsten Junker3, Hanne M. Lindegaard1, Kim Hoerslev-Petersen4 and Peter Junker1, 1Department of Rheumatology, Odense University Hospital, Odense, Denmark, 2Department of Rheumatology, Vejle Hospital, Vejle, Denmark, 3Institute of Molecular Medicine, Cardiovascular & Renal Research, University of Southern Denmark, Odense, Denmark, 4Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark

    Background/Purpose: Galectin-3 has been suggested as a pro-inflammatory mediator in Rheumatoid Arthritis(1). Thus, Galectin-3 is over-expressed in RA-synovitis and bone erosions were significantly decreased in…
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