Abstract Number: 808 • 2015 ACR/ARHP Annual Meeting
Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE
Background/Purpose: With higher prevalence of renal and cardiovascular diseases (CVD), as well as HTN, African American (AA) SLE patients experience accelerated damage accrual and excess…Abstract Number: 809 • 2015 ACR/ARHP Annual Meeting
Patients with SLE Who Are Anti-Factor Xa IgG Positive Are Less Likely to Have Atherosclerotic Plaque
Background/Purpose: Patients with SLE have an increased risk of cardiovascular disease (CVD), which is not fully explained by traditional risk factors and may be mediated…Abstract Number: 810 • 2015 ACR/ARHP Annual Meeting
Human Parvovirus B19 Nonstructural Protein 1 (NS1) Helicase Breaks Tolerance to Self dsDNA: A Model for Viral Induction of Autoimmunity
Background/Purpose: B19 virus (B19V) is common, infects all ages, and is associated with various clinical syndromes including SLE-like autoimmunity. We previously demonstrated that B19 NS1,…Abstract Number: 811 • 2015 ACR/ARHP Annual Meeting
Antibody Response to Periodontogenic Bacterium Aggregatibacter Actinomycetemcomitans and Lupus
Background/Purpose: Periodontitis is an inflammation of the soft and hard tissues supporting the tooth. Aggregatibacter actinomycetemcomitans (Aa), a gram negative bacterium, is strongly associated with…Abstract Number: 812 • 2015 ACR/ARHP Annual Meeting
SLAMF3 Mediated Co-Stimulation Promotes Activation of the IL-2/IL-2R/STAT5 Pathway and Regulatory T Cells Differentiation in Human Naïve CD4+ T Cells – Implications for SLE
Background/Purpose: SLE is a multisystem autoimmune disease that displays quantitative and qualitative deficiencies of regulatory T cells (Treg), notably because of a compromised IL-2 production.…Abstract Number: 813 • 2015 ACR/ARHP Annual Meeting
Expression of Inducible Costimulator Ligand (ICOSL) on CD4+ T Cells in Patients with Systemic Lupus Erythematosus
Background/Purpose: Inducible costimulator (ICOS) is an immunostimulatory receptor that belongs to the CD28/CTLA4 family. ICOSL (ICOS ligand), which belongs to the B7 family, is the…Abstract Number: 814 • 2015 ACR/ARHP Annual Meeting
Lupus Drives Atherosclerosis through CD4+CXCR3+ T Cells and Plasmacytoid Dendritic Cells
Background/Purpose: Accelerated atherosclerosis is the leading cause of death in systemic lupus erythematosus (SLE). How SLE promotes accelerated atherosclerosis remains elusive. The purpose of this…Abstract Number: 815 • 2015 ACR/ARHP Annual Meeting
Lys63-Polyubiquitination By the E3 Ligase Casitas B-Lineage Lymphoma-b Modulates Peripheral Regulatory T Cell Tolerance in Patients with Systemic Lupus Erythematosus
Background/Purpose: The interplay between effector and regulatory T cells (Tregs) is a key element among peripheral tolerance mechanisms in Systemic Lupus Erythematosus (SLE). Resistance to…Abstract Number: 816 • 2015 ACR/ARHP Annual Meeting
Incomplete Tolerance in Anergic B Cells in SLE: T Helper Signals Restore B Cell Receptor Signaling in Autoreactive Anergic B Cells By Upregulating CD45 Phosphatase Activity
Background/Purpose: We recently identified a human B cell population, which is naturally autoreactive and tolerized by functional anergy. This population was naïve, fully mature, negative…Abstract Number: 817 • 2015 ACR/ARHP Annual Meeting
Circulating Endothelial Cell (CEC) and CEC-Bound C4d Levels As Biomarkers of Systemic Lupus Erythematosus
Background/Purpose: Accelerated atherosclerotic disease has been widely recognized in patients with SLE. Circulating endothelial cells (CECs) are a rare cell population believed to detach from…Abstract Number: 818 • 2015 ACR/ARHP Annual Meeting
Cell-Bound Complement Activation Products (CB-CAP) Profiles in Patients with Pre-Systemic Lupus Erythematosus
Background/Purpose: The onset of SLE, a prototypical autoimmune disease characterized by immune dysregulation and consequential inflammatory tissue injury, may be insidious with non-specific symptoms. The…Abstract Number: 819 • 2015 ACR/ARHP Annual Meeting
Upregulation of Complement C3 and Alpha-2-Macroglobulin in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus
Background/Purpose: Various autoantibodies have been identified in cerebrospinal fluids (CSF) of neuropsychiatric systemic lupus erythematosus (NPSLE). They are supposed to form immune complex with complement…Abstract Number: 820 • 2015 ACR/ARHP Annual Meeting
Peripheral Blood and Disease Features Associated with Complement Components C3 and C4 in SLE
Background/Purpose: Decreases in peripheral blood levels of complement components of C3 and C4 are associated with SLE and often indicate a lupus flare. The aim…Abstract Number: 821 • 2015 ACR/ARHP Annual Meeting
Elevated Serum Levels of Soluble CD146 in Patients with Systemic Sclerosis
Background/Purpose: CD146 is a transmembrane glycoprotein belonging to Ig-superfamily. Human endothelial cells, activated fibroblasts and Th17 cells express CD146 that involved in angiogenesis, fibrosis and…Abstract Number: 822 • 2015 ACR/ARHP Annual Meeting
Beneficial Effect of Botulinum Toxin-a on Raynaud’s Phenomenon in Japanese Patients with Systemic Sclerosis: A Prospective, Open-Label Trial
Background/Purpose: Systemic scleroderma (SSc) is a generalized connective tissue disease characterized by fibrosis of the skin and internal organs, vascular dysfunction and immune disorder. Patients…
ACR Meeting Abstracts