Abstract Number: 2175 • 2014 ACR/ARHP Annual Meeting
Macrophages from the Synovium of Active Rheumatoid Arthritis Exhibit an Activin a- Dependent Pro-Inflammatory Profile
Background/Purpose: Synovial macrophages are key effector cells in rheumatoid arthritis (RA), where they are a major source of pro-inflammatory cytokines and contribute to the cartilage…Abstract Number: 2176 • 2014 ACR/ARHP Annual Meeting
Macrophages-Mediated Response to Uric Acid Crystals Is Modulated By Their Functional Polarization
Background/Purpose: Macrophages have been involved in both initiation and resolution of gout flares. Accordingly, these cells are characterized by their plasticity as the environment modulates…Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting
Class a Scavenger Receptor（SR-a）Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis
Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…Abstract Number: 2178 • 2014 ACR/ARHP Annual Meeting
Extensive Natural Killer Cell Receptor Phenotyping on NK and T Cells Discloses Differences in RA and Psa, Potentially Mirroring Diverse Immunoregulatory Functions
Background/Purpose Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are immune-mediated diseases, which share clinical features, but differ in the mechanisms, leading to aberrant immune responses.…Abstract Number: 2179 • 2014 ACR/ARHP Annual Meeting
The Monocyte-Phagocyte System in Gout: Enhanced Inflammasome Activity and Expansion of CD14++CD16+ Monocytes in Patients with Gout
Background/Purpose: The central role of the monocyte-macrophage system in gout has been highlighted during the last years. Macrophages initiate the inflammatory response to monosodium urate…Abstract Number: 2180 • 2014 ACR/ARHP Annual Meeting
Macrophage Depletion Ameliorates Nephritis Induced By Pathogenic Antibodies
Background/Purpose Kidney involvement affects up to 60% of lupus patients, and is responsible for significant morbidity and mortality. Previous studies using a variety of methods…Abstract Number: 2181 • 2014 ACR/ARHP Annual Meeting
Investigating Myeloid and Plasmacytoid Dendritic Cell Activation within the Synovium and Peripheral Blood of Rheumatoid Arthritis Patients
Background/Purpose: Dendritic cells (DC) are a heterogeneous population of professional antigen presenting cells which link both the innate and adaptive arms of the immune system.…Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting
Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases
Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…Abstract Number: 2183 • 2014 ACR/ARHP Annual Meeting
Release of Enzymatically Active Peptidyl Arginine Deiminases (PADs) By Neutrophils Allows Generation of Citrullinated Extracellular Autoantigens in the Synovial Fluid of Patients with Rheumatoid Arthritis
Background/Purpose Citrullinated proteins are important autoantigens in the inflamed joints of patients with rheumatoid arthritis (RA). Several of these proteins are derived from proteins generally…Abstract Number: 2184 • 2014 ACR/ARHP Annual Meeting
Selective Consumption of C2 Component in HCV Patients
Background/Purpose - Hepatitis C virus (HCV) causes immunologic disorders (vasculitis, myositis, arthritis) and high frequency of autoantibodies and mixed cryoglobulinemia (CRYO). Recently, we observed that…Abstract Number: 2185 • 2014 ACR/ARHP Annual Meeting
Alterations in B Cell Complement Processing Related to a Lupus-Associated Variant in Complement Receptor 2
Background/Purpose: We have recently identified a variant in intron 1 of complement receptor 2 (CR2/CD21) that is associated with decreased risk of lupus (rs1876453; Pmeta=4.2×10-4,…Abstract Number: 2186 • 2014 ACR/ARHP Annual Meeting
Clinical and Immunologic Correlates in Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies
Background/Purpose: Illicit cocaine use is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of clinical manifestations. However, the mechanisms linking…Abstract Number: 2187 • 2014 ACR/ARHP Annual Meeting
Revisiting RS3PE after Twenty Five Years: A Systematic Review of 250 Cases
Background/Purpose Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome is a rare inflammatory arthritis, first described by McCarty et al in 1985 characterised by…Abstract Number: 2150 • 2014 ACR/ARHP Annual Meeting
The Craniocervical Junction in Ankylosing Spondylitis: A Computed Tomography Based Study
Background/Purpose Available studies of craniocervical junction (CCJ) involvement in ankylosing spondylitis (AS) are based on conventional radiography, which has limited ability in the definition of…Abstract Number: 2151 • 2014 ACR/ARHP Annual Meeting
Abatacept Related Infections: No Association with Gammaglobulin Reduction
Background/Purpose A recent study reported that abatacept (ABA) reduces rheumatoid arthritis (RA) related autoantibodies and gammaglobulins levels. However, the possible association of these findings with…
ACR Meeting Abstracts