ACR Meeting Abstracts

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  • Abstract Number: 0368 • ACR Convergence 2023

    Surveying Psychological Resilience and Pain in a Cross-Section of JIA Patients

    Daniella Schocken and Tracy Ting, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Pain trajectories vary in JIA, with some patients developing chronic pain over the course of their illness. Adaptation and recovery under stressful or traumatic…
  • Abstract Number: 0293 • ACR Convergence 2023

    Characteristics and Outcomes of Idiopathic Inflammatory Myositis Associated Interstitial Lung Disease in Rural Appalachia

    FNU Rida Ul Jannat, Sayanika Kaur, Bathmapriya Balakrishnan, Vishal Deepak, Bhanusowmya Buragamadagu, Rachel Salyer and Ty Landis, West Virginia University Hospital, Morgantown, WV

    Background/Purpose: Interstitial lung disease (ILD) can affect up to 30% of the patients with idiopathic inflammatory myositis (IIM) and contributes significantly towards morbidity and mortality…
  • Abstract Number: 0363 • ACR Convergence 2023

    Allogenic Hematopoietic Stem Cell Transplant for Children with Refractory Systemic Juvenile Idiopathic Arthritis and sJIA-Associated Lung Disease: 6-month Post-Transplant Outcomes from an International Cohort

    Michael Matt1, Daniel Drozdov1, Rolla Abu-Arja2, Shanmuganathan Chandrakasan3, Kyla Driest2, Elvira Cannizzaro Schneider4, Despina Moshous5, Benedicte Neven5, Karen Onel6, Sampath Prahalad7, Susan Prockop8, Pierre Quartier5, Johannes Roth9, Donna Wall10, Ulrike Zeilhofer11, Scott Canna12, Alexei Grom1, Grant Schulert1 and Rebecca Marsh1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Nationwide Children's Hospital, Columbus, OH, 3Emory University School of Medicine, Atlanta, GA, 4Universitaetskinderspital Zurich, Zurich, Switzerland, 5Paris Cité Université and Necker Hospital, Paris, France, 6Hospital for Special Surgery, New York, NY, 7Emory University School of Medicine, Children's Pediatric Institute, Atlanta, GA, 8Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA, 9University of Ottawa, Ottawa, ON, Canada, 10The Hospital for Sick Children, Toronto, ON, Canada, 11Children's Hospital of Zurich, Zurich, Switzerland, 12Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Refractory systemic juvenile idiopathic arthritis (sJIA) in children can be complicated by repeated episodes of macrophage activation syndrome (MAS) or sJIA-related lung disease (sJIA-LD).…
  • Abstract Number: 0372 • ACR Convergence 2023

    Efficacy and Safety of Secukinumab in Juvenile Idiopathic Arthritis: Interim Results from the Extension of the JUNIPERA Trial

    Hermine Brunner1, Ivan Foeldvari2, Ekaterina Alexeeva3, Nuray Aktay Ayaz4, Grant Schulert5, Seza Ozen6, Artem Popov7, Athimalaipet V Ramanan8, Christiaan Scott9, Betul Sozeri10, Elena Zholobova11, Sudhanshu Chakraborty12, Xuan Zhu13, Ruvie Martin13, Sarah Whelan14, Sharonjeet Kaur15, Luminita Pricop13, Daniel J Lovell16, Alberto Martini17 and Nicolino Ruperto18, 1Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, 2Hamburger Zentrum fuer Kinder und Jugendrheumatologie, Rheumatology, Hamburg, Germany, 3National Scientific and Practical Center of Children's Health, Rheumatology, Moscow, Russia, 4Department of Pediatric Rheumatology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey, 5Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Hacettepe University Medical Faculty, Ankara, Turkey, 7Ural State Medical University Ekaterinburg, Sverdlovsk, Russia, 8Bristol Royal Hospital for Children & Translational Health Sciences, University of Bristol, Bristol, United Kingdom, 9Department of Paediatric Rheumatology, Red Cross War Memorial Children’s Hospital, University of Cape Town, Cape Town, South Africa, 10Division of Pediatric Rheumatology, University of Health Sciences, Ümraniye Training and Research Hospital, Istanbul, Turkey, 11First Moscow State Medical University, n.a. I.M.Sechenov, Moscow, Russia, 12IQVIA, Durrham, NC, 13Novartis Pharmaceuticals Corporation, East Hanover, NJ, 14Novartis Ireland Ltd, Dublin, Ireland, 15Novartis Pharma AG, Basel, Switzerland, 16UC Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, 17Università di Genova, Genova, Italy, 18IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, Genova, Italy

    Background/Purpose: Secukinumab has demonstrated efficacy and safety in patients with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) categories of juvenile idiopathic arthritis (JIA) for…
  • Abstract Number: 0375 • ACR Convergence 2023

    Treatment of Methotrexate Intolerance in Juvenile Idiopathic Arthritis Using Eye Movement Desensitization and Reprocessing (EMDR) Can Be Improved by Bi-lateral Alternating Stimulation Tactile (BLAST) Armbands

    Lea Höfel, Bruno Eppler, Johannes-Peter Haas and Boris Hugle, German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany

    Background/Purpose: Methotrexate (MTX) is commonly used in the treatment of children with juvenile idiopathic arthritis (JIA), and intolerance to the drug frequently leads to discontinuation…
  • Abstract Number: 0379 • ACR Convergence 2023

    Clinical Evolution of Patients Diagnosed of Juvenile Idiopathic Arthritis After the Transitional Care Consultation

    Alba Maria Torrat Noves1, Rebeca Perpiñan Perez2, Jose Ivorra Cortes1, Elena Grau Garcia1, Daniel Ramos Castro1, Pablo Francisco Muñoz Martínez3, Laura Mas Sanchez4, Carmen Riesco Barcena1, Anderson Victor Huaylla Quispe1, Samuel Leal Rodriguez1, Belen Villanueva Mañez1, Iago Alcantara Alvarez1, Isabel Martinez Cordellat1, Luis Gonzalez Puig1, Rosa Negueroles Albuixech1, Jose Eloy Oller Rodriguez1, Elvira Vicens Bernabeu1, Ernesto Tovar Sugrañes1, Marta De la Rubia Navarro4, Hikmat Charia1, Ines Canovas Olmos1, Carmen Najera Herranz1 and Jose Andres Roman Ivorra5, 1Rheumatology Department. HUP La Fe, Valencia, Spain, 2Universidad Catolica de Valencia San Vicente Martir, Valencia, Spain, 3Rheumatology Department. HUP La Fe, Sagunto, Spain, 4Rheumatology Department. HUP La Fe, Valéncia, Spain, 5Hospital Universitari i Politècnic la Fe, Valencia, Spain

    Background/Purpose: Juvenile idiopathic arthritis (JIA) encompasses a group of chronic arthritis that begin in childhood. According to the International League of Associations for Rheumatology (ILAR)…
  • Abstract Number: 0323 • ACR Convergence 2023

    A Randomized, Double-blind, Placebo-controlled, Repeat Injection, 52-Week Study to Evaluate the Efficacy and Safety of an Intra-articular Injection (IAI) of CNTX-4975-05 (CNTX) in Subjects with Chronic, Moderate-to-severe Osteoarthritis Knee Pain (MSOAKP) – Study 304

    James Connolly, James N Campbell, Randall Stevens and Colleen Newman, Centrexion Therapeutics Corporation, Boston, MA

    Background/Purpose: 30+ million US adults have OAKP. After years of using NSAIDs, analgesics, surgery and IAI, many patients remain with MSOAKP. CNTX is a 1…
  • Abstract Number: 0329 • ACR Convergence 2023

    Factors Associated with Suicidal Ideation Among Patients with Inflammatory Rheumatic Musculoskeletal Disease: A Case-Control Study

    Eike von Schlichting1, Jan Dieris-Hirche2, Imke Redeker3, Xenofon Baraliakos4 and Uta Kiltz5, 1Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, 2LWL-University Hospital, Department of Psychosomatic Medicine and Psychotherapy, Ruhr Universität Bochum, Bochum, Germany, 3Ruhr Universität Bochum, Bochum, Germany, 4Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 5Rheumazentrum Ruhrgebiet, Herne, Germany

    Background/Purpose: Mental health contributes to the morbidity of patients with inflammatory rheumatic musculoskeletal disease (iRMD). Despite extensive research conducted on the prevalence of depressive disorders,…
  • Abstract Number: 0325 • ACR Convergence 2023

    Understanding the Burden of Cutaneous Lupus: A Subset Analysis from the 2022 World Lupus Federation Global Impact (WLFGI) Patient Survey

    Nnenna Ezeh1, Joy Buie2, Mike Donnelly3, Daria McClamb3, Lydia Oberholtzer4, Jana Sharp4 and Joseph Merola5, 1Department of Dermatology; Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 2Lupus Foundation of America, York, SC, 3Lupus Foundation of America, Washington, DC, 4Sharp Insight, LLC, Montgomery County, MD, 5Harvard Medical School, Brigham and Women's Hospital, Newton, MA

    Background/Purpose: There is a paucity of data among a global population exploring the burden of CLE on patients, especially as compared to patients with SLE.…
  • Abstract Number: 0336 • ACR Convergence 2023

    Core Signs Associated with the Subtypes of Cutaneous Lupus Erythematosus: Concept Elicitation Interviews with Dermatologists and Rheumatologists

    victoria werth1, Annegret Kuhn2, Joseph F. Merola3, Joerg Wenzel4, Cristina Vazquez-Mateo5, Sanjeev Roy6, Erik Thomas5, Oliver Guenther7, Ying Sun7, Alexandra Lauer7, Almary Guerra Rodriguez8, Patricia Koochaki9 and Paul Kamudoni7, 1University of Pennsylvania, Wynnewood, PA, 2Amsterdam University Medical Center, Amsterdam, Netherlands, and University of Münster, Münster, Germany, 3Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4University Hospital of Bonn, Bonn, Germany, 5EMD Serono, Billerica, MA, 6Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany, 7the healthcare business of Merck KGaA, Darmstadt, Germany, 8Laife Reply GmbH, Frankfurt am Main, Germany, 9ICON Clinical Research LLC, Raleigh, NC

    Background/Purpose: Greater understanding of cutaneous signs and symptoms is needed to comprehensively define and measure cutaneous disease activity in lupus erythematosus. Herein, we interviewed dermatologic…
  • Abstract Number: 0346 • ACR Convergence 2023

    Use, Safety and Persistence of Biosimilars in Adult Patients Diagnosed with Juvenile Idiopathic Arthritis: Results from the Spanish Registry of Adverse Events of Targeted Therapies in Rheumatic Diseases (BIOBADASER)

    Juan José Bethencourt1, Lucia Otero-Valera2, JAVIER MANERO3, Eva Perez-Pampin4, Yanira Pérez Vera5, SARA MANRIQUE6, Maria Sagrario Bustabad Reyes7, Mercedes Freire González8, Dolores Ruiz-Montesinos9, Lourdes Mateo Soria10, Raquel Martín Domenech11, Manuel Moreno Ramos12, Fernando Alonso2 and Isabel Castrejon13, 1Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 2Spanish Society of Rheumatology, Madrid, Spain, 3Department of Rheumatology, Hospital Universitario Miguel Servet, Zaragoza, Spain, 4Rheumatology Department Complejo Hospitalario Universitario Santiago, Santiago de compostela, Spain, 5Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain, 6Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, 7Hospital Universitario de Canarias, La Laguna, Spain, 8Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 9Hospital Universitario Virgen Macarena, Sevilla, Spain, 10HOSPITAL GERMANS TRIAS I PUJOL, Badalona, Spain, 11Hopsital General de Elda, Alicante, Spain, 12Hospital Clínico Universitario Virgen dela Arrixaca, Murcia, Spain, 13Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood. The emergence of new biologic agents has led to changes in…
  • Abstract Number: 0349 • ACR Convergence 2023

    Disease Activity of Juvenil Idiopathic Arthritis in Transitional Care

    Karen Carpio Astudillo1, Daniel clemente Garulo2, Juan Carlos Lopez-Robledillo3, Camille Bourgeois Avella4, Laura Trives Folguera4, Amparo López López1, Jose María Alvaro-Gracias4, Indalecio Monteagudo Sáez1 and Juan carlos Nieto-Gonzalez5, 1Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2Pediatric Rheumatology Unit, Hospital Niño Jesús, Madrid, Spain, 3Hospital Infantil Universitario Niño Jesús, Madrid, Spain, 4Hospital General Universitario Gregorio Marañon, Madrid, Spain, 5Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) are a group of heterogeneous arthritis with onset in childhood. According to previous studies, this patients experience an improvement of…
  • Abstract Number: 0354 • ACR Convergence 2023

    Open-label Phase 3 Study of Intravenous Golimumab in Patients with Polyarticular Juvenile Idiopathic Arthritis: Pharmacokinetics, Effectiveness, Safety, and Immunogenicity over 252 Weeks

    Nicolino Ruperto1, Daniel J Lovell2, Sarah Ringold3, Xie L. Xu4, Jocelyn H. Leu3, Edwin Lam3, Yuhua Wang3, Alberto Martini5 and Hermine Brunner6, 1IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, Genova, Italy, 2UC Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, 3Janssen Research & Development, LLC, Spring House, PA, 4Janssen Research & Development, LLC, San Diego, CA, 5Universita degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genova, Italy, 6Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH

    Background/Purpose: The phase 3, Intravenous Golimumab in Pediatric Participants with Active Polyarticular-Course JIA Despite MTX (GO-VIVA) study demonstrated that golimumab (GLM) 80 mg/m2 at Week…
  • Abstract Number: 0356 • ACR Convergence 2023

    PRINTO Provisional Enthesitis/Spondylitis-Related JIA Criteria: Performance in Youth Classified as Axial Disease in Juvenile Spondyloarthritis

    Pamela F. Weiss1, Timothy G. Brandon2, Amita Aggarwal3, RUBEN BURGOS-VARGAS4, Robert Colbert5, Gerd Horneff6, Rik Joos7, Ronald Laxer8, Kirsten Minden9, Angelo Ravelli10, Nicolino Ruperto11, Judith Smith12, Matthew Stoll13, Shirley Tse8, Filip Van den Bosch14, Walter P. Maksymowych15, Robert Lambert16, David Biko2, Nancy A. Chauvin17, Michael L. Francavilla18, Jacob Jaremko15, Nele Herregods19, Ozgur Kasapcopur20, Mehmet YILDIZ21, Hemalatha Srinivasalu22, Ray Naden23 and Alison Hendry24, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, 4Hospital General de Mexico, Ciudad de México, Mexico, 5NIH/NIAMS, Bethesda, MD, 6Asklepios Klinik Sankt Augustin GmbH, Bonn, Germany, 7Ghent University, Basel, Switzerland, 8The Hospital for Sick Children, Toronto, ON, Canada, 9Charité University Medicine and German Rheumatism Research Center Berlin, Berlin, Germany, 10Direzione Scientifica, IRCCS Istituto Giannina Gaslini, Genova, Italy, 11IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, Genova, Italy, 12University of Wisconsin, Madison, WI, 13University of Alabama at Birmingham, Birmingham, AL, 14Department of Internal Medicine and Pediatrics, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 15University of Alberta, Edmonton, AB, Canada, 16Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 17The Cleveland Clinic, Hummelstown, PA, 18University of South Alabama College of Medicine, Mobile, AL, 19Ghent University Hospital, Ghent, Belgium, 20Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, 21Istanbul University-Cerrahpasa Department of Pediatric Rheumatology, Istanbul, Turkey, 22Children's National Hospital, Washington, DC, 23Auckland City Hospital, Auckland, New Zealand, 24Te Whatu Ora, Counties Manukau District, Middlemore Hospital, Auckland, New Zealand

    Background/Purpose: The Paediatric Rheumatology International Trials Organisation (PRINTO) recently undertook an effort to better harmonize the pediatric and adult arthritis criteria. These provisional criteria are…
  • Abstract Number: 0285 • ACR Convergence 2023

    Patient Reported Physical Function, Mental Health, and Treatment Patterns in Dermatomyositis

    Lisa Christopher-Stine1, Julie Paik1, Brendan M. Johnson2, Taryn Smith2, Jolie Feldman2 and Paul N. Mudd Jr.2, 1Johns Hopkins University, Baltimore, MD, 2Priovant Therapeutics, Durham, NC

    Background/Purpose: Dermatomyositis (DM) is a rare, debilitating, idiopathic inflammatory myopathy characterized by painful, itchy skin rash and proximal muscle weakness that can significantly impact daily…
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