Abstract Number: 311 • 2015 ACR/ARHP Annual Meeting
Comparison Between Intra Articular Ozone and Placebo in the Treatment of Knee Osteoarthritis: A Multicentric, Comparative, Randomized and Double-Blinded Clinical Trial
Background/Purpose: Osteoarthritis (OA) is a common, progressive condition, which is associated with severe pain, functional disability and impairment of health related quality of life, causing…Abstract Number: 312 • 2015 ACR/ARHP Annual Meeting
Safety, Efficacy and Biomarker Outcomes of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
Background/Purpose: Knee osteoarthritis (OA) is characterized by the destruction of articular cartilage, subchrondral bone alterations and varying degrees of synovitis. Current OA treatments are limited…Abstract Number: 313 • 2015 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Outcomes Using an Intra-Articular Injection (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study
Background/Purpose: Knee osteoarthritis (OA) is characterized by the destruction of articular cartilage, subchrondral bone alterations and varying degrees of synovitis. Current OA treatments are limited…Abstract Number: 314 • 2015 ACR/ARHP Annual Meeting
A Double-Blind, Randomized, Controlled, Four Parallel Arm, Dose-Finding Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Single Intra-Articular (IA) Injections of Fasitibant in Patients with Symptomatic OA of the Knee
Background/Purpose: Fasitibant (FAS) is a competitive, potent and selective antagonist of the bradykinin B2 receptor administered IA for SOAK. In response to positive outcomes in…Abstract Number: 315 • 2015 ACR/ARHP Annual Meeting
Structural Effects of Sprifermin in Knee Osteoarthritis: A Post-Hoc Analysis on Cartilage and Non-Cartilaginous Tissue Alterations
Background/Purpose: A randomized, double-blind, placebo-controlled phase 1b clinical trial of sprifermin (rhFGF18) in knee OA assessed central medial tibio-femoral compartment cartilage thickness on quantitative MRI…Abstract Number: 316 • 2015 ACR/ARHP Annual Meeting
Effect of Vitamin D on Effusion-Synovitis in Knee Osteoarthritis: a Randomized Controlled Trial
Background/Purpose: To examine the effect of vitamin D supplementation on synovial inflammation in patients with knee osteoarthritis (OA) and low vitamin D levels over 24…Abstract Number: 317 • 2015 ACR/ARHP Annual Meeting
Relation of Incident Bisphosphonate Use to Trajectory of Joint-Space Width
Background/Purpose: Trials regarding bisphosphonate (Bisph) effects in knee osteoarthritis (OA) have been conflicting, and are unable to provide insights into long-term effects. While Bisph may…Abstract Number: 318 • 2015 ACR/ARHP Annual Meeting
Dual Variable Domain-Immunoglobulin (Dvd-Ig™) Abt-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Αlpha and -1 Βeta in Subjects with Knee Osteoarthritis
Background/Purpose: ABT-981 is a novel human Dual-Variable Domain Immunoglobulin (DVD-Ig™) that inhibits interleukin (IL)-1α and IL-1β. The purpose of this study is to evaluate IL-1α…Abstract Number: 319 • 2015 ACR/ARHP Annual Meeting
Phase 1 Studies of Anti-Interleukin-1 Dual-Variable Domain Immunoglobulin in Healthy Subjects and Patients with Osteoarthritis
Background/Purpose: Interleukin (IL)-1 is a catabolic cytokine that plays an important role in pathogenesis and progression of osteoarthritis (OA). Two phase 1 clinical trials investigated…Abstract Number: 320 • 2015 ACR/ARHP Annual Meeting
Effectiveness of Bracing in Elderly with Knee Osteoartritis: A Randomized Controlled Trial
Background/Purpose: Osteoarthritis (OA) is highly prevalent in the elderly, with the knee being the most commonly affected joint in this population. Knee braces are often…Abstract Number: 321 • 2015 ACR/ARHP Annual Meeting
Effects of Bariatric Surgery on Long-Term Quality of Life Outcomes for Obese Patients with Osteoarthritis
Background/Purpose: Osteoarthritis (OA) remains a debilitating burden for patients and a challenge to their physicians, as there is no known cure. Obesity has been linked…Abstract Number: 322 • 2015 ACR/ARHP Annual Meeting
Reduction of Treatment Needed for Knee Osteoarthritis after Bariatric Surgery
Background/Purpose: Medical treatment for knee osteoarthritis (KOA) can be limited and risk morbidity. Weight loss reduces the arthritis burden and may preclude aggressive treatment. Bariatric…Abstract Number: 323 • 2015 ACR/ARHP Annual Meeting
Perioperative Interventions for Smoking Cessation in Hip and Knee Arthroplasty for Osteoarthritis and Other Non-Traumatic Diseases
Background/Purpose: Total knee and hip arthroplasty (TKA and THA) are very common surgeries performed in patients who suffer from pain and functional limitation due to…Abstract Number: 324 • 2015 ACR/ARHP Annual Meeting
Activity Limitations in Persons with Low, Medium, and High Levels of Pain Prior to Total Knee Replacement: Implications for Appropriateness and Efficacy
Background/Purpose: Historically, persons with knee OA considered for total knee replacement (TKR) have had severe pain, as reflected in high WOMAC scores, in addition to…Abstract Number: 325 • 2015 ACR/ARHP Annual Meeting
Best Performing Definition of Accelerated Knee Osteoarthritis
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA) that is associated with a knee injury and greater age, body…
ACR Meeting Abstracts