Abstracts Archive - Page 1885 of 2607 - ACR Meeting Abstracts

Abstract Number: 203 • 2015 ACR/ARHP Annual Meeting
Rescue of Copa Syndrome Cellular Phenotype By Autophagy Modifying Drugs
Levi Watkin^1,2, Briana Burns^1,2, Timothy Vece³ and Jordan S. Orange^1,2, ¹Baylor College of Medicine, Houston, TX, ²Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, ³Pulmonology, Texas Children's Hospital, Houston, TX
Background/Purpose: Autoimmunity is a diverse group of complex conditions that can include certain congenital genetic defects leading to loss of self-tolerance with subsequent imbalances of…
Abstract Number: 204 • 2015 ACR/ARHP Annual Meeting
Histone Methylation Profiling in Peripheral White Blood Cells As a Candidate Biomarker for Behcet’s Disease
Yoshimi Aizaki^1,2, Yasuto Araki^1,2, Kojiro Sato¹, Yuji Akiyama¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Behcet’s disease (BD) is a chronic recurrent, multisystem inflammatory disorder. The phenotypic characteristics include oral aphtha, genital ulcers, uveitis and skin lesions. No specific…
Abstract Number: 205 • 2015 ACR/ARHP Annual Meeting
Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Gonny Schmets¹, Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands
Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…
Abstract Number: 206 • 2015 ACR/ARHP Annual Meeting
Activation of Non-Canonical NF-Kappa B Signalling in Dendritic Cells Induces Extrathymic Autoimmune Regulator (AIRE) Expression
Leonie Huitema¹, Boy Helder¹, Ae-Ri Noort², Chrissta Maracle¹, Louis Boon³, Cristina Lebre⁴, Frans G.M. Kroese⁵ and Sander W. Tas⁶, ¹Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Bioceros, Utrecht, Netherlands, ⁴Div. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Immune regulation is necessary for limiting excessive immune responses and for preventing autoimmune diseases. Nuclear factor (NF)-κB signalling plays an important role in the…
Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity
Jorge Irizarry-Caro¹, Carmelo Carmona-Rivera¹, Elaine Novakovich¹, Venkataraman Subramaniam², Paul Thompson³, Mariana J. Kaplan⁴ and Peter C. Grayson⁵, ¹National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ³University of Massachusetts, Worcester, MA, ⁴Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting
Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous³, Vera M. Ripoll², Joanna C. Porter⁴ and Ian Giles⁵, ¹Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁴Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ⁵Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
Abstract Number: 210 • 2015 ACR/ARHP Annual Meeting
Phenotypically Divergences of Monocyte Subsets and Microparticles in Systemic Lupus Erythematosus Patients
Catalina Burbano¹, Gloria Vásquez², Mauricio Rojas³ and Diana Castano⁴, ¹Corporación Ciencias Básicas Biomédicas, Grupo de Inmunología celular e Inmunogenética, Universidad de Antioquia. Medellín, Antioquia, Colombia., Medellin, Colombia, ²Rheumatology, Universidad de Antioquia, Medellin, Colombia, ³Unidad de Citometría de Flujo, Universidad de Antioquia. Medellín, Antioquia, Colombia., Medellin, Colombia, ⁴Grupo Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia
Background/Purpose: Mononuclear phagocytes depurate apoptotic cells, microparticles (MPs), and immune complexes (IC), leading to a tolerant or inflammatory microenvironment. The MPs, vesicular structures mainly produced…
Abstract Number: 211 • 2015 ACR/ARHP Annual Meeting
The Epidemiology of Gout: Marked Increase in Incidence and Comorbidities over 20 Years
Mohanad Elfishawi¹, Nour Zleik¹, Zoran Kvrgic¹, Clement J. Michet Jr.², Cynthia S. Crowson³, Eric L. Matteson⁴ and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Several studies have suggested that the prevalence of gout has increased over recent years. The majority of this data has been derived from insurance…
Abstract Number: 212 • 2015 ACR/ARHP Annual Meeting
Rising Incidence and Prevalence of Gout in the Canadian General Population
Sharan K. Rai¹, J Antonio Avina-Zubieta², Natalie McCormick³, Mary De Vera⁴, Kamran Shojania⁵, Eric C. Sayre⁶ and Hyon K. Choi⁷, ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁴Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Gout is increasingly becoming recognized as the most common form of inflammatory arthritis worldwide; however, no Canadian general population-based data on the disease burden…
Abstract Number: 213 • 2015 ACR/ARHP Annual Meeting
A Method for Counting Monosodium Urate Crystals in the Synovial Fluid of Gout Patients
Paola Montagna, Renata Brizzolara, Carmela Ferrone, Stefano Soldano, Maurizio Cutolo and Marco A. Cimmino, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose: Gout is the most common form of arthritis, and its prevalence is increasing. The identification of monosodium urate (MSU) crystals in synovial fluid (SF)…
Abstract Number: 214 • 2015 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystal Interactions with Tenocytes: An in Vitro Model of Calcific Tendinitis
Nicola Dalbeth^1,2, Bregina Pool¹, Ashika Chhana³, Karen E. Callon², Dorit Naot³, Ryan Gao², Brendan Coleman⁴, Jillian Cornish¹ and Geraldine M. McCarthy⁵, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand, ⁴Orthopedic Surgery, Middlemore Hospital, Auckland, New Zealand, ⁵University College Dublin, Dublin, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals frequently deposit in tendons and may cause an acute inflammatory syndrome of calcific tendinitis. Tenocytes are the stromal cells…
Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 216 • 2015 ACR/ARHP Annual Meeting
Effects of Monosodium Urate Crystals on Mlo-Y4 Cell Viability; Is There a Role for Osteocytes in Erosive Gout?
Ashika Chhana¹, David Musson², Karen E. Callon³, Dorit Naot¹, Gregory Gamble³, Geraldine M. McCarthy^4,5, Jillian Cornish³ and Nicola Dalbeth³, ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴University College Dublin, Dublin, Ireland, ⁵Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Imaging and histology studies have identified monosodium urate (MSU) crystals present in subchondral bone in erosive gout, suggesting that these crystals could interact with…
Abstract Number: 217 • 2015 ACR/ARHP Annual Meeting
Circulating Levels of Neo-Epitopes Reflecting Connective Tissue Turnover As Biomarkers of Gout and Frequent Gout Attacks in Men
Ana Valdes¹, Tina Manon-Jensen², Wendy Jenkins³, Anne Sofie Siebuhr⁴, Morten Asser Karsdal⁴, Sally Doherty⁵, Abhishek Abhishek³, Helen Richardson³, Weiya Zhang⁶, Michael Doherty⁷ and Anne C. Bay-Jensen⁸, ¹Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ²Antibody Research Unit, Nordic Bioscience, 2370, Denmark, ³Devision of Rheumatology, University of Nottingham, NG5 1PB, England, ⁴Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁵Division of ROD, University of Nottingham, Nottingham, United Kingdom, ⁶Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁷Academic Rheumatology, City Hospital, Nottingham, United Kingdom, ⁸Biomarkers and Research, Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Recurrent flares constitute the main clinical burden of gout. The neo-epitope blood-based biomarkers, C1M and C3M, measuring matrix metalloproteinases (MMP)-mediated connective tissue degradation, have previously…
Abstract Number: 218 • 2015 ACR/ARHP Annual Meeting
Diet-Wide Association Study of Serum Urate Levels in 13,782 Individuals of European Ancestry
Tony R. Merriman¹, Nicola Dalbeth², Ruth Topless³ and Tanya Flynn³, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Otago, Dunedin, New Zealand
Background/Purpose: Gout is a consequence of an innate immune reaction to monosodium urate crystals deposited in joints. Acute gout attacks are commonly triggered by dietary…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].