Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
In recent years Xiralite, an ICG-enhanced fluorescence optical imaging (FOI) technology, has gained growing importance as a non-radioactive imaging technique for the detection of inflammatory processes in joints . It was the objective of our study to compare this new technique with conventional bone scans and with clinical findings in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients.
420 joints of 14 RA patients and 350 joints of 11 PsA patients were analysed by Xiralite, bone scan, and clinical evaluation. Due to the Xiralite system, both hands were the ROI in the study.
In the RA cohort, 94 out of 420 joints (22%) were identified as inflamed using the bone scan. By means of Xiralite, 97 (23%) inflamed joints were detected. In the clinical examination, 82 joints (19.5%) were found to be swollen.
In PsA patients 48 (14.5%) and 63 (19%) joints were found inflamed using the bone scan and Xiralite, respectively, and 42 out of 330 joints (13%) were swollen.
In 11 out of 14 RA patients (78.5%) and 8 out of 11 PsA patients (75%) the Xiralite and the bone scan produced consistent results in at least 50% of the number of inflamed joints. In 9 RA patients and 4 PsA patients the consistency of both methods was even 75% and higher.
Our data show comparable numbers of inflamed joints identified by Xiralite and the traditional bone scan with a high degree of consistency. Both techniques have been found equivalent for the identification of affected joints and superior to clinical evaluation. In PsA Xiralite identifies even more inflamed joints than to a bone scan.
 Werner, SG, Langer HE, Ohrndorf S et al. Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology. Ann Rheum Dis 2011; 71:504-510
To cite this abstract in AMA style:Polter J, Drynda S, Kekow J. Comparison of Bone Scan with Xiralite (FOI) in Patients with Rheumatoid Arthritis and Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/comparison-of-bone-scan-with-xiralite-foi-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis/. Accessed August 7, 2020.
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