Abstract Number: 188 • 2015 ACR/ARHP Annual Meeting
Whole-Body Synovial Uptake of a 99mtc-Labelled RGD Peptide Is Highly Correlated with Power Doppler Ultrasound
Background/Purpose: Musculoskeletal ultrasound, and specifically power Doppler ultrasound (PDUS), is more sensitive than clinical examination for the assessment of active synovitis in patients with rheumatoid…Abstract Number: 189 • 2015 ACR/ARHP Annual Meeting
Indocyanine Green (ICG) -Enhanced Fluorescence Optical Imaging (FOI) in Patients with Active Rheumatoid Arthritis; A Comparative Study with Ultrasound and Association with Biomarkers
Methods: Twenty-five active RA patients (mean disease durations 7.5 years and DAS28-ESR 5.90) who fulfilled 2010 RA classification criteria were consecutively enrolled in this study.…Abstract Number: 190 • 2015 ACR/ARHP Annual Meeting
Ultrasound Imaging with Elastography for the Medical Treatment of Dupuytren’s Contracture
Background/Purpose: Dupuytren’s contracture is a rheumatic disease characterized by an fibrotic reaction in the palmar aponeurosis, resulting in disability. Medical treatment with up to 3…Abstract Number: 191 • 2015 ACR/ARHP Annual Meeting
High Specificity of Spectral Nail Assessment in Psoriatic Arthritis Patients
Background/Purpose: Ultrasound evaluation of synovitis and enthesitis has changed the management of rheumatic diseases. In the present study we compare Power Doppler (PD) and Spectral…Abstract Number: 192 • 2015 ACR/ARHP Annual Meeting
Comparison of Bone Scan with Xiralite (FOI) in Patients with Rheumatoid Arthritis and Psoriatic Arthritis
Background/Purpose: In recent years Xiralite, an ICG-enhanced fluorescence optical imaging (FOI) technology, has gained growing importance as a non-radioactive imaging technique for the detection of…Abstract Number: 193 • 2015 ACR/ARHP Annual Meeting
Going Back to Basics – Redefining the Normal Pattern in Nailfold Capillaroscopy in a Large Healthy Population: Results of the German “Rheuma-Truck” Cohort
Background/Purpose: Capillaroscopy is as a useful diagnostic tool in various connective tissue diseases characterized by microangiopathy and vasculitis. Different pathological patterns especially for systemic sclerosis…Abstract Number: 194 • 2015 ACR/ARHP Annual Meeting
Events Upstream of Caspase-1 Activation in NLRP3-Mediated Cell Death in NOMID
Background/Purpose: Gain-of-function mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS), with neonatal-onset multisystem inflammatory disease (NOMID) being the…Abstract Number: 195 • 2015 ACR/ARHP Annual Meeting
Activation of the Pyrin Inflammasome through the RhoA Signaling Pathway in Familial Mediterranean Fever (FMF) and Hyperimmunoglobulinemia D Syndrome (HIDS)
Background/Purpose: Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause the autoinflammatory diseases familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS), respectively. …Abstract Number: 196 • 2015 ACR/ARHP Annual Meeting
The Pyrin Domain-Only Protein POP1 Inhibits NLRP3-Dependent Inflammatory Disease
Background/Purpose: In response to infections and tissue damage NLRP3 and ASC-containing inflammasome protein complexes are assembled, which promote caspase-1 activation, IL-1b and IL-18 processing and…Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…Abstract Number: 198 • 2015 ACR/ARHP Annual Meeting
CL-L1 and CL-K1 Complement Associated Pattern Recognition Molecules in Systemic Lupus Erythematosus
Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney…Abstract Number: 199 • 2015 ACR/ARHP Annual Meeting
Human Type 1 and Ncr-Negative Type 3 Innate Lymphoid Cells Accumulate in the Inflamed Synovium in Spondyloarthritis
Background/Purpose: Spondyloarthritis (SpA) is a major form of chronic inflammatory arthritis characterized by inflammation of axial and peripheral joints and by pathologic new bone formation…Abstract Number: 200 • 2015 ACR/ARHP Annual Meeting
Mast Cell Regulation of Aortic IL-6 Expression Involves Histamine-1 Receptor, Suppressor of Cyotkine Signaling-1 and IL-10
Background/Purpose: IL-6 plays an important role in the pathogenesis of large vessel vasculitis. Lipopolysaccharide (LPS), acting through toll-like receptor 4, enhances both the aortic expression…Abstract Number: 201 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells Are Present at Normal Human Enthesis Providing a Potential Mechanism for Spondyloarthropathy Pathogenesis
Background/Purpose: The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of IL-23 responsive, innate like lymphocytes at peripheral and spinal enthesis.…Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting
Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements
Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
ACR Meeting Abstracts