Abstracts Archive - Page 1874 of 2425 - ACR Meeting Abstracts

Abstract Number: 2684 • 2014 ACR/ARHP Annual Meeting
Association of Adam33 Polymorphisms with Systemic Lupus Erythematosus
Seong-Wook Kang¹, Seung-Taek Song¹, Su-Jin Yoo², Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴, In-Seol Yoo⁵, Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea, ⁵Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose A Disintegrin and Metalloprotease 33 (ADAM33) is a member of a family of genes that encode membrane-anchored proteins with a disintegrin and a metalloprotease…
Abstract Number: 2683 • 2014 ACR/ARHP Annual Meeting
The Discovery of Novel Splicing Variants of Neurogranin and Their Role in the Pathogenesis of Systemic Lupus Erythematosus
Xiaofang Luo¹, Xuelan He¹, Chaonan Wu¹, Juan Ni¹, Ling li Dong² and Shouxin Li², ¹Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Background/Purpose Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with a diverse array of clinical manifestations that is characterized by the production of antibodies…
Abstract Number: 2682 • 2014 ACR/ARHP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Regulates Transcriptional Activation of the T Cell Receptor CD3 Zeta Chain in Human T Cells
Vaishali Moulton¹, Andrew R. Gillooly² and George C. Tsokos³, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose T cells from patients with systemic lupus erythematosus (SLE) express reduced amounts of the critical CD3 zeta signaling chain, and are poor producers of…
Abstract Number: 2681 • 2014 ACR/ARHP Annual Meeting
Activated SLE-T Cells Enhance the Interferon-Alpha Production By Plasmacytoid Dendritic Cells Stimulated By RNA-IC
Dag Leonard¹, Maija-Leena Eloranta¹, Niklas Hagberg¹, Olof Berggren¹, Karolina Tandre¹, Gunnar Alm² and Lars Rönnblom¹, ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, Uppsala, Sweden
Background/Purpose A prominent interferon-α (IFNα) signature is seen in several autoimmune diseases including systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main IFNα…
Abstract Number: 2680 • 2014 ACR/ARHP Annual Meeting
DNA Hydroxymethylation Changes in CD4+T Cells from Patients with Systemic Lupus Erythematosus
Ming Zhao, Wei Liao, Bochen Zhu, Ruifang Wu and Qianjin Lu, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose Recent studies have uncovered 5-hydroxymethylcytosine (5hmC) as the sixth base of the genome, and that the Ten-eleven translocation (TET) family proteins is responsible for…
Abstract Number: 2679 • 2014 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus
Jeong-Hwa Kang¹, Young-Nan Cho¹, Hye Mi Jin¹, Hyun-Ju Jung¹, Sung-Ji Lee¹, Seung-Jung Kee² and Yong-Wook Park¹, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of…
Abstract Number: 2678 • 2014 ACR/ARHP Annual Meeting
UC-MSCs Inhibit T Cell Autophagy and Apoptosis in Patients with Systemic Lupus Erythematosus through Mitochondrial Transfer
Jinyun Chen¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose This study is aimed to investigate the role of umbilical cord derived mesenchymal stem cells (UC-MSCs) on autophagy and apoptosis in T cells from…
Abstract Number: 2677 • 2014 ACR/ARHP Annual Meeting
Decreased Levels of SRSF1 (Serin/Arginine-Rich Splicing Factor1) Induced Lower Levels of RasGRP1 in T Cells from Patients with Systemic Lupus Erythematosus
Takashi Kurita¹, Shinsuke Yasuda¹, Vaishali Moulton², Yuka Shimizu¹, Michihito Kono¹, Hideyuki Koide¹, Kenji Oku¹, Toshiyuki Bohgaki¹, Olga Amengual¹, Tetsuya Horita¹, George C. Tsokos³ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: Down-regulation of MAP kinase pathway has been recognized in T cells from patients with SLE that results in hypo-methylation of DNA. RasGRP1 is an…
Abstract Number: 2655 • 2014 ACR/ARHP Annual Meeting
Cerebral Small Vessel Disease in Systemic Lupus Erythematosus: Histopathological Study
Jamal A. Mikdashi¹, Rupal I Mehta² and Rudy J Castellani³, ¹Div of Rheumatology, Univ of Maryland Schl of Med, Baltimore, MD, ²pathology, University of Maryland School of Medicine, Baltimore, MD, ³Pathology, Univeristy of Maryland school of Medicine, Baltimore, MD
Background/Purpose Little is known about cerebral small vessel disease (CSVD) in SLE, compared to the mounting evidence of relating cardiovascular risk factors and inflammation to…
Abstract Number: 2654 • 2014 ACR/ARHP Annual Meeting
Cognitive Function in Systemic Lupus Erythematosus Patients with Past History of Neuropsychiatric Manifestations : A Longitudinal Study
Yang Gao¹, Yi Lo¹, Jacky Wan², Esther YY Lau² and Mo Yin Mok¹, ¹Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, ²Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been…
Abstract Number: 2673 • 2014 ACR/ARHP Annual Meeting
High-Throughput Sequencing of 219 Candidate Genes for Identification of SLE-Associated Risk Variants
Fabiana Farias¹, Maria Wilbe², Johanna Dahlqvist¹, Dag Leonard³, Sergey Kozyrev¹, Gerli Pielberg¹, Maija-Leena Eloranta³, Lars Rönnblom³ and Kerstin Lindblad-Toh^1,4, ¹Department of Medical Biochemistry and Microbiology, Uppsala University, Science for Life Laboratory, Uppsala, Sweden, ²Department of Immunology, Genetics and Pathology, Uppsala University, Science for Life Laboratory, Uppsala, Sweden, ³Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ⁴Broad Institute, Cambridge, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease, believed to arise from environmental triggering events in genetically predisposed individuals. To date, more than…
Abstract Number: 2672 • 2014 ACR/ARHP Annual Meeting
Characteristics of the Reproductive System in Systemic Lupus Erythematosus: A Cross-Sectional Survey with Pair-Matched Controls
Maria N Antoniol¹, Cecilia Reimundes², Cecilia Catoggio², Analia V Longo³, Analia P Alvarez³ and Carlos Perandones⁴, ¹Internal Medicine, CEMIC, Buenos Aires, Argentina, ²Rheumatology and Immunology, CEMIC, Buenos Aires, Argentina, ³Internal Medicine, Hospital Penna, Buenos Aires, Argentina, ⁴Rheumatology & Immunology, CEMIC, Buenos Aires, Argentina
Background/Purpose Patients with Systemic Lupus Erythematosus (SLE) present factors associated with the reproductive system that can increase the risk of the disease, but the literature…
Abstract Number: 2671 • 2014 ACR/ARHP Annual Meeting
Impact of Glucocorticoid Dose on Maternal and Fetal Outcomes in Lupus Pregnancies
Dafhne Miranda¹, Miguel A. Saavedra², Eduardo Gomez³, Alberto Daniel Rocha Muñoz⁴, Jorge Gaspar Ramos⁵ and Luis Javier Jara⁶, ¹Rheumatology, Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ²Rheumatology, Hospital de Especialidades Centro Médico La Raza, IMSS, Mexico City, Mexico, ³Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Mexico, ⁴Institute for Research in Rheumatology and Musculoskeletal System, Guadalajara, Jalisco, Mexico, ⁵Rheumatology Unit, Hospital de Especialidades. Centro Médico La Raza, IMSS, Distrito federal, Mexico, ⁶Direction of Education and Research in health, Instituto Mexicano del Seguro Social, D.F., Mexico
Background/Purpose Lupus flares during pregnancy can be treated with short courses of low to moderate doses of glucocorticoids (GCs). GCs are associated with several maternal…
Abstract Number: 2670 • 2014 ACR/ARHP Annual Meeting
Premature Delivery in Patients with Systemic Lupus Erythematosus
Valeria Arturi, Pierina Sansinanea, Mariana Alejandra Pera, Adrian Pablo Salas, Josefina Marcos, Ana Carolina Costi, Claudia Elizabeth Pena and Mercedes Argentina García, Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina
Background/Purpose: Premature delivery (PD) is one of the most important difficultiess in perinatology. An incidence on developing countries of around 19% and 5-7% in developed…
Abstract Number: 2669 • 2014 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus and Lactation: Factors Affecting Infant Feeding Choices in Women with SLE
Sara Wasserman¹ and Megan E. B. Clowse², ¹Duke University Medical Center, Durham, NC, ²Rheumatology, Duke University Medical Center, Durham, NC
Background/Purpose: Breastfeeding has been shown to improve maternal and infant wellbeing and long-term health, but it is currently unknown how often it is pursued in…

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