Abstract Number: 2695 • 2014 ACR/ARHP Annual Meeting
Alterations in B Cell Subsets and BAFF Levels in Autoimmune Rheumatic Diseases Treated with B Cell Depletion Therapy: Rituximab
Background/Purpose: Systemic lupus erythematosus (SLE) and granulomatosis with polyangiitis (GPA) are autoimmune diseases which develop secondary to immune self-tolerance failure. Both diseases are characterised in…Abstract Number: 2694 • 2014 ACR/ARHP Annual Meeting
B Lymphocyte Stimulator (BLyS) Promotes Dysregulated Monocyte Function in Systemic Lupus Erythematosus(SLE)
Background/Purpose SLE involves complex interactions between the innate and adaptive immune systems. Monocytes are increasingly recognised to play a key role in the dysregulated immune…Abstract Number: 2713 • 2014 ACR/ARHP Annual Meeting
The Relationship of Patient Reported Skin Symptoms to the Scleroderma HAQ, the Modified Rodnan Skin Score and Skin Pathology.
Background/Purpose: Changes in skin are a cardinal feature of systemic sclerosis (SSc). However, there are no SSc specific patient reported outcome measures validated for use…Abstract Number: 2712 • 2014 ACR/ARHP Annual Meeting
Nailfold Videocapillaroscopy in Healthy Children and Adolescents: Description of Patterns of Normality
Background/Purpose Video capillaroscopy (VCP) allows for the evaluation of capillary dimensions and to quantify the degree of microangiopathic alterations in autoimmune diseases. However, studies in…Abstract Number: 2711 • 2014 ACR/ARHP Annual Meeting
Joint and Tendon Involvement Predict Severe Disease Progression in Systemic Sclerosis: A Prospective Study
Background/Purpose Joint involvement is frequent and strongly contributes to impaired quality of life in systemic sclerosis (SSc). In a previous cross-sectional study, synovitis and tendon…Abstract Number: 2709 • 2014 ACR/ARHP Annual Meeting
Could a Fibroblast-Free Environment Protect the Microcirculation in Systemic Sclerosis? Evidence from Retinal Vascular Imaging Research
Background/Purpose: A primary endothelial cell dysfunction is thought to be involved in systemic sclerosis (SSc)-associated fibroproliferative vasculopathy of the microcirculation and small arterioles, even in…Abstract Number: 2710 • 2014 ACR/ARHP Annual Meeting
The New ACR-EULAR 2013 Systemic Sclerosis Classification Criteria Show Good Performance in a Capillaroscopy Clinic
Background/Purpose: To analyze the validity of the new 2013 ACR-EULAR Systemic Sclerosis (SSc) classification criteria versus SSc clinical diagnosis in patients from a capillaroscopy clinic…Abstract Number: 2708 • 2014 ACR/ARHP Annual Meeting
Post-Occlusive Reactive Hyperemia (PORH) Test Mirrors Vascular Changes in Systemic Sclerosis (SSc):a Laser Speckle Contrast (LASCA) Study
Background/Purpose Vascular involvement is a key feature of Systemic sclerosis (SSc) and involves both the micro and macrovasculature. Vascular changes are central in the disease’s…Abstract Number: 2707 • 2014 ACR/ARHP Annual Meeting
Systemic Sclerosis Related Calcinosis: Patients Provide What Specialists Want to Learn
Background/Purpose: Calcinosis is a disabling, rarely discussed manifestation of SSc for which the natural history and management is poorly understood. Last year, the Scleroderma Clinical…Abstract Number: 2706 • 2014 ACR/ARHP Annual Meeting
Ulnar and Radial Stenosis in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a chronic, autoimmune disease. Endothelial damage has been recognized as the initial pathogenic factor. The involvement of the microvasculature is…Abstract Number: 2704 • 2014 ACR/ARHP Annual Meeting
Fatigue in Systemic Sclerosis
Background/Purpose: Fatigue is a frequently reported disabling symptom for patients with systemic sclerosis (SSc). It has a major impact on overall quality of life including…Abstract Number: 2703 • 2014 ACR/ARHP Annual Meeting
Elevated Serum Levels of Endostatin in Mixed Connective Tissue Disease – Association with Pulmonary Fibrosis and Digital Ulcers
Background/Purpose Mixed Connective Tissue Disease (MCTD) is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and selected clinical features of…Abstract Number: 2702 • 2014 ACR/ARHP Annual Meeting
Key Roles for Mir-155 and Mir-21 in Progressive Lung Fibrosis Associated with Systemic Sclerosis (SSc-ILD)
Background/Purpose We have already reported that macrophage activation, and up-regulation of TGF-beta- and interferon-regulated genes are involved in progressive SSc-ILD. Micro-rnas (miRNA) are a class…Abstract Number: 2701 • 2014 ACR/ARHP Annual Meeting
Relevance of the 6-Minute Walking Test in Assessing the Severity and Outcome of Pulmonary Arterial Hypertension Associated with Systemic Sclerosis, without Extensive Interstitial Lung Disease
Background/Purpose In pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc), no study has yet evaluated the correlation between the 6-minute walking test (6MWT) distance…Abstract Number: 2700 • 2014 ACR/ARHP Annual Meeting
Clinical Phenotype of Systemic Sclerosis Patients with Anti-RNA Polymerase III Antibodies: A New French Cohort, Systematic Review and Meta-Analysis
Background/Purpose: Anti-RNA polymerase III antibodies (anti-RNAP III) are one of the most frequent antinuclear antibodies identified in systemic sclerosis (SSc), with an estimated prevalence of…
ACR Meeting Abstracts