Abstracts Archive - Page 1872 of 2607 - ACR Meeting Abstracts

Abstract Number: 3 • 2015 ACR/ARHP Annual Meeting
Cytokine Production Patterns in Osteoporosis Suggest a Pro-Inflammatory Bias
Khaled Al-Jarallah¹, Fawaz Azizieh², Diaa Shehab³, Raj Reghupathy⁴ and Renu Gupta⁵, ¹Medicine, Kuwait University, Kuwait, Kuwait, ²Gulf University for Science and Technology, Kuwait, Kuwait, ³Faculty of Medicine, Kuwait University, Kuwait, Kuwait, ⁴Microbiology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait, ⁵Radioliogy, Faculty of Medicine, Kuwait University, Kuwait, Kuwait
Background/Purpose: Considering the extent, predicted growth rates, and growing economic impact on health care, osteoporosis is a significant problem. In addition to hormones and nutrients,…
Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Thomas Dr. Umscheid³, Markus Prof. Dr. Schönburg⁴, Stefan Rehart⁵, Ulf Müller-Ladner² and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ³William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, ⁴Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁵Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
Abstract Number: 5 • 2015 ACR/ARHP Annual Meeting
Prospective Study of the Effect of Treatment with Adalumumab in Angiogenesis in Moderate or Severe Psoriasis for a Period of 6 Months
Montserrat Santos-Gómez¹, Leyre Riancho-Zarrabeitia¹, Ricardo Blanco¹, Carmen Gonzalez-Vela², Jose L. Hernández³, Susana Armesto⁴, Marcos A González López⁴, Javier Loricera¹, Vanesa Calvo-Río¹, María Marcellán⁴, Marta Drake⁵, Sandra Hermana-Ramírez², Enar Pons⁵, Patricia Fuentevilla¹, Alfonso Corrales¹, Trinitario Pina¹, Natalia Palmou¹ and Miguel Angel Gonzalez-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁴Dermatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁵Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain
Background/Purpose: Angiogenesis plays an important role in the pathogenesis of psoriasis. TNFa is an essential mediator that induces the expression of VEGF, which activates…
Abstract Number: 6 • 2015 ACR/ARHP Annual Meeting
The Novel Role of Corticotropin-Releasing Hormone and Urocortin1 on Sjogren’s Syndrome
Yuichi Yokoyama¹, Kiyoshi Matsui², Sachie Kitano², Tetsuya Furukawa³, Masahiro Sekiguchi², Naoto Azuma², Masayasu Kitano², Shinichiro Tsunoda², Tsuyoshi Iwasaki⁴ and Hajime Sano², ¹Division of Rheumatology, Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan, ²Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, ³Division ofRheumatology Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan, ⁴Department of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
Background/Purpose: Corticotropin releasing hormone (CRH) is the principal regulator of hypothalamus pituitary adrenal (HPA) axis. CRH and urocortin1 (UCN1) are member of the CRH family.…
Abstract Number: 7 • 2015 ACR/ARHP Annual Meeting
Influence of TNF on Anti-Inflammatory Tyrosine-Hydroxylase-Positive Synovial Cells in Rheumatoid Arthritis and Osteoarthritis
Zsuzsa Jenei-Lanzl, Markus Herrmann and Rainer Straub, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: In recent studies we demonstrated that catecholamines produced by tyrosine-hydroxylase-positive (TH+) synovial cells are able to mediate anti-inflammatory effects in rheumatoid arthritis (RA).a TNF…
Abstract Number: 10 • 2015 ACR/ARHP Annual Meeting
CD13/Aminopeptidase N Contributes to Angiogenesis and Monocyte Chemotaxis in Rheumatoid Arthritis
Rachel Morgan¹, M. Asif Amin¹, Jeffrey Ruth¹, Gautam Edhayan², Stephanie Rasmussen³ and David A. Fox¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Aminopeptidase N (CD13, EC 3.4.11.2) is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS), and as a soluble protein in serum…
Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting
Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes
Chiyoko Sekine, Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…
Abstract Number: 13 • 2015 ACR/ARHP Annual Meeting
Altered Soluble Mediators, Autoantibodies, and Lupus-Specific Connective Tissue Disease Questionnaire Scores Distinguish Blood Relatives with Incomplete Lupus from Unaffected Relatives and Relatives with Classified SLE
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris³, Teresa Aberle¹, Virginia C. Roberts¹, Joel M. Guthridge¹, Diane L. Kamen⁴, Gary S. Gilkeson⁵, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J Wallace⁷, David R. Karp⁸, Kathy L. Sivils⁹, John B. Harley¹⁰ and Judith A. James¹¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO, ⁴Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Blood relatives (Rel) of lupus patients have increased risk of SLE. Some have autoantibodies and SLE clinical features, but do not meet ≥ 4…
Abstract Number: 14 • 2015 ACR/ARHP Annual Meeting
The SLE Susceptibility Gene Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 (NOD-like receptor family pyrin domain containing 3) Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Min Sun Shin¹, Youna Kang¹, Elizabeth Wahl¹, Lin Leng¹, Richard Bucala¹ and Insoo Kang², ¹Yale University School of Medicine, New Haven, CT, ²Rheumatology Section, Yale University School of Medicine, New Haven, CT
Background/Purpose: The pathologic hallmarks of systemic lupus erythematosus (SLE or lupus) are altered immune responses to nuclear autoantigens with autoantibody production and subsequent tissue injury.…
Abstract Number: 15 • 2015 ACR/ARHP Annual Meeting
Regulation of Neutrophil Extravasation By Interleukin-8-Induced Intravascular Reactive Oxygen Species Production during the Inflammatory Response
María Jesús Dominguez-Luis¹, Estefanía Armas-González², Maria Teresa Arce-Franco³, Francisco Sanchez-Madrid⁴ and Federico Díaz-González⁵, ¹CIBICAN, Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, ²Universidad de La Laguna, Pharmacology Department, Tenerife, Spain, ³Rheumatology Service, Hospital Universitario de Canarias, Tenerife, Spain, ⁴Immunology Service, Hospital Universitario de La Princesa, Madrid, Spain, ⁵Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain
Background/Purpose: The extravasation and recruitment of leukocytes in damaged tissues is an essential component of the inflammatory response. Once in the inflammatory foci, neutrophils destroy…
Abstract Number: 16 • 2015 ACR/ARHP Annual Meeting
Rantes/CCL5 Selectively Induces MMP-1 and MMP-13 Production in Rheumatoid Arthritis Synovial Fibroblasts Via PKC-Î´ and JNK Pathways
Solomon A. Agere, Nahid Akhtar and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: RANTES/CCL5 (RANTES) is a C-C chemokine that binds to its receptor (CCR5) and initiates inflammatory processes in rheumatoid arthritis (RA) by facilitating leukocyte infiltration.…
Abstract Number: 17 • 2015 ACR/ARHP Annual Meeting
Disentangling the Role of Hypoxia-Inducible Factor 1 and 2 in the Adaption Process of Human Microvascular Endothelial Cells to Pathophysiological Hypoxia
Martin Hahne¹, Peggy Kunath², Mathias Mursell³, Cindy Strehl², Gerd Burmester⁴, Frank Buttgereit² and Timo Gaber², ¹Miltenyi Biotec GmbH, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³German Rheumatism Research Center (DRFZ), Berlin, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Angiogenesis is a prominent feature of the pathogenesis of RA. Although new blood vessels deliver oxygen to the augmented inflammatory cell mass, the neovascular…
Abstract Number: 18 • 2015 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts
Anil Singh^1,2, Mukesh Chourasia³ and Salahuddin Ahmed⁴, ¹Department of Pharmaceutical Science, Washington State University, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: TAK1 is one of the most important proteins in IL-1β signaling cascade that mediates downstream p38/JNK and NF-κB activation. In the present study, we…
Abstract Number: 19 • 2015 ACR/ARHP Annual Meeting
Pentagalloyl Glucose (PGG) Exhibits Anti-Rheumatic Activity in Human RA Synovial Fibroblasts and Rat Adjuvant-Induced Arthritis
Sadiq Umar¹, Gates Roe¹, Sabrina Fechtner¹ and Salahuddin Ahmed², ¹Department of Pharmaceutical Science, Washington State University College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: Pentagalloyl glucose (PGG) is a natural polyphenolic and water-soluble gallotannin that exhibits anti-cancer and anti-inflammatory activities. In the present study, we evaluated the efficacy…
Abstract Number: 20 • 2015 ACR/ARHP Annual Meeting
Role of the Epigenetic Regulator EZH2 in Proinflammatory Macrophage Polarization and Signaling in Rheumatoid Arthritis
Michelle Trenkmann¹, Eimear Linehan², Mary Canavan³, Douglas J. Veale⁴ and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St. Vincent's University Hospital Dublin, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ⁴St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: In rheumatoid arthritis (RA), synovial tissue macrophages (MΦ) are inherently involved in disease pathogenesis by producing inflammatory mediators and matrix-destructive enzymes. Depending on their…

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