ACR Meeting Abstracts

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  • Abstract Number: 2756 • 2014 ACR/ARHP Annual Meeting

    Treatment of Mucocutaneous Manifestations in Behçet’s Disease with Anakinra: A Pilot Open-Label Study

    Peter C. Grayson1, Yusuf Yazici2, Elaine Novakovich3, Elizabeth Joyal4, Raphaela T. Goldbach-Mansky4 and Cailin H. Sibley3,5, 1NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3National Institutes of Health Clinical Center, Bethesda, MD, 4NIAMS, National Institutes of Health Clinical Center, Bethesda, MD, 5Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR

    Background/Purpose: IL-1 blocking therapy shows promise in the treatment of Behçet’s eye disease, but its effect on mucocutaneous manifestations is unknown. Methods: 6 patients with…
  • Abstract Number: 2757 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety of ANTI-TNF ALPHA in BEHÇET Disease: A International Multicenter Registry of 122 Patients

    Hélène Vallet1, Sophie Rivière2, Alban Deroux3, Guillaume Moulis4, Olga Addimanda5, Carlo Salvarani6, Marc Lambert7, Philip Bielfeld8, Pascal Sève9, Jean Sibilia10, Jean Baptiste Fraison11, Yoland Schoindre12, Isabelle Marie13, Laurent Perard14, Thomas Papo15, Damien Sène16, Gaelle Leroux17, Valerie Royant18, Antoinette Perlat19, Xavier Mariette20, Olivier Lidove21, Olivier Fain22, Claire De Moreuil23, Gilles Blaison24, Phuc LE Hoang25, Eric Hachulla26, Bertrand Wechsler27, Barham Bodaghi28, Patrice Cacoub29 and David Saadoun30, 1Internal medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 2Internal Medicine, Lapeyronie, Montpellier, France, 3Internal Medicine, CHU Grenoble, Grenoble, France, 4Internal Medicine department, Toulouse, Toulouse, France, 5S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, 6Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 7CHRU Lille, Lille, France, 8CHU de Dijon, Dijon, France, 9Internal medicine, CHU Lyon, Lyon, France, 10Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 11Hôpital Jean Verdier, Bondy, France, 12DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, PARIS, France, 13CHU de Rouen, Rouen, France, 14Hospices civils de Lyon, Lyon, France, 15Hôpital Bichat, Paris, France, 16Hopital Lariboisière, service de Médecine Interne, Paris, France, 17Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 18Chartres, Chartres, France, 19Internal medicine, CHU de Rennes, Rennes, France, 20rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France, 21Médecine interne, Hôpital Croix-Saint-Simon, PARIS, France, 22Hôpital Saint Antoine, DHU i2B, Service de Médecine Interne, paris, France, 23CHU, Brest, France, 24Internal medicine, CHR, Colmar, France, 25Ophtalmology, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpétrière, Paris, France, 26Internal Medicine, National Scleroderma Centre, Lille CEDEX, France, 27Internal Medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 28Ophtalmology, Hôpital de la Pitié Salpêtrière, Paris, France, 29Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 30DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France

    Background/Purpose Behçet’s disease (BD) is a systemic large vessel vasculitis with recurrent genital and oral ulceration, uveitis, cardiovascular, joints, neurological or gut symptoms. Treatment of…
  • Abstract Number: 2758 • 2014 ACR/ARHP Annual Meeting

    Predictive Factors for the Response to Infliximab Therapy in Patients with Behçet’s Disease

    Salvatore D'Angelo1, Pietro Leccese1, Angela Padula1, Angelo Nigro1, Michele Gilio2, Antonio Carriero1, Carlo Palazzi1 and Ignazio Olivieri1, 1Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy, 2San Carlo Hospital, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy

    Background/Purpose: To identify the clinical factors predicting a good clinical response to Infliximab (IFX) therapy after 12 months in patients with Behçet’s disease (BD) refractory…
  • Abstract Number: 2759 • 2014 ACR/ARHP Annual Meeting

    Anti-TNF Treatment for Refractory Vascular Involvement of Behçet’s Syndrome

    Vedat Hamuryudan1, Emire Seyahi1, Melike Melikoglu2, Serdal Ugurlu1, Gulen Hatemi1, Sebahattin Yurdakul1 and Hasan Yazici2, 1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose: The optimal management of major vascular involvement in patients with Behçet’s syndrome (BS) is still a challenge. Methods: We reviewed the charts of 16…
  • Abstract Number: 2760 • 2014 ACR/ARHP Annual Meeting

    Interferon Alfa-Associated Depression in Patients with Behçet’s Syndrome

    Yasin Keskin1, Emire Seyahi2, Cagri Poyraz3, Serdal Ugurlu1, Yilmaz Ozyazgan4 and Hasan Yazici5, 1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Department of Psychiatry, Cerrahpasa Medical Faculty, University Of Istanbul, Istanbul, Istanbul, Turkey, 4Department of Ophthalmology, Cerrahpasa Medical Faculty University of Istanbul, Istanbul, Turkey, 5Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose: Interferon (IFN) is an effective immune-modulatory agent in the medical management of eye disease of Behçet’s syndrome (BS). The agent is frequently associated with…
  • Abstract Number: 2761 • 2014 ACR/ARHP Annual Meeting

    Increased Risk of Parenchymal Neurological Involvement in Behcet’s Syndrome Patients with Panuveitis

    Berivan Bitik1, Berna Goker2, Kubilay Sahin3, Yesim Sucullu Karadag4, Ridvan Mercan5, Abdurrahman Tufan1, Mehmet Akif Ozturk1, Fikri Ak4, Yasar Karaaslan6,7 and Seminur Haznedaroglu1, 1Internal Medicine-Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 2Department of Internal Medicine- Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 3Rheumatology, Ankara Numune Education and Research Hospital, Ankara, Turkey, 4Neurology, Ankara Numune Education and Research Hospital, Ankara, Turkey, 5Gazi University School of Medicine, Ankara, Turkey, 6Rheumatology, Hitit University, Corum, Turkey, 7Ankara Numune Training and Research Hospital, Ankara, Turkey

    Background/Purpose Behcet’s Syndrome (BS) is a systemic vasculitis which may involve multiple organ systems simultaneously. Most frequently, clinical findings in BS fit into well recognized…
  • Abstract Number: 2762 • 2014 ACR/ARHP Annual Meeting

    Atrophy of Hippocampal Region in Chronic Progressive Neuro-Behçet’s Disease

    Hirotoshi Kikuchi1, Kurumi Asako1, Maki Takayama1, Yoshitaka Kimura1, Akiko Okamoto1, Toshihiro Nanki1,2, Hajime Kono1 and Shunsei Hirohata3, 1Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan, 3Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Central nervous system involvement in Behçet's disease, usually called neuro-Behçet's disease (NB), can be classified into acute NB (ANB) and chronic progressive NB (CPNB)…
  • Abstract Number: 2763 • 2014 ACR/ARHP Annual Meeting

    Long-Term Outcome of Chronic Progressive Neurological Manifestations in Behcet’s Disease

    Shunsei Hirohata1, Hirotoshi Kikuchi2, Tetsuji Sawada3, Hiroko Nagafuchi4, Msataka Kuwana5, Mitsuhiro Takeno6 and Yoshiaki Ishigatsubo7, 1Int Med/Rheumatol & Infec Dis, Kitasato Univ School of Med, Kanagawa, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 3Internal Medicine 3, Tokyo Medical University, Tokyo, Japan, 4Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan, 5Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 6Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan, 7Int Med & Clin Immunology, Yokohama City Grad Schl of Med, Yokohama, Japan

    Background/Purpose: Chronic progressive neurological manifestations in Behcet's disease (BD) is characterized by progressive deterioration leading to disability either with or without a history of previous…
  • Abstract Number: 2764 • 2014 ACR/ARHP Annual Meeting

    S100B Astrocyte Protein May Serve As a Prognostic Factor in Reversible Cerebral Vasoconstrictive Syndromes

    Juan J. Maya1, Vikram Puvenna2,3,4, Chanda Brennan2,3,5, Seby John6, Ken Uchino7, Leonard H. Calabrese8, Damir Janigro2,4,9,10 and Rula Hajj-Ali11, 1Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, 2Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 3Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 4Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 5Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 69500 Euclid Avenue S10-C, Cleveland Clinic Foundation, Cleveland, OH, 7Neurology, Cleveland Clinic Foundation, Cleveland, OH, 8Cleveland Clinic Foundation, Cleveland, OH, 9Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 10Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 11Rheumatology, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Reversible Cerebral Vasoconstriction Syndromes (RCVS) are a group of disorders characterized by acute onset of recurrent thunderclap headaches with or without neurologic deficits. Radiologically,…
  • Abstract Number: 2765 • 2014 ACR/ARHP Annual Meeting

    Putative Blood Biomarkers of Reversible Cerebral Vasoconstriction Syndrome  

    Seby John1, Belinda Willard2, Leonard H. Calabrese2, Ken Uchino3, Tariq Hammad2, Stewart Tepper2, Mark Stillman2 and Rula A Hajj-Ali4, 19500 Euclid Avenue S10-C, Cleveland Clinic Foundation, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH, 3Neurology, Cleveland Clinic Foundation, Cleveland, OH, 4Rheumatology, Cleveland Clinic Foundation, Cleveland, OH

     Putative blood biomarkers of Reversible Cerebral Vasoconstriction Syndrome Background/Purpose The pathophysiology and molecular mechanisms of Reversible Cerebral Vasoconstriction Syndrome (RCVS) are unknown. Objective of the…
  • Abstract Number: 2766 • 2014 ACR/ARHP Annual Meeting

    Mycophenolate Mofetil in the Treatment of Primary  Central  Nervous  System  Vasculitis

    Carlo Salvarani1, Robert D. Brown Jr.2, Teresa J. H. Christianson2, John Huston III2, Francesco Muratore1, Caterina Giannini2 and Gene G. Hunder3, 1Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Mayo Clinic, Rochester, MN, 3Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose .  The optimal management  of primary central nervous system vasculitis (PCNSV) remains unclear.   Cyclophosphamyde (CYC) in combination with glucocorticoids (GCs) or GCs alone are…
  • Abstract Number: 2767 • 2014 ACR/ARHP Annual Meeting

    Core Outcome Domains and Potential Measurement Instruments in  polymyalgia Rheumatica (PMR) Using Omeract Filter 2.0

    Sarah Mackie1, Toby Helliwell2, Rodney Hughes3, E Brouwer4, Colin T. Pease5, Christian Mallen6, Maarten Boers7 and John R. Kirwan8, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 2Primary Care and Health Sciences, Keele University, Staffordshire, United Kingdom, 3Rheumatology, St. Peters Hospital, Chertsey Surrey, United Kingdom, 4Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 5Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, 7Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 8Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom

    Background/Purpose The OMERACT PMR specialist interest group was established to develop a core outcome measurement set for PMR using the methods of OMERACT filter 2.0.…
  • Abstract Number: 2768 • 2014 ACR/ARHP Annual Meeting

    Patient Reported Outcomes and Acute Phase Reactants in  Polymyalgia Rheumatica in Patients Treated with Prednisone Versus Modified-Release Prednisone

    Mauro Betelli, Giulia Erba, Massimo Ricci, Carlo Valena, Elisabetta Allevi, Marta Riva, Giorgia Grosso, Simona Barbarossa, Federica Bonomi and Maria Rosa Pozzi, Department of Internal Medicine, Rheumatology Outpatient Clinic - San Gerardo Hospital – Milano-Bicocca University, Monza, Italy

    Background/Purpose Polymyalgia rheumatica (PMR) is a chronic inflammatory disorder of the elderly, characterised by morning stiffness, pain and aching in the hip and shoulder girdles…
  • Abstract Number: 2769 • 2014 ACR/ARHP Annual Meeting

    Validation of New 2012 EULAR/ACR Classification Criteria for Polymyalgia Rheumatica: Comparison with the Previous Criteria in a Prospective Multi-Center Study

    Gulsen Ozen1, Seda Bas2, Ali Ugur Unal2, Gezmis Kimyon3, Ahmet Mesut Onat4, Meryem Can5, Alperen Mengi5, Ali Sahin6, Sema Yilmaz7, Havva Keskin8, Sadiye Murat8, Ayse Balkarli9, Veli Cobankara9, Omer Nuri Pamuk10, Yonca Cagatay11, Neslihan Yilmaz11, Ilker Yagci12, Pamir Atagunduz2, Sibel Z. Aydin13, Nevsun Inanc2 and Haner Direskeneli2, 1Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 2Department of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 3Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 4Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 5Department of Rheumatology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey, 6Department of Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey, 7Department of Rheumatology, Selcuk University School of Medicine, Konya, Turkey, 8Department of Physical Medicine and Rehabilitation, Goztepe Medeniyet University Faculty of Medicine, Istanbul, Turkey, 9Department of Rheumatology, Pamukkale University School of Medicine, Denizli, Turkey, 10Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, 11Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, 12Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey, 13Department of Rheumatology, Koc University Faculty of Medicine, Istanbul, Turkey

    Background/Purpose: To evaluate the diagnostic and discriminative ability of the new 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) classification…
  • Abstract Number: 2770 • 2014 ACR/ARHP Annual Meeting

    Polymyalgia Rheumatica Relapse and “Silence” Large Vessel Vasculitis. Is There Any Association?

    Stavros Chrysidis1, Philip Rask Lage-Hansen1 and Andreas P. Diamantopoulos2, 1Department of Rheumatology, Hospital of Southwest Denmark, Esbjerg, Denmark, 2Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway

    Background/Purpose Large Vessel Vasculitis (LVV) can present with heterogeneous clinical manifestations, which range from general symptoms (fever, loss of weight) to the classic symptoms of …
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