Abstracts Archive - Page 1858 of 2607 - ACR Meeting Abstracts

Abstract Number: 3065 • 2015 ACR/ARHP Annual Meeting
Evaluation and Validation of Case-Finding Algorithms for the Identification of Patients with Takayasu’s Arteritis in Large Healthcare Administrative Databases
Narender Annapureddy¹, Antoine G. Sreih², Kevin Byram³, George Casey⁴, Vince Frangiosa⁵, Michael George⁶, Rebecca Sharim⁵, Sapna Sangani⁷ and Peter A. Merkel⁷, ¹Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ²Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³Internal Medicine, Vanderbilt University, Nashville, TN, ⁴The Vasculitis Foundation, Kansas City, MO, ⁵Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁷Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: To facilitate clinical care and research, validated algorithms are needed to accurately identify patients with Takayasu's arteritis (TAK). This study sought to evaluate and…
Abstract Number: 3066 • 2015 ACR/ARHP Annual Meeting
Clinical Features and Treatments of Takayasu Arteritis Complicated with Ulcerative Colitis
Toshiki Nakajima¹, Hajime Yoshifuji¹, Chikashi Terao², Takao Fujii¹, Koichiro Ohmura¹, Yoshitaka Imura³, Kosaku Murakami⁴, Ran Nakashima¹, Naoichiro Yukawa¹ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Rheumatology & Clin Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Some cases with Takayasu arteritis (TAK) complicated with ulcerative colitis (UC) have been reported. We previously performed a multi-center surveillance of TAK patients complicated…
Abstract Number: 3067 • 2015 ACR/ARHP Annual Meeting
Microscopic Colitis in Patients with Takayasu Arteritis; A Potential Association Between the Two Disease Entities
Nilufer Alpay Kanitez¹, Bahtiyar Toz¹, Mine Gulluoglu², Burak Erer^1,3, Murat Inanc⁴, Bilger Cavus⁵, Raim Iliaz⁵, Cetin Karaca⁵ and Sevil Kamali¹, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Pathology, Istanbul University, Istanbul Faculty of Medicine, Ä°stanbul, Turkey, ³Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Ä°stanbul, Turkey, ⁵Department of Internal Medicine, Division of Gastroenterology, Istanbul University, Istanbul Faculty of Medicine, Ä°stanbul, Turkey
Background/Purpose: Takayasu's arteritis (TAK) is a chronic vasculitis of large-vessels, mainly affects the aorta and its branches in the middle-aged females. There are reports regarding…
Abstract Number: 3068 • 2015 ACR/ARHP Annual Meeting
Damage Assessment in Takayasu’s Arteritis
Antoine G. Sreih¹, Tanaz A. Kermani², David Cuthbertson³, Simon Carette⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁵, Carol McAlear⁸, Paul A. Monach⁹, Larry W. Moreland¹⁰, Christian Pagnoux¹¹, Philip Seo¹², Kenneth J. Warrington¹³, Steven R. Ytterberg¹⁴ and Peter A. Merkel⁸, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, University of California Los Angeles, Santa Monica, CA, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶McMaster University, Hamilton, ON, Canada, ⁷Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ¹⁰Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ¹²Division of Rheumatology, Johns Hopkins, Baltimore, MD, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN
Background/Purpose: This study aimed to describe disease-related damage in Takayasu's arteritis (TAK) and evaluate damage assessment tools using data from a large longitudinal cohort. …
Abstract Number: 3069 • 2015 ACR/ARHP Annual Meeting
Long Term Follow-up Results of Endovascular Repair in the Management of Arterial Stenosis Caused By Takayasu Arteritis
Aytac Gulcu¹, Naciye Sinem Gezer¹, Pinar Cetin², Servet Akar³, Nurullah Akkoc⁴, Ahmet Yigit Goktay¹ and Fatos Onen², ¹Radiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ³Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ⁴Department of Rheumatology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey
Background/Purpose: Takayasu arteritis (TA) is a chronic arteritis of the aorta and its major branches. Patients may require endovascular repair in long term follow up.…
Abstract Number: 3070 • 2015 ACR/ARHP Annual Meeting
Outcome of Pregnancies in Patients with Takayasu Arteritis with Special Focus on Risk Factors and Disease Activity
Noemie Abisror¹, Arsene Mekinian¹, Marc Lambert², Eric Hachulla³, Robin Dhote⁴, Catherine Chapelon⁵, Antoine Néel⁶, Amar Smail⁷, Frederic Vandergheynst⁸, Nihal Martis⁹, Jean Gabriel Fuzibet¹⁰, Françoise Sarrot-Reynauld¹¹, Marc Andre¹², Alain Fur¹³, Francois Maurier¹⁴, Julien Haroche¹⁵, Bertrand Godeau^16,17, Murielle Rondeau¹⁸, Frederic Renou¹⁹, Pauline Belenotti²⁰, Laure Swiader²⁰, Patrice Cacoub²¹, Bruno Devaux²², Luc Mouthon²³, Jean Baptiste Gaultier²⁴, Pascal Cathebras²⁵, Olivier Pourrat²⁶, Olivier Fain¹, Véronique Le Guern²⁷ and Nathalie Costedoat-Chalumeau²⁷, ¹Internal Medicine Department, Saint Antoine Hospital, Paris, France, ²CHU Lille, Lille, France, ³Department of Internal Medicine, University Lille Nord-de-France, Lille, France, ⁴Internal Medicine, Hospital Avicenne, Bobigny, France, ⁵Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁶Internal Medicine, Nantes University Hospital, Nantes, France, ⁷Internal Medecine, Amiens Hospital, Amiens, France, ⁸Internal Medicine, Erasme hospital, Bruxelles, Belgium, ⁹Internal medicine, Nice, France, ¹⁰Internal Medicine, Internal Medicine, Hôpital de l'Archet 1, CHU de Nice, Nice, France, ¹¹Internal medicine, Grenoble, France, ¹²Internal medicine, Clermont Ferrand, France, ¹³Internal medicine, Troyes, France, ¹⁴HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ¹⁵Internal Medecine, Pitié-Salpêtrière hospital, Paris, France, ¹⁶Henri Mondor, Créteil, France, ¹⁷Internal Medicine, University of Paris, AP-HP, Hôpital Mondor Créteil, Creteil, France, ¹⁸Internal medicine, Strasbourg, France, ¹⁹Internal medicine, Saint Denis, France, ²⁰Internal medicine, Marseille, France, ²¹Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ²²Internal medicine, Coulommiers, France, ²³Paris Descartes University, UPRES-EA 4058, Department of Internal Medicine, Cochin Hospital, Paris, France, ²⁴Internal medicine, Saint Etienne, France, ²⁵Internal Medicine, University Hospital St Etienne, St Etienne, France, ²⁶Internal medicine, Poitiers, France, ²⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France
Background/Purpose: Takayasu arteritis (TA) is a large-vessel vasculitis that affects young women of childbearing age. We aimed to analyze the outcome of pregnancies in TA…
Abstract Number: 3071 • 2015 ACR/ARHP Annual Meeting
Takayasu’s Arteritis and Pregnancy
Cloé Comarmond¹, Tristan Mirault², Lucie Biard³, Jacky Nizard⁴, Marc Lambert⁵, Bertrand Wechsler⁶, Eric Hachulla⁵, Laurent Chiche⁷, Fabien Koskas⁸, Julien Gaudric⁹, Philippe Cluzel¹⁰, Emmanuel Messas¹¹, Mathieu Resche Regon¹², Jean-Charles Piette¹³, Patrice Cacoub¹³ and David Saadoun¹⁴, ¹DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ²Service de Médecine Vasculaire HEGP, Paris, France, ³Biostatistics, Saint-Louis Hospital, Paris, France, ⁴Department of obstetrics and gynaecology, Pitié-Salpêtrière Hospital, Paris, France, ⁵CHU Lille, Lille, France, ⁶Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ⁷Service de Chirurgie Vasculaire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ⁸Department of Internal Medicine and 2Laboratory I3 « Immunology, Immunopathology, Immunotherapy », UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, ⁹Department of Vascular surgery GHPS, Paris, France, ¹⁰Cadiovascular Imaging and Interventional Radiology, Pitié-Salpétrière, Paris, France, ¹¹HEGP hospital Vascular and cardiology Department, paris, France, ¹²biostatistics Saint Louis Hospital, paris, France, ¹³Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁴Department of Internal Medicine and clinical Immunology. French National Reference Center for Autoimmune Diseases. DHU I2B (Inflammation, Immunotherapy and Biotherapy), UPMC, Paris VI, Hôpital Pitié Salpétrière, AP-HP, UPMC, Univ Paris 06, Paris, France
Background/Purpose: To assess the relation between Takayasu's arteritis (TA) and pregnancy outcome. Methods: This study included 240 pregnancies in 96 patients fulfilling ACR and/or Ishikawa…
Abstract Number: 3072 • 2015 ACR/ARHP Annual Meeting
Childhood Takayasu Arteritis. a Single Center Experience
Florence A. Aeschlimann¹, Susanne Benseler², Ronald Laxer¹, Diane Hebert³, Shehla Sheik⁴ and Rae S.M. Yeung¹, ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
Childhood Takayasu Arteritis – A Single Center ExperienceBackground/Purpose: Takayasu Arteritis is a large vessel vasculitis that rarely affects children. Data on childhood TA (cTA) are…
Abstract Number: 3073 • 2015 ACR/ARHP Annual Meeting
Patterns of Vascular Involvement in Childhood Takayasu Arteritis
Florence A. Aeschlimann¹, Simon Eng², Lars Grosse-Wortmann³, Susanne Benseler⁴, Ronald Laxer¹, Diane Hebert⁵ and Rae S.M. Yeung¹, ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²151 Beecroft Rd., Apt. 604, University of Toronto, Toronto, ON, Canada, ³Divisyon of Cardiologz, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada, ⁵Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Takayasu arteritis (TA) is the most common large vessel vasculitis and may presents in childhood. Different angiographic classification systems based on adults with TA…
Abstract Number: 3074 • 2015 ACR/ARHP Annual Meeting
The Shared Rheumatoid Arthritis HLA-DRB1 Susceptibility Epitope Shapes the Molecular Orientation of Citrulline and the Autoreactive T Cell Receptor Repertoire
Jurgen van Heemst¹, Stephen Scally², Soi Cheng Law³, Diane van der Woude⁴, Carol Hitchon⁵, David B. Robinson⁶, T. W. J. Huizinga⁷, Hugh H Reid⁸, René E. M. Toes⁷, Hani El-Gabalawy⁹, Jamie Rossjohn¹⁰ and Ranjeny Thomas¹¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Monash University, Melbourne, Australia, ³The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Melbourne, Australia, ⁹University of Manitoba Arthritis Center, Winnipeg, MB, Canada, ¹⁰Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, England, ¹¹Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Large-scale genomic studies have identified many genetic associations with autoimmune diseases, but the precise pathogenetic mechanisms by which the associated genes impact disease susceptibility…
Abstract Number: 3075 • 2015 ACR/ARHP Annual Meeting
Salivary Gland FcRL4+ B-Cells Are a Potential Source of Progenitor Cells for MALT Lymphoma in Primary Sjögren’s Syndrome
Erlin A. Haacke¹, Frans G.M. Kroese², Philip Kluin³, Petra M. Meiners⁴, Annie Visser⁵, Fred K.L. Spijkervet⁶ and Hendrika Bootsma⁷, ¹Pathology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Pathology and Medical Biology, UMCG Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, UMC Groningen, Groningen, Netherlands, ⁶Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: Patients with primary Sjögren's Syndrome (pSS) have an increased risk of non-Hodgkin's lymphoma, predominantly of the Mucosa Associated Lymphoid Tissue (MALT) type, which commonly…
Abstract Number: 3076 • 2015 ACR/ARHP Annual Meeting
Interferon Gamma (IFNg) Is the Driving Mediator of Secondary Hemophagocytic Lymphohistiocytosis (sHLH) in TLR9-Mediated Pathogenesis in Mice and Is Correlated to Disease Parameters in Children
Cristina De Min¹, Vanessa Buatois¹, Laurence Chatel¹, Laura Cons², Francoise Richard³, Claudia Bracaglia⁴, Fabrizio De Benedetti⁵, Marie Kosco-Vilbois¹ and Walter Ferlin¹, ¹NovImmune S.A., Geneva, Switzerland, ²NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, ³NovImmune SA, Geneva, Switzerland, ⁴Pediatric Medicine, Division of Rheumatology, Rome, Italy, ⁵Division of Rheumatology, Department of Pediatric Medicine, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
Background/Purpose: Life-threatening hyperinflammatory syndromes caused by severe hypercytokinemia include primary (p) and secondary (s) hemophagocytic lymphohistiocytosis (HLH). Increased circulating levels of interferon gamma (IFNg) in…
Abstract Number: 3077 • 2015 ACR/ARHP Annual Meeting
Anakinra in Patients with Cortico-Dependent Idiopathic Recurrent Pericarditis: A Randomised Double-Blind Placebo-Controlled Withdrawal Trial
Antonio Brucato¹, Massimo Imazio², Silvia Maestroni¹, Davide Faustino Cumetti³, Anna Valenti¹, Renzo Marcolongo⁴, George Lazaros⁵, Mara Carraro², Fiorenzo Gaita², Gian Luca Erre⁶, Martina Finetti⁷, Marco Gattorno⁷ and Alberto Martini⁸, ¹Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ²Cardiology, Maria Vittoria Hospital, Torino, Italy, ³Internal Medicine, Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁴Clinical Immunology, Hospital of Padova, Padova, Italy, ⁵Department of Cardiology, Hippokration General Hospital, Athens, Greece, ⁶Rheumatology, Hospital of Sassari, Sassari, Italy, ⁷Pediatry, G. Gaslini Institute, Genova, Italy, ⁸Istituto G. Gaslini, Pediatria II, PRINTO, and University of Genoa, Genoa, Italy
Background/Purpose: Patients with recurrent pericarditis either do not respond or are intolerant to treatment with NSAIDs drugs, corticosteroids and colchicine. We aimed to assess the…
Abstract Number: 3078 • 2015 ACR/ARHP Annual Meeting
ABCG2 rs2231142 predicts Poor Response to Allopurinol in Patients with Gout
Lisa K. Stamp¹, Mary Wallace², Tony R. Merriman³, Amanda Phipps-Green⁴, Ruth Topless^4,5, Jill Drake⁶, Paul Tan⁷, Nicola Dalbeth⁸ and Rebecca Roberts⁴, ¹Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²Surgical Sciences, University of Otago, Dunedin, New Zealand, ³Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ⁴University of Otago, Dunedin, New Zealand, ⁵Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁶Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand, ⁷University of Auckland, Auckland, New Zealand, ⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Many patients fail to reach target serum urate (SU) on allopurinol. Although the most common causes of inadequate response are non-adherence and low dosing…
Abstract Number: 3079 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Riociguat in Patients with Pulmonary Arterial Hypertension (PAH) Associated with Connective Tissue Disease (CTD)
Christopher P. Denton¹, J. Gerry Coghlan², Hossein-Ardeschir Ghofrani³, Friedrich Grimminger³, Jianguo He⁴, Gabriela Riemekasten⁵, Dario Vizza⁶, Annette Boeckenhoff⁷, Christian Meier⁸, Janethe de Oliveira Pena⁹ and Marc Humbert¹⁰, ¹Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom, ²Royal Free London NHS Foundation Trust, London, England, ³University of Giessen and Marburg Lung Center, Giessen, Germany, ⁴Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁵Clinic of Rheumatology and Clinical Immunology, Berlin, Germany, ⁶La Sapienza University of Rome, Rome, Italy, ⁷Bayer Pharma AG, Wuppertal, Germany, ⁸Bayer Pharma AG, Berlin, Germany, ⁹Bayer HealthCare Pharma, Whippany, NJ, ¹⁰Université Paris-Sud, Laboratoire d’Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999, Le Kremlin–Bicêtre, France
Background/Purpose: PAH associated with CTD (PAH-CTD) has a worse prognosis than idiopathic/familial PAH. Here we report a prospective subgroup analysis of patients with PAH-CTD from…

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