Abstracts Archive - Page 1852 of 2425 - ACR Meeting Abstracts

Abstract Number: 2999 • 2014 ACR/ARHP Annual Meeting
Development of a Composite Index for Clinical Trials in Early Diffuse Cutaneous Systemic sclerosis—the Combined Response Index in Systemic Sclerosis
Dinesh Khanna¹, Veronica Berrocal², Edward Giannini³, Maureen Mayes⁴, Peter A. Merkel⁵, Jeffrey Siegel⁶, James R. Seibold⁷, Murray Baron⁸, Philip J. Clements⁹, Yannick Allanore¹⁰, Virginia D. Steen¹¹, Christopher P. Denton¹², Oliver Distler¹³, Sindhu R. Johnson¹⁴, Marco Matucci-Cerinic¹⁵, Lazlo Czirjak¹⁶, Janet E. Pope¹⁷, Susanna Proudman¹⁸, Weng Kee Wong¹⁹, Athol U. Wells²⁰ and Daniel E. Furst⁹, ¹University of Michigan Scleroderma Program, Ann Arbor, MI, ²Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI, ³Ped Rheum/Pav 2-129, Childrens Hosp Med Ctr, Cincinnati, OH, ⁴Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ⁵Vasculitis Center, E5, Boston University School of Medicine, Boston, MA, ⁶Genentech, South San Francisco, CA, ⁷Scleroderma Research Consultants LLC, Avon, CT, ⁸Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁹University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ¹⁰Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ¹¹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, ¹³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁴Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹⁵Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, ¹⁶Immunology and Rheumatology, University of Pécs, Pécs, Hungary, ¹⁷Medicine, Western University, London, ON, Canada, ¹⁸Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ¹⁹Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, ²⁰Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom
Background/Purpose: Diffuse systemic sclerosis (dcSSc) is a multisystem disease that involves skin and internal organs. Our objective was to develop a composite response index in…
Abstract Number: 3000 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Sclerosis Subsets As Predictors of Mortality and Morbidity
Hebah Alhajeri¹, Marie Hudson^2,3, Canadian Scleroderma Research Group CSRG⁴ and Murray Baron⁵, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Division of Rheumatology, McGill University, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Identifying systemic sclerosis (SSc) subsets that predict mortality and morbidity could provide useful prognostic information. We undertook this study to compare the predictive ability…
Abstract Number: 3001 • 2014 ACR/ARHP Annual Meeting
Targeting IL-6 By Both Passive or Active Immunization Strategies Prevents Inflammation-Driven Skin Fibrosis
Jerome Avouac¹, Lucille Desallais², Maxime Fréchet³, Muriel Elhai³, Jean François Zagury² and Yannick Allanore¹, ¹Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ²Chaire de Bioinformatique, Laboratoire Génomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et Métiers, Paris, France, ³INSERM U1016, Cochin Institute, Paris, France
Background/Purpose: Interleukin 6 (IL-6) is a pleiotropic cytokine involved in inflammatory and autoimmune processes. Preliminary data have suggested that IL-6 might contribute to systemic sclerosis…
Abstract Number: 3002 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of a Newly Discovered HGF Receptor Carboxy-Terminal Fragment in Systemic Sclerosis
Yuichiro Shirai¹, Ilia Atanelishvili², Tanjina Akter¹, Richard Silver³ and Galina Bogatkevich¹, ¹Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ³Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is an irreversible fibrotic disorder with interstitial lung disease (ILD) being a major complication and leading cause of mortality. African American…
Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting
Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells
Tetsuo Toyama¹, Yoshihide Asano¹, Takehiro Takahashi¹, Ryosuke Saigusa¹, Yohei Ichimura¹, Takashi Taniguchi¹, Shinji Noda¹, Kaname Akamata¹, Shinichi Sato¹, Takafumi Kadono¹ and Koichi Shudo², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Reseach Foundation ITSUU Laboratory, Tokyo, Japan
Background/Purpose: Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…
Abstract Number: 3004 • 2014 ACR/ARHP Annual Meeting
Autoantibody-Mediated Raynaud’s Phenomenon: Animal Model and Human Disease
Dana P. Ascherman^1,2, Yunjuan Zang³, Laisel Martinez⁴, Judith Pignac-Kobinger⁵, Irina Fernandez³ and Eric L. Greidinger^3,4, ¹Medicine/Rheumatology, University of Miami, Miami, FL, ²Rheumatology, Miami VAMC, Miami, FL, ³Rheumatology, University of Miami, Miami, FL, ⁴Miami VAMC, Miami, FL, ⁵University of Miami, Miami, FL
Background/Purpose: Raynaud’s Phenomenon (RP) is frequently seen in autoimmune conditions, but an autoimmune basis for RP has not been established. Methods: Sera derived from anti-RNP+…
Abstract Number: 3005 • 2014 ACR/ARHP Annual Meeting
Essential Role for Alternately Spliced Tenascin C and TLR4 Signaling in Persistent Organ Fibrosis
Swati Bhattacharyya^1,2, Wenxia Wang¹, Luisa Morales-Nebreda³, Katja Lakota³, Robert Lafyatis⁴, Monique E. Hinchcliff⁵, GR Scott Budinger³, Zenshiro Tamaki³ and John Varga⁶, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…
Abstract Number: 3006 • 2014 ACR/ARHP Annual Meeting
Activation of the Thromboxane A2 Receptor By 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma
Pei-Suen Tsou¹, George Zakhem², Beatrix Balogh², M. Asif Amin³, Phillip Campbell⁴, Gautam Edhayan³, Ray A. Ohara³, Elena Schiopu³, Dinesh Khanna¹, Alisa E. Koch^2,5 and David A. Fox³, ¹University of Michigan Scleroderma Program, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive deposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
Abstract Number: 3007 • 2014 ACR/ARHP Annual Meeting
Can Knee Pain be Prevented through Diet and Exercise Among Those at High Risk? the Look Ahead Study
Daniel White¹, Tuhina Neogi², W. Jack Rejeski³, Michael Walkup³, Cora E. Lewis⁴, Michael Nevitt⁵, Capri Foy³ and David T. Felson², ¹Clinical Epidemiology Training, Boston Univ School of Med, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Wake Forest University, Winston-Salem, NC, ⁴Preventive Medicine, The University of Alabama at Birmingham, Birmingham, AL, ⁵Epidemiology and Biostatistics, UCSF, San Francisco, CA
Background/Purpose: Weight loss combined with exercise is effective for reducing pain and improving function in adults with knee pain. However, it is not known if…
Abstract Number: 3008 • 2014 ACR/ARHP Annual Meeting
High Prevalence of Subclinical Ultrasonographic Enthesopathy and Synovitis in Patients with Inflammatory Bowel Disease without Clinical Signs or Symptoms of Spondyloarthritis
Esther Vicente¹, Silvia Pérez-Esteban², María Chaparro³, Francisco Rodríguez-Salvanés⁴, Lorena Vega⁴, Santos Castañeda¹ and Javier P Gisbert⁵, ¹Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ²Rheumatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ³Gastroenterology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁴Epidemiologic Research Unit, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁵Gastroenterology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose Musculoskeletal manifestations as peripheral arthritis, axial disease and enthesitis are present in 10-62% of Inflammatory Bowel Disease (IBD) patients. Ultrasonography is more sensitive than…
Abstract Number: 3009 • 2014 ACR/ARHP Annual Meeting
Stem Cell Augmentation for Cardiovascular Risk in Rheumatoid Arthritis
Nidhi Garg¹, Ashit Syngle² and Pawan Krishan¹, ¹Deptt. of Pharmaceutical Sciences & Drug Research, Punjabi University Patiala, India, Patiala, India, ²Cardio Rheuma, Healing Touch City Clinic, Fortis Multispeciality Hospital, Chandigarh, India
Background/Purpose: Bone marrow derived stem cells, endothelial progenitor cells (EPCs), protect against atherosclerotic vascular damage by overcoming endothelial damage. However, EPCs are depleted in RA…
Abstract Number: 3010 • 2014 ACR/ARHP Annual Meeting
The Development and Evaluation of a Self-Monitoring and Patient-Initiated Follow-up Service for People with Rheumatoid or Psoriatic Arthritis on Methotrexate
Hayley McBain^1,2, Michael Shipley³, Abigail Olaleye³, Samantha Moore⁴, Shashi Hirani⁵ and Stanton Newman⁶, ¹Health Services Research and Management Division, City University London, London, United Kingdom, ²Community Health Newham, East London Foundation Trust, London, United Kingdom, ³University College Hospital London, London, United Kingdom, ⁴Rheumatology, University College London, London, United Kingdom, ⁵City University London, London, United Kingdom, ⁶School of Community & Health Sciences, City University London, London, United Kingdom
Background/Purpose: Patient-initiated services in rheumatology have been found to be cost-saving without compromising the clinical or psychosocial well-being of patients with rheumatoid arthritis. Self-monitoring is…
Abstract Number: 3011 • 2014 ACR/ARHP Annual Meeting
Ambulatory Gait Analysis in Clinical Practice: Single or Dual Task Conditions?
Bernard Auvinet¹, Claude Touzard² and Vincent Goëb³, ¹Rheumatology Unit, Polyclinic, LAVAL, France, ²Gerontology Unit, Hospital of Laval, LAVAL, France, ³Rheumatology, Amiens University Hospital, Amiens, France
Background/Purpose Interest in ambulatory gait analysis is increasing thanks to validated gait analysis apparatus dedicated to clinical practice. Such methodology has to be reproducible, sensitive,…
Abstract Number: 3012 • 2014 ACR/ARHP Annual Meeting
Needs Assessment Survey – Evaluation of Sexual Dysfunction Among Patients at a Tertiary Rheumatology Clinic
Sharon Nesher Peleg¹, Ori Elkayam², Bruria Yahini¹ and Jacob N. Ablin³, ¹Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Background/Purpose Sexual function is a major component of wellbeing and is adversely affected by many disease states. Previous studies have demonstrated various aspects of sexual…
Abstract Number: 3013 • 2014 ACR/ARHP Annual Meeting
The Reserve Capacity Model in Patients with Rheumatoid Arthritis: Understanding the Relationship of Socioeconomic Status, Psychosocial Resources, Mood, and Pain
Desiree Azizoddin^1,2, Taylor Draper^1,2, Sarah Ormseth³, Perry M. Nicassio⁴, Michael R. Irwin⁴, Michael Weisman⁵ and Hilary Wilson², ¹Psychology, Loma Linda University, Loma Linda, CA, ²Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, ³University of California, Los Angeles, Los Angeles, CA, ⁴Cousins Center for PNI, University of California, Los Angeles, Los Angeles, CA, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
The Reserve Capacity Model in Patients with Rheumatoid Arthritis: Understanding the Relationship of Socioeconomic Status, Psychosocial Resources, Mood, and Pain. Background/Purpose: The reserve capacity model…

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