Abstracts Archive - Page 1850 of 2607 - ACR Meeting Abstracts

Abstract Number: 2944 • 2015 ACR/ARHP Annual Meeting
Presepsin (sCD14 subtype) Concentration Is Elevated and Reflects Disease Activity in Systemic Lupus Erythematous Patients
Kohei Tsujimoto¹, Masaaki Fujita², Yutaka Shinkawa², Iku Shirasugi¹, Masashi Taniguchi¹, Saori Hatachi³ and Masato Yagita⁴, ¹Department of Clinical Immunology and Rheumatology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ²Department of Clinical Immunology and Rheumatology C, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ³Department of Rheumatology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan, ⁴Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan
Background/Purpose: Presepsin (sCD14 subtype) has recently been identified as a novel biomarker for predicting sepsis. Because presepsin is produced as a consequence of cellular phagocytosis,…
Abstract Number: 2945 • 2015 ACR/ARHP Annual Meeting
Diffuse Alveolar Hemorrhage in SLE: Risk Factors, Response to Therapy, and Survival
Nayef M. Kazzaz¹, Patrick S. Coit², Emily E. Lewis³, W Joseph McCune⁴, Amr H. Sawalha² and Jason S. Knight², ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI, ⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI
Background/Purpose: While diffuse alveolar hemorrhage (DAH) is recognized as a life-threatening complication of SLE, little is known about its risk factors and response to therapy. …
Abstract Number: 2946 • 2015 ACR/ARHP Annual Meeting
Mortality Among SLE Patients in the National Data Bank for Rheumatic Diseases
Kaleb Michaud¹, Sofia Pedro² and Patricia P. Katz³, ¹Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Medicine/Rheumatology, University of California San Francisco, San Francisco, CA
Background/Purpose: To investigate risk of mortality among SLE patients cohort in the NDB.Methods: Systemic lupus erythematous (SLE) and non-inflammatory rheumatic disease (NIRD) patients were studied…
Abstract Number: 2947 • 2015 ACR/ARHP Annual Meeting
Association of Anti-NR2 and U1RNP Antibodies with Neurotoxic Inflammatory Mediators in Cerebrospinal Fluid from Patients with Neuropsychiatric Systemic Lupus Erythematosus
Seiko Kondo-Ishikawa¹, Takao Fujii², Nozomi Ishigooka¹, Kosaku Murakami¹, Ran Nakashima¹, Yoshitaka Imura¹, Motomu Hashimoto², Naoichiro Yukawa¹, Hajime Yoshifuji¹, Koichiro Ohmura¹ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: Autoantibodies (auto Abs) in cerebrospinal fluid (CSF) and inflammatory mediators (IMs) may be involved in the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE). Previous…
Abstract Number: 2948 • 2015 ACR/ARHP Annual Meeting
How Do Patients with Newly Diagnosed SLE Present? a Multicenter Cohort Analysis to Inform the Development of New Classification Criteria for SLE
Marta Mosca¹, Zahi Touma², Karen H. Costenbader³, Bimba F. Hoyer⁴, Chiara Tani¹, Alexander Fine⁵, Sara Tedeschi³, Jorge Medina-Rosas⁶, Valentina Lorenzoni⁷, Gian Domenico Sebastiani⁸, Thomas Dorner⁹ and on behalf of the SLE Classification Criteria Steering committee, ¹University of Pisa, Pisa, Italy, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Charité University Medicine, Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Berlin, Germany, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶University of Toronto, Toronto, ON, Canada, ⁷SSSUP, Pisa, Italy, ⁸Osp. San Camillo, Roma, Italy, ⁹Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Charité University Medicine, Berlin, Germany
Background/Purpose: SLE onset may be insidious with clinically evident disease developing over years. Current SLE classification criteria may not classify patients with early SLE well.…
Abstract Number: 2949 • 2015 ACR/ARHP Annual Meeting
Differential Serum Cytokine Profile in Patients with Systemic Lupus Erythematosus and Posterior Reversible Encephalopathy Syndrome: A Single-Center Study
Jorge Alcocer-Varela¹, Diana Gómez-Martín¹, Javier Merayo-Chalico² and Ana Barrera-Vargas¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are susceptible to the development of posterior reversible encephalopathy syndrome (PRES). The main theory about the physiopathology of…
Abstract Number: 2950 • 2015 ACR/ARHP Annual Meeting
Using Electronic Health Record Algorithms to Accurately Identify Patients with Systemic Lupus Erythematosus
April Barnado¹, Joshua C. Denny² and Leslie J. Crofford¹, ¹Medicine, Vanderbilt University, Nashville, TN, ²Biomedical Informatics, Medicine, Vanderbilt University, Nashville, TN
Background/Purpose: To harness the data in electronic health records (EHRs) and administrative databases to study systemic lupus erythematosus (SLE), it is important to identify patients…
Abstract Number: 2951 • 2015 ACR/ARHP Annual Meeting
Anti-NR2 Antibody and Blood-Brain Barrier Disruption in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction
Gaurav Gulati¹, Philip Iffland², Damir Janigro², Bin Zhang³ and Michael Luggen⁴, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ³Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Immunology, University of Cincinnati Medical Center, Cincinnati, OH
Background/Purpose: Cognitive Dysfunction (CD) is one of the most common manifestations of neuropsychiatric SLE (NPSLE) and one of the most devastating. The pathogenesis of CD…
Abstract Number: 2952 • 2015 ACR/ARHP Annual Meeting
Diagnosis of Primary Neuropsychiatric Systemic Lupus Erythematosus: Attribution Models Versus Physician Judgment
Antonis Fanouriakis^1,2, Cristina Pamfil³, Simona Rednic³, Prodromos Sidiropoulos¹, George Bertsias^4,5 and Dimitrios Boumpas^5,6,7, ¹Rheumatology, Clinical Immunology, and Allergy, University of Crete, Medical School, University Hospital, Heraklion, Greece, ²Foundation of Research and Technology, University of Molecular Biology and Biotechnology, Heraklion, Greece, ³Rheumatology, University of Medicine and Pharmacy, Cluj-Napoca, Romania, ⁴Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece, ⁵Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology-Hellas, Heraklion, Crete, Greece, ⁶Biomedical Research Foundation, Academy of Athens, Athens, Greece, ⁷Clinical Immunology and Rheumatology, National And Kapodistrian University of Athens, Medical School, Athens, Greece
Background/Purpose: Attribution of neuropsychiatric manifestations to systemic lupus erythematosus per se (“primary NPSLE”) is challenging and depends largely on physician judgment based on clinical and…
Abstract Number: 2953 • 2015 ACR/ARHP Annual Meeting
The Emergency Room and SLE: What Characteristics Are Associated with Increased Emergency Room Utilization in Lupus Patients?
Kimberly Trotter¹, Kichul Ko¹, Gabrielle Liu¹ and Tammy Utset², ¹Medicine, University of Chicago, Chicago, IL, ²University of Chicago, Chicago, IL
Background/Purpose: There is sparse data examining the characteristics of SLE patients who frequent the emergency room (ER). Data suggest that lupus patients with certain sociodemographic…
Abstract Number: 2954 • 2015 ACR/ARHP Annual Meeting
Serum and CSF Biomarkers of Neuropsychiatric Involvement in Primary Sjogren Syndrome and Systemic Lupus Erythematosus
Maria Boge Lauvsnes¹, Anne Bolette Tjensvoll², Ingeborg Kvivik³, Roald Omdal⁴ and Chaim Putterman⁵, ¹Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ³Reasearch Department, Stavanger University Hospital, Stavanger, Norway, ⁴Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁵Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Neuropsychiatric manifestations are commonly observed in both SLE and primary Sjšgren's syndrome (pSS). However, making an accurate diagnosis can be challenging. Multiple serum and…
Abstract Number: 2955 • 2015 ACR/ARHP Annual Meeting
Cognitive Impairment in Lupus Patients: Identification of the Best Screening Test and Assessment for Associated Factors
Stephanie Nantes¹, Murray Urowitz^2,3, Dafna Gladman², Jiandong Su², Ashneet Dhaliwal¹ and Zahi Touma², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: There is an unmet need for a screening test of cognitive function that can be administered in clinic in patients with SLE. We…
Abstract Number: 2956 • 2015 ACR/ARHP Annual Meeting
Patients’ Reported Perceived Deficits Questionnaire – 5-Item Is Not Valid to Screen for Cognitive Impairment in Lupus
Stephanie Nantes¹, Murray Urowitz², Dafna Gladman², Ashneet Dhaliwal¹ and Zahi Touma², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: It is unclear whether cognitive complaints in patients with SLE are indicative of true Cognitive Impairment (CI) or underlying depression or anxiety. To determine:…
Abstract Number: 2957 • 2015 ACR/ARHP Annual Meeting
25-Hydroxyvitamin D3 Deficiency Independently Predicts Cognitive Impairment in Patients with Systemic Lupus Erythematosus: Results from a Controlled Study
Sen Hee Tay^1,2 and Anselm Mak^2,3, ¹National University of Singapore, Singapore, Singapore, ²National University Health System, Singapore, Singapore, ³Medicine, National University of Singapore, Singapore, Singapore
Background/Purpose: Cognitive dysfunction has been reported in 20-80% of systemic lupus erythematosus (SLE) patients. Converging evidence has indicated the importance of vitamin D as a…
Abstract Number: 2958 • 2015 ACR/ARHP Annual Meeting
Vitamin D, Cognition and Cerebral Structural Abnormalities in Childhood- Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Mariana Postal², Aline Tamires Lapa², Bruna B Siqueira³, Karina Pelicari², Paula T Fernades³, Roberto Marini Sr.⁴ and Simone Appenzeller⁵, ¹Pediatrics, State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁵Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: About 16-95% of SLE patients have vitamin D insufficiency. Vitamin D levels, especially vitamin D deficiency, are associated with cognitive performance in adults. We…

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