ACR Meeting Abstracts

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  • Abstract Number: 1448 • ACR Convergence 2025

    Influence of Sex on the Therapeutic Persistence of Guselkumab in Psoriatic Disease: a Retrospective National Cohort Study

    Laure Gossec1, Pascal Claudepierre2, Arnaud Constantin3, Denis Jullien4, Samira Chaalal5, Julie Baraut5, Laure Cipiere5, Laurène Gautier6, Pierre Lemire7 and Thierry Passeron8, 1Sorbonne Universite and Pitie-Salpetriere Hospital, Paris, France, 2Department of Rheumatology, CHU Henri Mondor, AP-HP, Créteil, France, Creteil, France, 3Department of Rheumatology, Toulouse University Hospital, Toulouse University and INSERM U1291, France, Toulouse, France, 4Hospices Civils de Lyon, Hôpital E. Herriot Department of Dermatologie, Lyon F-69003 ; CIRI, Centre International de Recherche en Infectiologie, Team EIA : Epidermal immunity & Allergy, INSERM, U1111; Univ Lyon; Université de Lyon 1; Ecole Normale Supérieure de Lyon; CNRS, UMR 5308, Lyon, France., Lyon, France, 5Johnson & Johnson, Issy les moulineaux, France, 6Johnson & Johson, Issy les Moulineaux, France, 7IQVIA, Real World Solutions, Paris, France, Paris, France, 8Johnson & Johnson, Nice, France

    Background/Purpose: Psoriatic disease, including psoriasis (Pso) and psoriatic arthritis (PsA), seems to affect male and female patients differently in clinical presentation, disease progression and advanced…
  • Abstract Number: 1386 • ACR Convergence 2025

    Characterization and Progression of Localized Amyloidosis in Sjogren’s Syndrome: Evidence Long-Term (1995-2025) Follow-Up of a Cohort compared to Literature Review.

    Hoang Nguyen1, Philip Moresco2, Antoine Chiu2, Asha Patnaik3 and Peter Gorevic4, 1Stony Brook University-Renaissance School of Medicine- Department of Rheumatology, Jamaica, NY, 2Stony Brook University -Renaissance School of Medicine, Stony Brook, NY, 3Stony Brook University Hospital, Stony Brook, NY, 4Stony Brook University, Stony Brook, NY

    Background/Purpose: -Sjogren’s syndrome (SS) is a chronic autoimmune disorder, defined by keratoconjunctivitis sicca (KCS), specific serologies, and a significant risk of extra-exocrine disease manifestations and…
  • Abstract Number: 1325 • ACR Convergence 2025

    Plasma Matrix Metalloproteinases and Heart Failure Outcomes in Rheumatoid Arthritis

    Tate Johnson1, Michael Duryee1, Punyasha Roul2, Grant Cannon3, Gary Kunkel4, Beth Wallace5, Isaac Smith6, John Richards7, Katherine Wysham8, Gail Kerr9, Andreas Reimold10, Pascale Schwab11, Daniel Anderson12, Joshua Baker13, Geoffrey Thiele1, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3University of Utah and Salt Lake City VA, Salt Lake City, UT, 4University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 5Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 6Duke University Hospital, Durham, NC, 7Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 8VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 9Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 10Dallas VA Medical Center, Dallas, TX, 11VA Portland and Oregon Health & Science University, Portland, OR, 120587964, Durham, NC, 13University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The mechanisms of heart failure (HF) risk in RA remain incompletely understood. HF with preserved ejection fraction (HFpEF) is over-represented in RA, which may…
  • Abstract Number: 1358 • ACR Convergence 2025

    Real-World Evidence for the Superiority of Subcutaneous Methotrexate in RA: A Comparative Observational Study with Ultrasonographic Assessment

    Masatsugu Komagamine1, Sari Taguchi2, Masataka Komagamine2, Tetsuji Naka1 and Minoru Fujimoto1, 1Division of Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan, 2Komagamine Rheumatology and Orthopedic Clinic, Morioka, Japan

    Background/Purpose: Methotrexate (MTX) is a foundational agent in the management of rheumatoid arthritis (RA). While oral MTX is widely prescribed, its subcutaneous (SC) formulation may…
  • Abstract Number: 1398 • ACR Convergence 2025

    Reproductive Challenges and Cardiovascular Risks in Sjögren’s Syndrome and Systemic Sclerosis: A Meta-Analysis of Fertility, Pregnancy Outcomes, and Maternal Cardiac Health

    R. Mohamad Javier1, Bernadus Bramantyo2, Arkan Berlian3, Mahardika Nugraha4, Azzura Simanulang1, Eko Setyo Herwanto5, Athaya Febriantyo Purnomo6, Jonathan Jonathan7, Ananingati Ananingati5, Budi Prakoso8 and Aisyah Rizki Nirmala Hanum5, 1University of Indonesia Hospital, Jakarta Selatan, Jakarta Raya, Indonesia, 2Sardjito General Hospital, Daerah Istimewa Yogyakarta, Yogyakarta, Indonesia, 3Dr. Cipto Mangunkusumo Hospital, Jakarta Barat, Jakarta Raya, Indonesia, 4Universitas Islam Sultan Agung, KOTA SEMARANG, Jawa Tengah, Indonesia, 5Universitas Muhammadiyah Malang, Malang, Jawa Timur, Indonesia, 6Saiful Anwar General Hospita, Malang, Jawa Timur, Indonesia, 7RSUD Kalideres, Jakarta, Jakarta Raya, Indonesia, 8Department of Internal Medicine, RST dr Soepraoen, Malang, Jawa Timur, Indonesia

    Background/Purpose: Autoimmune rheumatic diseases such as Sjögren’s Syndrome (SS) and Systemic Sclerosis (SSc) can significantly impact reproductive health and increase maternal cardiovascular risk. These conditions…
  • Abstract Number: 1443 • ACR Convergence 2025

    Long-Term Safety and Efficacy of Upadacitinib in Patients With Psoriatic Arthritis: 5-Year Results From the Phase 3 SELECT-PsA 1 Study

    Iain McInnes1, Koji Kato2, Marina Magrey3, Joseph Merola4, mitsumasa kishimoto5, Derek Haaland6, Ivan Lagunes7, Laura Coates8, Yanxi Liu9, Erin Mancl10, Bhumik Parikh11 and Charles Phillips12, 1University of Glasgow, Glasgow, United Kingdom, 2Abbvie. Inc, North Chicago, IL, 3Case Western Reserve University School of Medicine/University Hospitals Cleveland, Richfield, OH, 4UT Southwestern Medical Center, Dallas, TX, 5Kyorin University School of Medicine, Tokyo, Japan, 6The Waterside Clinic, Oro Medonte, ON, Canada, 7Abbvie Inc, North Chicago, IL, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom, 9Abbvie Inc, Florham Park, NJ, 10AbbVie, Chicago, IL, 11AbbVie, Hillsborough Township, NJ, 12AbbVie Inc, Princeton, NJ

    Background/Purpose: We evaluated safety and efficacy of upadacitinib (UPA) versus adalimumab (ADA) at week 260 (5-years) from the long-term extension of SELECT-PsA 1.Methods: Randomized patients…
  • Abstract Number: 1450 • ACR Convergence 2025

    The Novel Digital Therapeutic Axia Improves Disease Activity, Functionality, and Quality of Life in Axial Spondyloarthritis Patients: Results from a Randomized Controlled Trial (Bechterew-App Trial)

    Patrick-Pascal Strunz1, Tobias Heusinger2, Maxime Le Maire2, Anna Fleischer3, Karsten Sebastian Luetkens4, Patricia Possler2, Michael Gernert1, Hannah Labinsky5, Robert Leppich6, Astrid Schmieder7, Ludwig Hammel8, Billy Sperlich9, Matthias Fröhlich1 and Marc Schmalzing10, 1University Hospital of Wuerzburg, Department of Medicine II, Rheumatology/ Immunology, Wuerzburg, Germany, 2University of Wuerzburg, Wuerzburg, Germany, 3University Hospital of Wuerzburg, Department of Medicine II, Psychosomatics, Wuerzburg, Germany, 4University Hospital of Wuerzburg, Institute of Diagnostic and Interventional Radiology, Wuerzburg, Germany, 5University Hospital of Wuerzburg, Würzburg, Germany, 6University Hospital of Wuerzburg, Chair of Software Engineering (Informatik II), Department of Computer Science, Wuerzburg, Germany, 7University Hospital Würzburg, Department of Dermatology, Venereology, and Allergology, Wuerzburg, Germany, 8Deutsche Vereinigung Morbus Bechterew e. V., Schweinfurt, Germany, 9Integrative and Experimental Exercise Science and Training, Institute for Sports Science, Wuerzburg, Germany, 10Department of Medicine II, Rheumatology/ Immunology,University Hospital of Wuerzburg, Wuerzburg, Bayern, Germany

    Background/Purpose: Axia is a novel digital therapeutic (DTx) specifically designed for patients with axial spondyloarthritis (axSpA), in compliance with the European Medical Device Regulation (MDR).…
  • Abstract Number: 1336 • ACR Convergence 2025

    Effectiveness of new initiators of tofacitinib and other biologic/targeted synthetic DMARDs in patients with rheumatoid arthritis

    Katherine Liao1, Chandrasekar Gopalakrishnan2, Jinoos Yazdany3, Griffith Bell4, Suraj Mothi5, Genevieve Gauthier6, Arne Yndestad7 and Milena Gianfrancesco8, 1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Boston, MA, USA, Boston, MA, 2OM1 Inc, Boston, MA, USA, Boston, 3UCSF, San Francisco, CA, 4Pfizer Inc, New York, NY, USA, Boston, MA, 5OM1 Inc, Boston, MA, USA, Boston, MA, 6Pfizer Canada ULC, Kirkland, QC, Canada, Montreal, Canada, 7Pfizer Inc, Oslo, Norway, Oslo, Norway, 8Pfizer Inc, New York, NY, USA, New York, NY

    Background/Purpose: Though the efficacy and safety profile of tofacitinib in RA has been established in prior trials, the effectiveness of tofacitinib in routine care settings…
  • Abstract Number: 1459 • ACR Convergence 2025

    Fungal Infections, Including Candida, in Patients With Active Psoriatic Arthritis (PsA) Treated With Secukinumab: A Pooled Analysis of 9 Phase 3 Trials

    Shikha Singla1, Linda Grinnell-Merrick2, Weibin Bao3, Artem Zharkov4 and Abhijeet Danve5, 1Medical College of Wisconsin, Milwaukee, WI, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, Hanover, NJ, 4Novartis Pharma AG, Basel, Switzerland, 5Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT

    Background/Purpose: PsA is a chronic inflammatory disease characterized by joint pain, swelling and stiffness, and is often accompanied by cutaneous changes linked to psoriasis. Patients…
  • Abstract Number: 1366 • ACR Convergence 2025

    Cost Per Responder Analysis of Certolizumab Pegol Versus Adalimumab in Patients with Moderate to Severe Active Rheumatoid Arthritis and High Rheumatoid Factor Levels: A Payer Perspective from Canada and Brazil

    Rémi Marty1, Baran Ufuktepe2, Nicola Tilt3, Flore Decuypere4, Angela Blake3, Sandeep Kiri3 and Mohammed Soomro3, 1UCB Pharma, Brussels, Belgium, Anderlecht, Belgium, 2UCB Pharma Istanbul, Turkey, istanbul, Turkey, 3UCB Pharma, Slough, United Kingdom, Slough, United Kingdom, 4UCB Pharma Brussels, Belgium, Brussels, Belgium

    Background/Purpose: According to the 2022 EULAR recommendations for the management of rheumatoid arthritis (RA), the presence of rheumatoid factor (RF), particularly at high levels, is…
  • Abstract Number: 1408 • ACR Convergence 2025

    When Damage and Disability Diverge: Unraveling Sex-Based Drivers of Axial Spondyloarthritis Burden

    Claudia Marques1, Gustavo Resende2, Carla Saad3, Adriana Marinho4, Andressa Soares5, Beatriz Paiva6, Cleandro Pires7, Débora Rodrigues8, Glaucio Castro9, Guilherme Bulbol10, Jamile Carneiro11, Manuella Ochtrop12, José Mauro Fernandes13, Maria Bernadete Gavi14, Maria Eduarda Veiga3, Michel Yazbek15, Nara Cavalcanti16, Natalia Machado17, Olivio Malheiro18, Rafael Bassara Macedo19, Rejane Vieira20, Ricardo Lage18, Rita Menin21, Rywka Golebiovski22, Sandra Ribeiro10, Thauana Oliveira22, Valquiria Diniz14, Percival Sampaio-Barros23 and Marcelo Pinheiro24, 1Hospital das Clinicas - Universidade Federal de Pernambuco - UFPE, Recife, Pernambuco, Brazil, 2Hospital das Clinicas UFMG, Belo Horizonte, Brazil, 3Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, 4Fundação Hospital do Acre - AC, Rio Branco, Brazil, 5Hospital Universitário da Universidade Federal de Santa Catarina (UFSC) - SC, Florianópolis, Brazil, 6Faculdade de Medicina da Universidade Federal do Amazonas (UFAM) - AM, Manaus, Brazil, 7UNB, Brasilia, Distrito Federal, Brazil, 8Fundação Hospital do Acre - AC, Rio Branco, Acre, Brazil, 9Hospital Governador Celso Ramos (HCR) - SC, Florianópolis, Santa Catarina, Brazil, 10Faculdade de Medicina da Universidade Federal do Amazonas (UFAM) - AM, Manaus, Amazonas, Brazil, 11Hospital de Base do Distrito Federal (HBDF) - DF, Brasilia, Distrito Federal, Brazil, 12Hospital Universitário Pedro Ernesto / UERJ - RJ, Rio de Janeiro, Rio de Janeiro, Brazil, 13Universidade Federal do Maranhão (UFMA) - MA, São Luiz, Maranhao, Brazil, 14Universidade Federal do Espírito Santo (UFES) - ES, Vitória, Espirito Santo, Brazil, 15Universidade Estadual de Campinas (UNICAMP) - SP, Campinhas, Sao Paulo, Brazil, 16Hospital das Clínicas da Universidade Federal de Pernambuco (UFPE) - PE, Recife, Pernambuco, Brazil, 17Universidade Fedral do Paraná (UFPR) - PR, Curitiba, Parana, Brazil, 18Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG) - MG, Belo Horizonte, Minas Gerais, Brazil, 19Rheumatology Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (USP), Sao Paulo, Sao Paulo, Brazil, 20Universidade Estadual do Ceará (UECE) - CE, Fortaleza, Ceara, Brazil, 21Faculdade de Medicina de São José do Rio Preto (FAMERP) - SP, São José do Rio Preto, Sao Paulo, Brazil, 22Escola Paulista de Medicina (EPM) - Universidade Federal de São Paulo (UNIFESP) - SP, São Paulo, Sao Paulo, Brazil, 23Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, Brazil, 24UNIFESP/ EPM, São Paulo, São Paulo, Brazil

    Background/Purpose: Sex differences in axial spondyloarthritis (axSpA) are well recognized, but their clinical consequences remain understudied in real-world settings. This study aimed to assess sex-based…
  • Abstract Number: L11 • ACR Convergence 2024

    Rheumatology Diagnostics Utilizing Artificial Intelligence (ANA Reader©) for ANA Pattern Identification and Titer Quantification

    May Choi1, Farbod Moghaddam1, Mohammad Sajadi1, Ann E. Clarke1, Sasha Bernatsky2, Karen Costenbader3, Irene Chen4, Murray Urowitz5, John Hanly6, Caroline Gordon7, Sang-Cheol Bae8, Juanita Romero-Diaz9, Jorge Sanchez-Guerrero10, Daniel Wallace11, David Isenberg12, Anisur Rahman13, Joan Merrill14, Paul Fortin15, Dafna Gladman16, Ian Bruce17, Michelle Petri18, Ellen Ginzler19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Susan Manzi22, Andreas Jönsen23, Graciela Alarcón24, Ronald Van Vollenhoven25, Cynthia Aranow26, Meggan Mackay26, Guillermo Ruiz-Irastorza27, S. Sam Lim28, Murat Inanç29, Kenneth Kalunian30, Soren Jacobsen31, Christine Peschken32, Diane Kamen33, Anca Askanase34, Marvin Fritzler35 and Mina Aminghafari1, 1University of Calgary, Calgary, AB, Canada, 2Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 4UC Berkeley and UCSF, Berkeley, CA, 5Self employed, Toronto, ON, Canada, 6Dalhousie University, Halifax, NS, Canada, 7University of Birmingham, Birmingham, United Kingdom, 8Hanyang University Medical Center, Seoul, South Korea, 9The National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, 10Krembil Research Institute, Toronto, ON, Canada, 11Cedars Sinai Medical Center, Studio City, CA, 12Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, United Kingdom, 13University College London, London, United Kingdom, 14Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Centre ARThrite - CHU de Québec - UniversitéLaval, Quebec, QC, Canada, 16University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 17Queen's University Belfast, Belfast, United Kingdom, 18Johns Hopkins University School of Medicine, Baltimore, MD, 19SUNY Downstate Health Sciences University, New York, NY, 20UNC physician network, Chapel Hill, NC, 21Northwestern University, Chicago, IL, 22Allegheny Health Network, Pittsburgh, PA, 23Lund University, Lund, Sweden, 24The University of Alabama at Birmingham, Oakland, CA, 25Amsterdam UMC, Amsterdam, Netherlands, 26Feinstein Institutes for Medical Research, New York, NY, 27Biobizkaia Health Research Institute, Bilbao, Spain, 28Emory University, Atlanta, GA, 29Istanbul University, Istanbul, Turkey, 30UC San Diego, La Jolla, CA, 31Rigshospitalet, Copenhagen, Denmark, 32University of Manitoba, Winnipeg, MB, Canada, 33Medical University of South Carolina, Johns Island, SC, 34Columbia University Medical Center, New York, NY, 35Mitogen Diagnostics Corp, Calgary, AB, Canada

    Background/Purpose: Antinuclear antibody (ANA) immunofluorescence (IFA) patterns and titers are a key part of rheumatology diagnostics, however, there is considerable intra- and inter-laboratory variability with…
  • Abstract Number: L13 • ACR Convergence 2024

    Anifrolumab Long-Term Treatment Is More Effective Against Organ Damage Than Standard of Care Alone: Results from an External Control Arm Study on Organ Damage in Phase 3 Clinical Trials and the University of Toronto Lupus Clinic Cohort

    Zahi Touma1, Ian Bruce2, Richard A. Furie3, Eric Morand4, Raj Tummala5, Shelly Chandran6, Gabriel Abreu7, Jacob Knagenhjelm7, Kellyn Arnold8, Hopin Lee8, Eleanor Ralphs8, Danuta Kielar9, Aleksander Bedenkov9 and Miina Waratani9, 1Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 2Queen's University Belfast, Belfast, United Kingdom, 3Northwell Health, Manhasset, NY, 4Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 5BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 6Astrazeneca, Mississauga, ON, Canada, 7BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 8IQVIA, London, United Kingdom, 9Biopharmaceuticals Medicine, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: In SLE, persistent disease activity, disease flares and long-term glucocorticoid (GC) use all contribute to organ damage accrual. The effects of novel therapies on…
  • Abstract Number: L15 • ACR Convergence 2024

    LEVI-04, a Novel neurotrophin-3 Inhibitor, Substantially Improves Pain and Function Without Deleterious Effects on Joint Structure in People with Knee Osteoarthritis: A Randomized Controlled Phase II Trial

    Philip Conaghan1, Ali Guermazi2, Nathaniel Katz3, Asger Bihlet4, Dror Rom5, Michael Perkins6, Bernadette Hughes6, Claire Herholdt6, Iwona Bombelka6 and Simon Westbrook6, 1University of Leeds, Leeds, United Kingdom, 2Boston University, West Roxbury, MA, 3Rin Sof Innovation, Ltd, Boston, MA, 4NBCD A/S, Soeborg, Denmark, 5Prosoft Clinical, Chesterbrook, 6Levicept Ltd, Ramsgate, United Kingdom

    Background/Purpose: There is an urgent need for new therapies to treat OA. Excess neurotrophins (NT) are implicated in OA and other painful conditions. Previous OA…
  • Abstract Number: L14 • ACR Convergence 2024

    A Withdrawal Study of Colchicine in Behçet Syndrome

    Basak Sirin1, Sinem Nihal Esatoglu2, Hasan Yazıcı3 and Gulen Hatemi4, 1Istanbul University- Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey, 2Istanbul University- Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul,Türkiye/Istanbul University- Cerrahpaşa, Behcet's Disease Research Center, Istanbul, Turkey, 3Academic Hospital, Istanbul, Turkey, 4Istanbul University- Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul,Türkiye/Istanbul University- Cerrahpaşa, Behcet's Disease Research Center, Istanbul,Türkiye, Istanbul, Turkey

    Background/Purpose: Previous randomized controlled studies reported conflicting results regarding the effectiveness of colchicine on oral ulcers in Behçet syndrome (BS). A randomized drug discontinuation design…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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