Abstracts Archive - Page 1796 of 2425 - ACR Meeting Abstracts

Abstract Number: 1604 • 2015 ACR/ARHP Annual Meeting
Cardiovascular Disease in a Large Incident Cohort of Early Inflammatory Arthritis
Lillian Barra¹, Janet E. Pope², Carol Hitchon³, Gilles Boire⁴, Daming Lin⁵, J Carter Thorne⁶, Diane Tin⁷, Edward C. Keystone⁸, Boulos Haraoui⁹, VP Bykerk⁶ and CATCH, ¹Medicine, Division of Rheumatology, Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶University of Toronto, Toronto, ON, Canada, ⁷The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁹Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada
Cardiovascular Disease in a Large Incident Cohort of Early Inflammatory Arthritis Background/Purpose: Rheumatoid Arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD).…
Abstract Number: 1605 • 2015 ACR/ARHP Annual Meeting
Enhanced Oxidant Signaling in Inflammatory Macrophages in Rheumatoid Arthritis (RA) and in Coronary Artery Disease (CAD)
Tsuyoshi Shirai¹, Benedikt Schaefgen¹, Barbara Wallis¹, Eric L. Matteson², Themistocles L. Assimes³, David G. Harrison⁴, Jorg Goronzy⁵ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Stanford University School of Medicine, Stanford, CA, ⁴Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: RA patients have a 2-fold increased risk of developing coronary artery disease (CAD) regardless of traditional risk factors. Atherosclerosis, the underlying process in CAD,…
Abstract Number: 1606 • 2015 ACR/ARHP Annual Meeting
Telomere Damage in Rheumatoid Arthritis
Yinyin Li¹, Jihang Ju¹, Thomas M. Bush², Mark C. Genovese³, Jorg Goronzy¹ and Cornelia M. Weyand⁴, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Medicine/Rheumatology, Santa Clara Valley Medical Center, San Jose, CA, ³Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Production of anti-CCP autoantibodies, the hallmark of rheumatoid arthritis (RA), is dependent on T cell help, positioning T cells into a pinnacle position in…
Abstract Number: 1607 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a Dose-Dependent Manner
Chikashi Terao¹, Noriyuki Yamakawa², Koichiro Yano³, I.M. Markusse⁴, Katsunori Ikari³, Shinji Yoshida³, Moritoshi Furu⁵, Motomu Hashimoto⁵, Hiromu Ito⁵, Takao Fujii⁶, Koichiro Ohmura⁷, Kosaku Murakami⁷, Meiko Takahashi², Masahide Hamaguchi⁸, Yasuharu Tabara², Atsuo Taniguchi³, Shigeki Momohara³, Soumya Raychaudhuri⁹, Cornelia F. Allaart¹⁰, Hisashi Yamanaka¹¹, Tsuneyo Mimori¹² and Fumihiko Matsuda¹³, ¹Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴LUMC, Leiden, Netherlands, ⁵Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Dept of Rheum/Clinical Immun, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁷Dept of Rheum & Clinical Immun, Kyoto Univ Grad School of Med, Kyoto, Japan, ⁸Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan, ⁹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁰Rheumatology, LUMC, Leiden, Netherlands, ¹¹Tokyo Women's Medical University, Tokyo, Japan, ¹²Dept of Rheum & Clinical Immun, Kyoto Univ Grad Schl of Med, Kyoto, Japan, ¹³Genomic Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed correlates associated with the speed of joint destruction,…
Abstract Number: 1608 • 2015 ACR/ARHP Annual Meeting
Protective Role of the Vitamin D Receptor Apai (rs7975232) Polymorphism Against Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis from Northern Spain
Raquel López-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, Gema Robledo², Begoña Ubilla¹, Veronica Mijares¹, Javier Llorca³, Montserrat Robustillo-Villarino⁴, Alfonso Corrales¹, Carlos González-Juanatey⁵, Jose A. Miranda-Filloy⁶, Trinitario Pina⁷, Ricardo Blanco⁷, Esther Vicente⁸, Juan José Alegre⁹, Cesar Magro¹⁰, Enrique Raya¹¹, Beatriz Tejera¹², Marco A Ramírez Huaranga¹³, Ivan Ferraz-Amaro¹², Santos Castañeda¹⁴, Javier Martín² and Miguel A. Gonzalez-Gay^1,15, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ³Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁴Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, ⁷Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁸Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, ⁹Rheumatology, Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ¹⁰Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, ¹¹Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ¹²Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ¹³Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ¹⁴Rheumatology, H.U. La Princesa, Madrid, Spain, ¹⁵Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Several vitamin D receptor (VDR) polymorphisms have been associated with cardiovascular (CV) and autoimmune diseases. Carotid plaques are surrogate markers of severe atherosclerotic disease.…
Abstract Number: 1609 • 2015 ACR/ARHP Annual Meeting
Lack of Association Between ZHX2, Lepr, Gckr and ASCL1 and Carotid Intima-Media Thickness, Carotid Plaques and Cardiovascular Disease in Patients with Rheumatoid Arthritis
Raquel López-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, Montserrat Robustillo-Villarino², Alfonso Corrales¹, Javier Llorca³, Carlos González-Juanatey⁴, Begoña Ubilla¹, Jose A. Miranda-Filloy⁵, Veronica Mijares¹, Trinitario Pina⁶, Ricardo Blanco⁶, Juan José Alegre², Marco A Ramírez Huaranga⁷, Maria D Mínguez Sánchez⁷, Carmen Gomez Vaquero⁸, Luis Rodriguez Rodriguez⁹, Benjamin Fernandez Gutierrez⁹, Alejandro Balsa¹⁰, Dora Pascual-Salcedo¹⁰, Francisco Lopez Longo¹¹, Patricia E. Carreira¹², Cesar Magro¹³, Enrique Raya¹⁴, Beatriz Tejera¹⁵, Ivan Ferraz-Amaro¹⁵, Esther Vicente¹⁶, Isidoro González-Alvaro¹⁶, Santos Castañeda¹⁷, Javier Martín¹⁸ and Miguel A. Gonzalez-Gay^1,19, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ³Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁷Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ⁸Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁰Department of Rheumatology, Hospital La Paz, Madrid, Spain, ¹¹Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹²Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹³Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, ¹⁴Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ¹⁵Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ¹⁶Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, ¹⁷Rheumatology, H.U. La Princesa, Madrid, Spain, ¹⁸Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ¹⁹Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ZHX2 rs11781551 polymorphism…
Abstract Number: 1610 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Changes Observed in Rheumatoid Arthritis Joint Tissue Are Detectable in CD4+ Naive T Cells from Peripheral Blood
Calliope Holingue¹, Brooke Rhead¹, Michael Cole¹, Xiaorong Shao¹, Hong L. Quach¹, Diana Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison⁵, Vladimir Chernitskiy⁶, Wei Wang⁷, Gary S. Firestein⁸, Lisa F. Barcellos¹ and Lindsey A. Criswell⁵, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Div Of Rheumatology, Division of Rheumatology, UCSF, San Francisco, CA, ⁴Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁵Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁶Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁸Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Aberrant DNA methylation patterns have previously been associated with rheumatoid arthritis (RA) [MIM 180300]. Our study aimed to determine whether differentially methylated CpGs in…
Abstract Number: 1611 • 2015 ACR/ARHP Annual Meeting
Gene Expression Profiling Reflects Increased Expression of Coronary Artery Disease Associated Genes in a Case-Control Matched Study of Patient with Rheumatoid Arthritis
Erica Peart¹, Kim Huffman², William E. Kraus³, Phil Beineke⁴, Jim Wingrove⁴ and Steve Rosenberg⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Durham Veterans Affairs Medical Center, Durham, NC, ³Duke Pepper Center, Durham, NC, ⁴CardioDx, Redwood City, CA
Background/Purpose: Peripheral blood gene expression profiling has been used to identify gene signatures which reflect a variety of pathologic conditions. The CorusCAD¨ test is a…
Abstract Number: 1612 • 2015 ACR/ARHP Annual Meeting
Association of Single Nucleotide Polymorphisms of PADI4 and HLA-DRB1 Alleles with Susceptibility to Rheumatoid Arthritis-Related Lung Diseases
Seung-Cheol Shim¹, In-Seol Yoo², Su-Jin Yoo¹, Young Kim¹, Jinhyun Kim³ and Seong-Wook Kang², ¹Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose: Lung diseases (LD) are common extra-articular manifestations in rheumatoid arthritis (RA). Recent studies have shown the association of RA-LD with anti-citrullinated protein antibodies. The…
Abstract Number: 1613 • 2015 ACR/ARHP Annual Meeting
Expression of the Genes Facilitating Methotrexate Action within Rheumatoid Subcutaneous Nodules
Emma Houlder¹, Melanie Millier², John Highton³, Lisa K. Stamp⁴ and Paul Hessian², ¹Medicine, University of Otago, Dunedin, New Zealand, ²Department of Medicine, University of Otago, Dunedin, New Zealand, ³Dept of Medicine, University of Otago, Dunedin, New Zealand, ⁴Medicine, University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose: Methotrexate (MTX) is the most frequently used DMARD in the treatment of rheumatoid arthritis (RA). There are known links between the use of MTX…
Abstract Number: 1614 • 2015 ACR/ARHP Annual Meeting
The Impact of High Risk Susceptible Gene LILRA3 on Joint Inflammation in Rheumatoid Arthritis
Mengru Liu¹, Yan Du², Jing Zhang¹, Fanlei Hu¹, Li Zheng³, Yingni Li³, Jianping Guo¹ and Z. Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China, ³Peking University People's Hospital, Beijing, China
Background/Purpose: Leukocyte immunoglobulin-like receptor A3 (LILRA3) is a putatively secreted protein belongs to the leukocyte immunoglobulin-like receptor (LILR) family. Based on our research that LILRA3…
Abstract Number: 1615 • 2015 ACR/ARHP Annual Meeting
Lack of Replication of the Association Between Anti-Citrullinated Fibrinogen and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Ariana Montes¹, Alfonso Corrales², Manuel Calaza³, Raquel López-Mejías⁴, José Antonio Parra⁵, Miguel Angel Gonzalez-Gay⁶ and Antonio Gonzalez⁷, ¹Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Laboratorio Investigacion 10 and Rheumatology Unit. Instituto Investigacion Sanitaria.Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ⁴Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ⁵Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁷Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
Background/Purpose: A recent study has suggested that the excess cardiovascular (CV) risk observed in patients with rheumatoid arthritis (RA) could be partially explained by immune-complexes…
Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting
Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)
Rachel Audo^1,2, Bernard Combe^3,4, Michael Hahne⁵ and Jacques Morel⁶, ¹Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁴Montpellier University, Montpellier, France, ⁵IGMM-CNRS UMR5535, Montpellier, France, ⁶Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
Abstract Number: 1617 • 2015 ACR/ARHP Annual Meeting
Evidence for Citrullinated Inhibitor of DNA Binding 1 (Id1) As a Novel Autoantigen Candidate in Rheumatoid Arthritis
Ray A. Ohara¹, Gautam Edhayan¹, W. Alexander Stinson², Phillip L. Campbell¹, Henriette A. Remmer³, M. Asif Amin¹, David A. Fox¹ and Jeffrey H. Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Biomedical Research Core Facilities, Proteomics & Peptide Synthesis Core, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA-binding 1 (Id1) is a nuclear transcription factor actively transcribed in endothelial progenitor cells and in cells that exhibit hyperproliferative responses such…
Abstract Number: 1618 • 2015 ACR/ARHP Annual Meeting
The Protective Effect of HLA-DRB1*13 Alleles during Specific Phases in the Development of ACPA-Positive RA
J. van Heemst¹, A.H. Hensvold², X. Jiang², H. van Steenbergen¹, L. Klareskog², T. W. J. Huizinga¹, A.H.M. van der Helm- van Mil¹, A.I. Catrina², René E. M. Toes¹, K. Lundberg² and Diane van der Woude¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Karolinska Institute, Stockholm, Sweden
Background/Purpose: HLA-DRB1*13 alleles are associated with protection from anti-citrullinated protein antibody (ACPA-)positive rheumatoid arthritis (RA). It is however unknown at which phase of disease development…

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