Abstract Number: 2914 • 2016 ACR/ARHP Annual Meeting
Association of Radiographic Findings in Hand X-Ray with Autoantibodies in Patients with Systemic Sclerosis
Background/Purpose: Musculoskeletal involvement is a major complication for patients with systemic sclerosis (SSc). Various radiographic abnormalities are observed, especially in hands, however, the detailed prevalence…Abstract Number: 2915 • 2016 ACR/ARHP Annual Meeting
An Increased Circulating Level of Periostin in Patients with Systemic Sclerosis: Associations with Functional Impairment in Various Affected Organs
Background/Purpose: Periostin is one of the matricellular proteins, a class of ECM-related molecules defined by their ability to modulate cell–matrix interactions. Several lines of evidences…Abstract Number: 2916 • 2016 ACR/ARHP Annual Meeting
The Number of Micro-Haemorrhages and Micro-Thrombosis Detected By Nailfold Videocapillaroscopy Is a Good Predictor of Disease Activity in Systemic Sclerosis: The Validation Study of NEMO Score
Background/Purpose: In a previous study it was demonstrated that, in patients with systemic sclerosis (SSc) the cumulative number of micro-haemorrhages (MH) and micro-thrombosis (MT) (the…Abstract Number: 2917 • 2016 ACR/ARHP Annual Meeting
Nailfold Capillaroscopy and Mortality in Systemic Sclerosis
Background/Purpose: To test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). Methods: One hundred and seventy SSc…Abstract Number: 2918 • 2016 ACR/ARHP Annual Meeting
The Clinical Relevance of Common ANA Patterns in Systemic Sclerosis
Background/Purpose: Antinuclear antibody (ANA) test is positive in nearly 95% of patients with systemic sclerosis (SSc) [1]. We aim to identify the clinical relevance of…Abstract Number: 2919 • 2016 ACR/ARHP Annual Meeting
Prevalence of Antiphospholipid Antibodies and Their Clinical Associations in Systemic Sclerosis: Data from a French Cohort
Background/Purpose: Antiphospholipid antibodies (aPL) have been found in patients with various autoimmune and rheumatic diseases, including systemic sclerosis (SSc). However, in the absence of clinical…Abstract Number: 2920 • 2016 ACR/ARHP Annual Meeting
The Effect of Rituximab on B Cells in Skin and Peripheral Blood in Systemic Sclerosis
Background/Purpose: Open-label studies provided evidence for possible efficacy of rituximab (RTX) in systemic sclerosis (SSc). Previously, we reported on a randomized placebo-controlled clinical trial in…Abstract Number: 2921 • 2016 ACR/ARHP Annual Meeting
Patient Participation in Patient Reported Outcome Instrument Development in Systemic Sclerosis
Background/Purpose: The patient perspective captured using Patient-Reported Outcome (PRO) instruments provide valuable insight into the patient condition not always captured by physician-derived assessment tools. Target…Abstract Number: 2922 • 2016 ACR/ARHP Annual Meeting
Disability, Fatigue, and Their Associates in Early Diffuse Cutaneous Systemic Sclerosis
Background/Purpose: ESOS (European Scleroderma Observational Study) was a prospective observational study of 326 patients with early diffuse cutaneous systemic sclerosis (dcSSc) from 50 centres. Here…Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…Abstract Number: 2924 • 2016 ACR/ARHP Annual Meeting
Terminally Differentiated CD8 T Cell Subset Has Distinct Signiture in RA
Background/Purpose: Previous reports showed that both CD4 and CD8 T cells were related to the RA disease activity, such as Th17, follicular helper 2, and…Abstract Number: 2925 • 2016 ACR/ARHP Annual Meeting
Programmed Cell Death (PD)-1 May Play a Significant Role in the Pathogenesis of Rheumatoid Arthritis
Background/Purpose: PD-1 is a co-inhibitory transmembrane protein with a significant effect on immune regulation. Several studies have shown elevated expression levels of PD-1 on T…Abstract Number: 2926 • 2016 ACR/ARHP Annual Meeting
Rorc Positive Th17, Th17/Th1, and Th17.1 Cells from the Blood of Treatment NaïVe RA Patients Differ in IL-17A but Are All Pathogenic When Co-Cultured with RA Synovial Fibroblasts
Background/Purpose: T cells play a central role in the early stages of rheumatoid arthritis (RA). In this context, we have shown increased proportions of memory…Abstract Number: 2927 • 2016 ACR/ARHP Annual Meeting
Mechanisms Regulating the Loss of Tregs in CD11c-Flip-KO Mice That Contribute to the Spontaneous Development of Inflammatory Arthritis
Background/Purpose: CD11c-Flip-KO (HUPO) mice spontaneously develop inflammatory, erosive arthritis. We previously demonstrated that T regulatory cells (Tregs) were reduced in HUPO mice and that the…Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting
Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)
Background/Purpose: The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
ACR Meeting Abstracts