Abstracts Archive - Page 1781 of 2425 - ACR Meeting Abstracts

Abstract Number: 1378 • 2015 ACR/ARHP Annual Meeting
AMP-Activated Protein Kinase As an Anti-Inflammatory Target for Methotrexate
Cornelia Cudrici¹, Amma Agyemang¹, Martin Pelletier¹, Gregory Steinberg² and Richard M. Siegel¹, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Department of Medicine, Division of Endocrinology,McMaster University, Hamilton, ON, Canada
Background/Purpose: Methotrexate (MTX) is a first-line medication effective in multiple forms of inflammatory arthritis. The anti-inflammatory effects of MTX are more prolonged than its plasma…
Abstract Number: 1379 • 2015 ACR/ARHP Annual Meeting
High Serum IgG4 Concentration Is a Risk Factor for Relapse in IgG4-Related Disease
Sho Sendo¹, Jun Saegusa¹, Akira Onishi², Ikuko Naka¹, Kosaku Tsuda¹, Takaichi Okano¹, Kengo Akashi¹, Soshi Takahashi¹, Miwa Nishida¹, Keisuke Nishimura¹, Yo Ueda¹, Yoshinori Kogata³, Goichi Kageyama¹, Goh Tsuji⁴, Shunichi Kumagai⁵ and Akio Morinobu¹, ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Department for Rheumatology, Kobe University Hospital, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Kobe University Hospital, Kobe, Japan, ⁴Center for Rheumatic disease, Shinko Hospital, Kobe, Japan, ⁵Center for Rheumatic Disease, Shinko Hospital, Kobe, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized systemic fibro-inflammatory disease of unknown etiology with multi-organ involvement. Although the organ involvement in IgG4-RD usually improve…
Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting
Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients
Aurélie Grados¹, Mikael Ebbo¹, Christelle Piperoglou², Matthieu Groh³, Alexis Regent⁴, Maxime Samson⁵, Benjamin Terrier⁶, Nathalie Morel⁷, Sylvain Audia⁵, Francois Maurier⁸, Julie Graveleau⁹, Mohamed Hamidou¹⁰, Amandine Forestier¹¹, Sylvain Palat¹², Emanuelle Bernit¹, Gilles Kaplanski¹³, Frederique Retornaz¹⁴, Bernard Bonotte⁵, Catherine Farnarier¹⁵, Jean-Robert Harle¹⁶, Nathalie Costedoat-Chalumeau⁷, Frederic Vely¹⁷ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Immunology, CIML, AP-HM, Marseille, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Service de médecine interne, Hôpital Cochin, Paris, France, ⁵Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Medecine Interne Hotel Dieu Nantes, Nantes, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, ¹²Service de Medecine Interne, CHU limoges, Limoges, France, ¹³Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, ¹⁴Conseil General 13 cellule recherche, Marseille, France, ¹⁵Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, ¹⁶Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, ¹⁷CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
Abstract Number: 1381 • 2015 ACR/ARHP Annual Meeting
The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease
Hirofumi Nishikawa¹, Yoshinori Taniguchi¹, Yoshiko Shimamura¹, Kosuke Inoue¹, Taro Horino¹, Susumu Nishiyama², Yasuhiko Yoshinaga² and Yoshio Terada¹, ¹Kochi University, Nankoku, Japan, ²Kurashiki Medical Center, Kurashiki, Japan
Background/Purpose: To evaluate the relationship between cholinesterase, number of organ involvement and serum fibrotic markers in Japanese patients with IgG4-related disease (IgG4-RD). Methods: The clinical…
Abstract Number: 1382 • 2015 ACR/ARHP Annual Meeting
Clinical and Serum IgG4 Characteristics of a Unique British Columbian IgG4-Related Disease Cohort
Luke Chen¹, Andre Mattman², Sujin Park³, Brian Skinnider⁴, Graham Slack⁴ and Mollie Carruthers⁵, ¹Hematology, University of British Columbia, Vancouver, BC, Canada, ²Medical Biochemistry, University of British Columbia, Vancouver, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Pathology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that is known to have protean manifestations and variably elevated serum IgG4 concentrations. We present the serum…
Abstract Number: 1383 • 2015 ACR/ARHP Annual Meeting
T-Cell Subset Analysis in IgG4-Related Disease and Lymphocyte-Variant Hypereosinophilic Syndrome
Mollie Carruthers¹, Bakul Dalal², Sujin Park³, Graham Slack², Andre Mattman⁴ and Luke Chen⁵, ¹Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, University of British Columbia, Vancouver, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Medical Biochemistry, University of British Columbia, Vancouver, BC, Canada, ⁵Hematology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: IgG4-related disease (IgG4-RD) and lymphocyte-variant hypereosinophilic syndrome (L-HES) share elevated peripheral eosinophilia and IgE levels as well as common clinical features including atopy, cutaneous…
Abstract Number: 1384 • 2015 ACR/ARHP Annual Meeting
Comparison of IgG4-Related and Non-IgG4-Related Retroperitoneal Fibrosis; A 12 Year Retrospective Study
Piyush Poddar^1,2, Steven Billings³, Leonard H. Calabrese⁴ and Carmen E. Gota⁵, ¹Rheumatology, Sanford Medical center, Bismarck, ND, ²Rheumatology, Cleveland Clinic, Cleveland, OH, ³Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH
Comparison of IgG4-related and Non-IgG4-related Retroperitoneal fibrosis; a 12 year Retrospective Study Background/Purpose: Retroperitoneal fibrosis (RPF) is a rare disease characterized by a progressive proliferation…
Abstract Number: 1385 • 2015 ACR/ARHP Annual Meeting
Efficacy and Tolerance of Rituximab in IgG4-Related Disease: A Retrospective Multicentric Study in 24 Patients
Mikael Ebbo¹, Aurélie Grados¹, Maxime Samson², Clarisse Carra-Dallière³, Agnieszka Pozdzik⁴, Pierre Labauge³, Sylvain Palat⁵, Jean-Marie Berthelot⁶, Jean-Loup Pennaforte⁷, Alain Wynckel⁸, Celine Lebas⁹, Thomas Quémeneur¹⁰, Karine Dahan¹¹, Jean-Jacques Boffa¹¹, Bertrand Godeau¹², Nicolas Limal¹², Franck Carbonnel¹³, Anne Herber¹⁴, Gaëlle Leroux¹⁵, Patrice Cacoub¹⁶, Alexis Mathian¹⁷, Eric Hachulla¹⁸, Nathalie Costedoat-Chalumeau¹⁹, Jean-Robert Harle²⁰ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ³Neurology, CHRU de Montpellier, Montpellier, France, ⁴Nephrology, Erasme Hospital, Cliniques Universitaires de Bruxelles, Bruxelles, Belgium, ⁵Service de Medecine Interne, CHU limoges, Limoges, France, ⁶Rhumatologie, CHU Nantes, Nantes, France, ⁷Internal Medicine, CHU de Reims, Reins, France, ⁸Nephrolohy, CHU de Reims, Reims, France, ⁹Nephrology, CHRU de Lille, Lille, France, ¹⁰CH Valenciennes, Valenciennes, France, ¹¹Nephrology, Tenon Hospital, Paris, France, ¹²Internal Medicine, Mondor Hospital, Creteil, France, ¹³Gastro-enterology, CHU Bicêtre, Le Kremlin Bicêtre, France, ¹⁴Gastro-enterology, CH de Chartres, Chartres, France, ¹⁵Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ¹⁶Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹⁷Internal Medecine Department, Pitie-Salpetriere Hospital, Paris, France, ¹⁸FAI²R, Hôpital Claude Huriez, CHRU Lille, LILLE, France, ¹⁹Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ²⁰Internal Medicine, Aix-Marseille Université, APHM, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition with characteristic histopathological lesions. Nearly all anatomic sites can be involved with a risk of organ…
Abstract Number: 1386 • 2015 ACR/ARHP Annual Meeting
Malignancy Prevalence Is Increased Among Patients before the Onset of IgG4-Related Disease
Zachary Wallace¹, John H. Stone², Hyon K. Choi³, Na Lu³ and Carly Wallace⁴, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology Unit, Massachusetts General Hospital, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disease of unclear etiology. Studies have suggested that patients with IgG4-RD may be at increased risk of…
Abstract Number: 1387 • 2015 ACR/ARHP Annual Meeting
Thoracic Paravertebral Masses and IgG4-Related Disease: Report of 8 Cases and Review of the Literature
Zachary Wallace¹, Sian Lim¹, John H. Stone², Micheal McInnis³ and Amita Sharma⁴, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ³Radiology Department, Thoracic Imaging, Massachusetts General Hospital, Boston, MA, ⁴Department of Radiology, Thoracic Imaging, Massachusetts General Hospital, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition that often leads to tumefactive lesions. We describe a common but under-recognized radiologic finding in this…
Abstract Number: 1388 • 2015 ACR/ARHP Annual Meeting
Adalimumab in Patients with Inactive, Non-Infectious Uveitis Requiring Systemic Treatment
Quan Dong Nguyen¹, Shree Kumar Kurup², Pauline Merrill³, John Sheppard⁴, Joachim Van Calster⁵, Andrew D Dick⁶, Glenn Jaffe⁷, Friederike Mackensen⁸, James T. Rosenbaum^9,10, Ariel Schlaen¹¹, Anne Camez¹², Samir Tari¹³, Martina Kron¹², Alexandra Song¹³ and Antoine Brezin¹⁴, ¹Truhlsen Eye Institute, University of Nebraska, Omaha, NE, ²Wake Forest Baptist Medical Center, Winston-Salem, NC, ³Rush University Medical Center, Chicago, IL, ⁴Lions Medical Eye Bank of Eastern Virginia, Norfolk, VA, ⁵University Hospitals Leuven, Leuven, Belgium, ⁶Bristol Eye Hospital, Bristol, United Kingdom, ⁷Duke University, Durham, NC, ⁸Heidelberg University Hospital, Heidelberg, Germany, ⁹Dever's Eye Institute, Legacy Hospital, Portland, OR, ¹⁰Division of Rheumatology, Oregon Health and Science University, Portland, OR, ¹¹Austral University, Buenos Aires, Argentina, ¹²Abbvie Deutschland GmbH & Co KG, Ludwigshafen, Germany, ¹³AbbVie Inc., North Chicago, IL, ¹⁴Université Paris Descartes, Hôpital Cochin, Paris, France
Background/Purpose: To assess adalimumab (ADA) efficacy and safety in corticosteroid-dependent patients with inactive non-infectious, intermediate, posterior, or panuveitis enrolled in the international, double-masked trial, VISUAL…
Abstract Number: 1389 • 2015 ACR/ARHP Annual Meeting
A Meta-Analysis of the Prevalence of the Ocular Manifestations in All Inflammatory Rheumatic Diseases
Jacqueline Hayworth¹ and Janet E. Pope², ¹Medicine, University of Western Ontario and U of Toronto, Toronto, ON, Canada, ²University of Western Ontario, London, ON, Canada
Background/Purpose: Many inflammatory rheumatic diseases (IRD) are associated with ocular involvement. The prevalence of these complications is not fully known. This meta-analysis was performed to…
Abstract Number: 1390 • 2015 ACR/ARHP Annual Meeting
Hidradenitis Suppuritiva Is Associated with Inflammatory Eye Disease
Abrahim U. Syed¹, Didem Uzunaslan², Careen Y. Lowder³, Sunil Srivastava³, Juan J. Maya¹ and Rula A Hajj-Ali⁴, ¹Internal Medicine, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³Cole Eye Institute, Cleveland Clinic, Cleveland, OH, ⁴Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Hidradenitis Suppurativa (HS) is an inflammatory skin condition that can cause profound morbidity. Patients can present with recurrent nodules, sinus tract formation, abscesses and/or…
Abstract Number: 1391 • 2015 ACR/ARHP Annual Meeting
Differential Expression of Interferon Gamma in Exudate from Hidradenitis Suppurativa Lesions Compared to Chronic Wounds
Anirban Banerjee¹, Victoria K. Shanmugam^1,2, Sean McNish¹ and Kara Couch¹, ¹Division of Rheumatology, The George Washington University, Washington, DC, ²Director, Division of Rheumatology, The George Washington University, Washington, DC
Background/Purpose: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease which affects 1% to 4% of young adults. The purpose of the current study was…
Abstract Number: 1392 • 2015 ACR/ARHP Annual Meeting
Azathioprine May be an Effective Steroid Sparing Agent in Patients with Isolated Recurrent Pericarditis
Adam Brown¹, Xiaobo Liu² and Soumya Chatterjee³, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Isolated Recurrent pericarditis (IRP) is a disease with high morbidity. IRP refers to recurrent pericarditis not associated with an autoimmune rheumatic disease or cardiac…

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