ACR Meeting Abstracts

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  • Abstract Number: 1301 • 2015 ACR/ARHP Annual Meeting

    Pain Central Sensitization Assessed By Functional Magnetic Resonance Imaging in Patients with Knee Osteoarthritis

    Jordi Monfort1, Jesus Pujol2, Marina Lopez3, Jone Llorente3, Gerard Martinez2, Didac Macià2, Francisco Montañés3, Miguel Angel Campillo3, Pedro Benito Ruiz4 and Joan Deus2, 1Rheumatology Department, Hospital del Mar, Barcelona, Spain, 2Magnetic Ressonance Imaging Unit, Barcelona, Spain, 3Rheumatology Department, Barcelona, Spain, 4Rheumatology Service, Hospital del Mar, Barcelona, Spain

    Background/Purpose: An important aspect in chronic pain is central sensitization (CS) which involves increased responsiveness of the central neurons and it is clinically expressed like…
  • Abstract Number: 1302 • 2015 ACR/ARHP Annual Meeting

    Inflammation Signs on Magnetic Resonance Imaging in Chronic or Recurrent Gonarthritis Treated with Intra-Articular Infliximab or Corticosteroids

    Gülsah Akdemir1, Arie E. van der Bijl2, Badelog J.E. de Lange-Brokaar3, T. W. J. Huizinga1, Cornelia F. Allaart1 and Margreet Kloppenburg3, 1Rheumatology, LUMC, Leiden, Netherlands, 2Isala Klinieken, Zwolle, Netherlands, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: To evaluate synovial inflammation on magnetic resonance imaging (MRI) before treatment and changes after treatment with intra-articular (i.a.) infliximab (IFX) or methylprednisolone (MP) injections…
  • Abstract Number: 1303 • 2015 ACR/ARHP Annual Meeting

    Is MRI More Sensitive Than Conventional Radiographs to Detect Hand Osteoarthritis Progression over 5 Years Follow-up?

    Ida K. Haugen1, Barbara Slatkowsky-Christensen2, Karwan Faraj3 and Tore K. Kvien4, 1P.O. Box 23, Diakonhjemmet Hospital, Vinderen, Norway, 2Diakonhjemmet Sykehus, Revmatologisk Avd, Oslo, Norway, 3Radiology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose : Conventional radiographs (CR) are currently the imaging modality of choice for evaluation of structural hand osteoarthritis (OA) progression. Lately Magnetic Resonance Imaging (MRI)…
  • Abstract Number: 1304 • 2015 ACR/ARHP Annual Meeting

    Studying MR-Detected Inflammation in Symptom-Free Persons from the General Population to Generate Ramris-Based Reference Values

    L. Mangnus1, H.W. van Steenbergen2, M. Reijnierse3 and A.H.M. van der Helm- van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: It is recommended by an EULAR imaging taskforce that MR-detected inflammation is useful in the diagnostic process of Rheumatoid Arthritis. This recommendation is based…
  • Abstract Number: 1305 • 2015 ACR/ARHP Annual Meeting

    Prevalence of MR-Detected Ramris-Defined Erosions in the General Population

    L. Mangnus1, H.W. van Steenbergen2, M. Reijnierse3 and A.H.M. van der Helm- van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The diagnostic value of Magnetic Resonance (MR) imaging for Rheumatoid Arthritis (RA) is undetermined. The main value of MR is its sensitive depiction of…
  • Abstract Number: 1306 • 2015 ACR/ARHP Annual Meeting

    MRI Erosions in Undifferentiated Arthritis. Different Associations with the Collagen IIA N-Terminal Propeptide (PIIANP) and Galectin-3 in Pre-RA and Other Arthritides

    Saida Farah Issa1, Anne Duer2, Mikkel Østergaard3, Hanne Lindegaard1, Kim Hørslev-Petersen4, Merete Lund Hetland5, Jakob M. Møller6, Anne Friesgaard Christensen7 and Peter Junker1, 1Department of Rheumatology, Odense University Hospital, Odense, Denmark, 2Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, 3Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 4Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 5DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, 6Department of Radiology, Copenhagen University Hospital Herlev, Herlev, Denmark, 7Department of Rheumatology, Vejle Hospital, Vejle, Denmark

    Background/Purpose: Galectin-3 has been implicated as a mediator of inflammation and erosive progression in animal arthritis and rheumatoid arthritis(RA). The type IIA procollagen peptide(PIIANP) is…
  • Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting

    Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?

    Matthew Jessome1, Michael Tomizza1, Karen A. Beattie2, William G. Bensen2, Raja Bobba2, Alfred Cividino2, Patrick D. Emond2, Chris Gordon2, Lawrence Hart2, George Ioannidis2, Maggie Larche2, Arthur Lau3, Ruben Tavares2, Stephen Tytus2 and Jonathan D. Adachi2, 1McMaster University, Hamilton, ON, Canada, 2St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3Division of Rheumatology, McMaster University, Hamilton, ON, Canada

    Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
  • Abstract Number: 1308 • 2015 ACR/ARHP Annual Meeting

    MRI Measures of Disease Activity and Joint Damage Are Associated with Patient-Reported Outcomes in Rheumatoid Arthritis

    Joshua Baker1, Philip G. Conaghan2, Daniel Baker3, Paul Emery4 and Mikkel Østergaard5, 1Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, 2University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 3Immunology, Centocor Inc., Malvern, PA, 4Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 5Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark

    Background/Purpose: We used data from a large clinical trial of golimumab (GO-BEFORE) to comprehensively assess associations between magnetic resonance imaging (MRI) measures of synovitis, osteitis,…
  • Abstract Number: 1309 • 2015 ACR/ARHP Annual Meeting

    Defining an Acceptable Level of MRI Inflammation in Rheumatoid Arthritis

    Joshua Baker1, Mikkel Østergaard2, Daniel Baker3, Paul Emery4 and Philip G. Conaghan5, 1Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 3Immunology, Centocor Inc., Malvern, PA, 4Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 5University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom

    Background/Purpose: Imaging-detected inflammation persists in many rheumatoid arthritis (RA) patients despite therapy. We used data from two clinical trials of golimumab to determine thresholds for…
  • Abstract Number: 1310 • 2015 ACR/ARHP Annual Meeting

    Efficacy of Abatacept in Patients with Rheumatoid Arthritis Assessed By MRI Scans of Bilateral Hands

    Yuji Kukida1, Akiko Kasahara1, Takahiro Seno1,2, Yu Isoda1, Tomoya Sagawa1, Takuya Inoue1, Naoka Kamio1, Risa Sagawa1, Takashi Kida1, Amane Nakabayashi1, Hidetake Nagahara3, Ken Murakami1, Aihiro Yamamoto1, Satoshi Morita4, Hirotoshi Ito5, Masataka Kohno1 and Yutaka Kawahito1, 1Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2Department of Rheumatic Diseases and Joint Function, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 3Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 4Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Department of Radiology, Kajiicho Medical Imaging Center, Kyoto, Japan

    Background/Purpose: Previous radiographic and MRI studies have demonstrated that abatacept (ABT) can inhibit the progression of bone and joint destruction in patients with rheumatoid arthritis…
  • Abstract Number: 1311 • 2015 ACR/ARHP Annual Meeting

    Effect of a Non Biologic Treat-to-Target Strategy on MRI-Determined Inflammatory and Destructive Changes in Early Rheumatoid Arthritis – Results from a 2-Year Investigator-Initiated Double-Blind Randomized Controlled Clinical Trial

    Signe Moller-Bisgaard1,2, Bo Jannik Ejbjerg2, Iris Eshed3, Kim Horslev-Petersen4, Merete Lund Hetland5, Anne G. Jurik6, Jørgen Vallø7, Henrik Thomsen8, Trine Torfing9, Kristian Stengaard-Pedersen10, Peter Junker11, Niels Steen Krogh12, Tine Lottenburger13, Torkell Ellingsen14, Lis Smedegaard Andersen15, Ib Hansen10, Henrik Skjødt16, Anders Svendsen14, Ulrik Tarp10, Jan Pødenphant15, Jens Kristian Pedersen7, Hanne Lindegaard14 and Mikkel Østergaard1, 1Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 2Department of Rheumatology, Slagelse University Hospital, Slagelse, Denmark, 3Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, 4Reumatologi, Kong Christian X's Gigthospital, Grasten, Denmark, 5DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 6Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, 7University Hospital at Southern Denmark, Odense, Denmark, 8Department of Radiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark, 9Department of Radiology, University Hospital at Southern Denmark, Odense, Denmark, 10Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 11University of Southern Denmark, Odense, Denmark, 12ZiteLab ApS, Copenhagen, Denmark, 13Department of Rheumatology, University Hospital at Southern Denmark, Vejle, Denmark, 14Department of Rheumatology, Odense University Hospital, Odense, Denmark, 15Department of Rheumatology, Copenhagen University Hospital, Gentofte, Denmark, 16Center for Rheumatology and Spine Diseases, Glostrup Hopital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark

    Background/Purpose: MRI has proved to be more sensitive than clinical examination and x-ray for detection of inflammatory and destructive joint changes in early rheumatoid arthritis…
  • Abstract Number: 1312 • 2015 ACR/ARHP Annual Meeting

    Radiocarpal Cartilage Matrix Changes 3-Months after Anti-TNF Treatment for Rheumatoid Arthritis – Feasibility Study Using MR T1ρ� Imaging

    Eric Ku1, Valentina Pedoia2, Matthew Tanaka3, Ursula Heilmeier1, John Imboden4, Jonathan D. Graf5, Thomas M. Link6 and Xiaojuan Li7, 1Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 2Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 3University of California Berkeley, Berkeley, CA, 4Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, 5Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 6Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 7Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA

    Background/Purpose: Standard assessment of Rheumatoid Arthritis (RA) on MRI relies on semi-quantitative joint space narrowing scores that are not sensitive to cartilage focal lesions or…
  • Abstract Number: 1313 • 2015 ACR/ARHP Annual Meeting

    Tumour Necrosis Factor Inhibitor Treatment Normalises Hand Bone Loss in a Minority of Rheumatoid Arthritis Patients Treated in Clinical Practice. Results from the Copenhagen Osteoarthritis Study and the Danbio Registry

    Lykke Midtbøll Ørnbjerg1, Mikkel Østergaard1, Trine David Jensen2, Pernille Bach Mortensen2, Lars Hyldstrup2, Pernille Boyesen3, Anja Thormann1, Ulrik Tarp1, Wolfgang Bøhme1, Hanne Lindegaard1, Uta Engling Poulsen1, Annette Hansen1, Annette Schlemmer1, Niels Graudal1, Anne Rødgaard Andersen1, Jakob Espesen1, Gina Kollerup1, Bente Glintborg1, Ole Rintek Madsen1, Dorte Vendelbo Jensen1 and Merete Lund Hetland1, 1DANBIO, On behalf of Depts of Rheumatology, North, South, Central, Zealand and Capital Region, Copenhagen, Denmark, 2Dept. of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Rheumatoid arthritis (RA) is characterised by progressive joint destruction and loss of periarticular bone mass. Thus hand bone loss (HBL) has been proposed as…
  • Abstract Number: 1314 • 2015 ACR/ARHP Annual Meeting

    Quantitative MRI Measurement of Tenosynovitis Demonstrates Differing Responses of Synovitis and Tenosynovitis after RA Treatment

    Michael A. Bowes1, Gwenael Guillard1, Graham R. Vincent2, Jane E. Freeston3, Edward M. Vital4, Paul Emery5 and Philip G. Conaghan6, 1Imorphics, Manchester, United Kingdom, 2Imorphics Ltd, Manchester, United Kingdom, 3LIMM Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds Gen Infirmary, Leeds, United Kingdom, 6University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom

    Background/Purpose: Inflammation of the tendon sheaths (tenosynovitis) is a recognised component of rheumatoid arthritis (RA). A comprehensive assessment of inflammation will require the inclusion of…
  • Abstract Number: 1315 • 2015 ACR/ARHP Annual Meeting

    Detecting Subtle Changes in Bone Structure Following Three-Month Anti-TNF Theraphy Using High-Resolution Peripheral Quantitative Computed Tomography

    Matthew Tanaka1, Favian Su2, Min Hee Lee3,4, Andrew J. Burghardt5, Thomas M. Link4, Jonathan D. Graf6, John Imboden7 and Xiaojuan Li8, 1University of California Berkeley, Berkeley, CA, 2Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 3Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea, 4Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 5Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 6Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 7Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, 8Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA

    Background/Purpose: Radiographs have been traditionally used to detect bone erosions and joint space narrowing (JSN) in rheumatoid arthritis (RA), but they are not sensitive to…
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