Abstracts Archive - Page 1769 of 2607 - ACR Meeting Abstracts

Abstract Number: 2563 • 2016 ACR/ARHP Annual Meeting
Hypoxia Induce Slug Expression Via JAK/STAT3 Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyungjin Kim¹, Hyemin Jeong², Jaejoon Lee², Hoon-Suk Cha¹, Eun-Mi Koh³, Eun-Jung Park⁴ and Young Hee Eun¹, ¹Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Division of Rheumatology, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea
Background/Purpose: Accumulating evidence implicates hypoxia in the pathogenesis of rheumatoid arthritis (RA). The effect of hypoxia on the expression of Slug, a transcriptional repressor that…
Abstract Number: 2564 • 2016 ACR/ARHP Annual Meeting
Autophagy Alteration Affects Migration and Proliferation of Rheumatoid Arthritis Fibroblast-like Synoviocytes Stimulated By IL-17A
Ji-Min Kim¹, Jihye Bang², Hye-Jin Jeong³, Chang-Nam Son¹ and Sang-Hyon Kim¹, ¹Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ²Keimyung University School of Medicine, Daegu, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Autophagy is required to ensure cellular homeostasis. Perturbations in autophagy have been reported to be involved in the pathogenesis of several diseases such as…
Abstract Number: 2565 • 2016 ACR/ARHP Annual Meeting
Common Biomarker Elevations in Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
Karen Fernandez¹, Tracy Doyle², Lisa Harlow³, Ivan O. Rosas⁴ and Dana P. Ascherman⁵, ¹Rheumatology, University of Miami Miller School of Medicine, Miami, FL, ²Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ³Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ⁴BWH - Pulmonary, Brigham and Women's Hospital, Boston, MA, ⁵Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose: Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) which contributes to increased morbidity and mortality. Clinico-epidemiological data indicate some overlap…
Abstract Number: 2566 • 2016 ACR/ARHP Annual Meeting
Hexokinase 2 As a Novel Metabolic Target for Rheumatoid Arthritis
Marta Fernandez Bustamante¹, Ricard Garcia-Carbonell², Jeffrey Smith², Gary Firestein¹, Shigeki Miyamoto² and Monica Guma¹, ¹Medicine, UCSD, La Jolla, CA, ²Pharmacology, UCSD, La Jolla, CA
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Up-regulated…
Abstract Number: 2567 • 2016 ACR/ARHP Annual Meeting
The Effect of Fibroblast Growth Factor 4 on the Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Xiaoxue Feng¹, Shangling Zhu¹, Weixiang Peng², Fang Liu³, Baiyu Zhang¹ and Jianlin Huang¹, ¹Department of Internal Medicine, Division of Rheumatology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Internal Medicine, Division of Rheumatology, Zhu Hai People's Hospital, Zhuhai, China, ³Department of Internal Medicine, Division of Rheumatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background/Purpose: Fibroblast-like synoviocytes (FLSs) contribute to synovial hyperplasia in rheumatoid arthritis (RA). Fibroblast growth factor 4 (FGF4) is a potent mitogen for tumor cells. The…
Abstract Number: 2568 • 2016 ACR/ARHP Annual Meeting
ARL15 expressed By Rheumatoid Arthritis Synovial Fibroblasts Regulates IL6 and Plays a Role in Apoptosis and Hypoxia
SUJIT KASHYAP¹, Patralika Chattopadhyaay¹, Anuj kumar Pandey¹, Uma Kumar², Chandra Shekhar Yadav³ and B.K Thelma¹, ¹DEPARTMENT OF GENETICS, UNIVERSITY OF DELHI SOUTH CAMPUS, NEW DELHI, India, ²Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India, ³Orthopaedics, All India Institute of Medical Sciences, New Delhi, India
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic, inflammatory condition that affects more than 1% population globally. Several studies suggest RA to be controlled by a…
Abstract Number: 2569 • 2016 ACR/ARHP Annual Meeting
Restoration of Decreased Lymphocyte Counts and the Shift to Th1 and Effector Memory CD8+T Cell Subsets Associate with Spontaneous Regression of Lympho-Proliferative Disorders Developed in RA Patients Treated with Methotrexate
Shuntaro Saito¹, Katsuya Suzuki¹, Kunihiro Yamaoka¹, Koichi Amano², Michihide Tokuhira³ and Tsutomu Takeuchi¹, ¹Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ²Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan, ³Department of Hematology, Saitama Medical Center, Saitama Medical University., Saitama, Japan
Background/Purpose: Methods: Forty-three RA patients complicated with LPD were identified and 76 control patients were selected. Among the 43 LPD patients, 28 were regressive and…
Abstract Number: 2570 • 2016 ACR/ARHP Annual Meeting
Pyruvate Regulates Reactive Oxygen Species (ROS) Production, Dysfunction and Aberrant Metabolism of Mitochondria in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
Jeong Yeon Kim^1,2, Shin Eui Kang^2,3, Hyun Jung Yoo^3,4, Ji Soo Park¹, Eun Young Lee², Eun Bong Lee² and Yeong Wook Song^3,4, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: In rheumatoid arthritis (RA), fibroblast-like synoviocyte (FLS) is a key component of invasive synovium and mediates inflammation and destruction of joint. Recently, change of…
Abstract Number: 2571 • 2016 ACR/ARHP Annual Meeting
Distinct Oral and Fecal Community Profiles Enriched in Opportunistic Pathogens in RA Patients and First Degree Relatives Are Influenced By Environmental Risk Factors, Including Smoking, Dental History and Lung Infection
Helen Benham^1,2,3, Muralidhara Maradana⁴, Vanessa Anne Lakis¹, Paraic O Cuiv⁵, John Wood⁶, Lisa Nagl¹, Nishta Rammouth¹, Clare Owens³, Joshua Daly⁷, Nancy Lachner⁷, Mark Morrison¹, Philip Hugenholtz⁷, Kim-Anh Lê Cao¹ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, ²University of Queensland School of Medicine, Brisbane, Australia, ³Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁴Translational Research Institute, The University of Queensland Diamantina Institute, Wooloongabba, Australia, ⁵Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology Department, Princess Alexandra Hospital, Woolloongabba, Australia, ⁷The University of Queensland, Australian Centre for Ecogenomics, Brisbane, Australia
Background/Purpose: In the Rheumatoid Arthritis (RA) prodrome, genetic predisposition intersects with environmental risk factors, such as smoking, periodontal disease and respiratory infection, however no studies…
Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting
Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis
Laura Vidal-Bralo¹, Eva Pérez-Pampin¹, Rosana Varela¹, Juan J Gomez-Reino¹, Steve Horvath² and Antonio Gonzalez¹, ¹Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…
Abstract Number: 2573 • 2016 ACR/ARHP Annual Meeting
Galectin 1 As Potential Prognostic Biomarker in Rheumatoid Arthritis
Amalia Lamana¹, Ana Triguero-Martinez², Iria V. Seoane³, Hortensia de la Fuente⁴, Carmen Martinez-Mora⁵, Ana M. Ortiz Garcia⁶, Rosario García-Vicuña⁶, Rosa P Gomariz⁷ and Isidoro Gonzalez-Alvaro⁶, ¹Rheumatology, Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, ²Rheumatology Service, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain, ³Department of Cell Biology, Faculty of Biology, Universidad Complutense de Madrid, Madrid, Spain, ⁴Immunology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain, ⁵Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁶Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁷Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain
Background/Purpose: Galectin 1 (Gal1) is a type of lectin expressed in a wide variety of tissues and organs. In the immune context, is broadly described…
Abstract Number: 2574 • 2016 ACR/ARHP Annual Meeting
IL-22 As a Biomarker for Erosive Disease in Rheumatoid Arthritis
Jan Leipe, Hendrik Schulze-Koops and Alla Skapenko, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Consistent with models of experimental arthritis implicating IL-22 – in the development of joint destruction could previously demonstrate that elevated IL-22 serum levels were…
Abstract Number: 2575 • 2016 ACR/ARHP Annual Meeting
The Presence of Staphylococcal Toxins in the Urine of Patients with Rheumatoid Arthritis
Laura Grace¹, Marwan Bukhari², Robert Lauder³, Lisa Bishop^4,5 and Adam Taylor¹, ¹Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ²Royal Lancaster Infirmary, Lancaster, United Kingdom, ³Biomedical & Life Sciences, Lancaster University, Lancaster, United Kingdom, ⁴Biomedical and Life Sciences, Lancaster University, Lancaster, United Kingdom, ⁵University Hopsitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a disease of unknown etiology;with a pathogenesis that is due to a mixture of genetic, immunological and environmental factors. A…
Abstract Number: 2576 • 2016 ACR/ARHP Annual Meeting
uPAR Promotes Tumor-like Biologic Role of Fibroblast-like Synoviocytes through PI3K/Akt Signaling Pathway in Patients with Rheumatoid Arthritis
Yan Liu¹, Yunfeng Pan² and Song Guo Zheng³, ¹Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Urokinase-type plasminogen activator receptor (uPAR), is a multi-functional receptor on cell surface, widely present in endothelial cells, fibroblasts, and a variety of malignant cells.…
Abstract Number: 2577 • 2016 ACR/ARHP Annual Meeting
Elevated Matrix Metalloproteinases Levels in Oral Fluids of Most Rheumatoid Arthritis Patients, Even without Frank Periodontitis
Sheila Arvikar¹, Hatice Hasturk², Klemen Strle³, Marcy Bolster⁴, Deborah Collier⁵, Alpdogan Kantarci² and Allen C. Steere⁶, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Rheumatology, Massachusetts General Hospital, Boston, MA, ⁶Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. However, little information is available about inflammatory responses in oral fluids…

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