Abstracts Archive - Page 1760 of 2425 - ACR Meeting Abstracts

Abstract Number: 1060 • 2015 ACR/ARHP Annual Meeting
The View of Healthy Persons on the Impact of Spondyloarthritis on Functioning and Health: Results of a Best-Worst Scaling Based on the ASAS Health Index
Ivette Essers^1,2, Mickaël Hiligsmann³, Uta Kiltz⁴, Nick Bansback⁵, Juergen Braun⁴, Désirée van der Heijde⁶ and Annelies Boonen^1,7, ¹School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Health Services Research, University of Maastricht, Maastricht, Netherlands, ⁴Rheumazentrum Ruhrgebiet, Herne, Germany, ⁵School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ⁶Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: The ASAS Health Index (HI) is a disease-specific questionnaire (QoL) for patients with spondyloarthritis (SpA) aiming to measure functioning and health. The ASAS HI…
Abstract Number: 1061 • 2015 ACR/ARHP Annual Meeting
Patients with Fibromyalgia (FM) Do Not Fulfill Classification Criteria for Axial Spondyloarthritis (axSpA) but Patients with Axspa May Fulfill Classification Criteria for FM
Xenofon Baraliakos¹, Andrea Regel¹, Uta Kiltz¹, Hans-Jürgen Menne², Friedrich Dybowski³, Manfred Igelmann⁴, Ludwig Kalthoff³, Dietmar Krause⁵, Ertan Saracbasi¹, Elmar Schmitz-Bortz⁶ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology practice, Dortmund, Germany, ³Private rheumatology office, Herne, Germany, ⁴Private Rheumatology office, Bochum, Germany, ⁵Internistische und rheumatologische Gemeinschaftspraxis, Gladbeck, Germany, ⁶Rheumatology practice, Hattingen, Germany
Background/Purpose: Both patients with axial spondyloarthritis (axSpA) and patients with fibromyalgia (FM) are suffering from pain. The new ASAS classification criteria for axSpA have been…
Abstract Number: 1062 • 2015 ACR/ARHP Annual Meeting
Predictive Validity of the ASAS-Classification Criteria for Axial and Peripheral Spondyloarthritis – a Final Analysis
Robert Landewé¹, Alexandre Sepriano^2,3, Martin Rudwaleit⁴, Joachim Sieper^4,5, Désirée van der Heijde⁶ and on behalf of ASAS , ¹Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ²Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands, ³Rheumatology, Hospital de Egas Moniz - CHLO, Lisbon, Portugal, Lisbon, Portugal, ⁴Rheumatology, Charité - Campus Benjamin Franklin, Berlin, Germany, Berlin, Germany, ⁵German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands
Background/Purpose: The Assessment of SpondyloArthritis international Society (ASAS) cohort has been established to validate the ASAS criteria for axial spondyloarthritis (axSpA) and peripheral spondyloarthritis (pSpA),…
Abstract Number: 1063 • 2015 ACR/ARHP Annual Meeting
Admissions and Readmissions of Patients with Systemic Lupus Erythematosus Is a Major Cause of Direct and Indirect Health Care Costs
Allen P. Anandarajah¹, Ugo Awa², Christine Izzo³, Kate Burns⁴, Ummara Shah⁵, Jennifer H. Anolik⁶ and Christopher T. Ritchlin⁷, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²Medicine, University of Rochester Medical Center, Rochester, NY, ³Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, ⁶University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease that can affect multiple organ systems and is associated with high morbidity. Reports estimate that the…
Abstract Number: 1064 • 2015 ACR/ARHP Annual Meeting
Feasibility and Validity of Patient Reported Outcome Measurement Information System (PROMIS) in SLE
Shanthini Kasturi¹, Jayme C. Burket², Jessica Berman¹, Kyriakos A. Kirou¹, Alana B. Levine¹, Lisa R. Sammaritano¹ and Lisa Mandl^1,3, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ³Department of Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Accurate measurement of patient reported outcomes (PROs) is particularly important in SLE, a heterogeneous disease in which similar symptoms can have disparate impact across…
Abstract Number: 1065 • 2015 ACR/ARHP Annual Meeting
Atherosclerotic Vascular Events in a Multinational SLE Inception Cohort: Description and Predictive Risk Factors over a 15 Year Period
Murray Urowitz^1,2, Dafna Gladman¹, Nicole Anderson³, Jiandong Su¹ and Systemic Lupus Erythematosus International Collaborating Clinics (SLICC), ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: A large multicentre multinational inception cohort was established to study risk factors for atherosclerosis (AS) in SLE. We aim to describe all vascular events…
Abstract Number: 1066 • 2015 ACR/ARHP Annual Meeting
Temporal Trends and Outcomes of Acute Myocardial Infarction in Systemic Lupus Erythematosus Hospitalizations
Narender Annapureddy¹, Achint Patel², Rabi Yacoub³, Krishna Pakanati⁴, Shiv Agarwal⁵, Priya Simoes⁶, Sunil Kamat⁷, Alexandre Benjo⁸ and Girish Nadkarni⁹, ¹Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ²Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Gateway Medical Center, Clarksville, TN, ⁵Cardiology, University of Arkansas Medical Sciences, Little Rock, AR, ⁶Internal Medicine, St.Lukes Roosevelt Hospital Center at Mount Sinai, New York, NY, ⁷Critical Care, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India, ⁸Ochsner Clinic Foundation, New Orleans, NY, ⁹Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Cardiovascular disease remains the most common cause of mortality in Systemic lupus erythematosus (SLE). Some studies suggest that mortality due to acute myocardial infarction…
Abstract Number: 1067 • 2015 ACR/ARHP Annual Meeting
Sex Differences in Rates of End-Stage Renal Disease and Death Among Medicaid Patients with Incident Lupus Nephritis
Anna R. Broder¹, Candace H. Feldman², Anand Kumthekar³, Michail Alevizos⁴, Hongshu Guan⁵, Medha Barbhaiya⁶ and Karen H. Costenbader⁷, ¹Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Medicine, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, ⁴Medicine, Albert Einstien College of Medicine/Jacobi Medical Center, Bronx, NY, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Internal Medicine, Weill Cornell Medical College, New York, NY, ⁷Rheumatology, Brigham & Women's Hospital, Boston, MA
Background/Purpose: Prior studies suggest that males with lupus nephritis (LN) may have worse outcomes than females. However, the majority of these studies, are from tertiary-care…
Abstract Number: 1068 • 2015 ACR/ARHP Annual Meeting
Assessment of 10-Year Risk of Myocardial Infarction or Stroke in SLE
Michelle Petri¹ and Laurence S Magder², ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
B Background/Purpose: In 2013 the American College of Cardiology (ACC) and the American Heart Association (AHA) developed a new formula to estimate the 10-year risk…
Abstract Number: 1069 • 2015 ACR/ARHP Annual Meeting
Child’s HLA-DRB1 Genotype Increases Maternal Risk of Systemic Lupus Erythematosus: Results from the Mother-Child Immunogenetic Study in Autoimmunity
Giovanna I. Cruz¹, Xiaorong Shao², Hong L. Quach², Janelle Noble³, Nikolaos Patsopoulos⁴, Michael Busch⁵, Darrell Triulzi⁶, Wendy S.W. Wong⁷, Benjamin Solomon⁷, John Niederhuber⁷, Lindsey A. Criswell⁸ and Lisa F. Barcellos², ¹School of Public Health, University of California, Berkeley, Berkeley, CA, ²Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ³Children's Hospital Oakland Research Institute, Oakland, CA, ⁴Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁵Blood Systems Research Institute, San Francisco, CA, ⁶Institute of Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Medical Genomics, Inova Translational Medicine Institute, Falls Church, VA, ⁸Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: SLE [MIM 152700] disproportionately affects women of reproductive age and pregnant patients are more likely to experience flares. Fetal microchimerism (FMC), or the persistence…
Abstract Number: 1070 • 2015 ACR/ARHP Annual Meeting
CD 14(C-159T) Polymorphism and Soluble CD14 Are Associated with Increased Disease Activity and Nephritis in SLE
Sarit sekhar Pattanaik¹, Aditya kumar Panda², Rashmi ranjan Sahoo¹, Rina Tripathy³ and Bidyut kumar Das¹, ¹Medicine, SCB Medical College, Cuttack, India, ²Centre for Life science, Central University of Jharkand, Ranchi, India, ³Biochemistry, SCB Medical College, Cuttack, India
Background/Purpose: Cluster of differentiation 14 (CD14) plays an important role in innate immune system as a co-receptor in TLRs (2, 4, 7 and 9) signaling.…
Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting
Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis
Evan Der¹, Kemal Akat², Robert Clancy³, Beatrice Goilav⁴, Anna R. Broder⁵, H. Michael Belmont⁶, Peter M. Izmirly⁷, Nicole Jordan⁸, Tao Wang⁹, James Pullman¹⁰, Daniel Schwartz¹⁰, Ming Wu¹¹, Thomas Tuschl², Jill P. Buyon³ and Chaim Putterman¹², ¹Albert Einstein College of Medicine, Bronx, NY, ²Rockefeller University, New York, NY, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁵Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ⁶Hosp for Joint Disease, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY, ⁸Montefiore Medical Center, New York, NY, ⁹Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, ¹⁰Pathology, Albert Einstein College of Medicine, Bronx, NY, ¹¹Pathology, New York University School of Medicine, New York, NY, ¹²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…
Abstract Number: 1072 • 2015 ACR/ARHP Annual Meeting
Baseline Gene Expression Profiles in 1760 Patients from Two Phase III Trials of BAFF/BLyS Blockade in SLE
Robert W Hoffman¹, Joan T Merrill², Marta E. Marta Alarcón Riquelme³, Michelle Petri⁴, Ernst R Dow⁵, Eric Nantz⁶, Laura K Nisenbaum⁵, Krista M Schroeder⁶, Wendy J Komocsar⁶, Narayanan B Perumal⁵, Matthew D Linnik⁶, Guilherme V Rocha⁶ and Richard E Higgs⁶, ¹Immunology-Medical, Eli Lilly and Company, Indianapolis, IN, ²OMRF, Oklahoma, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Johns Hopkins Lupus Center, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Eli Lilly and Company, Indiananpolis, IN, ⁶Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Elevated Type-I interferon (IFN) signature characterizes at least 50% of adults with SLE and has been associated with autoantibodies and more severe disease in…
Abstract Number: 1073 • 2015 ACR/ARHP Annual Meeting
B Cell Subsets Are Epigenetically and Transcriptionally Dysregulated in Systemic Lupus Erythematosus
Emily Blalock¹, Chris Scharer², Ben Barwick², Scott Jenks³, Bridget Neary³, Jeremy Boss² and Ignacio Sanz^3,4, ¹Emory University School of Medicine, Atlanta, GA, ²Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, ³Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁴Medicine, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by multiple B cell abnormalities, including the production of autoantibodies, a major contributing factor to disease pathogenesis. Epigenetic…
Abstract Number: 1074 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Patterns in Naïve CD4+ T Cells Identify Epigenetic Susceptibility Loci for Malar Rash and Discoid Rash in Systemic Lupus Erythematosus
Paul Renauer¹, Patrick Coit¹, Matlock A. Jeffries², Joan T. Merrill³, W Joseph McCune⁴, Kathleen Maksimowicz-McKinnon⁵ and Amr H. Sawalha⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁵Rheumatology, Henry Ford Hospital, Detroit, MI, ⁶Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneous clinical manifestations, autoantibody production, and epigenetic dysregulation in T cells. We sought…

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