Abstract Number: 1015 • 2015 ACR/ARHP Annual Meeting
Contribution of TNF and Type I Interferon to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice
Background/Purpose: Male C57Bl/6 (WT) mice develop transient inflammation in response to K/BxN serum transfer and show a corresponding pain state, which persists beyond the resolution…Abstract Number: 1016 • 2015 ACR/ARHP Annual Meeting
Collagen Antibodies Induce Pain-like Behavior in Mice Independent of Inflammation and Complement Activation but Requires Fcγrs
Background/Purpose: Collagen Antibody Induced Arthritis (CAIA) is an acute mouse model of rheumatoid arthritis (RA). It is induced by an intravenous injection of a cocktail…Abstract Number: 1017 • 2015 ACR/ARHP Annual Meeting
A Novel Mechanism of Arthritis-Induced Pain: Activation of Sensory Neurons By Autoantibodies
Background/Purpose: Joint pain is one of the main reasons for patients with rheumatoid arthritis (RA) to seek medical care. Collagen type II (CII) antibodies (Abs)…Abstract Number: 1018 • 2015 ACR/ARHP Annual Meeting
A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons
Background/Purpose: Cleavage of aggrecan in the interglobular domain (E373-374A) by ADAMTS-4/5 is an early event in osteoarthritis pathogenesis. Further cleavage by MMPs (N341-342F) releases a…Abstract Number: 1019 • 2015 ACR/ARHP Annual Meeting
Brain Functional Connectivity Differentially Predicts Response to Two Centrally Acting Analgesics in Fibromyalgia
Background/Purpose: Recently, several functional brain imaging techniques including functional magnetic resonance imaging (fMRI) have been proposed to be useful in probing the mechanisms of action…Abstract Number: 1020 • 2015 ACR/ARHP Annual Meeting
Abnormal Resting State Functional Connectivity in Chronic Fatigue Syndrome Patients: An Arterial Spin-Labeling fMRI Study
Background/Purpose: Myalgic encephalitis/chronic fatigue syndrome (CFS) is a debilitating disorder characterized by disabling fatigue and cognitive dysfunction. However, little is known regarding the neural mechanisms…Abstract Number: 1021 • 2015 ACR/ARHP Annual Meeting
Nucleic Acids Sensing Receptors RIG-I and MDA5 As Potential Amplifiers of the Interferon Signature in Childhood Onset Systemic Lupus Erythematosus
Background/Purpose: Defective or sustained activation of Interferon (IFN) signaling has been associated with enhanced susceptibility to systemic lupus erythematosus (SLE). The cytosolic RIG-I-like receptors (RLRs),…Abstract Number: 1022 • 2015 ACR/ARHP Annual Meeting
Identification of Shared Genomic Regions in Distantly Related Pairs of Cases with Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a complex genetic trait. While several risk variants have been identified using genome wide studies, a substantial component of…Abstract Number: 1023 • 2015 ACR/ARHP Annual Meeting
Tumor Necrosis Factor-a (TNF-a) and Interferon Gamma Inducible Protein-10 (IP-10) As Predictors of Active Disease Status in Localized Scleroderma
Background/Purpose: Localized scleroderma has both inflammatory and fibrotic components contributing to its effect on the skin and underlying tissue. The extent and duration of…Abstract Number: 1024 • 2015 ACR/ARHP Annual Meeting
Disruptions in Folate Homeostasis May Lead to Increased Risk for Methotrexate Intolerance in Juvenile Idiopathic Arthritis
Background/Purpose: Despite widespread use, there remain no clear predictors of methotrexate (MTX) response or toxicity in Juvenile Idiopathic Arthritis (JIA). With the utilization of new…Abstract Number: 1025 • 2015 ACR/ARHP Annual Meeting
Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI): Genotype-Phenotype Correlation
Background/Purpose: STING-Associated Vasculopathy with Onset in Infancy (SAVI) is an IFN-mediated disease caused by gain-of-function mutations in TMEM173, the gene encoding the stimulator of interferon…Abstract Number: 1026 • 2015 ACR/ARHP Annual Meeting
Microrna-125a-5p Has Increased Expression in Active Systemic Juvenile Idiopathic Arthritis and Is an Essential Modulator of Regulatory Macrophage Phenotypes in Vitro
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, characterized by a predominance of mononuclear phagocytic effector cells, compared to the lymphocyte…Abstract Number: 1027 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Disease Activity Assessment Frequencies in Clinical Practices Do Not Support Treat-to-Target Care
Background/Purpose: Treat-to-Target (T2T) recommendations for rheumatoid arthritis (RA) care include standardized frequencies of disease activity (DA) assessment based on DA level. For this study, "on…Abstract Number: 1028 • 2015 ACR/ARHP Annual Meeting
Improving Pneumococcal Immunization Rates Among Immunocompromised Adolescent Patients at a Tertiary Care Children’s Hospital
Background/Purpose: Streptococcus pneumoniae is a leading cause of severe infections, including pneumonia and meningitis, among immunocompromised patients. The administration of both the 13-valent pneumococcal conjugate…Abstract Number: 1029 • 2015 ACR/ARHP Annual Meeting
Improving Gout Outcomes Using a Disease Management Program within an Integrated Health System
Background/Purpose: Gout is a chronic inflammatory arthritis which can be effectively managed. The American College of Rheumatology published evidenced based gout management guidelines. These guidelines…
ACR Meeting Abstracts