Abstracts Archive - Page 1747 of 2425 - ACR Meeting Abstracts

Abstract Number: 864 • 2015 ACR/ARHP Annual Meeting
Anticytokine Autoantibody Profiling in Five Types of Systemic Vasculitis
Sarthak Gupta^1,2, Seema K. Patel², Mary Blake², Massimo G. Gadina², Wanxia L. Tsai², Simon Carette³, David Cuthbertson⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁵, Carol A. McAlear⁸, Larry W. Moreland⁹, Paul A. Monach¹⁰, Christian Pagnoux³, Philip Seo¹¹, Ulrich Specks¹², Antoine G. Sreih¹³, Steven R. Ytterberg¹⁴, Sarah K. Browne^1,15, Steven M. Holland¹, Mariana J. Kaplan², Peter A. Merkel¹⁶, Peter C. Grayson² and Vasculitis Clinical Research Consortium, ¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, ⁷Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹³Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁵Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, ¹⁶Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Anticytokine autoantibodies (ACAs) are pathogenic in many hematologic, pulmonary and infectious diseases. Evaluation in autoimmune diseases, including systemic lupus erythematosus (SLE), shows that ACAs…
Abstract Number: 865 • 2015 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By Dual Energy X-Ray Absorptiometry (DXA) As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta², Alexis Regent¹, Pascal Cohen¹, Alice Berezne¹, Xavier Puéchal¹, Claire Le Jeunne¹, Luc Mouthon¹, Christian Roux², Loïc Guillevin¹ and Benjamin Terrier¹, ¹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ²Rheumatology B Department, Hôpital Cochin, Paris, France
Background/Purpose: Studies have shown a strong prevalence of cardiovascular events among patients with systemic necrotizing vasculitides (SNV). Recent studies indicate that visceral adipose tissue (VAT)…
Abstract Number: 866 • 2015 ACR/ARHP Annual Meeting
High Rate and Bimodal Pattern of Severe Infection in a Selected ANCA Associated Vasculitis Cohort
Esra Aydın¹, Bahtiyar Toz², Burak Erer², Mustafa Erelel³, Ahmet Gocmez⁴, Ahmet Gul⁵, Murat Inanc², Lale Ocal⁵ and Sevil Kamali², ¹Department of Internal Medicine,, istanbul faculty of medicine, istanbul, Turkey, ²Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Pulmonology, Istanbul University Istanbul Faculty of Medicine Department of Pulmonology, istanbul, Turkey, ⁴Department of Radiology, Istanbul University Istanbul Faculty of Medicine, istanbul, Turkey, ⁵Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose : Increased rate of severe infection (SI) in patients who exposed to immunosuppressive drugs has been a well-known complication in inflammatory rheumatic diseases. However,…
Abstract Number: 867 • 2015 ACR/ARHP Annual Meeting
Simultaneous Measurement of 25-Hydroxyvitamin D and Procalcitonin in Granulomatosis with Polyangiitis (GPA): Differentiation of Activity from Infection?
Mariana O Perez¹, Ricardo M. Oliveira², Valéria Caparbo^3,4, Mauricio Levy-Neto⁵, Eloisa Bonfá⁴ and Rosa M R Pereira³, ¹Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²RDO Diagnósticos Médicos, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology DIvision, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Vitamin D acts as innate and adaptive immune response immunomodulator. 25-hydroxyvitamin D (25OHD) deficiency was reported to be associated with autoimmune diseases flares and…
Abstract Number: 868 • 2015 ACR/ARHP Annual Meeting
Risk Factors for Cytomegalovirus Reactivation in Patients with Antineutrophil Cytoplasmic Antibody -Associated Vasculitis
Yuichiro Ota¹, Yuko Kaneko², Takahiko Kurasawa³, Kunihiro Yamaoka⁴, Katsuya Suzuki⁴ and Tsutomu Takeuchi⁵, ¹Division of Rheumatology, Department of Internal Medicine., Keio University School of Medicine., Tokyo, Japan, ²Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Saitama Medical Ctr, Kawagoe, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁵Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a disease entity characterized by inflammatory cell infiltration and necrosis of blood vessel walls. AAV usually needs…
Abstract Number: 869 • 2015 ACR/ARHP Annual Meeting
Lymphoma in Patients with Granulomatosis with Polyangiitis
Karin Hjorton¹, Erik Hellbacher¹, Christer Sundstrom², Eva Baeckstrom¹ and Ann Knight¹, ¹Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ²Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background/Purpose: The risk of malignancy in patients with Granulomatosis with Polyangiitis (GPA) is increased, as shown in several previous studies. The risk of lymphoma has…
Abstract Number: 870 • 2015 ACR/ARHP Annual Meeting
Development of an Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Patient-Reported Outcome Measure: Identification of Salient Themes and Candidate Questionnaire Item Development
Joanna Robson¹, Susan Ashdown², Jill Dawson³, Ebony Easley⁴, Don Gebhart⁵, Katherine Kellom⁶, Georgia Lanier⁷, Carol McAlear⁸, Nataliya Milman⁹, Jacqueline Peck¹⁰, Judy A. Shea¹¹, Gunnar Tomasson¹², Raashid Luqmani¹³, Peter F. Cronholm⁴ and Peter A. Merkel⁸, ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, University of Oxford, Oxford, United Kingdom, ²NONE, Banbury, United Kingdom, ³Nuffield Department of Population Health HSRU, University of Oxford, Oxford, United Kingdom, ⁴Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA, ⁵NONE, Columbus, OH, ⁶PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, United Kingdom, ⁷NONE, Framingham, MA, ⁸Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, ¹⁰NONE, Oxford, United Kingdom, ¹¹Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, United Kingdom, ¹²Rheumatology Section, Boston University, Boston, MA, ¹³Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs), including granulomatosis with polyangiitis (Wegener's, (GPA), eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA), and microscopic polyangiitis (MPA),…
Abstract Number: 871 • 2015 ACR/ARHP Annual Meeting
Clinicians’ Perspective on Aspects of ANCA-Associated Vasculitis That Influence Patients’ Function and General Health: A Delphi Exercise Based on the International Classification of Function, Disability and Health
Nataliya Milman¹, Peter Tugwell², Annelies Boonen³ and Peter A. Merkel⁴, ¹Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, ²Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, ³Maastricht University Medical Center, Maastricht, Netherlands, ⁴Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: ANCA-associated vasculitis (AAV) is a multisystem condition that results in significant level of morbidity and functional limitations for many patients. Previous studies showed that…
Abstract Number: 872 • 2015 ACR/ARHP Annual Meeting
Work Limitations and Disability in Patients with Systemic Vasculitis
Emma Ali Bateman¹, Sherry Rohekar², Christian Pagnoux³ and Lillian Barra¹, ¹Medicine, Division of Rheumatology, Western University, London, ON, Canada, ²Western University, London, ON, Canada, ³Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: Despite recent advances in the treatment of systemic vasculitis (SV), direct consequences of the disease leading to impairments in physical and mental function can…
Abstract Number: 873 • 2015 ACR/ARHP Annual Meeting
The ANCA-Vasculitis Index of Damage (AVID): Performance of a New Damage Instrument
Eli Miloslavsky^1,2, Na Lu³, Sebastian Unizony³, Hyon K. Choi³, Peter A. Merkel⁴, Philip Seo⁵, Robert F. Spiera⁶, Carol A. Langford⁷, Gary S. Hoffman⁷, Cees Kallenberg⁸, E. William St.Clair⁹, Nadia Tchao¹⁰, Fernando Fervenza¹¹, Paul A. Monach¹², Ulrich Specks¹³ and John H. Stone¹⁴, ¹Division of Rheumatology, Massachusetts General Hopsital, Boston, MA, ²Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ³Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Division of Rheumatology, Johns Hopkins, Baltimore, MD, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology/Clin Immunol AA21, Univer Med Center Groningen, Groningen, Netherlands, ⁹Rheumatology and Immunology, Duke University, Durham, NC, ¹⁰ITN, San Francisco, CA, ¹¹Mayo Clinic, Rochester, MN, ¹²Rheumatology, Boston University School of Medicine, Boston, MA, ¹³Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Damage related to active disease or its treatment is an important outcome measure in ANCA-associated vasculitis (AAV). The Vasculitis Damage Index (VDI), the principal…
Abstract Number: 874 • 2015 ACR/ARHP Annual Meeting
The Short Term Damage Burden in Vasculitis and Vasculitis Mimics As Measured By the Vasculitis Damage Index
Alberto Floris^1,2, Jan Sznajd^3,4, Katarzyna Wawrzycka-Adamczyk^1,5, Joanna Robson⁶, Anthea Craven⁷, Peter A. Merkel⁸, Richard A. Watts⁹, Raashid Luqmani³ and DCVAS investigators, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Rheumatology Unit, University Clinic, Cagliari, Italy, Monserrato, Italy, ³Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁴Jagiellonian University Medical College, Kraków, Poland, ⁵Jagiellonian University Medical College, Cracow, Poland, ⁶Rheumatology, University of Oxford, Oxford, United Kingdom, ⁷Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology Department Ipswich Hospital, University of East Anglia, Ipswich, United Kingdom
Background/Purpose: Damage in vasculitis, which is due to both the vasculitic process itself and the complications of treatment, accumulates over time and accounts for significant…
Abstract Number: 875 • 2015 ACR/ARHP Annual Meeting
Differences in Early Damage Patterns in Various Forms of Primary Systemic Vasculitis
Katarzyna Wawrzycka-Adamczyk^1,2, Joanna Robson³, Alberto Floris^1,4, Jan Sznajd^2,5, Anthea Craven⁶, Richard A. Watts⁷, Peter A. Merkel⁸, Raashid Luqmani⁵ and DCVAS investigators, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Jagiellonian University Medical College, Kraków, Poland, ³Rheumatology, University of Oxford, Oxford, United Kingdom, ⁴Rheumatology Unit, University Clinic, Cagliari, Italy, Monserrato, Italy, ⁵Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁶Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁷Rheumatology Department Ipswich Hospital and University of East Anglia, Ipswich, United Kingdom, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Immunosuppressive agents have changed the outcome of the systemic vasculitides from invariably fatal to chronic conditions associated with damage as a result of disease,…
Abstract Number: 876 • 2015 ACR/ARHP Annual Meeting
Damage Develops Early and Is Common in Children with Chronic Systemic Vasculitis
Lorraine O'Neill¹, Marinka Twilt², Susanne Benseler³, Dirk Föll⁴, David A. Cabral⁵ and Raashid Luqmani⁶, ¹University of Oxford, Oxford, United Kingdom, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Pediatrics, University of Calgary, Toronto, ON, Canada, ⁴University of Muenster, Muenster, Germany, ⁵Pediatrics/Rm K4-121, BC Children's Hospital, Vancouver, BC, Canada, ⁶Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: The chronic primary systemic vasculitides are a group of rare conditions with affected patients subject to a significant burden of morbidity from both the…
Abstract Number: 877 • 2015 ACR/ARHP Annual Meeting
Improved Survival in Granulomatosis with Polyangiitis: A Population-Based Study
Ju Ann¹, Hyon K. Choi², Sharan K. Rai³, Eric C. Sayre⁴ and J Antonio Avina-Zubieta^5,6, ¹Experimental Mediine, University of British Columbia, Richmond, BC, Canada, ²Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada, Richmond, BC, Canada, ⁵Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada
Background/Purpose: Granulomatosis with Polyangiitis (GPA) is associated with an increased risk of mortality. However, recent mortality trends in GPA are largely unknown, particularly in the…
Abstract Number: 878 • 2015 ACR/ARHP Annual Meeting
Significance of Interstitial Pneumonitis in Microscopic Polyangiitis
Kensuke Nakanishi and Mitsuyo Kinjo, Rheumatology, Okinawa Chubu Hospital, Uruma, Japan
Background/Purpose: Microscopic polyangiitis (MPA) is often associated with lung involvement, including alveolar hemorrhage and interstitial pneumonitis (IP). Clinical characteristics of IP in MPA have not…

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