Abstracts Archive - Page 1742 of 2425 - ACR Meeting Abstracts

Abstract Number: 789 • 2015 ACR/ARHP Annual Meeting
Direct Coombs Positivity in SLE
Nour Abou Assalie¹, Wei Fu² and Michelle Petri³, ¹Saint Agnes Hospital, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The Coombs test is now one of the SLICC classification criteria for SLE classification. We investigated the association of the Coombs test with other…
Abstract Number: 790 • 2015 ACR/ARHP Annual Meeting
An Intervention to Improve Quality of Life for African-American Lupus Patients
Edith M. Williams¹, Johnese Bostic², Alyssa Adkins³, Larisa Bruner², Jiajia Zhang², Diane L. Kamen⁴ and Jim Oates⁴, ¹Institute for Partnerships to Eliminate Health Disparities, University of South Carolina, Columbia, SC, ²University of South Carolina, Columbia, SC, ³University of South Carolina, Greenville, SC, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The Intervention to Improve Quality of life for African-AmericaN lupus patients (IQAN) Project is designed to examine whether a uniquely tailored intervention program can…
Abstract Number: 791 • 2015 ACR/ARHP Annual Meeting
Impact of Online Education and Social Media Intervetion for Self-Management in Adolescents with SLE
Lisabeth Scalzi¹ and Nancy J. Olsen², ¹Internal Medicine andPediatrics, Hershey Medical Center, Hershey, PA, ²Divsion of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA
Background/Purpose: Self-management (SM) skills are vital to the physical and emotional health adolescents with systemic lupus erythematosus (SLE). These self-management skills may also affect successful…
Abstract Number: 792 • 2015 ACR/ARHP Annual Meeting
Incidence and Persistence of Cervical Human Papillomavirus Infection in Mexican Systemic Lupus Erythematosus Women
Claudia Mendoza Pinto¹, Mario García-Carrasco^2,3, Verónica Vallejo-Ruiz⁴, Socorro Méndez-Martínez⁵, Alejandro Taboada-Cole⁶, José Luis Totolhua Ramírez⁷, Julio Reyes-Leyva⁴ and Aurelio López-Colombo⁸, ¹Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico, ³Inmunología y Reumatología, Universidad Autónoma de Puebla, Puebla, Mexico, ⁴Molecular Biology and Virology Laboratory, CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁵Research Coordination Delegation, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁶Systemic Autoimmune Disease Research Unit, HGR 36, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁷Department of Pathology, HGR 36, Instituto Mexicano del Seguro Social, Puebla, Mexico, ⁸State Research and Education Department, UMAE,Hospital de Especialidades, Instituto Mexicano del Seguro Social, Puebla, Mexico
Background/Purpose: The risk of high-grade squamous intraepithelial lesions is significantly increased in SLE patients compared with healthy female controls. High-risk human papillomavirus infection (HR-HPV) is…
Abstract Number: 793 • 2015 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Promote the Generation of CD206+ Macrophage and Increase Its Phagocytic Activity in Systemic Lupus Erythematosus
Wei Deng, Weiwei Chen, Zhuoya Zhang, Saisai Huang, Wei Kong, Yue Sun, Xuebing Feng, Xiaojun Tang, Genhong Yao and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 794 • 2015 ACR/ARHP Annual Meeting
CD163+ Macrophages Display Mixed Polarizations in Discoid Lupus Skin
Benjamin Chong¹, Lin-chiang Tseng¹, Gregory Hosler², Noelle Teske¹, Song Zhang³, David R. Karp⁴, Nancy J. Olsen⁵ and Chandra Mohan⁶, ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Propath, Dallas, TX, ³Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, ⁴UT Southwestern Medical Center, Dallas, TX, ⁵Divsion of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, ⁶Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus. Lesional skin of DLE patients contains macrophages that may transition from…
Abstract Number: 795 • 2015 ACR/ARHP Annual Meeting
High Mobility Group Box-1 (HMGB1) Affects Macrophage Polarization and Phagocytosis in Systemic Lupus Erythematosus Patients
Fleur Schaper¹, Gerda Horst¹, Karina de Leeuw¹, Hendrika Bootsma¹, Pieter C Limburg², Peter Heeringa³, Marc Bijl⁴ and Johanna Westra⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Internal Medicine and Rheumatology, Martini Hospital, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
High mobility group box-1 (HMGB1) affects macrophage polarization and phagocytosis in systemic lupus erythematosus patients. F Schaper, G Horst, K de Leeuw, H Bootsma, PC…
Abstract Number: 796 • 2015 ACR/ARHP Annual Meeting
Single Cell Gene Expression Studies in Lupus Patient Monocytes Reveal a Unique Anti-Inflammatory Population of Non-Classical Monocytes Associated with Clinical Quiescence
Zhongbo Jin¹, Wei Fan^2,3, Mark A. Jensen⁴, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin⁵, Ashima Makol⁶, Floranne C. Ernste⁷, Thomas Osborn⁷, Kevin G. Moder⁵, Vaidehi Chowdhary⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ³Mayo Clinic, Rochester, MN, ⁴Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Our previous gene expression studies in sorted immune cell populations in SLE has shown that different cell types from the same blood sample demonstrate…
Abstract Number: 797 • 2015 ACR/ARHP Annual Meeting
Divergent Phenotypic Patterns Between Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive Individuals Reveal Distinct Differences in B Cell and Myeloid Populations Among Ethnicities
Samantha Slight-Webb¹, Rufei Lu², Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder that arises from genetic and environmental factors. Thus, patients with different ancestral backgrounds display differences in…
Abstract Number: 798 • 2015 ACR/ARHP Annual Meeting
Keratinocyte-Associated IL-6 Is Elevated in Cutaneous Lupus Rashes and Production of IL-6 By Keratinocytes Is Enhanced in Non-Involved Lupus Skin
Jasmine Stannard¹, Emily Myers², Tamra J. Reed³, Lori Lowe⁴ and J. Michelle Kahlenberg⁵, ¹Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ²Georgetown University, Washington, DC, ³Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease with severe complications such as immune-complex mediated nephritis and scarring skin lesions. Treatment modalities for…
Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting
Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes
Celine C. Berthier¹, Jasmine Stannard², Emily Myers³, William Swindell⁴, Lori Lowe⁴, Tamra J. Reed⁵, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁶, ¹Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ²Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies. Phenotypic presentation and risk of systemic lupus manifestations differs by…
Abstract Number: 800 • 2015 ACR/ARHP Annual Meeting
A High-Throughput System for Quantification of in Vitro Neutrophil Extracellular Trap Formation with Fluorescence Immunocytochemistry
Tineke Kraaij¹, Sylvia Kamerling¹, Ton Rabelink¹, René E. M. Toes², Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, LUMC, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Neutrophil extracellular traps (NETs) consist of decondensed chromatin and antimicrobial peptides and are able to trap and kill pathogens. Several studies suggest a pathogenic…
Abstract Number: 801 • 2015 ACR/ARHP Annual Meeting
Artesunate Modulates Atherosclerosis Related Factors through the Inhibition of STAT1
Xuebing Feng¹, Weiwei Chen², Lihui Xiao¹ and Lingyun Sun², ¹Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: While type I interferon (IFN) has been linked to atherosclerosis progression in systemic lupus erythematosus (SLE), little is known about its regulation and intervention.…
Abstract Number: 802 • 2015 ACR/ARHP Annual Meeting
Identification of Cyclin-Dependent Kinase 1 As a Novel Regulator for Controlling Type I Interferon Signaling in Systemic Lupus Erythematosus
Lingling Wu¹, Bo Qu¹, Yuting Qin¹ and Nan Shen^1,2, ¹Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²The Center for Autoimmune Genomics and Etiology (CAGE),Cincinnati Children’s Hospital Medical Center,Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose: Type I interferon (IFN) signaling has been a central pathogenic pathway in systemic lupus erythematosus (SLE). The application of specific inhibitors of IFN pathway has emerged…
Abstract Number: 803 • 2015 ACR/ARHP Annual Meeting
Interferon-Alpha Mediated Lowering of Pentraxin-3 Levels in Systemic Lupus Erythematosus?
Lina Wirestam¹, Helena Enocsson², Christopher Sjöwall², Thomas Skogh², Maija-Leena Eloranta³, Lars Rönnblom³ and Jonas Wetterö², ¹Department of Clinical & Experimental Medicine, Rheumatology/AIR, Linkoping, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping, Sweden, ³Medical Sciences, Rheumatology clinic, Uppsala, Sweden
Background/Purpose: The type I interferon (IFN) system is important in the pathogenesis of systemic lupus erythematosus (SLE). We have previously shown an inhibitory effect of…

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