Abstracts Archive - Page 1737 of 2607 - ACR Meeting Abstracts

Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease
Elena Pachera¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj¹, Rucsandra Dobrota¹, Matthias Brock³, Fina Kurreeman⁴, Jeska K. de Vries-Bouwstra⁴, Tobias Messemaker⁴, Carol Feghali-Bostwick⁵, Jeorg HW Distler⁶, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ³Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁶Internal Medicine 3, University of Erlangen, Erlangen, Germany
Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…
Abstract Number: 2071 • 2016 ACR/ARHP Annual Meeting
Expression of Neuraminidase 1 (NEU1) Is Upregulated in the Lungs of Scleroderma Patients with Pulmonary Fibrosis, and Gene Delivery of NEU1 to Mouse Lungs Elicits Accumulation of CD8+ Lymphocytes and Collagen
Irina G. Luzina^1,2, Anne E. Wyman^1,2, Virginia Lockatell², Zahid Noor², Nevins W. Todd^1,2, Simeon E. Goldblum^1,2 and Sergei P. Atamas^1,2, ¹Baltimore VA Medical Center, Baltimore, MD, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: We and others have previously reported that pulmonary fibrosis in patients with scleroderma is accompanied by pulmonary accumulation of predominantly CD8+ T lymphocytes. Earlier…
Abstract Number: 2072 • 2016 ACR/ARHP Annual Meeting
Fli1-Haploinsufficient Dermal Fibroblasts Promote Skin-Localized Transdifferentiation of Th2- and Th17-like Regulatory T Cells
Ryosuke Saigusa¹, Yoshihide Asano², Takuya Miyagawa², Megumi Hirabayashi², Kouki Nakamura¹, Shunsuke Miura³, Takashi Yamashita², Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama², Takashi Taniguchi¹, Ayumi Yoshizaki², Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity/inflammation, vasculopathy, and tissue fibrosis. Fli1 is a member of Ets family transcription…
Abstract Number: 2073 • 2016 ACR/ARHP Annual Meeting
Jumonji Domain Containing Protein 3 (JMJD3) As a Novel Epigenetic Mechanism of Fibroblast Activation By Regulation of Fra-2
Christina Bergmann¹, Amelie Brandt², Clara Dees³, Yun Zhang¹, Neng-Yu Lin⁴, Chih-Wei Chen¹, Tatjana Mallano⁵, Ruifang Liang³, Pui-See Kam⁶, Oliver Distler⁷, Georg Schett³ and Joerg HW Distler³, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine III, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Friedrich Alexander University, Erlangen, Germany, ⁵Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁶Internal Medicine III, University of Erlangen-Nuremberg, Erlangen, Germany, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Prolonged endogenous activation of fibroblasts is a major hallmark of fibrosing disorders such as Systemic Sclerosis (SSc). It results in tissue fibrosis, organ failure…
Abstract Number: 2074 • 2016 ACR/ARHP Annual Meeting
Herpes Zoster and the Risk of Incident Giant Cell Arteritis
Bryant R. England¹, Ted R. Mikuls², Fenglong Xie³, Shuo Yang³, Lang Chen³ and Jeffrey Curtis⁴, ¹Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Antigenic triggers initiating granulomatous inflammation in giant cell arteritis (GCA) have yet to be elucidated. Recently, histopathological studies of temporal arteries from GCA patients…
Abstract Number: 2075 • 2016 ACR/ARHP Annual Meeting
No Detection of Varicella-Zoster Virus in Temporal Arteries of Patients with Giant Cell Arteritis
Francesco Muratore¹, Stefania Croci², Ione Tamagnini³, Alessandro Zerbini², Salvatore Bellafiore⁴, Lucia Belloni⁵, Luigi Boiardi⁶, Alessandra Bisagni⁷, Maria Parmeggiani⁸, Alberto Cavazza⁹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ³Pathology Unit, Department of Oncology, Arsicpedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁷Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁸. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁹Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Recent studies found an high prevalence of varicella-zoster virus (VZV) infection in temporal arteries (TAs) from both temporal artery biopsy (TAB)-positive and TAB-negative giant…
Abstract Number: 2076 • 2016 ACR/ARHP Annual Meeting
Impact of Vasculitis on Employment and Income: An Online Survey of Participants in the Rare Diseases Clinical Research Network – Vasculitis Clinical Research Consortium Patient Contact Registry
Lillian Barra¹, Renee Borchin², Cristina Burroughs³, Simon Carette⁴, George Casey⁵, Carol A McAlear⁶, Antoine Sreih⁷, Kalen Young⁵, Peter A. Merkel⁸, Christian Pagnoux⁹ and Vasculitis Clinical Research Consortium and the Vasculitis Patient-Powered Research Network , ¹Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²University of South Florida, Tampa, FL, ³Vasculitis center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁴Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Vasculitis Foundation, Kansas city, MN, ⁶Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁷Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, ⁹Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada
Background/Purpose: Work disability associated with rheumatic diseases accounts for an important part of the costs of these conditions. Few studies have investigated disability among patients…
Abstract Number: 2077 • 2016 ACR/ARHP Annual Meeting
Impact of Diabetes, Angiotensin Converting Enzyme Inhibitor or Angiotensin II Receptor Blocker Use, and Statin Use on Presentation and Outcomes in Patients with Giant Cell Arteritis
Jocelyn Ma^1,2, Nader A. Khalidi³, Ola Wierzbicki², Abdallah Al Qethami⁴, Simon Carette⁵ and Christian Pagnoux⁶, ¹Department of Family Medicine, University of Toronto, Toronto, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, ⁴Internal Medicine/Adult Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Few retrospective studies in giant cell arteritis (GCA) previously reported, separately, that 1) patients with diabetes had less positive temporal artery biopsies (TAB), 2)…
Abstract Number: 2078 • 2016 ACR/ARHP Annual Meeting
Global Ethnic and Geographic Differences in the Clinical Features of ANCA-Associated Vasculitis
Fiona Pearce¹, Anthea Craven², Peter A. Merkel³, Raashid Luqmani⁴ and Richard A. Watts⁵, ¹Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom, ²Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ³Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁴NDORMS , Rheumathology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁵Rheumatology Department, Ipswich Hospital, Ipswich, Great Britain
Background/Purpose: There are few data on clinical profiles of ANCA-associated vasculitis (AAV) and or ANCA specificity in different ethnic populations. This study examined differences in…
Abstract Number: 2079 • 2016 ACR/ARHP Annual Meeting
Incidence and Risk of Pneumocystis Jirovecii Pneumonia Following Rituximab Treatment in Granulomatosis with Polyangiitis in the United States: An Analysis from a National Database
Sirada Panupattanapong¹, Anthony R. French², Andrew J. White², Margaret A. Olsen³, Maya Rendulic⁴ and Mary E. Hartman⁵, ¹Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, ²Division of Pediatric Rheumatology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, ³Division of Infectious Disease, Washington University School of Medicine, St. Louis, MO, ⁴Center for Administrative Data Research, Washington University School of Medicine, St. Louis, MO, ⁵Division of Pediatric Critical Care Medicine, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO
Background/Purpose: Pneumocystis Jirovecii pneumonia (PJP) is a life-threatening complication in granulomatosis with polyangiitis (GPA). Guidelines from EULAR for ANCA-associated vasculitis (AAV) recommend institution of PJP…
Abstract Number: 2080 • 2016 ACR/ARHP Annual Meeting
Three Simple Tests to Raise the Index of Suspicion for Fibromyalgia in Primary Care
Amanda W. St. John¹, Jonathan H. Aebischer², Robert M. Bennett³, Madeleine J. Sanford², Kaitlin Z. Haws⁴ and Kim D. Jones³, ¹Anesthesiology and Pain Medicine, Oregon Health & Science University, Portland, OR, ²Department of Family Medicine, Oregon Health & Science University, Portland, OR, ³Schools of Nursing and Medicine, Oregon Health & Science University, Portland, OR, ⁴Department of Internal Medicine and Geriatrics, Oregon Health & Science University, Portland, OR
Background/Purpose: 356 patients were studied (mean age 50 ± 16.3 years, 70% female). Chart review revealed that 53 (15%) of these patients carried a…
Abstract Number: 2081 • 2016 ACR/ARHP Annual Meeting
Dermal Temperature Is an Excelent Prognostic Indicator to Guide RA Therapy
JoAnn Ball¹ and Maria Greenwald², ¹rheumatology, Desert Medical Advances, Palm Deseret, CA, ²Rheumatology, Desert Medical Advances, Palm Desert, CA
Background/Purpose: Nurses and rheumatology extenders can rapidly identify rheumatoid arthritis (RA) patients who flare, with high predictive value for which individual is at high risk…
Abstract Number: 2082 • 2016 ACR/ARHP Annual Meeting
Identification of Major Clinical Characteristics and Linear Correlations Among DAS28, HAQ and Morning Stiffness Time Using Smart System of Disease Management (SSDM)
Jianlin Huang¹, Hongzhi Wang², Jing Yang³, Wenqiang Fan⁴, Hua Wei⁵, Rong Mu⁶, Xinwang Duan⁷, Xiangyuan Liu⁸, Fang He⁹, Zhenchun Zhang¹⁰, Fei Xiao¹¹, Hui Xiao¹¹, Yuhua Jia¹¹, Yuan Liu¹¹, Li Zhang¹¹, Bing Wu¹¹ and Xiaofeng Li¹², ¹Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, ²The First Hospital of Jiaxing, Jiaxing, China, ³Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ⁴Department of rheumatology, Central Hospital of XinXiang, Henan, XinXiang, China, ⁵No 98,Nantong West Rd,Yangzhou, Northern Jiangsu People's Hospital, Yangzhou, China, ⁶Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ⁷Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, ⁸Department of Rheumatology and Immunology, Peking University Third hospital, Bei jing, China, ⁹Central Hospital of Sui Ning, Sichuan, Suining, China, ¹⁰People's Hospital of Linyi, Shandong, Linyi, China, ¹¹Gothic Internet Technology Corporation, Shanghai, China, ¹²The Second Affiliated Hospital of Shanxi Medical College, Taiyuan, China
Background/Purpose: There are more than 5 million rheumatoid arthritis (RA) patients in China, but only 5,000 rheumatologists. Treat-to-target (T2T) is a widely accepted cretria as…
Abstract Number: 2083 • 2016 ACR/ARHP Annual Meeting
Comparing the Electronic Patient Reported Outcome (ePro) Tool Versus the Paper Reported Outcome (pPro) Tool in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol
Charles Inderjeeth¹, Warren Raymond² and Andrisha Inderjeeth³, ¹Rheumatology And Rehab and Aged Care, University of western Australia, North Metro Health Service, Perth WA, Australia, ²Rheumatology and Geriatric Medicine, Sir Charles Gairdner Hospital and University of Western Australia, Nedlands, Australia, ³Sir Charles Gairdner Hospital, Perth, Australia
Background/Purpose: Clinical disease activity for patients with rheumatoid arthritis requires frequent monitoring for optimal management. Patient reported outcome (PRO) tools provide information that complements physician’s…
Abstract Number: 2084 • 2016 ACR/ARHP Annual Meeting
Effects of a Web-Based Patient Decision Aid on Biologics for Rheumatoid Arthritis: A Proof-of-Concept Study
Linda Li¹, Chris Shaw², Diane Lacaille¹, Elaine Yacyshyn³, C. Allyson Jones⁴, Paul Adam⁵, Cheryl Koehn⁶, Alison Hoens⁷, Jasmina Geldman⁸, Charles Goldsmith⁹, Eric C. Sayre⁸ and Nick Bansback¹⁰, ¹Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ²School of Interactive Arts and Technology, Simon Fraser University, Surrey, BC, Canada, ³University of Alberta, Edmonton, AB, Canada, ⁴Physical Therapy, University of Alberta, Edmonton, AB, Canada, ⁵Mary Pack Arthritis Program, Vancouver, BC, Canada, ⁶Arthritis Consumer Experts, Vancouver, BC, Canada, ⁷Dept of Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ⁸Arthritis Research Canada, Richmond, BC, Canada, ⁹Faculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada, ¹⁰School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
Background/Purpose : Under the treat-to-target approach for patients with rheumatoid arthritis (RA), a biologic agent is considered when the target is not met despite trying…

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