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  • Abstract Number: 2010 • 2016 ACR/ARHP Annual Meeting

    Predictive Factors of Adherence to Treatment in an International Prospective Study of Blood Hydroxychloroquine Levels in SLE Patients with Flares

    Nathalie Costedoat-Chalumeau1, Frédéric A. Houssiau2, Peter M. Izmirly3, Véronique Le Guern4, Sandra V. Navarra5, Meenakshi Jolly6, Guillermo RUIZ-IRASTORZA7, Eric Hachulla8, Nancy Agmon-Levin9, Yehuda Shoenfeld10, Francesca Dall'Ara11, Jill P. Buyon12, Christophe Deligny13, Ricard Cervera14, Estibaliz Lazaro15, Holy Bezanahary16, Gabriel Baron17, Gaëlle Leroux18, Nathalie Morel4, Jean-Francois Viallard19, Christian Pineau20, Lionel Galicier21, Ronald van Vollenhoven22, Angela Tincani23, Hanh Nguyen24, Guillaume Gondran25, Noel Zahr26, Jacques Pouchot27, Jean Charles Piette28, Michelle Petri29 and David A. Isenberg30, 1Internal Medicine, Cochin University Hospital, Paris, France, 2Rheumatology, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, 3New York University School of Medicine, New York, NY, 4Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, 5Rheumatology, University of Santo Tomas Hospital, Manila, Philippines, 6Rush, Chicago, IL, 7Cruces University Hospital, Barakaldo, Spain, 8Internal Medicine, Lille University Hospital, Lille, France, 9Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv, Israel, 10Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel, 11University of Pavia, Pavia, Italy, 12Medicine, New York University School of Medicine, New York, NY, 13Zobda Quitman Hospital, Rheumatology and Internal Medicine, Fort de France, Martinique, 14Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, 15Centre François Magendie, CHU de Bordeaux, Pessac, France, 16Internal Medicine, University Hospital of Limoges, Limoges, France, 17Hôpital Hôtel Dieu, Paris, France, 18Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, 19Internal Medecine, Haut Lévèque Hospital, Bordeaux, France, 20Rheumatology, MUHC, Montreal, QC, Canada, 21Clinical Immunology, St Louis Hospital, Paris, France, 22Amsterdam Rheumatology Center, Amsterdam, Netherlands, 23Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 24Centre of Rheumatology. Medicine., University College of London Hospital, london, United Kingdom, 25Internal Medicine Department, Limoges, France, 26Pitié Salpêtrière, Pharmacological, Pitié Salpêtrière, Paris, France, 27Internal Medicine Department, European Hospital Georges Pompidou, Paris, France, 28Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, 29Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 30Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Non-adherence to treatment, a major cause of continued lupus activity and flares, may be difficult to recognize. In this international prospective study, we evaluated…
  • Abstract Number: 2011 • 2016 ACR/ARHP Annual Meeting

    Enteric-Coated Mycophenolate Sodium Versus Azathioprine for Patients with Moderate/Severe Active Systemic Lupus Erythematosus: Results from a Phase 3, Randomized, Parallel, Multicentre Study

    Josefina Cortés-Hernández1, luis Sáez-Comet2, Mercedes Pérez-Conesa2, M Rubio Rivas3, Francesca Mitjavila4, A. Castro Salomó5, Sandra Parra6, J. Cuquet Pedragosa7, Vera Ortiz-Santamaría8, M. Mauri Plana9, Segundo Bujan-Rivas10, P Suñé Martin11, Xavier Vidal12 and Josep Ordi-Ros13, 1Internal Medicine Department, Vall d´Hebron Hospital, Barcelona, Spain, 2Internal Medicine, Miguel Servet University Hospital, Zaragoza, Spain, 3Internal Medicine, hopital Universitario Bellvitge, Barcelona, Spain, 4Internal Medicine, Bellvitge University Hospital, Barcelona, Spain, 5Hospital Universitari de Reus, Spain, Reus, Spain, 6Internal Medicine, Sant Joan de Reus University Hospital, Reus, Spain, 7Internal Medicine, Granollers University Hospital, Granollers, Spain, 8Rheumatology, Hospital General. Granollers., Granollers, Spain, 9Internal Medicine, Mataró Hospital, Mataró, Spain, 10Vall d'Hebron Hospital, Barcelona, Barcelona, Spain, 11Pharmacy Department, Vall d'Hebron Hospital, Barcelona, Spain, 12Statistical Department, Vall d'Hebron Hospital, Barcelona, Spain, 13Internal Medicine, Systemic Autoimmune disease Research Unit. Hospital Vall d'Hebron., Barcelona, Spain

    Background/Purpose: Treatment of non-renal manifestations in systemic lupus erythematosus (SLE) remains challenging. To date, available data on the efficacy, safety and steroid-sparing effects of non-biological…
  • Abstract Number: 2012 • 2016 ACR/ARHP Annual Meeting

    Utility of the Lupus Low Disease Activity State Definition in Discriminating Responders in the Phase IIb Muse Trial of Anifrolumab in Systemic Lupus Erythematosus

    E. Morand1, A. Berglind2, T. Sheytanova2, R. Tummala3 and G. Illei3, 1Monash University, Melbourne, Australia, 2AstraZeneca, Mölndal, Sweden, 3MedImmune, Gaithersburg, MD

    Background/Purpose: Preliminary validation of a Lupus Low Disease Activity State (LLDAS) definition has demonstrated that LLDAS attainment is associated with reduced damage accrual in patients…
  • Abstract Number: 2013 • 2016 ACR/ARHP Annual Meeting

    BIIB059, a Monoclonal Antibody Targeting BDCA2, Shows Evidence of Biological Activity and Early Clinical Proof of Concept in Subjects with Active Cutaneous SLE

    Richard Furie1, Victoria P. Werth2, Joseph Merola3, Wenting Wang4, Dania Rabah4, Catherine Barbey4, Cynthia Carrillo-Infante4, Taylor Reynolds4, Lauren Stevenson4, David Martin4 and Nathalie Franchimont4, 1Division of Rheumatology, Northwell Health, Great Neck, NY, 2Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, 3Harvard Medical School, Boston, MA, 4Biogen, Cambridge, MA

    Background/Purpose:  Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). BDCA2 is a plasmacytoid dendritic cell (pDC)-specific receptor that, upon…
  • Abstract Number: 2014 • 2016 ACR/ARHP Annual Meeting

    A Deep Insight into Causes and Predictors of Death in Systemic Sclerosis

    Muriel Elhai1, Christophe Meune2, Jerome Avouac1, Fazia Amrouche3, Eric Hachulla4, Alexandra Balbir-Gurman5, Gabriela Riemekasten6, Paolo Airò7, Patricia E. Carreira8, Yannick Allanore9 and on behalf of EUSTAR co-authors, 1Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, 2Paris XIII University, Bobigny, France, 3Paris Descartes University, Cochin Hospital, Paris, France, 4CHU Lille, Lille, France, 5B Shine Department of Rheumatology, Rambam Health Care Campus,. Rappaport Faculty of Medicine, Technion, Haifa, Israel, 6Department of Rheumatology, University of Luebeck, Lübeck, Germany, 7Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, 8Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, 9Immunogenetics, Cochin Institute, Paris, France

    Background/Purpose :   Systemic sclerosis (SSc), a connective tissue disease, is associated with high mortality rates.  The main causes and risk factors for death are…
  • Abstract Number: 2015 • 2016 ACR/ARHP Annual Meeting

    The Systemic Sclerosis Disease State Is Associated with Specific Alterations in Gastrointestinal Microbiota in Two Independent Cohorts

    Elizabeth R. Volkmann1, Anna-Maria Hoffmann-Vold2, Yu-Ling Chang3, Jonathan Jacobs4, Philip J. Clements4, Martin Kummen2, Johannes R. Hov2, Kirsten Tillisch1, Venu Lagishetty1, Oyvind Midtvedt5, Øyvind Molberg5 and Jonathan Braun3, 1University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 2Oslo University Hospital, Oslo, Norway, 3Pathology and Laboratory Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 4Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 5Rheumatology, Oslo University Hospital, Oslo, Norway

    Background/Purpose: A single center study demonstrated that systemic sclerosis (SSc) patients have a distinct colonic microbial consortium (based on lavage specimens) compared with healthy controls…
  • Abstract Number: 2016 • 2016 ACR/ARHP Annual Meeting

    Esophageal Disease in Systemic Sclerosis: Does Heritability Play a Role?

    Latifa Fakoya1, Kathryn Peterson2, Andrew Gawron2, Jathine Wong3, Mary Beth Scholand4, Allen D. Sawitzke5 and Tracy M. Frech6,7, 1Internal Medicine/Rheumatology, University of Utah, Salt Lake City, UT, 2Internal Medicine/Gastroenterology, University of Utah, Salt Lake City, UT, 3University of Utah, Salt Lake, UT, 4University of Utah, Salt Lake City, UT, 5Rheumatology, Univ of Utah, Salt Lake City, UT, 6Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, 7Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT

    Background/Purpose: Systemic sclerosis (SSc) associated gastroesophageal reflux disease (GERD) can cause symptoms of dysphagia and heartburn, and is associated with esophagitis, stricture, Barrett’s esophagus, and…
  • Abstract Number: 2017 • 2016 ACR/ARHP Annual Meeting

    Performance of Modified Rodnan Skin Score in Early Diffuse Cutaneous Scleroderma-Analysis from 4 International Cohorts

    Dinesh Khanna1, Susanna Proudman2,3, Tracy M. Frech4, Svetlana Nihtyanova5, Robyn T. Domsic6, Veronica J. Berrocal7, Wendy Stevens8, Mandana Nikpour9 and Christopher P.Denton10, 1University of Michigan, Ann Arbor, MI, 2Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 3Discipline of Medicine, University of Adelaide, Adelaide, Australia, 4Div of Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT, 5Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, 6Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 7Div of Rheumatology, University of Michigan, Ann Arbor, MI, 8Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, 9Melbourne University, Melbourne, Australia, 10Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom

    Background/Purpose:  The modified Rodnan skin score (mRSS) is used as a primary outcome measure in clinical trials of dcSSc. EUSTAR analysis has proposed that a…
  • Abstract Number: 2018 • 2016 ACR/ARHP Annual Meeting

    A Clinical Risk Prediction Model for Skin Thickness Progression in Early Diffuse Scleroderma

    Robyn T. Domsic1, Mary Lucas2, Virginia D. Steen3 and Thomas A. Medsger Jr.4, 1Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, University of Pittsburgh Scleroderma Center, Pittsburgh, PA, 3Rheumatology, Georgetown University Medical Center, Washington, DC, 4Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose:   Systemic sclerosis (SSc) is a rapidly evolving field with multiple potential therapeutic agents under development and several active clinical trials focused on treating…
  • Abstract Number: 2019 • 2016 ACR/ARHP Annual Meeting

    Faces in Motion: Clinical Subtyping in Scleroderma Using Changes in Forced Vital Capacity

    Colin Ligon1, Peter Schulam2, Suchi Saria3, Fredrick M. Wigley4, Robert Wise5 and Laura K. Hummers6, 1Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, 2Johns Hopkins University, Baltimore, MD, 3Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 4Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, 5Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Prognostication in scleroderma has historically depended on using static measures such as antibody status and extent of skin involvement to stratify risk of mortality…
  • Abstract Number: 2020 • 2016 ACR/ARHP Annual Meeting

    Making the Case for Self-Management Education:  Marketing Lessons Learned from Qualitative Research

    Teresa J. Brady1, Bithiah Lafontant2, Tai Baker3 and Rebecca Ledsky4, 1Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, 2FHI 360, Washington, DC, 3Centers for Disease Control and Prevention, Atlanta, GA, 4Social Marketing and Communication, FHI 360, Washington, DC

    Background/Purpose: Self-management education (SME) uses educational and behavioral strategies to help people with arthritis (PWA) and other chronic conditions (CC) develop healthy behaviors and gain…
  • Abstract Number: 2021 • 2016 ACR/ARHP Annual Meeting

    Development of an Item Bank on Disease and Treatment Associated Knowledge of Rheumatoid Arthritis to Improve Patient Engagement in Care

    Marieke J. de Jonge1, Martijn A.H. Oude Voshaar2, Anita M.P. Huis1, Mart A.F.J. van de Laar2, Marlies E.J.L. Hulscher1 and Piet L.C.M. van Riel1,3, 1Radboud university medical center, Radboud Institute for Health Sciences, IQ healthcare, Nijmegen, Netherlands, 2University of Twente, Department of Psychology, Health and Technology, Enschede, Netherlands, 3Bernhoven, Department of Rheumatology, Uden, Netherlands

    Background/Purpose: Patient involvement and personalization of healthcare have become increasingly important in managing chronic diseases. Knowledge about their disease and its treatment is an important…
  • Abstract Number: 2022 • 2016 ACR/ARHP Annual Meeting

    Developing a Gout Needs Assessment Incorporating Patient Perspective on  Self-Management, Self-Efficacy and Disease Specific Knowledge, to Inform a Patient Education Initiative

    Adam Rifaat1, Adena Batterman2, Roberta Horton2 and Theodore R. Fields1, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Social Work Programs, Hospital for Special Surgery, New York, NY

    Background/Purpose: Gout is the most common inflammatory arthritis in adults, with great impact on quality of life. Despite excellent therapeutic options, outcomes remain suboptimal. Research supports…
  • Abstract Number: 2023 • 2016 ACR/ARHP Annual Meeting

    Patient Barriers to Osteoporosis Screening in a Medical Clinic: Why Underserved Patients Who Follow Recommendations for Colonoscopy and Mammography Fail to Get Their DXA Scans

    Suzana John1, Sonam Kiwalkar2, Hamdy Mohamed Abdelaziz Ahmed1 and Walter Polashenski3, 1Internal Medicine, Rochester General Hospital, Rochester, NY, 2internal medicine, Rochester general hospital, Rochester, NY, 3Internal medicine, Rochester general hospital, rochester, NY

    Background/Purpose:  Osteoporosis is a silent disease until it is complicated by fractures. Fractures are common; they place an enormous medical and personal burden on the elderly and take a major economic toll…
  • Abstract Number: 2024 • 2016 ACR/ARHP Annual Meeting

    Effect of a Revised Counselor Training on Skills Development and Knowledge of Volunteers with Systemic Lupus Erythematosus

    Melissa T. Flores1, Jillian A. Rose2, Priscilla Toral1, Roberta Horton1 and Janice Karbachinskiy3, 1Social Work Programs, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3New York-Presbyterian Hospital Weill Cornell, New York, NY

    Background/Purpose: A needs assessment was conducted on an evidenced-based, national lupus telephone peer counseling service, ongoing since 1988, with 30,000+ client contacts to date. We…
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