ACR Meeting Abstracts

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  • Abstract Number: 502 • 2015 ACR/ARHP Annual Meeting

    Decreased Vaccine Responses in Rheumatoid Arthritis Patients Receiving Anti-TNF Treatment and Relationship to B Cell Subsets

    Jennifer Barnard1, Nida Meednu2, Kelly Callahan1, Karen Boyle3, Lynette Keyes-Elstein3, Beverly Welch4, Ellen Goldmuntz5 and Jennifer H. Anolik1, 1University of Rochester Medical Center, Rochester, NY, 2Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 3Rho Federal Systems, Inc., Chapel Hill, NC, 46610 Rockledge Dr., NIAID/NIH, Bethesda, MD, 5DAIT, NIAID/NIH, Bethesda, MD

    Background/Purpose: TNF is a key pro-inflammatory cytokine in normal immune responses and pathologically in the rheumatoid arthritis (RA) synovium, thus representing a key treatment target…
  • Abstract Number: 503 • 2015 ACR/ARHP Annual Meeting

    Predictors for Attaining Remission at Two Consecutive Visits in Newly Diagnosed Early RA Patients

    T. Martijn Kuijper1, J.J. Luime2, P.H.P. de Jong3, A. H. Gerards4, Derkjen van Zeben5, I. Tchetverikov6, P.B.J. de Sonnaville7, M. van Krugten8, B. Grillet9, Mieke Hazes10 and A.E.A.M. Weel11,12, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Department of Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, 4Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 5Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 6Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands, 7Oosterschelde Hospital, Goes, Netherlands, 8Rheumatology, Admiraal de Ruyter Hospital, Vlissingen, Netherlands, 9Rheumatology, ZorgSaam Hospital, Terneuzen, Netherlands, 10Rheumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 11Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 12Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands

    Background/Purpose: Early and intensive treatment with DMARDs are essential for remission induction in newly diagnosed RA patients. However, demographic, psychosocial and disease related factors may…
  • Abstract Number: 504 • 2015 ACR/ARHP Annual Meeting

    Influence of CDAI Measurement on the Decision of Community Rheumatologists to Initiate or Change Biologic Treatment

    Alan K. Matsumoto1, Herbert S. B. Baraf2, Janna Radtchenko3, Jason Drenning4 and Bruce Feinberg5, 1Rheumatology, Arthritis & Rheumatism Assoc, Wheaton, MD, 2The Center for Rheumatology and Bone Research, Wheaton, MD, 3Health Care Analytics, Cardinal Health, Dallas, TX, 4Healthcare Analytics, Cardinal health, Dallas, TX, 5Cardinal Health, Dublin, OH

    Background/Purpose: Periodic measurement of disease activity using validated tools such as the Clinical Disease Activity Index (CDAI) is considered an important aspect of care for…
  • Abstract Number: 505 • 2015 ACR/ARHP Annual Meeting

    Comparative Effectiveness and Time to Response Among Abatacept, Adalimumab, Certolizumab, Etanercept, Infliximab, Rituximab and Tocilizumab in a Real World Routine Care Registry

    Yusuf Yazici1, Hannah Bernstein1 and Christopher Swearingen2, 1Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Pediatrics & Biostatistics, University of Arkansas, Little Rock, AR

    Background/Purpose: With the availability of multiple biologic agents, each with different modes of action, use of real world registries provide the manner in which to…
  • Abstract Number: 506 • 2015 ACR/ARHP Annual Meeting

    Evaluation of Persistence and Outcomes in Patients Treated with TNF and Non-TNF Biologics Following Treatment Clinical Pathway in Rheumatoid Arthritis

    Alan K. Matsumoto1, Herbert S. B. Baraf2, Janna Radtchenko3, Jason Drenning4 and Bruce Feinberg5, 1Rheumatology, Arthritis & Rheumatism Assoc, Wheaton, MD, 2The Center for Rheumatology and Bone Research, Wheaton, MD, 3Health Care Analytics, Cardinal Health, Dallas, TX, 4Healthcare Analytics, Cardinal health, Dallas, TX, 5Cardinal Health, Dublin, OH

    Background/Purpose: Use of biologic agents for the treatment of rheumatoid arthritis continues to grow rapidly, with the cost of these agents putting a significant strain…
  • Abstract Number: 507 • 2015 ACR/ARHP Annual Meeting

    Meta-Analysis of the Time Course of the Response to Adalimumab Plus Methotrexate or Methotrexate Monotherapy in Clinical Trials of Patients with Rheumatoid Arthritis

    Xin Wang1, Arthur Kavanaugh2, Désirée van der Heijde3, Maxime Dougados4, Stefan Florentinus1, Yihan Li1, Iain Sainsbury1 and Josef S. Smolen5, 1AbbVie Inc., North Chicago, IL, 2University of California San Diego, La Jolla, CA, 3Leiden University Medical Center, Leiden, Netherlands, 4René Descartes University and Hôpital Cochin, Paris, France, 5Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: Adalimumab (ADA) plus methotrexate (MTX) and MTX treatments for rheumatoid arthritis (RA) have been assessed in phase 2–4 clinical trials. This meta-analysis used 5…
  • Abstract Number: 508 • 2015 ACR/ARHP Annual Meeting

    Impact of Race on Patient Global Scores and the Misclassification of Disease Activity

    Shriyanka Jain1, Uzma Khan1, Amy Lundholm2 and Martin Bergman3, 1Internal Medicine, Mercy Catholic Medical Center, Darby, PA, 2Rheumatology, Roger Williams Medical Center, Providence, RI, 3Medicine, Drexel University College of Medicine, Philadelphia, PA

    Background/Purpose: Disease activity measurement is a cornerstone of the Treat to Target strategy. However, all currently used measures include a Patient Global Score (PtGLB )…
  • Abstract Number: 509 • 2015 ACR/ARHP Annual Meeting

    In Early Undifferentiated Polyarthritis, 14-3-3η Seroreversion or Sustained Negativity Is Associated with Better Radiographic Outcomes, Even in DAS-28 Remitters

    Gilles Boire1,2, Nathalie Carrier3, Artur de Brum-Fernandes1,4, Patrick Liang1,4, Ariel Masetto2,5, Yuan Gui6, Jane Savill6, Sara Michienzi6, Henri Ménard7, Walter Maksymowych8 and Anthony Marotta6, 1Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 2Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, 3Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 4Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 5Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 6Augurex Life Sciences Corp., Vancouver, BC, Canada, 7MSK Research Axis, McGill University Health Center Research Institute, Montreal, QC, Canada, 8Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Advancements in RA treatment approaches with DMARDs and biological agents have enabled disease remission goals that were previously considered unattainable. The concept of "tight…
  • Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting

    Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare

    Susan M. Goodman1, Rivka Friedlander2, Caroline Figgie2, Alessandra B. Pernis3, Cristina T. Rozo4, Ellen M. Gravallese5, Edward F. DiCarlo6, Laura T. Donlin7, Mark P. Figgie8, Reena Khianey9, Anh Hoang1, Kathleen Andersen10, Luvana Chowdhury11 and VP Bykerk12, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Research, Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 4535 East 70th Street, Hospital for Special Surgery, New York, NY, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Orthopaedics, Hospital for Special Surgery, New York, NY, 9Medicine, Hospital for Special Surgery, New York, NY, 10Hospital for Special Surgery, New York, NY, 11Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, 12Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
  • Abstract Number: 511 • 2015 ACR/ARHP Annual Meeting

    Pretreatment Prediction of Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/Soluble Receptors in Individual Rheumatoid Arthritis Patient

    KAZUYUKI YOSHIZAKI, Organic Fine Chemicals, The Institute of Scientific and Industrial Research, Osaka University, Suita, Japan

    Background/Purpose: In clinical practice in rheumatoid arthritis (RA), it has been noted that each anti-rheumatic therapy delivers a different outcome for individual RA patients and…
  • Abstract Number: 512 • 2015 ACR/ARHP Annual Meeting

    Physical Function and Inflammatory Activity in Rheumatoid Arthritis Patients. Is Disease Duration Important?

    Emmanuel Bertiller1, Facundo Vergara1, Maria de los Angeles Gallardo1, Javier Rosa2, Erika Catay3, Marina Scolnik1, Maria Victoria Garcia4, Mirtha Sabelli5 and Enrique R. Soriano6, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio,, Buenos Aires, Argentina, 4Internal Services, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 5Cabrera 2964 Piso 6, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 6Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: HAQ (Health Assessment Questionnaire) assesses functional disability in rheumatoid arthritis (RA) patients. Correlation between HAQ and disease activity might change according to the length…
  • Abstract Number: 513 • 2015 ACR/ARHP Annual Meeting

    Cumulative Association of Genetic Variants with Rheumatoid Joint Damage Progression in Mexican Americans and European Americans

    Rector Arya1, Inmaculada del Rincon2, Jose Felix Restrepo3, Vidya S Farook4, Christopher P Jenkinson5, Ravindranath Duggirala6 and Agustin Escalante7, 1Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 4Genetics, Texas Biomedical Research Institute, San Antonio, TX, 5University of Texas Health Science Center at San Antonio, San Antonio, TX, 6Regional Academic Health Center, Harlingen, TX, 7Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: Genealogical and genetic association studies have suggested that joint damage in rheumatoid arthritis (RA) may be heritable. We and others have found a number…
  • Abstract Number: 514 • 2015 ACR/ARHP Annual Meeting

    MRI Bone Oedema at Enrollment Predicts the Development of Rapid Radiographic Progression at 1 Year Toward Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort       

    Yoshikazu Nakashima1, Mami Tamai2, Toru Michitsuji3, Toshimasa Shimizu2, Shoichi Fukui4, Masataka Umeda1, Ayako Nishino1, Tomohiro Koga3, Shin-ya Kawashiri5, Naoki Iwamoto2, Kunihiro Ichinose2, Yasuko Hirai4, Hideki Nakamura4, Tomoki Origuchi6 and Atsushi Kawakami4, 1Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 4Nagasaki University, Nagasaki, Japan, 5Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan, 6Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan

    Background/Purpose: To clarify whether MRI bone oedema predicts the development of rapid radiographic progression (RRP) in Nagasaki University Early Arthritis Cohort patients with early-stage rheumatoid…
  • Abstract Number: 515 • 2015 ACR/ARHP Annual Meeting

    Are Changes in Autoantibody Levels Reflecting Change in Prognosis of Rheumatoid Arthritis?

    Manuel Unger1, Farideh Alasti1, Paul Studenic1, Josef S. Smolen2,3 and Daniel Aletaha1, 1Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 22nd Department of Medicine, Hietzing Hospital, Vienna, Austria, 3Department of Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria

    Background/Purpose: The presence of rheumatoid factor (RF) and antibodies against citrullinated peptides (ACPA) is associated with progression of joint damage in patients with rheumatoid arthritis…
  • Abstract Number: 516 • 2015 ACR/ARHP Annual Meeting

    Immunological and Ultrasound Characteristics of Patients with Rheumatoid Arthritis in Clinical Remission – Can We Use These to Predict Outcomes?

    Hanna Gul1, Maria Jesus Isorna Porto2, Elizabeth M.A. Hensor3, Frederique Ponchel4, Richard J. Wakefield5 and Paul Emery6, 1Rheumatology, Leeds Institute of Rheumatology and Musculoskeletal Medicine, Leeds, United Kingdom, 2Internal Medicine, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, 3NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 4Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 5University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Remission is the key treatment goal in rheumatoid arthritis (RA).  Although clinical remission is increasingly achieved, many patients progress both structurally and functionally. We…
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