Abstracts Archive - Page 1715 of 2607 - ACR Meeting Abstracts

Abstract Number: 1737 • 2016 ACR/ARHP Annual Meeting
Adherence to Subcutaneous Biological Therapies Among Inflammatory Arthropaty Patients from a University Hospital
Catalina Gómez-Arango¹, M. Luz García-Vivar¹, Montserrat Alonso-Diez², M. Milagros Alvarez-Lavin², Eva Galindez-Agirregoikoa³, Olaia Fernández-Berrizbeitia³, Esther Ruíz-Lucea¹, Juan María Blanco-Madrigal¹, Jose Francisco Garcia-Llorente¹, Lidia Estopiñán-Fortea³, Ignacio Torre-Salaberri⁴, Edurne Guerrero-Basterretxea³, Itziar Calvo-Zorrilla³, Amaia Bilbao-González⁵ and Natalia Rivera-García⁵, ¹Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ²Pharmacy Department, Basurto University Hospital, Bilbao, Spain, ³Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁴Rheumaytology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁵Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Rheumatic inflammatory arthropaties such as Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) and Spondyloarthrities (SpA) are chronic diseases that require adequate therapies, sometimes biological drugs,…
Abstract Number: 1738 • 2016 ACR/ARHP Annual Meeting
Secukinumab for the Treatment of Psoriatic Arthritis: Comparative Effectiveness Versus Adalimumab Using a Matching-Adjusted Indirect Comparison
Peter Nash¹, Iain B McInnes², Philip J Mease³, Ernest H. Choy^4,5, Howard Thom⁶, Chrysostomos Kalyvas⁷, Kunal Gandhi⁸, Shephard Mpofu⁹ and Steffen Jugl⁹, ¹Department of Medicine, University of Queensland, Brisbane, QLD, Australia, ²University of Glasgow, Glasgow, United Kingdom, ³Swedish Medical Center and University of Washington, Seattle, WA, ⁴Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁵CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom, ⁶University of Bristol, Bristol, United Kingdom, ⁷MAPI Group, Houten, Netherlands, ⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab (SEC) and adalimumab (ADA) are approved for the treatment of active PsA in adults with an inadequate response to conventional DMARDs. A head-to-head…
Abstract Number: 1739 • 2016 ACR/ARHP Annual Meeting
Comparative Effectiveness of Secukinumab and Adalimumab in Ankylosing Spondylitis As Assessed By Matching-Adjusted Indirect Comparison: An Analysis Based on All Pivotal Phase 3 Clinical Trial Data
Walter P Maksymowych¹, Vibeke Strand², Peter Nash³, Howard Thom⁴, Andreas Karabis⁵, Kunal Gandhi⁶, Brian Porter⁶ and Steffen Jugl⁷, ¹University of Alberta, Edmonton, AL, ²Stanford University School of Medicine, Palo Alto, CA, ³Department of Medicine, University of Queensland, Brisbane, QLD, Australia, ⁴University of Bristol, Bristol, United Kingdom, ⁵MAPI Group, Houten, Netherlands, ⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁷Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab (SEC) and adalimumab (ADA) are approved for the treatment of patients with active AS. However, there are no head-to-head randomized controlled trials (RCTs)…
Abstract Number: 1740 • 2016 ACR/ARHP Annual Meeting
Long-Term Improvements in Physical Function of DMARD-Naive and DMARD/Biologic-Experienced Psoriatic Arthritis Patients Treated with Apremilast: Data from a Large Database of 4 Phase III Clinical Trials
Philip J Mease¹, Alvin F Wells², Jürgen Wollenhaupt³, Stephen Hall⁴, Filip van Den Bosch⁵, Eric Lespessailles⁶, Melissa McIlraith⁷, Dianne Nguyen⁷, Lichen Teng⁷ and Christopher J Edwards⁸, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Rheumatology & Immunotherapy Center, Franklin, WI, ³Schön Klinik Hamburg Eilbek, Hamburg, Germany, ⁴Monash University, CabriniHealth, Melbourne, Australia, ⁵UZ Gent, Gent, Belgium, ⁶University of Orléans, Orléans, France, ⁷Celgene Corporation, Summit, NJ, ⁸University Hospital Southampton, Southampton, United Kingdom
Background/Purpose: Improving and preserving patient (pt) physical function is an important goal in managing psoriatic arthritis (PsA). Apremilast (APR) has been shown to improve signs…
Abstract Number: 1741 • 2016 ACR/ARHP Annual Meeting
Patients with Active Psoriatic Arthritis Achieving Minimal Disease Activity with Secukinumab Treatment Demonstrate Sustained Improvement of Function and Quality of Life
Laura C. Coates¹, Philip J Mease², Laure Gossec³, Bruce Kirkham⁴, Lawrence Rasouliyan⁵, Shephard Mpofu⁶, Steffen Jugl⁶, Chetan Karyekar⁷ and Kunal Gandhi⁷, ¹University of Leeds, Leeds, United Kingdom, ²Rheumatology and Internal Medicine, Swedish Medical Center and University of Washington, Seattle, WA, ³Rheumatology Department, Hôpital Pitié Salpêtrière, Paris 06 University, Paris, France, ⁴Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, ⁵RTI Health Solutions, Barcelona, Spain, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Secukinumab, a fully human anti–IL-17A monoclonal antibody, previously demonstrated higher minimal disease activity (MDA)1 response rates and sustained improvements in patient reported outcomes2 among…
Abstract Number: 1742 • 2016 ACR/ARHP Annual Meeting
Effect of DMARD Therapies on NSAID Intake, Quality of Life, and Physical Functioning in Patients with Ankylosing Spondylitis
Gulay KINIKLI¹, Gizem Irem KINIKLI², Sevilay KARAHAN³, Ayten YUKSEK⁴, Askin ATES⁵ and Murat TURGAY⁶, ¹Department of Rheumatology, Ankara University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, ²Hacettepe University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation, Ankara, Turkey, ³Hacettepe University, Faculty of Medicine, Department of Biostatistics, Ankara, Turkey, ⁴Department of Rheumatology, Ankara Ibn_i Sina Hospital, Department of Rheumatology, Ankara, Turkey, ⁵Ankara University, Faculty of Medicine, Department of Internal Medicine, Rheumatology, Ankara, Turkey, ⁶Ankara University, Faculty of Medicine, Department of Internal Medicine, Rheumatology,, Ankara, Turkey
Background/Purpose: Conventional treatments include NSAID and physiotherapy remain the mainstay of treatment in Ankylosing Spondylitis (AS). After the failure of conventional therapy, DMARD therapies are…
Abstract Number: 1743 • 2016 ACR/ARHP Annual Meeting
Prevalence of Inflammatory Neck Pain in a Cohort of Patients with Psoriatic Arthritis and Its Association with Clinical and Radiographic Features
Osvaldo Luis Cerda, Margarita Landi, Cecilia Zaffarana, Josefina Gallino Yanzi, Emilce Schneeberger and Gustavo Citera, Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose: Cervical inflammatory pain is very common and rarely studied in patients with Psoriatic Arthritis (PsA). The purpose of our study was to evaluate the…
Abstract Number: 1744 • 2016 ACR/ARHP Annual Meeting
Expression of C1q By Podocytes at Late Stages of Proliferative Lupus Glomerulonephritis
Hongyang Wang¹, Ou Jin², Niansheng Yang³, Chao Dai¹, Sun-sang Sung¹, Felicia Gaskin⁴ and Shu Man Fu⁵, ¹Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ²Rheumatology, Sun Yat-sen University Third Affiliated Hospital, Guangzhou, China, ³Rheumatology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China, ⁴Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁵Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: In NZM2328 (NZM), a mouse model of proliferative lupus glomerulonephritis (GN), lupus GN can be categorized to four stages, i.e. normal, acute GN (aGN),…
Abstract Number: 1745 • 2016 ACR/ARHP Annual Meeting
Disturbance of Renal Circadian Rhythm in Lupus Nephritis
Rakesh Mishra¹, Ramalingam Bethunaickan², Weijia Zhang³ and Anne Davidson⁴, ¹Feinstein Institute, Manhasset, NY, ²Autoimmune and musculosketal diseases, Feinstein Institute for Medical Research, Manhasset, NY, ³Nephrology, Mount Sinai School of Medicine, New York, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Circadian rhythm is a universal phenomenon that allows organisms to anticipate and respond to changes in their environment by regulating sleep and feeding patterns,…
Abstract Number: 1746 • 2016 ACR/ARHP Annual Meeting
Immune Complex-Induced IL-6 Production By Lupus Prone Mesangial Cells Is Mediated By Neuraminidase Activity
Tamara K. Nowling¹, Kamala Sundararaj² and Leah Siskind³, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Pharmacology and Toxicology, University of Louisville, Louisville, KY
Background/Purpose: We made the novel observation that glycosphingolipid (GSL) levels and neuraminidase (NEU) (an enzyme that mediates GSL catabolism) activity/expression are altered in the kidneys…
Abstract Number: 1747 • 2016 ACR/ARHP Annual Meeting
Dissecting the Role of Single Complement Deficiencies in a Novel Model for Apoptotic Cell-Induced Lupus
Lucrezia Colonna¹, Clayton J. Sontheimer², Lena M. Tanaka³, Kelly L. Hudkins⁴, Charles E. Alpers⁴, Keith B. Elkon¹ and YuFeng Peng³, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Pediatric Rheumatology, University of Washington, Seattle, WA, ³Division of Rheumatology, University of Washington, Seattle, WA, ⁴Pathology, University of Washington, Seattle, WA
Background/Purpose: The role of complement in Systemic Lupus Erythematosus (SLE) is complex as complement deficiencies in early components of the classical pathway cause lupus with…
Abstract Number: 1748 • 2016 ACR/ARHP Annual Meeting
Effects of Anti-High Mobility Group Box 1 Antibody for MRL/Lpr lupus-Prone Mice
Haruki Watanabe¹, Katsue S. Watanabe¹, Keyue Liu², Minglu Yan¹, Sumie Hiramatsu¹, Sonia Zeggar¹, Keiji Ohashi¹, Eri Katsuyama¹, Yoshia Miyawaki¹, Michiko Morishiata³, Takayuki Katsuyama¹, Mariko Narazaki¹, Noriko Tatebe¹, Tomoko Kawabata¹, Ken-ei Sada¹, Masahiro Nishibori² and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Background/Purpose: High mobility group box 1 (HMGB1) is a ubiquitous non-histone nuclear protein that exerts proinflammatory functions in the extracellular milieu. Here we evaluate the…
Abstract Number: 1749 • 2016 ACR/ARHP Annual Meeting
The Role of Mucosal-Associated Invariant T (MAIT) Cells in Lupus Dermatitis
Goh Murayama¹, Asako Chiba², Hirofumi Amano³, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake⁴, ¹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan, ⁴Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by MHC-related molecule-1 (MR1) and express a semi-invariant TCRa chain: Va7.2-Ja33 in…
Abstract Number: 1750 • 2016 ACR/ARHP Annual Meeting
Down-Regulation of microRNA-200a-3p, Targeting C-Terminal Binding Protein-2 (CtBP2), Is Involved in Hypoproduction of IL-2 in SLE-Derived T Cells
Eri Katsuyama¹, Yan Minglu¹, Katsue Sunahori-Watanabe¹, Sonia Zeggar¹, Sumie Hiramatsu¹, Keiji Ohashi¹, Haruki Watanabe¹, Takayuki Katsuyama¹, Noriko Toyota-Tatebe², Ken-ei Sada¹ and Jun Wada¹, ¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease caused by genetic and epigenetic mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs, post-transcriptionally regulate the…
Abstract Number: 1751 • 2016 ACR/ARHP Annual Meeting
Coagulation Pathway Function in Ischemia/Reperfusion Tissue Injury in Autoimmune Prone Mice
Rachel C. Robbins¹, Christopher Tracy², Jess Edison¹, Suzette Peng³ and Chantal Moratz⁴, ¹Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Walter Reed National Military Medical Center, Bethesda, MD, ³Food and Drug Administration, Silver Spring, MD, ⁴Uniformed Services University, Bethesda, MD
Results: Tissue Factor Pathway Inhibitor (TFPI) and Anti-thrombin III (ATIII) resulted in reduction of tissue injury, as determined by histopathology scoring. However, TFPI was significantly…

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