Abstracts Archive - Page 1713 of 2425 - ACR Meeting Abstracts

Abstract Number: 352 • 2015 ACR/ARHP Annual Meeting
Low Bone Density Is Associated with Atherosclerotic Disease in Patients with Psoriatic Arthritis
Eirik Ikdahl^1,2, Hege Kilander Høiberg³, Silvia Rollefstad², Andreas P Diamantopoulos^4,5, Grunde Wibetoe², Arthur Kavanaugh⁶, Inge C Olsen⁷, Tore K. Kvien⁷, Anne Grete Semb⁸ and Glenn Haugeberg⁹, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁴Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, ⁵Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁶University of California San Diego, La Jolla, CA, ⁷Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁸Diakonhjemmet Hospital, Oslo, Norway, ⁹Rheumatology, The Norwegian University of Science and Technology, Trondheim, Norway
Background/Purpose: There is an evidence vacuum concerning the mechanisms underlying the high atherosclerotic cardiovascular disease (ASCVD) burden in patients with psoriatic arthritis (PsA). In the…
Abstract Number: 353 • 2015 ACR/ARHP Annual Meeting
A Longitudinal Cohort Study of Weekly Teriparatide, Denosmab, and Bisphosphonates for Prevention of Vertebral Fractures in Glucocorticoid-Induced Osteoporosis
Hisaji Oshima¹, Mari Ushikubo¹, Kumiko Akiya¹, Ikuko Tanaka², Shigenori Tamaki² and Keisuke Izumi³, ¹Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ²NAGOYA Rheumatology Clinic, Nagoya, Japan, ³National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Although weekly teriparatide (56.5ug, wTPTD) and denosmab (DMAB) have been developed as potent anti-osteoporotic agents, effects of these agents on prevention of osteoporotic fractures…
Abstract Number: 354 • 2015 ACR/ARHP Annual Meeting
Association Between Bone and Clinical Parameters in Ankylosing Spondylitis
Vladimira Boyadzhieva¹, Mariana Ivanova², Nikolay Stoilov¹, Rumen Stoilov³, Rasho Rashkov⁴, Didier Hans⁵ and Rozier Berengere⁵, ¹Rheumatology, University Hospital (MHAT) St Ivan Rilski, Sofia, Bulgaria, ²University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria, ³University Hospital (MHAT) St Ivan Rilski, Sofia, Bulgaria, ⁴Department of Rheumatology, MHAT Sveti Ivan Rilski, Sofia, Bulgaria, ⁵Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatological disease of unknown origin that primarily affects the axial skeleton, including the sacroiliac joints and spine,…
Abstract Number: 355 • 2015 ACR/ARHP Annual Meeting
The Clinical and Genetic Spectrum of Low Alkaline Phosphatase in Adults
Leyre Riancho-Zarrabeitia¹, Maria T. García-Unzueta², Jair A. Tenorio³, Juan Gómez-Gerique⁴, Víctor L Ruiz Pérez³, Karen E. Heath³, Pablo Lapunzina³ and José A. Riancho⁵, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Institute of Medical and Molecular Genetics. Hospital U. La Paz. IdiPAZ. Autonomous University of Madrid. CIBERER., Madrid, Spain, ⁴Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. University of Cantabria, Santander, Spain
Background/Purpose: Different from infantile forms, adult forms of hypophosphatasia have less severe manifestations and may go unrecognized. Low serum levels of alkaline phosphatase (ALP), the…
Abstract Number: 356 • 2015 ACR/ARHP Annual Meeting
Assessment of the Effect of 12 Months Administration of Denosumab in Patients with Rheumatic Diseases
Kosuke Ebina¹, Makoto Hirao², Jun Hashimoto³, Keisuke Hagihara⁴, Hideki Yoshikawa⁵ and Takaaki Noguchi⁶, ¹Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan, ²Orthopaedic Surgery, Osaka University, Graduate School of Medicine, Suita, Japan, ³Dept of Rheumatology, Osaka-Minami Medical Center, Kawachinagano City, Japan, ⁴Kampo Medicine, Osaka University, Graduate School of Medicine, Suita, Japan, ⁵Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan, ⁶Orthopaedic Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan
Background/Purpose: In patients with rheumatic diseases (RD), pro-inflammatory cytokines induce receptor activator of nuclear factor kappa-B ligand (RANKL), which plays a crucial role in inducing…
Abstract Number: 357 • 2015 ACR/ARHP Annual Meeting
Human Parathyroid Hormone for Preventing and Treating Glucocorticoid-Induced Osteoporosis: Cochrane Systematic Review and Meta-Analysis
Akira Onishi¹, Akira Sato², Masahiro Iwasaku² and Toshi Furukawa², ¹Department for Rheumatology, Kobe University Hospital, Kobe, Japan, ²Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan
Background/Purpose: Although glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis, providing effective treatment remains a challenge. Bisphosphonates are currently recommended for treatment and…
Abstract Number: 358 • 2015 ACR/ARHP Annual Meeting
Bone Microstructure Assessed By Hrpqct in Subjects with Hyperuricemia without Arthritis
Roland Kocijan¹, Arastoo Nia¹, Christian Muschitz², David Simon³, Corinna Geiger¹, Judith Haschka⁴, Arnd Kleyer³, Sara Bayat⁵, Juergen Rech⁵, Annemarie Kocijan⁶, Larissa Dzirlo⁷, Monika Graninger⁷ and Heinrich Resch¹, ¹Medical Department II, Karl Landsteiner Society for Gastroenterology and Rheumatology, St. Vincent Hospital, Vienna, Austria, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Optimal Essen e.U., Vienna, Austria, ⁷Medical Department III, St. Vincent Hospital, Vienna, Austria
Background/Purpose: Gouty arthritis is a common inflammatory joint disorder and hyperuricemia (HU) is known to be the main risk factor. Beside clinical signs of inflammation…
Abstract Number: 359 • 2015 ACR/ARHP Annual Meeting
Diminished Health-Related Quality of Life As Measured By the Short Form-10 in Children with Hypophosphatasia
Thomas J. Weber¹, Eileen K. Sawyer², Scott Moseley² and Priya S. Kishnani¹, ¹Duke University Medical Center, Durham, NC, ²Alexion Pharmaceuticals, Cheshire, CT
Background/Purpose: Hypophosphatasia is a rare metabolic disease caused by loss-of-function mutation(s) in the gene encoding the tissue non-specific alkaline phosphatase (ALP). In children, low tissue…
Abstract Number: 360 • 2015 ACR/ARHP Annual Meeting
Massive Elimination of Multinucleated Osteoclasts By Eupatilin Is Due to Dual Inhibition of Transcription and Cytoskeletal Rearrangement
Myeung Su Lee¹, Ju-Young Kim², Chang-Hoon Lee³, Wan-Hee Yoo⁴, Won Seok Lee⁴, Myong-Joo Hong⁵ and Jaemin Oh², ¹Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ²Anatomy, Wonkwang University, Iksan, South Korea, ³Rheumatology, Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ⁴Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ⁵Internal Medicine, Presbyterian Medical center, Jeonju, South Korea
Background/Purpose: Osteoporosis is an ageing-associated diseases requiring better therapeutic modality. Eupatilin is a major flavonoid from Artemisia. We aimed to evaluate the effects of eupatilin on…
Abstract Number: 361 • 2015 ACR/ARHP Annual Meeting
Sodium Intake and Osteoporosis. Findings from the Women’s Health Initiative
Laura Carbone¹, Karen Johnson², Ying Huang³, Mary Pettinger⁴, Thomas Fridtjof⁵, Jane A. Cauley⁶, Carolyn Crandall⁷, Lesley Tinker⁸, Meryl LeBoff⁹, Jean Wactawksi-Wende¹⁰, Monique Bethel¹¹, Wenjun Li¹² and Ross Prentice³, ¹Rheumatology, Georgia Regents University, Augusta, GA, ²Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, ³Biostatistics, University of Washington, Seattle, WA, ⁴Fred Hutcinson Cancer Research Center, Seattle, WA, ⁵University of Tennessee Health Science Center, Memphis, TN, ⁶Department of Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ⁷Medicine, University of California Los Angeles, Los Angeles, CA, ⁸Fred Hutchinson Cancer Research Center, Seattle, WA, ⁹Brigham and Women's Hospital, Boston, MA, ¹⁰University of Buffalo, Buffalo, NY, ¹¹Internal Medicine, Georgia Regents University, Augusta, GA, ¹²Medicine, Division of Preventive Medicine, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: The relationship of sodium intake to bone mineral density (BMD) in postmenopausal women has not been established, and no study to date has examined…
Abstract Number: 362 • 2015 ACR/ARHP Annual Meeting
Reference Curves of Bone Parameters Obtained By High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) in Healthy Women from 20 to 85 Years Old
Jackeline Couto Alvarenga¹, Henrique Fuller², Sandra G. Pasoto², Stephanie Boutroy³ and Rosa M R Pereira⁴, ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³INSERM U831 and Université de Lyon, Lyon, France, ⁴Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Bone is a dynamic tissue, and its formation and resorption are continuous processes that promote changes throughout the life of the organism, and changes…
Abstract Number: 363 • 2015 ACR/ARHP Annual Meeting
Determination of the Osteoporotic Vertebral Fractures By a New Quantitative Approach: Intervertebral Volume Index
Omer Kuru¹, Yasemin Ulus², Halil Sen², Bunyamin Sahin³ and Ayhan Bilgici², ¹Physical Medicine And Rehabilitation Division of Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey, ²Physical Medicine and Rehabilitation Division of Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey, ³Anatomy, Ondokuz Mayis University School of Medicine, Samsun, Turkey
Background/Purpose: Vertebral fractures caused by osteoporosis are quite common and have a negative effect on quality of the life. But they may not be clinically…
Abstract Number: 364 • 2015 ACR/ARHP Annual Meeting
Very High Frequency of Fragility Fractures Associated with High-Dose Glucocorticoids in Postmenopausal Women: A Retrospective Study
Goichi Kageyama¹, Takaichi Okano¹, Yuzuru Yamamoto¹, Keisuke Nishimura¹, Daisuke Sugiyama², Jun Saegusa¹, Goh Tsuji³, Shunichi Kumagai⁴ and Akio Morinobu¹, ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan, ³The Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, ⁴The Center of Rheumatic Diseases, Shinko Hospital, Kobe, Japan
Background/Purpose: To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease.Methods: A retrospective study of patients who were treated with high-dose…
Abstract Number: 365 • 2015 ACR/ARHP Annual Meeting
Can We Use Bone Turnover Markers As Targets for Antiresorptive Treatment in Postmenopausal Osteoporosis? an Analysis from Two Phase 3 Clinical Trials
JP Brown¹, P Dakin², P Hadji³, MR McClung⁴, PD Miller⁵, J-Y Reginster⁶, RB Wagman², A Wang² and E McCloskey⁷, ¹Laval University and CHU de Québec (CHUL) Research Centre, Quebec City, QC, Canada, ²Amgen Inc., Thousand Oaks, CA, ³Philipps-University of Marburg, Marburg, Germany, ⁴Oregon Osteoporosis Center, Portland, OR, ⁵Colorado Center for Bone Research, Lakewood, CO, ⁶University of Liège, Liège, Belgium, ⁷University of Sheffield, Sheffield, United Kingdom
Background/Purpose: Bone turnover markers (BTMs) respond faster than bone mineral density as an indicator of response to therapy in osteoporotic patients; however, it remains unclear…
Abstract Number: 366 • 2015 ACR/ARHP Annual Meeting
Cost-Effective Osteoporosis Treatment Intervention Thresholds Based on FRAX in Portugal
Andréa Marques¹, Oscar Lourenço², Ortsäter Gustaf³, Fredrik Borgström³ and Jose Da Silva⁴, ¹Rheumatology, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal, ²Centro de Estudos e Investigação em Saúde da Universidade de Coimbra, Faculty of Economics. University of Coimbra, Coimbra, Portugal, ³Quantify Research, Stockholm, Sweden, ⁴Faculty of Medicine. University of Coimbra, Coimbra, Portugal
Background/Purpose: The aim of the present study was to identify the FRAX®Port (FRAX® validated for Portugal) ten-year major and hip osteoporotic fracture probabilities, above which…

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