Abstracts Archive - Page 1710 of 2607 - ACR Meeting Abstracts

Abstract Number: 1662 • 2016 ACR/ARHP Annual Meeting
The Association Between Radiologic Progression and Serum Levels of Potential Markers of Bone Formation in Ankylosing Spondylitis Patients
Ali Erhan Ozdemirel¹, Firas Doghanji², Orhan Kucuksahin³, Duygu Tecer⁴, Sebnem Ataman⁵, Ayse Peyman Yalcin² and huseyin tutkak⁶, ¹Rheumatology Department, Dıskapı Yıldırım Beyazıt Training And Research Hospital, Ankara, Turkey, ²Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ³Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, ⁴Physical Medicine and Rehabilitation, Division of Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey, ⁵Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, ⁶ankara university immunology, ankara, Turkey
Background/Purpose: The association between inflammation and spinal damage in Ankylosing Spondylitis (AS) remains unclear. Tumor necrosis factor-α (TNF- α) plays pivotal role in inflammatory process…
Abstract Number: 1663 • 2016 ACR/ARHP Annual Meeting
Assessment of Serum Calprotectin and Osteoprotegerin Levels in a Cohort of Spanish Patients with Axial Spondyloarthritis
Fernanda Genre¹, Carlos Fernández-Díaz¹, Javier Rueda-Gotor¹, Raquel López-Mejías¹, Sara Remuzgo-Martínez¹, Begoña Ubilla¹, Veronica Mijares¹, Alfonso Corrales¹, Virginia Portilla¹, Patricia Fuentevilla¹, Luis Rodriguez-Rodriguez², Ricardo Blanco¹, José Luis Hernandez³ and Miguel Angel Gonzalez-Gay^1,4,5, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ²Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ³Bone Metabolism Unit, Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, RETICEF, Santander, Spain, ⁴School of Medicine, University of Cantabria, Santander, Spain, ⁵Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Calprotectin is a protein involved in several cellular processes including immunomodulation1. Elevated levels of this protein have been observed in inflammatory diseases, since it…
Abstract Number: 1664 • 2016 ACR/ARHP Annual Meeting
Protein Fingerprinting Screening Specific Proteins in Serum of Patients with Ankylosing Spondylitis
Dan Ma¹, gailian Z², Ke Xu³ and Liyun Zhang³, ¹Department of rheumatology, Shanxi Academy of Medical Sciences, Shanxi DaYi Hospital, Taiyuan, China, ²Shanxi Academy of Medical Sciences,Shanxi Dayi Hospital, Department of Rheumatology, China, taiyuan, China, ³Department of Rheumatology, Shanxi Academy of Medical Sciences, Shanxi DaYi Hospital, Taiyuan, China
Background/Purpose: To study the specific biomarkers by surface-enhanced laser desorption ionization/time of flight mass spectrometry (SELDI-TOF-MS) and protein chip in serum of patients with ankylosing…
Abstract Number: 1665 • 2016 ACR/ARHP Annual Meeting
Validation of Germ Line Epigenetic Variants Associated with Psoriatic Disease
Remy Pollock¹, Laila Zaman¹, Vinod Chandran² and Dafna D Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Heritable epigenetic phenomena may play a role in the parent-of-origin effect observed in psoriasis and psoriatic arthritis (PsA). A previous epigenome-wide association study (EWAS)…
Abstract Number: 1666 • 2016 ACR/ARHP Annual Meeting
Micrornas Mir-30b-5p, Mir-34a-5p, and Mir-431-3p Are Highly Expressed in the Plasma of Patients with Ankylosing Spondylitis
Abdul Haseeb¹, Tariq M. Haqqi¹ and Marina N. Magrey², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH
Background/Purpose: The role of miRNAs in immune and inflammatory diseases is increasing exponentially. miRNAs are present in the human plasma in stable form. We proposed…
Abstract Number: 1667 • 2016 ACR/ARHP Annual Meeting
Diagnostic Value of Anti-CD74 Antibodies in Axial Spondyloarthritis: Results from a Population with Low HLA-B27 Prevalence Background
Nelly Ziade¹, Fouad Fayad¹, Iyad Mallak², Georges Merheb³, Torsten Witte⁴ and Xenofon Baraliakos⁵, ¹Rheumatology, Hotel Dieu de France Hospital and Saint Joseph University, Beirut, Lebanon, ²Radiology, Hotel-Dieu de France and Saint-Joseph University, Beirut, Lebanon, ³Internal Medicine, Notre Dame des Secours University Hospital, Jbeil, Lebanon, ⁴Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ⁵Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA) is still frequently diagnosed late and its pathogenesis is still unclear. Although a strong genetic association of axSpA with HLA-B27 is…
Abstract Number: 1668 • 2016 ACR/ARHP Annual Meeting
Selective Inhibition of Tumor Necrosis Factor-α Receptor 2 (TNFR2) Activity Alleviates Psoriasiform Inflammation in Mouse Models
Unnikrishnan Chandrasekharan¹, Chad Braley², Jennifer Harvey³, Zeneng Wang¹, Paul DiCorleto⁴ and M. Elaine Husni⁵, ¹Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH, ²Department of Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, ³Department of Cellular and Molecular, Cleveland Clinic, Cleveland, OH, ⁴Division of Research and Sponsored Programs, Kent State, kent, OH, ⁵Rheumatology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Tumor necrosis factor-α (TNF) activates two receptors globally, TNFR1 and TNFR2. Neutralizing antibodies or soluble TNF receptors can inactivate TNF, blocking activity of both…
Abstract Number: 1669 • 2016 ACR/ARHP Annual Meeting
Type 3 Innate Lymphoid Cells Numbers in Peripheral Blood Predict Ustekinumab (Stelara) Therapy Responsiveness in Psoriatic Disease Cases with Subclinical Imaging Enthesopathy
Yasser El-Sherbiny¹, Laura Savage², Miriam Wittmann³, Mark J. D. Goodfield⁴ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Ustekinumab1 targets the common p40 sub-unit of interleukin-12 (IL-12/interleukin-23 (IL-23). In patients treated with Ustekinumab for psoriasis where patients were selected on the basis of…
Abstract Number: 1670 • 2016 ACR/ARHP Annual Meeting
Cytokine Expression in Groups of Psoriatic Arthritis Patients Characterised By Specific HLA Genotypes and Clinical Features
Musaab Elmamoun¹, Wilco de Jager², Sytze de Roock³, Muhammad Haroon⁴, Robert Winchester⁵, Stephen R. Pennington⁶ and Oliver FitzGerald⁷, ¹Rheumatology, St. Vincent's University Hospital, Department of Rheumatology, Dublin 4, Ireland, ²Dept Immunology, UMC Utrecht, Utrecht, Netherlands, ³Immunology, University Medical Center, Utrecht, Netherlands, ⁴St. Vincent's University Hospital, Department of Rheumatology, Dublin, Ireland, ⁵Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁶Proteome Research Centre, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland, ⁷St. Vincent's University Hospital, Department of Rheumatology. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease with diverse clinical and radiographic manifestations. A number of human leukocyte antigen (HLA) alleles have been found…
Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 1672 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Activation of Canonical Wnt Signaling By Targeting LRP6 in Ankylosing Spondylitis
Jinxian Huang¹, Zhihua Yin², Zhongchao Fu³, Zhizhong Ye³ and Lijun Zhang⁴, ¹Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, ²Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ³The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ⁴The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Background/Purpose: Aberrant regulation of the Wnt pathway is a key element in the pathogenesis of Ankylosing spondylitis (AS). We previously found that miR-29a was significantly…
Abstract Number: 1673 • 2016 ACR/ARHP Annual Meeting
Characteristic Phenotypes of Peripheral T Cells and Efficacy of Biological Dmards in Patients with Psoriatic Arthritis
Ippei Miyagawa¹, Shingo Nakayamada², Satoshi Kubo³, Kazuhisa Nakano², Yusuke Miyazaki³, Maiko Yoshikawa⁴ and Yoshiya Tanaka⁵, ¹University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan, ⁵University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Biological DMARDs (bDMARDs) such as adalimumab (ADA), infliximab (IFX), ustekinumab (UST) and secukinumab (SEC) become available and efficacious in patients with psoriatic arthritis (PsA).…
Abstract Number: 1674 • 2016 ACR/ARHP Annual Meeting
Do TNF Inhibitors Change the Progression of Sacroiliitis?
Deeba Minhas¹, MinJae Lee^2,3, Mohammad H. Rahbar³, Lianne S. Gensler⁴, John D. Reveille⁵ and Michael Weisman¹, ¹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Medicine, University of Texas Health Science Center at Houston, Houston, TX, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴Medicine/Rheumatology, UCSF, San Francisco, CA, ⁵Rheumatology, University of Texas-McGovern Medical School, Houston, TX
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the sacroiliac (SI) joints and spine causing structural changes seen on clinical radiography. Studies have…
Abstract Number: 1675 • 2016 ACR/ARHP Annual Meeting
Triptolide Inhibits Th17 Differentation By JAK2/STAT3 Signal Pathway in Inflammation of Ankylosing Spondylitis
Hongxiao Liu¹, Junyao Song¹, Ziqi Xu¹, Xinghua Feng¹, Quan Jiang² and YaNan Zhao³, ¹Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Rheumatology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ³Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, BeiJing, China
Background/Purpose: Th17 plays important role in pathogenesis of AS inflammation, and its main effector, IL-17, was the critical effector on mediating it. Activated of Th17…
Abstract Number: 1676 • 2016 ACR/ARHP Annual Meeting
Methotrexate and Anti-Tumor Necrosis Treatment Improve Endothelial Function in Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Gia Deyab¹, Ingrid Hokstad², Stefan Agewall³, Torstein Lyberg⁴, Jon Elling Whist⁵, Milada Cvancarova Småstuen⁶, Gunnbjørg Hjeltnes⁷ and Ivana Hollan^8,9,10,11, ¹Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, ²Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, ³University of Oslo, Oslo, Norway, ⁴Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, ⁵Innlandet Hospital Trust, Lillehammer, Norway, ⁶Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, ⁷Medicine, Innlandet Hospital Trust, Lillehammer, Norway, ⁸Harvard Medical School, Boston, MA, ⁹Department of Medicine, Brigham and Women's Hospital, Boston, MA, ¹⁰Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ¹¹Innlandet Hospital Trust, Brumunddal, Norway
Background/Purpose: Inflammatory rheumatic diseases (IRDs) are associated with accelerated atherosclerosis, which progression is related to inflammation (1). One of the first stages in atherogenesis is…

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