ACR Meeting Abstracts

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  • Abstract Number: 184 • 2015 ACR/ARHP Annual Meeting

    Rheumatologists and Musculoskeletal Ultrasound: Discrepancy Between Attitudes, Desire and Reality in Routine Practice in South East England

    Antigoni Grigoriou1 and Patrick Kiely2, 1Rheumatology, St George's Univeristy Hospitals NHS Foundation Trust, London, United Kingdom, 2Rheumatology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom

    Background/Purpose: The use of musculoskeletal ultrasound (MSK US) in routine care is expanding. The number of rheumatologists using or seeking to learn the technique is…
  • Abstract Number: 185 • 2015 ACR/ARHP Annual Meeting

    Success Rate and Utility of Ultrasound Guided Synovial Biopsies in Clinical Practice

    Aurélie Najm, Benoît Le Goff and Yves Maugars, Rheumatology, Rheumatology, Nantes, France

    Background/Purpose: Histological and bacteriological analysis of synovial tissue (ST) can be useful in the diagnosis of arthritis of undetermined origin. Ultrasound can assist this biopsy…
  • Abstract Number: 186 • 2015 ACR/ARHP Annual Meeting

    B Flow, a Novel Ultrasound Modality in the Assessment of Synovitis in RA

    Darren Tabechian1, Laura C Coates2, Jennifer H. Anolik1 and Ralf G. Thiele1, 1University of Rochester Medical Center, Rochester, NY, 2LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom

    Background/Purpose: B flow is a vascular ultrasound (US) technique in which the high resolution aspect of gray scale US is optimized to demonstrate movement of…
  • Abstract Number: 187 • 2015 ACR/ARHP Annual Meeting

    Detection of Power Doppler Ultrasound Signals in Rheumatic Diseases Using Superb Microvascular Imaging (SMI): Comparison with Conventional Power Doppler Ultrasound

    Kazuhiro Yokota1, Takuma Tsuzuki Wada2, Yuji Akiyama2 and Toshihide Mimura3, 1Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Irama, Japan, 2Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma, Japan, 3Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: The detection of power Doppler (PD) ultrasound signals in joints may be considered as the presence of joint inflammation, i.e., synovitis which is a…
  • Abstract Number: 188 • 2015 ACR/ARHP Annual Meeting

    Whole-Body Synovial Uptake of a 99mtc-Labelled RGD Peptide Is Highly Correlated with Power Doppler Ultrasound

    Toby Garrood1, Matthew Morrison2, Dharsha Shivapatham3, Khaldoun Chaabo1, Fahim Ul-Hassan4, Jim Ballinger4, Gary Cook5 and Andrew P. Cope6, 1Rheumatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 2GE Healthcare, Amersham, United Kingdom, 3Department of Rheumatology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 4Nuclear Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 5Imaging Sciences, Kings College London, London, United Kingdom, 6Academic Department of Rheumatology, King´s College London, London, United Kingdom

    Background/Purpose: Musculoskeletal ultrasound, and specifically power Doppler ultrasound (PDUS), is more sensitive than clinical examination for the assessment of active synovitis in patients with rheumatoid…
  • Abstract Number: 189 • 2015 ACR/ARHP Annual Meeting

    Indocyanine Green (ICG) -Enhanced Fluorescence Optical Imaging (FOI) in Patients with Active Rheumatoid Arthritis; A Comparative Study with Ultrasound and Association with Biomarkers

    Shin-ya Kawashiri1,2, Ayako Nishino3, Masataka Umeda3, Shoichi Fukui1, Yoshikazu Nakashima3, Naoki Iwamoto1, Kunihiro Ichinose1, Hideki Nakamura1, Tomoki Origuchi4, Kiyoshi Aoyagi2 and Atsushi Kawakami3, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 4Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Methods: Twenty-five active RA patients (mean disease durations 7.5 years and DAS28-ESR 5.90) who fulfilled 2010 RA classification criteria were consecutively enrolled in this study.…
  • Abstract Number: 190 • 2015 ACR/ARHP Annual Meeting

    Ultrasound Imaging with Elastography for the Medical Treatment of Dupuytren’s Contracture

    Paul John DeMarco1, Alan K. Matsumoto1, Nicole Thomas2, Megan Bishop1, Andrew Gregory DeMarco3, Guada Respicio1, Ashley Beall1, Robert Rosenberg1, Theresa Bass-Goldman1 and Herbert S. B. Baraf1, 1The Center for Rheumatology and Bone Research, Wheaton, MD, 2Rheumatology, Georgetown University Hospital, Washington DC, DC, 3Duquesne University, Pittsburgh, PA

    Background/Purpose:  Dupuytren’s contracture is a rheumatic disease characterized by an fibrotic reaction in the palmar aponeurosis, resulting in disability.  Medical treatment with up to 3…
  • Abstract Number: 191 • 2015 ACR/ARHP Annual Meeting

    High Specificity of Spectral Nail Assessment in Psoriatic Arthritis Patients

    JOSE ALEXANDRE MENDONÇA, 4Rheumatology Unit, Hospital da Pontifícia Universidade Católica (PUC) de Campinas, Campinas, Brazil, Porto Alegre, Brazil; Rheumatology, Instituto de Pesquisa Clínica of Campinas – IPECC, Campinas, Brazil

    Background/Purpose:  Ultrasound evaluation of synovitis and enthesitis has changed the management of rheumatic diseases. In the present study we compare Power Doppler (PD) and Spectral…
  • Abstract Number: 192 • 2015 ACR/ARHP Annual Meeting

    Comparison of Bone Scan with Xiralite (FOI) in Patients with Rheumatoid Arthritis and Psoriatic Arthritis

    Joerg Polter, Susanne Drynda and Jörn Kekow, Clinic for Rheumatology, Vogelsang-Gommern, Germany

    Background/Purpose: In recent years Xiralite, an ICG-enhanced fluorescence optical imaging (FOI) technology, has gained growing importance as a non-radioactive imaging technique for the detection of…
  • Abstract Number: 193 • 2015 ACR/ARHP Annual Meeting

    Going Back to Basics – Redefining the Normal Pattern in Nailfold Capillaroscopy in a Large Healthy Population: Results of the German “Rheuma-Truck” Cohort

    Moritz Schröder, Department of Rheumatology and Hiller Research Institute, Heinrich-Heine University, Duesseldorf, Germany

    Background/Purpose: Capillaroscopy is as a useful diagnostic tool in various connective tissue diseases characterized by microangiopathy and vasculitis. Different pathological patterns especially for systemic sclerosis…
  • Abstract Number: 194 • 2015 ACR/ARHP Annual Meeting

    Events Upstream of Caspase-1 Activation in NLRP3-Mediated Cell Death in NOMID

    Jehad H. Edwan, Raphaela Goldbach-Mansky and Robert A. Colbert, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Gain-of-function mutations in NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS), with neonatal-onset multisystem inflammatory disease (NOMID) being the…
  • Abstract Number: 195 • 2015 ACR/ARHP Annual Meeting

    Activation of the Pyrin Inflammasome through the RhoA Signaling Pathway in Familial Mediterranean Fever (FMF) and Hyperimmunoglobulinemia D Syndrome (HIDS)

    Yong Hwan Park, Geryl Wood, Daniel Kastner and Jae Jin Chae, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, NIH/NHGRI, Bethesda, MD

    Background/Purpose: Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause the autoinflammatory diseases familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS), respectively. …
  • Abstract Number: 196 • 2015 ACR/ARHP Annual Meeting

    The Pyrin Domain-Only Protein POP1 Inhibits NLRP3-Dependent Inflammatory Disease

    Lucia Almeida1, Sonal Khare2, Alexander Misharin3, Rajul Patel2, Rojo Ratsinmandresy2, Melissa Wallin2, Harris R. Perlman4, David Greaves5, Hal M. Hoffman6, Andrea Dorfleutner1 and Christian Stehlik2, 1Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Medicine/Rheumatology, Northwestern University, Chicago, IL, 4Feinberg School of Medicine, Northwestern University, Chicago, IL, 5University of Oxford, oxford, England, 6University of California at San Diego, San Diego, CA

    Background/Purpose: In response to infections and tissue damage NLRP3 and ASC-containing inflammasome protein complexes are assembled, which promote caspase-1 activation, IL-1b and IL-18 processing and…
  • Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting

    Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice

    Rebecca Baum1, Kerstin Nundel1, Sudesh Pawaria1,2, Shruti Sharma1, Patricia Busto1, Tara Robidoux1, Katherine A. Fitzgerald1, Ellen M. Gravallese3 and Ann Marshak-Rothstein1, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 3Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…
  • Abstract Number: 198 • 2015 ACR/ARHP Annual Meeting

    CL-L1 and CL-K1 Complement Associated Pattern Recognition Molecules in Systemic Lupus Erythematosus

    Anne Troldborg1, Steffen Thiel2, Lisbeth Jensen3, Magdalena Janina Laska2, Søren Hansen4, Bent Deleuran5,6, Jens Christian Jensenius2 and Kristian Stengaard-Pedersen5, 1clinical medicine, Aarhus University, Aarhus, Denmark, 2Biomedicine, Aarhus University, Aarhus, Denmark, 3Biomedicin, Aarhus University, Aarhus, Denmark, 4Department of cancer and inflammation research, University of Southern Denmark, Odense, Denmark, 5Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 6Biomedicin, Aarhus University, 8000, Denmark

    Background/Purpose: The complement system is one of the key players in the pathogenesis of systemic lupus erythematosus (SLE). Collectin liver 1 (CL-L1) and collectin kidney…
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