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  • Abstract Number: 1392 • 2016 ACR/ARHP Annual Meeting

    Familial Aggregation of Autoimmune Diseases in Childhood and Adulthood Systemic Lupus Erythematosus

    Nailu A. Sinicato1, Luciana de Oliveira2, Aline Tamires Lapa2, Lilian Tereza Costallat3, Roberto Marini Sr.4, Timothy B. Niewold5 and Simone Appenzeller6, 1Pediatrics, State University of Campinas, Campinas, Brazil, 2Medicine, State University of Campinas, Campinas, Brazil, 3RUA EZEQUIEL MAGALHAES,26, Unicamp, Campinas, Brazil, 4Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, 5Rheumatology and Immunology, Mayo Clinic, Rochester, MN, 6Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil

    Background/Purpose:  Genetic factors play a role in SLE, evidenced by the high sibling risk ratio (λs=8–29) and higher concordance rates between monozygotic twins (>35%) compared…
  • Abstract Number: 1393 • 2016 ACR/ARHP Annual Meeting

    Mycophenolic Acid Pharmacokinetics in Childhood-Onset Systemic Lupus Erythematosus Patients of Hispanic Ethnicity in a Single Center

    Anna Carmela Sagcal-Gironella1, Marietta De Guzman1, Daping Zhang2, Lorita Agu2 and Diana Chow2, 1Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 2Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX

    Background/Purpose: Mycophenolic acid (MPA) is the biologically active metabolite of mycophenolate mofetil (MMF), a widely used immunosuppressant in the treatment of childhood-onset systemic lupus erythematosus…
  • Abstract Number: 1394 • 2016 ACR/ARHP Annual Meeting

    A Pilot Study of Consensus Treatment Plans for Induction Therapy in Childhood Proliferative Lupus Nephritis

    Jennifer C. Cooper1, B. Anne Eberhard2, Marilynn Punaro3, Stacy P. Ardoin4, Hermine I. Brunner5, Joyce Hsu6, Linda Wagner-Weiner7, Kelly Rouster-Stevens8, Laura E. Schanberg9, Marisa Klein-Gitelman10, Emily von Scheven11 and CARRA Registry Investigators, 1Pediatrics, Divison of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Cohen Children's Medical Center of New York, New Hyde Park, NY, 3Texas Scottish Rite Hospital for Children, Dallas, TX, 4Pediatric & Adult Rheumatology, Ohio State University, Columbus, OH, 5Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Pediatric Rheumatology, Stanford University, Palo Alto, CA, 7Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, 8Pediatric Rheumatology, Emory University School of Medicine, Atlanta, GA, 9Pediatrics, Duke Medical Center, Durham, NC, 10Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, 11Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA

    Background/Purpose:   Childhood-onset systemic lupus erythematous (cSLE) patients are at higher risk for renal disease than those with adult-onset disease. Mycophenolate mofetil (MMF) and intravenous…
  • Abstract Number: 1395 • 2016 ACR/ARHP Annual Meeting

    Regional Brain Gray Matter Volume Loss in Children and Adolescents with SLE

    Andrea Knight1, Michelle Vickery2, Jimit Doshi3, Guray Erus4, Arastoo Vossough5 and Susan Furth6, 1Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 2PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 3Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, 4Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, 5Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 6Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
  • Abstract Number: 1396 • 2016 ACR/ARHP Annual Meeting

    Cognitive Function in Children with SLE Nephritis: A Cross-Sectional Comparison to Children with Other Glomerular Chronic Kidney Diseases

    Andrea Knight1,2,3, Matthew Matheson4, Susan Furth5, Brad Warady6, Stephen Hooper7 and Amy Kogon8, 1Division of Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 3Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, 4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 5Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 6Division of Nephrology, Children's Mercy Hospital, Kansas City, MO, 7Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC, 8Division of Nephrology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH

    Background/Purpose: Children with lupus nephritis (LN) are at risk for cognitive impairment due to effects on the brain from systemic inflammation and from potential effects…
  • Abstract Number: 1397 • 2016 ACR/ARHP Annual Meeting

    Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index (CLASI) and Skindex-29 with Cutaneous Childhood Lupus Erythematosus (cSLE)

    Ashwaq Aleed, CCHMC, cincinnati, OH; Pediatric, Qassim University, Qassim, Saudi Arabia

    Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index (CLASI) and Skindex-29 with Cutaneous Childhood Lupus Erythematosus (cSLE) *Ashwaq AlEÕed, **Nora Al Mutairi ,…
  • Abstract Number: 1398 • 2016 ACR/ARHP Annual Meeting

    Practice-Based Differences Between Pediatric Rheumatologists and Dermatologists Caring for Children with Discoid Lupus

    Lisa Arkin1, Kaveh Ardalan2, Heather Brandling-Bennett3, Yvonne Chiu4, Benjamin Chong5, Megan Curran6, Raegan Hunt7, Amy Paller8, Victoria P. Werth9,10, Marisa Klein-Gitelman6, Emily von Scheven11 and for the CARRA SLE workgroup, 1Department of Dermatology and Pediatrics;, University of Wisconsin School of Medicine & Public Health/American Family Children’s Hospital, Madison, WI, 2Division of Rheumatology; Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Dermatology; Department of Pediatrics, Seattle Children’s Hospital/University of Washington School of Medicine, Seattle, WA, 4Department of Dermatology and Pediatrics, Medical College of Wisconsin / Children's Hospital of Wisconsin, Milwaukee, WI, 5Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, 6Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago/Northwestern University Feinberg School of Medicine, Chicago, IL, 7Departments of Dermatology and Pediatrics, Baylor College of Medicine / Texas Children’s Hospital, Houston, TX, 8Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 9Dermatology, University of Pennsylvania, Philadelphia, PA, 10Dermatology, Veterans Affairs Medical Center, Philadelphia, PA, 11Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Discoid lupus erythematosus (DLE) is rare in children.  There are no consensus guidelines for management or screening for evolution to systemic lupus erythematosus (SLE).…
  • Abstract Number: 1399 • 2016 ACR/ARHP Annual Meeting

    Transitioning Lupus Patients from Pediatric to Adult Rheumatology

    Joyce Hui-Yuen1, Ashlea Cook2, Lisa F. Imundo3, Amy Starr2, Andrew Eichenfield4 and Anca D. Askanase5, 1North Shore-Long Island Jewish Health System, Lake Success, NY, 2Pediatric Rheumatology, Columbia University Medical Center, New York, NY, 3Assoociate Professor of Pediatrics in Medicine - Rheumatology, Columbia University Medical Center, New York, NY, 4Morgan Stanley Children's Hospital of NY-Presbyterian, Columbia University, New York, NY, 5Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY

    Background/Purpose: Pediatric rheumatologists have successfully improved the life expectancy and quality of life of children with systemic lupus (cSLE). cSLE has higher morbidity and mortality…
  • Abstract Number: 1400 • 2016 ACR/ARHP Annual Meeting

    Preliminary Validation of the Turkish Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY) in a Single Center

    Gozde Yucel1, Sezgin Sahin2, Amra Adrovic2, Kenan Barut2, Ela Tarakci3, Ahmet Arvas4, Nandini Moorthy5 and Ozgur Kasapcopur6, 1Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 2Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, 3Istanbul University, Faculty of Health Science, Division of Physiotherapy and Rehabilitation, Istanbul, Turkey, 4Istanbul University, Cerrahpasa Medical School, Department of Pediatrics, Istanbul, Turkey, 5Robert Wood Johnson Medcal School, Department of Pediatric Rheumatology, New Brunswick, NJ, 6Department of Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey

    Background/Purpose: Juvenile systemic lupus erythematosus (SLE) is a chronic multisystemic disease with an episodic course which is prevalent in all cultures with wide-ranging effects on…
  • Abstract Number: 1401 • 2016 ACR/ARHP Annual Meeting

    Ultrasonography of Major Salivary Glands in Juvenile SjöGren’s Syndrome − Preliminary Findings in a Multi-Center Study

    Daniel S. Hammenfors1, Valeria Valim2, Vibke Lilleby3, Blanca Bica4, Sandra Gofinet Pasoto5, Clovis Silva6, Juan Carlos Nieto7, Scott Lieberman8, Akaluck Thatayatikom9, Roland Jonsson10, Johan G. Brun11 and Malin V. Jonsson12, 1Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 2Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, 3Rheumatology, Oslo University Hospital, Oslo, Norway, 4Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil, 5Internal Medicine, Division of Rheumatology - Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 6Department of Pediatric Rheumatology, Federal University of São Paulo, São Paulo, Brazil, 7Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain, 8Pediatrics (Division of Rheumatology), University of Iowa Children's Hospital, Iowa City, IA, 9University of Florida, Gainesville, FL, 10Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 11Department of Clinical Science, University of Bergen, Norway, Bergen, Norway, 12Department of Clinical Dentistry, Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway

    Background/Purpose: Juvenile Sjögren’s syndrome (jSS) is a rare, poorly defined and possibly underdiagnosed condition. Mean age of diagnosis is approximately 10 years, with major salivary…
  • Abstract Number: 1402 • 2016 ACR/ARHP Annual Meeting

    Meeting the Needs of Adolescents with Autoimmune Diseases, the Development of a Clinical Transition Pathway

    Margot Walter1, Johanna M.W. Hazes2, Radboud JEM Dolhain3, Philomine A. van Pelt4, A. Dijk van5 and Sylvia S.M. Kamphuis6, 1Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, 2Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, 3Rheumatology, University Medical Center Rotterdam, Rotterdam, Netherlands, 4Rheumatology, Erasmus MC, Rotterdam, Netherlands, 5Sophia Children's Hospital, Erasmusmc, Rotterdam, Netherlands, 6Pediatric Rheumatology, Sophia Children's Hospital – Erasmus University Medical Centre, Rotterdam, Netherlands

    Background/Purpose: Evidence based recommendations for transitional programs are available. Despite this, half of Young People (YP) do not make a successful transfer and implementation of…
  • Abstract Number: 1403 • 2016 ACR/ARHP Annual Meeting

    Systematic Appraisal of the American College of Rheumatology Clinical Practice Guidelines

    Ali Duarte-Garcia1, Milena Cavalcante2, Senada Arabelovic3 and John B. Wong2, 1Medicine, Tufts Medical Center, Boston, MA, 2Tufts Medical Center, Boston, MA, 3Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: The ACR practice guidelines establish U.S. and international treatment recommendations. We sought to characterize the quality of the guidelines using the Appraisal of Guidelines…
  • Abstract Number: 1404 • 2016 ACR/ARHP Annual Meeting

    Systematic Review and Appraisal of Quality Measures for Inflammatory Arthritis

    Matthew Cooper1 and Claire E H Barber2, 1University of Calgary, Calgary, AB, Canada, 2Rheumatology, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Quality measures are metrics health professionals can monitor to improve care delivery and patient outcomes. To be measurable they must include a specified numerator,…
  • Abstract Number: 1405 • 2016 ACR/ARHP Annual Meeting

    Quality Measures in High Priority Rheumatologic Diseases: A Systematic Literature Review and Analysis

    Melissa Wells1, Stephanie Giattino1, Malithi Jayasundara1, Lisa Criscione-Schrieber1, Arif Kamal2 and Eugene William St.Clair1, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Oncology, Duke University Medical Center, Durham, NC

    Background/Purpose: To identify published quality measures in rheumatoid arthritis (RA), osteoarthritis (OA), osteoporosis, spondyloarthropathy (SpA) and gout for the purpose of summarizing the existing measures…
  • Abstract Number: 1406 • 2016 ACR/ARHP Annual Meeting

    Towards Harmonized Data Collection in Rheumatoid Arthritis (RA): The EULAR Task Force for Standardizing a Minimum Data Collection for RA Observational Research

    Helga Radner1, Elena Nikiphorou2, Katerina Chatzidionysiou3, Laure Gossec4, Kimme L. Hyrich5, Codruta Zăbălan6, Yvonne JL van Eijk-Hustings7, Paula Williamson8, William G Dixon9, Johan Askling10 and The EULAR Task Force for standardising minimum data collection in Rheumatoid Arthritis observational research, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Whittington Hospital, London, United Kingdom, 3Department of Medicine, Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Paris 06 University and AP-HP, Hôpital Pitié Salpêtrière, Paris, France, 5Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 6Romanian League against Rheumatism, BUCHAREST, Romania, 7Patient&Care, Maastricht University Medical Centre, Maastricht, Netherlands, 8Clinical Trials Research Centre, University of Liverpool, Liverpool, United Kingdom, 9Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, Great Britain, 10Dept. of Medicine, Rheumatology Unit & Clinical Epidemiology Unit, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Collaborative research is compromised by heterogeneity of data collection in observational rheumatoid arthritis (RA) databases. Therefore a EULAR taskforce has been convened to develop…
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