Abstract Number: 8 • 2015 ACR/ARHP Annual Meeting
Bay 11-7085 Induces Glucocorticoid Receptor Activation and Autophagy to Initiate Human Synovial Fibroblast Cell Death
Background/Purpose: BAY 11-7085 is an inhibitor of IκBα phosphorylation that leads to NF-κB inactivation and downregulation of inflammation in mouse model of asthma, in articular…Abstract Number: 9 • 2015 ACR/ARHP Annual Meeting
Serum Visfatin Levels in Patients with Axial Spondyloarthitis and Early Rheumatoid Arthritis: Relation to Inflammation and Bone Changes
Background/Purpose: Visfatin may represent a novel biomarker of disease severity. Serum visfatin levels are elevated in patients with early rheumatoid arthritis (ERA) and axial spondyloarthritis…Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting
Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months
Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…Abstract Number: 1 • 2015 ACR/ARHP Annual Meeting
The Integrin Very Late Antigen-4 Plays a Key Role in the Recruitment of B Cells at the Inflammatory Foci
Background/Purpose: Experimental data suggest that B cells must migrate and accumulate into the synovial membrane to exert their pathogenic role in rheumatoid arthritis (RA). Leukocyte…Abstract Number: 3 • 2015 ACR/ARHP Annual Meeting
Cytokine Production Patterns in Osteoporosis Suggest a Pro-Inflammatory Bias
Background/Purpose: Considering the extent, predicted growth rates, and growing economic impact on health care, osteoporosis is a significant problem. In addition to hormones and nutrients,…Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…Abstract Number: 5 • 2015 ACR/ARHP Annual Meeting
Prospective Study of the Effect of Treatment with Adalumumab in Angiogenesis in Moderate or Severe Psoriasis for a Period of 6 Months
Background/Purpose: Angiogenesis plays an important role in the pathogenesis of psoriasis. TNFa is an essential mediator that induces the expression of VEGF, which activates…Abstract Number: 6 • 2015 ACR/ARHP Annual Meeting
The Novel Role of Corticotropin-Releasing Hormone and Urocortin1 on Sjogren’s Syndrome
Background/Purpose: Corticotropin releasing hormone (CRH) is the principal regulator of hypothalamus pituitary adrenal (HPA) axis. CRH and urocortin1 (UCN1) are member of the CRH family.…Abstract Number: 7 • 2015 ACR/ARHP Annual Meeting
Influence of TNF on Anti-Inflammatory Tyrosine-Hydroxylase-Positive Synovial Cells in Rheumatoid Arthritis and Osteoarthritis
Background/Purpose: In recent studies we demonstrated that catecholamines produced by tyrosine-hydroxylase-positive (TH+) synovial cells are able to mediate anti-inflammatory effects in rheumatoid arthritis (RA).a TNF…Abstract Number: 10 • 2015 ACR/ARHP Annual Meeting
CD13/Aminopeptidase N Contributes to Angiogenesis and Monocyte Chemotaxis in Rheumatoid Arthritis
Background/Purpose: Aminopeptidase N (CD13, EC 3.4.11.2) is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS), and as a soluble protein in serum…Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting
Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes
Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…Abstract Number: 13 • 2015 ACR/ARHP Annual Meeting
Altered Soluble Mediators, Autoantibodies, and Lupus-Specific Connective Tissue Disease Questionnaire Scores Distinguish Blood Relatives with Incomplete Lupus from Unaffected Relatives and Relatives with Classified SLE
Background/Purpose: Blood relatives (Rel) of lupus patients have increased risk of SLE. Some have autoantibodies and SLE clinical features, but do not meet ≥ 4…Abstract Number: 14 • 2015 ACR/ARHP Annual Meeting
The SLE Susceptibility Gene Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 (NOD-like receptor family pyrin domain containing 3) Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Background/Purpose: The pathologic hallmarks of systemic lupus erythematosus (SLE or lupus) are altered immune responses to nuclear autoantigens with autoantibody production and subsequent tissue injury.…Abstract Number: 15 • 2015 ACR/ARHP Annual Meeting
Regulation of Neutrophil Extravasation By Interleukin-8-Induced Intravascular Reactive Oxygen Species Production during the Inflammatory Response
Background/Purpose: The extravasation and recruitment of leukocytes in damaged tissues is an essential component of the inflammatory response. Once in the inflammatory foci, neutrophils destroy…Abstract Number: 16 • 2015 ACR/ARHP Annual Meeting
Rantes/CCL5 Selectively Induces MMP-1 and MMP-13 Production in Rheumatoid Arthritis Synovial Fibroblasts Via PKC-δ and JNK Pathways
Background/Purpose: RANTES/CCL5 (RANTES) is a C-C chemokine that binds to its receptor (CCR5) and initiates inflammatory processes in rheumatoid arthritis (RA) by facilitating leukocyte infiltration.…
ACR Meeting Abstracts