Abstracts Archive - Page 1680 of 2607 - ACR Meeting Abstracts

Abstract Number: 1209 • 2016 ACR/ARHP Annual Meeting
Sporadic Hemophagocytic Lymphohistiocytosis (sHLH): A Polygenic Disease? a Report of French National, Prospective, Cohort of 205 Patients
Coralie Bloch-Queyrat^1,2, Jean Philippe Jais³, Marine Gil⁴, Brigitte Bader-Meunier⁵, Olivier Hermine^6,7 and Genevieve de Saint-Basile⁴, ¹Clinical Research Unit, University Hospital Paris Seine Saint Denis, AP-HP, Bobigny, France, ²Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications INSERM U 1163 / CNRS ERL 8254 Institut IMAGINE, Paris, paris, France, ³Biostatstical Departement, Department of biostatistics Necker Enfants Malades Hospital, AP-HP, Paris, France, ⁴Normal and pathological homeostasis of the immune system laboratory Institut IMAGINE Paris, Paris, France, ⁵Pediatric Rheumatology & Immunology, Pediatric Rheumatology & Immunology, Necker hospital, Imagine Institution, Paris, France, ⁶Department of Hematology, Hôpital Necker, Paris, France, ⁷Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications INSERM U 1163 / CNRS ERL 8254 Labex on Red cell and iron metabolism Institut IMAGINE, Paris, France
Background/Purpose: The role of genetic factors in the occurrence and/or severity of sHLH is not yet known. Therefore, from 2010 to 2016, we performed a…
Abstract Number: 1210 • 2016 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of Psoriatic Arthritis in Italian Population
Mariagrazia Catanoso¹, Pierluigi Macchioni¹, Salvatore D'Angelo², Antonio Marchesoni³, Roberta Ramonda⁴, Alberto Cauli⁵, Fabio Massimo Perrotta⁶, Roberto Bortolotti⁷, Guseppe Provenzano⁸, Giovanni Pistone⁹, Katya Boito¹⁰, Cristina Giuliani¹¹, Paolo Garagnani¹¹, Davide Gentilini¹², Mariana Lofrano¹³, Laura Rotunno¹⁴, Mariagrazia Lorenzin¹⁵, Ignazio Olivieri¹³, Alessandro Mathieu¹⁶, Guido Valesini¹⁷, Giuseppe Paolazzi⁷, Roberto Baricchi¹⁸, Anna Maria Di Blasio¹², Luigi Boiardi¹⁹, Claudio Franceschi²⁰ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, matera, Italy, ³Rheumatology Unit, Orthopedic Institute G. Pini, Milano, Italy, ⁴Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, ⁵University of Cagliari, Cagliari, Italy, ⁶Rheumatology Unit, Sapienza University, Department of Internal Medicine and Medical Specialties, Roma, Italy, ⁷Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, ⁸Reumatology Unit, Villa Sofia-CTO Hospital, Palermo, Italy, ⁹Rheumatology Unit, ARNAS Civico, Di Cristina e Benfratelli Hospital, Palermo, Italy, ¹⁰Transfusion Medicine Unit,, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy, ¹¹Laboratory of Molecular Anthropology, Centre for Genome Biology University, Bologna, Italy, ¹²Laboratory of Molecular Biology, Istituto Auxologico Italiano, IRCCS, Milano, Italy, ¹³Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera, Italy, ¹⁴Orthopedic Institute G.Pini, Rheumatology Unit, Milano, Italy, ¹⁵Department of Medicine, University of Padova - Rheumatology Unit, Padova, Italy, ¹⁶Department of Medical Sciences, Rheumatology Unit - University of Cagliari, Cagliari, Italy, ¹⁷Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Roma, Italy, ¹⁸Transfusion Medicine Unit, IRCCS S. Maria Nuova Hospital, Reggio Emilia, Italy, ¹⁹Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, ²⁰Laboratory of Molecular Anthropology & Centre for Genome Biology University of Bologna, Bologna, Italy
rexm-rs12191877 (p=4.87 x10-10, OR 1.731, 95%CI =1.46-2.06), exm-rs4947248 (p=1.98 x10-9 , OR 1.56, 95%CI = 1.35-1.80). Moreover, in PsA patients we identified signals of association…
Abstract Number: 1211 • 2016 ACR/ARHP Annual Meeting
Allele-Dependent Binding of a Viral Protein to Autoimmune Disease-Associated Genetic Variants
Matthew T. Weirauch¹, Daniel Miller¹, Leah C. Kottyan², Ignacio Ibarra³, Sayeed Syed⁴, Xiaoting Chen¹, Erin Zoller¹, Arthur Lynch¹, Connor Schroeder¹, Josh Lee¹, Albert Magnussen¹, Ally Yang⁵, Timothy R. Hughes⁵, Joo-Seop Park¹, Charles Vinson⁴ and John B. Harley^6,7, ¹Cincinnati Childrens Hospital, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology, Cincinnati Childrens Hospital, Cincinnati, OH, ³EMBL, Heidelberg, Germany, ⁴NCI, Bethesda, MD, ⁵University of Toronto, Toronto, ON, Canada, ⁶US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH
Methods: We tested the hypothesis that some autoimmune variants might act by altering the binding of the EBV-encoded transcription factor ZTA, consequently resulting in downstream…
Abstract Number: 1212 • 2016 ACR/ARHP Annual Meeting
A Combined Large Scale Meta-Analysis Identifies COG6 As a Novel Shared Risk Locus for Rheumatoid Arthritis and Systemic Lupus Erythematosus
Ana Márquez¹, Laura Vidal-Bralo², Luis Rodriguez-Rodriguez³, Miguel Angel González-Gay⁴, Alejandro Balsa⁵, Isidoro Gonzalez-Alvaro⁶, Patricia Carreira⁷, Norberto Ortego Centeno⁸, Maria del Mar Ayala Gutierrez⁹, Francisco José García-Hernández¹⁰, Francisca González Escribano¹¹, José Mario Sabio¹², Carles Tolosa¹³, Ana Suárez¹⁴, Antonio Gonzalez¹⁵, Leonid Padyukov¹⁶, Jane Worthington¹⁷, Timothy J. Vyse^18,19, Marta E. Alarcon Riquelme^20,21 and Javier Martín¹, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ³Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ⁵Department of Rheumatology and Institute for Health Research (IdiPAZ), University Hospital La Paz, Madrid, Spain, ⁶Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁷Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁸Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁹Department of Internal Medicine, Hospital Carlos Haya, Málaga, Spain, ¹⁰Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹¹Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain, ¹²Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Spain, ¹³Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Spain, ¹⁴Department of Functional Biology, Immunology Area, Faculty of Medicine, University of Oviedo, Oviedo, Spain, ¹⁵Laboratorio de Investigación 10 and Rheumatology Unit, Instituto de Investigación Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁶Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ¹⁷Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁸Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ¹⁹Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, ²⁰Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, ²¹Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: One of the main limitations of the association studies in autoimmunity is the difficulty in identifying genetic risk variants with modest effects, given the…
Abstract Number: 1213 • 2016 ACR/ARHP Annual Meeting
Targeted Next-Generation Sequencing of 128 Genes Associated with Rheumatoid Arthritis
Khai Pang Leong¹, Liuh Ling Goh², Edward Yu Wing Chee², Petrina Pei Qin Lim², Grace Li-Xian Toh², Ee Tzun Koh³ and Tan Tock Seng Hospital Rheumatoid Arthritis Study Group, ¹Rheumatology/Allerg/Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ²Clinical Research & Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore, ³Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: Through genome-wide association scans (GWAS), more than 120 genes have been found to be associated with rheumatoid arthritis (RA). This study aims to search…
Abstract Number: 1214 • 2016 ACR/ARHP Annual Meeting
Autoantibody Reactivities Correlated with SLE Disease Activity Identified By the SLE-key® iCHIP® Platform
Chaim Putterman¹, Pennina Safer², Keren Jakobi², Rachel Sorek², Ilana Gilkaite², Kyle Ferber³, Steve Wallace³, Amanda Harris Altice³, D. Scott Batty³ and Irun R Cohen^2,4, ¹Albert Einstein College of Medicine, Bronx, NY, ²ImmunArray LTD, Rehovot, Israel, ³ImmunArray Inc., Richmond, VA, ⁴Immunology, Weizmann Institute of Science, Rehovot, Israel
Background/Purpose: We have developed an antigen microarray technology to study antibody profiles to elucidate and diagnose clinical states of SLE patients – the iCHIP® SLE-key®…
Abstract Number: 1215 • 2016 ACR/ARHP Annual Meeting
Interferon Signature Genes Are Differentially Expressed Between Microscopic Polyangiitis and Systemic Lupus Erythematosus Peripheral Blood Transcriptomes
Aya Kawasaki¹, Daisuke Tsukui², Yuya Kondo³, Yoshitaka Kimura², Kurumi Asako², Hiroshi Furukawa¹, Hajime Kono², Takayuki Sumida⁴ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Interferon (IFN) signature has been established in the peripheral blood of the patients with systemic lupus erythematosus (SLE) by transcriptome analyses, indicating a role…
Abstract Number: 1216 • 2016 ACR/ARHP Annual Meeting
Sjogren’s Syndrome-Associated Transcripts Show Correlation with Objective Measures of Dryness
John A. Ice¹, Indra Adrianto¹, Astrid Rasmussen¹, Kiely Grundahl², Michelle L. Joachims³, Graham B. Wiley¹, Jennifer A. Kelly¹, Glen D. Houston⁴, David M. Lewis⁴, Lida Radfar⁵, Donald U. Stone^6,7, Barbara M. Segal⁸, Nelson L. Rhodus⁹, Joel M. Guthridge³, James Chodosh^10,11, Raj Gopalakrishnan¹², Andrew J.W. Huang¹³, Pamela J Hughes¹⁴, Michael D. Rohrer¹⁵, Judith A. James^1,16,17, Courtney G. Montgomery¹, R. Hal Scofield^1,17,18, Patrick Gaffney¹, Kathy L. Sivils³ and Christopher J. Lessard¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁸Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁰Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹¹Harvard Medical School, Boston, MA, ¹²Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota School of Dentistry, Minneapolis, MN, ¹³Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO, ¹⁴Department of Oral and Maxillofacial Surgery, Oregon Health & Science University School of Dentistry, Portland, OR, ¹⁵Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ¹⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disorder in which exocrine dysfunction can lead to chronic, debilitating dryness. Expression studies in SS have identified…
Abstract Number: 1217 • 2016 ACR/ARHP Annual Meeting
Identification of Sjogren’s Syndrome-Associated Long Non-Coding RNAs That Are Co-Expressed with Key Protein-Coding Transcripts Involved in Dysregulated Interferon Responses
John A. Ice¹, Indra Adrianto¹, Michelle L. Joachims², Jennifer A. Kelly², Graham B. Wiley¹, Astrid Rasmussen¹, Kiely Grundahl³, Glen D. Houston⁴, David M. Lewis⁴, Lida Radfar⁵, Donald U. Stone^6,7, Joel M. Guthridge², Barbara M. Segal⁸, Nelson L. Rhodus⁹, James Chodosh^10,11, Raj Gopalakrishnan¹², Andrew J.W. Huang¹³, Pamela J Hughes¹⁴, Michael D. Rohrer¹⁵, Judith A. James^16,17,18, Courtney G. Montgomery¹, R. Hal Scofield^1,18,19, Patrick Gaffney¹, Kathy L. Sivils^2,16 and Christopher J. Lessard^1,16, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁸Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁰Harvard Medical School, Boston, MA, ¹¹Massachusetts Eye and Ear Infirmary, Boston, MA, ¹²Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota School of Dentistry, Minneapolis, MN, ¹³Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO, ¹⁴Department of Oral and Maxillofacial Surgery, Oregon Health & Science University School of Dentistry, Portland, OR, ¹⁵Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁹US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: The “interferon signature”, marked by transcriptional upregulation of interferon (IFN)-inducible (IFI) genes, is a common finding in Sjögren’s syndrome (SS) that is associated with…
Abstract Number: 1218 • 2016 ACR/ARHP Annual Meeting
Extensive Genetic Overlap of Traits Related to Gout, Hyperuricemia and Its Comorbidities
Richard J. Reynolds¹, Marguerite Irvin², Gustavo de los Campos³, Hwasoon Kim³, Jasvinder Singh⁴ and Ana Vazquez³, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³Michigan State University, East Lansing, MI, ⁴University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Gout and hyperuricemia (serum urate > 7 mg/dL) typically present in the context of one or more comorbidities including type-2 diabetes, chronic renal disease,…
Abstract Number: 1219 • 2016 ACR/ARHP Annual Meeting
Differential Peripheral Blood DNA Methylation Patterns Are Predictive of Radiographic OA Progression
Matlock A. Jeffries¹, Madison Andrews², Judith A. James³, Mary Beth Humphrey⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine/Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis, but data regarding extraarticular tissues are…
Abstract Number: 1220 • 2016 ACR/ARHP Annual Meeting
Comparison of Healthcare Utilization of Patients with Rheumatoid Arthritis Who Are Anti-Cyclic Citrullinated Peptide Antibody Positive Versus Negative
L Rosenblatt¹, K Price¹, Y Doleh¹, A Szymialis¹, M Eaddy², A Ogbonnaya², H-C Shih² and L Lamerato³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Xcenda, LLC, Palm Harbor, FL, ³Henry Ford Health System, Detroit, MI
Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibody is a marker used in the diagnosis of RA, and it may be useful in identifying patients who are…
Abstract Number: 1221 • 2016 ACR/ARHP Annual Meeting
Environmental Scan of Rheumatoid Arthritis Patient Registries Around the World: An Omeract Initiative
Natalia V. Zamora¹, Maria A. Lopez-Olivo², Robin Christensen³, Niti Goel^4,5, Lars Erik Kristensen⁶, Vibeke Strand⁷, Jeffrey R. Curtis⁸, Beverly Shea⁹ and Maria Suarez-Almazor¹⁰, ¹Section of Rheumatology and Clinical Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁴Rheumatology Center of Excellence, Quintiles, Durham, NC, ⁵Duke University School of Medicine, Durham, NC, ⁶The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁷Biopharmaceutical Consultant, Portola Valley, CA, ⁸Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Science Centre Hamilton, Ontario, ON, Canada, ¹⁰Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Patient registries both disease-and drug-based complement information obtained from clinical trials. Long-term outcomes studies can provide information useful for patients. The Agency for Healthcare…
Abstract Number: 1222 • 2016 ACR/ARHP Annual Meeting
A Systematic Review of Consumer Perceived Health Service Needs Related to Osteoarthritis
Michelle C Papandony¹, Anita E Wluka¹, Flavia M Cicuttini¹, Yuanyuan Wang¹, Louisa Chou¹, Kalupahana L Seneviwickrama¹, Kaye Lasserre², Andrew Teichtahl^1,3 and Andrew M Briggs⁴, ¹Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia, ²Monash University, Melbourne, Australia, ³Baker Heart IDI, Melbourne, Australia, ⁴Arthritis and Osteoporosis Victoria, Melbourne, Australia
Background/Purpose: Osteoarthritis (OA) is a common cause of pain and disability. The patients’ perception of health care influences their involvement in management, affecting health…
Abstract Number: 1223 • 2016 ACR/ARHP Annual Meeting
The Cost of Confronting Osteoporosis:Cost Study of a Fracture Liaison Service
Gabor Major^1,2, Rod Ling^3,4, Andrew Searles^3,4, Fiona Niddrie⁵, Ayano Nakayama⁶, Elizabeth Holliday^4,7, John Attia^4,7 and Nikolai Bogduk^4,6, ¹Rheumatology, Bone and Joint Institute, John Hunter Hospital NSW Australia, Newcastle, Australia, ²Medicine, University of Newcastle, Newcastle, Australia, ³Health Economics, Hunter Medical Research Institute, Newcastle, Australia, ⁴University of Newcastle, Newcastle, Australia, ⁵Rheumatology, Bone and Joint Institute,John Hunter Hospital, Newcatle, Australia, ⁶Rheumatology, Bone and Joint Institute,John Hunter Hospital, Newcastle, Australia, ⁷Hunter Medical Research Institute, Newcastle, Australia
Background/Purpose: Services that actively seek out and identify patients with fractures following a minimal trauma injury have been promoted as the most effective means of…

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