Abstract Number: 3076 • 2015 ACR/ARHP Annual Meeting
Interferon Gamma (IFNg) Is the Driving Mediator of Secondary Hemophagocytic Lymphohistiocytosis (sHLH) in TLR9-Mediated Pathogenesis in Mice and Is Correlated to Disease Parameters in Children
Background/Purpose: Life-threatening hyperinflammatory syndromes caused by severe hypercytokinemia include primary (p) and secondary (s) hemophagocytic lymphohistiocytosis (HLH). Increased circulating levels of interferon gamma (IFNg) in…Abstract Number: 3077 • 2015 ACR/ARHP Annual Meeting
Anakinra in Patients with Cortico-Dependent Idiopathic Recurrent Pericarditis: A Randomised Double-Blind Placebo-Controlled Withdrawal Trial
Background/Purpose: Patients with recurrent pericarditis either do not respond or are intolerant to treatment with NSAIDs drugs, corticosteroids and colchicine. We aimed to assess the…Abstract Number: 3078 • 2015 ACR/ARHP Annual Meeting
ABCG2 rs2231142 predicts Poor Response to Allopurinol in Patients with Gout
Background/Purpose: Many patients fail to reach target serum urate (SU) on allopurinol. Although the most common causes of inadequate response are non-adherence and low dosing…Abstract Number: 3079 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Riociguat in Patients with Pulmonary Arterial Hypertension (PAH) Associated with Connective Tissue Disease (CTD)
Background/Purpose: PAH associated with CTD (PAH-CTD) has a worse prognosis than idiopathic/familial PAH. Here we report a prospective subgroup analysis of patients with PAH-CTD from…Abstract Number: 3080 • 2015 ACR/ARHP Annual Meeting
Histone H2AX Phosphorylation As a Measure of DNA Double Strand Breaks and a Marker of Environmental Stress and Disease Activity in Lupus
Background/Purpose: Studies suggested that defective or inefficient DNA double strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death,…Abstract Number: 3081 • 2015 ACR/ARHP Annual Meeting
IRF5 Deletion Prevents the SLE-like Disease Initiated By Dendritic Cell-Specific Loss of Caspase 8
Background/Purpose: Previous studies implicate dendritic cells (DCs) in the initiation and persistence of systemic lupus erythematosus (SLE). While DCs from SLE patients exhibit elevated activation,…Abstract Number: 3082 • 2015 ACR/ARHP Annual Meeting
Nanogel Based Delivery of an Inhibitor of Calcium/ Calmodulin- Dependent Protein Kinase 4 Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
Background/Purpose: Treatment of autoimmune diseases is still based on the use of general immunosuppressive drugs which invariably cause severe side effects. This fact has compelled…Abstract Number: 3083 • 2015 ACR/ARHP Annual Meeting
Antibody Array Based Proteomic Screening of 274 Serum Markers in Systemic Lupus Erythematosus
Background/Purpose: Given that early detection of renal involvement in systemic lupus erythematosus (SLE) and prompt management of the disease can have a significant impact on…Abstract Number: 3084 • 2015 ACR/ARHP Annual Meeting
Progression of Lupus Pathology Is Correlative with Cardiac Magnetic Resonance Imaging Abnormalities, Diminished Function, and Inflammatory Histopathology in an Animal Model
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease causing inflammation throughout the body and cardiovascular involvement is a significant contributor to morbidity and mortality…Abstract Number: 3085 • 2015 ACR/ARHP Annual Meeting
Platelet Activation and Endothelial Reactivity in the Pathogenesis of Tissue Inflammation/Injury in Systemic Lupus Erythematosus
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk for widespread endothelial dysfunction, vascular thromboses, and premature cardiovascular disease. Enhanced platelet activation and…Abstract Number: 3086 • 2015 ACR/ARHP Annual Meeting
The Same Multidimensional Patient Health Assessment Questionnaire Used to Assess RAPID3 in Rheumatoid Arthritis, Osteoarthritis and Other Rheumatic Diseases Can Provide Quantitative Clues to Recognize and Document Comorbid Fibromyalgia
Background/Purpose: An MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data) is a 2 sided, 1 page questionnaire which is completed by patients in…Abstract Number: 3087 • 2015 ACR/ARHP Annual Meeting
Cell Bound Complement Activation Products in Multianalyte Assay with Algorithm Have Utility in Distinguishing Primary Fibromyalgia from Systemic Lupus Erythematosus
Background/Purpose : Our objective was to prospectively establish the performance characteristics of a cell bound complement activation products (CB-CAPS) in a multi-analyte assay with algorithm…Abstract Number: 3088 • 2015 ACR/ARHP Annual Meeting
Genome Wide Expression Analyses Reveal Potentially Novel Drug Targets in Fibromyalgia
Background/Purpose: Currently there are three drugs approved by the FDA for the treatment of fibromyalgia (FM), and there appears to be a paucity of drugs…Abstract Number: 3089 • 2015 ACR/ARHP Annual Meeting
Evaluation of Learned Helplessness, Perceived Self-Efficacy and Functional Capacity in Patients with Fibromyalgia and Rheumatoid Arthritis
Background/Purpose: Chronic diseases involve cognitive and emotional aspects of patients. One relevant cognitive factor is the learned helplessness (LH), defined as an inadequate perception of…Abstract Number: 3090 • 2015 ACR/ARHP Annual Meeting
Fibromyalgia Predicts Two-Year Changes in Functional Status in Rheumatoid Arthritis Patients
Background/Purpose: The prevalence of fibromyalgia (FM) is 10-20% in rheumatoid arthritis (RA) patients, compared to 2-3% in the general population. Previous studies have shown that…
ACR Meeting Abstracts