ACR Meeting Abstracts

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  • Abstract Number: 3031 • 2015 ACR/ARHP Annual Meeting

    Dalazatide (ShK-186), a Kv1.3 Channel Inhibitor That Targets Effector Memory T Cells: Ex Vivo Studies in Pediatric Systemic Lupus Erythematosus

    Megan Yuasa1, David Peckham2, Anne M. Stevens3, Shawn P. Iadonato2 and Ernesto J. Muñoz-Elías4, 1Seattle Children's Res Institute, Seattle Children's Research Institute, Seattle, WA, 2Kineta Inc, Seattle, WA, 3Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, 4Translational Immunology & Preclinical Development, Kineta, Inc., Seattle, WA

    Background/Purpose: The voltage-gated potassium channel Kv1.3 is highly expressed on activated T effector memory cells (TEM), is essential for T cell activation, and thus is…
  • Abstract Number: 3032 • 2015 ACR/ARHP Annual Meeting

    Role of Adenosine and Neutrophils in Inflammation Associated with Mutations in CECR1 Gene

    Kyawt W. Shwin1,2, Carmelo Carmona-Rivera3, Wanxia Tsai4, Chya-chia Richard Lee5,6, Elaine Novakovich7, Deborah L. Stone8, Amanda K. Ombrello8, Raphaela Goldbach-Mansky9, Massimo Gadina10, Daniel Kastner11, Ivona Aksentijevich12,13, Mariana J. Kaplan7 and Peter C. Grayson14,15, 1NIAMS, National Institutes of Health, BETHESDA, MD, 2Translational Autoinflammatory Diseases Section, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 4Translational Immunology, Office of Science and Technology, National Institutes of Health, Bethesda, MD, 5National Cancer Institute, National Institutes of Health, Bethesda, MD, 6Laboratory of Pathology, NCI, National Institutes of Health, BETHESDA, MD, 7Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 8National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 10Translational Immunology, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, MD, 11Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, 12NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, 13Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 14National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 15NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD

    Background/Purpose: The phenotype of patients afflicted by deficiency of adenosine deaminase 2 (DADA2) due to mutations in CECR1encoding ADA2 protein shares many features with idiopathic…
  • Abstract Number: 3033 • 2015 ACR/ARHP Annual Meeting

    Polyarteritis Nodosa and Cutaneous Arteritis: Are They Distinct Diseases?

    Fatma Alibaz-Oner1, Matthew J. Koster2, Cynthia S. Crowson3, Ashima Makol2, Steven R. Ytterberg2, Eric L. Matteson2 and Kenneth J. Warrington2, 1Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis predominantly targeting medium-sized visceral arteries.  Cutaneous arteritis (CA) is generally limited to the medium-sized vessels…
  • Abstract Number: 3034 • 2015 ACR/ARHP Annual Meeting

    A Comparative Metabolomic Evaluation of Behcet’s Disease with Arthritis and Seronegative Arthritis Using Synovial Fluid

    Joong Kyong Ahn1, Sooah Kim2, Jungyeon Kim2, Jiwon Hwang3, Hyungjin Kim4, Hyemin Jeong5, Yeong Hee Eun6, Chan Hong Jeon7, Jaejoon Lee5, Eun-Mi Koh5, Kyoung Heon Kim2 and Hoon-Suk Cha8, 1Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, 3Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Department of medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 5Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 6Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 7Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, 8Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: Behcet’s disease (BD) is a chronic, complex systemic vasculitis of unknown etiology characterized by orogenital ulcers, uveitis, and arthritis. Arthritis and arthralgias in BD…
  • Abstract Number: 3035 • 2015 ACR/ARHP Annual Meeting

    HLA B51 and Possible Associated Autoimmune Disorders Other Than Behcets Disease: A Retrospective Cohort Study

    Luis Salayandia1, Wilmer Sibbitt Jr.1, Arthur Bankhurst2, Roderick Fields3, Gladys Cook4, Konstantin Konstantinov5 and Suzanne Emil1, 1Rheumatology, University of New Mexico, Albuquerque, NM, 2Rheum/ MSC 105550, University of NM Med Ctr, Albuquerque, NM, 3Rheumatology, University of New Mexico, Albquerque, NM, 4Rheumatology, UNM, Albuquerque, NM, 51 University Of New Mexico, University of New Mexico, Albuquerque, NM

    Background/Purpose:  The diagnostic utility of HLA B51 in association with Behcet’s disease has been clearly identified; however the correlation of HLA B51 with other autoimmune…
  • Abstract Number: 3036 • 2015 ACR/ARHP Annual Meeting

    The Association Between Behcet’s Disease, Myelodysplastic Syndrome and Trisomy 8

    Won-Seok Lee1, Yun Jung Choi2, Myong-Joo Hong3, Chang-Hoon Lee4, Myeung Su Lee5, Young Sun Suh6, Sang-Il Lee7, Yong Gon Cho8 and Wan-Hee Yoo9, 1Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, jeonju, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, JeonJu, South Korea, 3Internal Medicine, Presbyterian Medical center, Jeonju, South Korea, 4Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, 5Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, 6Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 7Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, 8Department of Laboratory medicine, Chonbuk National University Medical School and Hospital, Jeonju, South Korea, 9Division of Rhuematology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital-Chonbuk National University, Jeonju, South Korea

    Background/Purpose: Behcet’s disease (BD) is a systemic vasculitis, whereas myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic disorders characterized by ineffective hematopoiesis. Some…
  • Abstract Number: 3037 • 2015 ACR/ARHP Annual Meeting

    Serum Anti-Lysozyme Is Associated with Disease Activity of Behcet’s Disease

    Jin Su Park1, Mi-il Kang2, You Jung Ha3, Yong-Beom Park4, Soo-Kon Lee5 and Sang-Won Lee6, 1Department of Internal Medicine, NHIS Ilsan Hospital, Goyang-si Gyeounggi-do, South Korea, 2Department of Internal Medicine, Dankook University Hospital, Cheonan-si Chungcheongnam-do, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 4Yonsei University College of Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul, South Korea, 5Internal Medicine, Yonsei Univ College of Med, Seoul, South Korea, 6Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Background/Purpose: To investigate the association between autoantibodies against non- myeloperoxidase (MPO) neutrophil granule antigens and activity of Behcet’s disease (BD). Methods: We consecutively enrolled 51…
  • Abstract Number: 3038 • 2015 ACR/ARHP Annual Meeting

    Serum CXCL8, 10 and 12 Are Increased in Patients with Behcet’s Disease and CXCL10 Levels Are Correlated with Number of Erythema Nodosum

    Sang Jin Lee1,2, Hyun Jung Yoo3, Hyun Mi Kwon4, Jin Young Moon4, Jin Kyun Park5, Eun Young Lee5, Eun Bong Lee4 and Yeong Wook Song5, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 2Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Parmarcy, Seoul National University, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea

    Background/Purpose: Chemokines are multifunctional mediators that control leukocyte recruitment into the inflammatory sites and enhance immune responses. It remains to be investigated which chemokines are…
  • Abstract Number: 3039 • 2015 ACR/ARHP Annual Meeting

    Possible Contribution of HLA-A0207, B5201 and IL-23 Receptor Polymorphism in Ocular Behçet Disease

    Toshikatsu Kaburaki1, Shinji Harihara2, Rie Tanaka3, Hiromasa Sawamura4, Ai Nishi4, Atsushi Hatamochi5, Jun Shimizu6, Masumi Takeuchi7, Shoji Kuwata8, Hidetoshi Kawashima9 and Fujio Takeuchi10, 1Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Division of Anthropology, Department of Biological Science, The University of Tokyo Graduate School of Science, Tokyo, Japan, 3Department of Ophtalmology, The University of Tokyo Graduate School of Medicine,, Tokyo, Japan, 4Department of Ophtalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 5Department of Dermatology, Dokkyo Medical University, Tochigi, Japan, 6Department of Neurology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 7Teikyo University Support Center for Women Physicians and Researchers, Teikyo University School of Medicine, Tokyo, Japan, 8Third Department of Internal Medicine, Teikyo University Chiba Medical Center, Teikyo University School of Medicine, Chiba, Japan, 9Department of Ophthalmology, Jichi Medical University, Tochigi, Japan, 10Department of Allergy and Rheumatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Behçet's disease (BD) is known to be associated with HLA-B*51:01 and HLA- A*26:01 in many different ethnic groups. Recently, HLA-A*02:07, IL-10 and IL23R-IL12RB polymorphisms…
  • Abstract Number: 3040 • 2015 ACR/ARHP Annual Meeting

    Predictive Factors of Long-Term Clinical Outcome in Patients with Ocular Involvement Secondary to Behcet’s Syndrome

    Rosaria Talarico1, Michele Figus2, Anna d'Ascanio1, Rossella Neri1, Chiara Baldini1, Chiara Tani3 and Marta Mosca1, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, Pisa, Italy, 3University of Pisa, Pisa, Italy

    Background/Purpose: Behçet's syndrome (BS) is a multisystemic, chronic relapsing inflammatory disease classified among the vasculitis. Eye involvement represent one of the most serious manifestation of…
  • Abstract Number: 3041 • 2015 ACR/ARHP Annual Meeting

    Long Term Biological Therapy in Uveitis Refractory Due to Behçet’s Disease. Multicenter Study of 165 Patients. 

    Montserrat Santos-Gómez1, Vanesa Calvo-Río1, Ricardo Blanco1, Emma Beltran2, Juan Sánchez Bursón Sr.3, Marina Mesquida4, Alfredo Adan4, M. Victoria Hernández5, F.Javier López-Longo6, Marisa Hernandez Grafella7, Elia Valls Pascual8, Lucía Martinez-Costa9, Agusti Sellas-Fernandez10, Miguel Cordero11, Manuel Díaz-Llopis12, Roberto Gallego13, Jose L. García Serrano14, JL Callejas Rubio15, Norberto Ortego-Centeno16, Jose M Herreras17, Alejandro Fonollosa18, Angel M. Garcia-Aparicio19, Olga Maiz Alonso20, Ana Blanco21, Ignacio Torre22, Cruz Fernández- Espartero23, Vega Jovani24, Diana Peiteado25, David Diaz Valle26, Esperanza Pato26, Juan Cruz27, Carlos Férnandez Cid28, Elena Aurrecoechea29, Miriam García-Arias30, Miguel Angel Caracuel-Ruiz31, Carlos Alberto Montilla Morales32, Antonio Atanes-Sandoval33, Félix Francisco34, Santos Insua35, Senen González-Suárez36, Amalia Sánchez-Andrade37, Fernando Gamero38, Luis Francisco Linares39, Fredeswinda Romero40, A. Javier García-González41, Raquel Almodóvar González42, Enrique Minguez43, Carmen Carrasco Cubero44, Alejandro Olivé45, Julio Vázquez46, Oscar Ruiz Moreno47, Fernando Jiménez-Zorzo48, Javier Manero48, Santiago MuÑoz Fernandez49, Cristina Fernández-Carballido50, Esteban Rubio Romero51, Fred Antón Pagés52, Javier Toyos-Saenz de Miera53, Myriam Gandía54, Carmen Gonzalez-Vela55, Enrique Raya56, Natalia Palmou1, Leyre Riancho-Zarrabeitia1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 3Rheumatology, Hospital de Valme., Sevilla, Spain, 4Ophthalmology, Hospital Clinic, Barcelona, Spain, 5Arthritis Unit, Rheumatology, Hospital Clinic, Barcelona, Spain, 6Hospital Gregorio Marañón, Madrid, Spain, 7Ophthalmology., Hospital General Universitario de Valencia, Valencia, Spain, 8Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, 9Ophthalmology, Hospital Universitario Dr Peset, Valencia, Spain, 10Rheumatology, Hospital Universitario Valle Hebron, Barcelona, Spain, 11Ophthalmology, Hospital de León, León, Spain, 12Hospital Universitario La Fe, Valencia, Spain, 13Ophthalmology, Hospital Universitario La Fe, Valencia, Spain, 14Ophthalmology, Hospital Universitario San Cecilio, Granada, Spain, 15Hospital Universitario San Cecilio, Granada, Spain, 16Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 17Ophthalmology, Hospital Universitario, IOBA, Valladolid, Spain, 18Ophtalmology, Hospital de Cruces, Bilbao, Spain, 19Rheumatology, Hospital Virgen de la Salud, Toledo, Spain, 20Rheumatology, Donostia University Hospital, Donostia, Spain, 21Ophthalmology, Donostia University Hospital, Donostia, Spain, 22Rheumatology, Hospital de Basurto, Bilbao, Spain, 23Rheumatology, Hospital La Zarzuela, Madrid, Spain, 24Rheumatology, Hospital General de Alicante, Alicante, Spain, 25Rheumatology, Hospital La Paz, Madrid, Spain, 26Hospital Clínico San Carlos, Madrid, Spain, 27Rheumatology, Hospital de Pontevedra, Pontevedra, Spain, 28Ophthalmology, Hospital de Pontevedra, Pontevedra, Spain, 29Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, 30Rheumatology, Hospital La Princesa, Madrid, Spain, 31Plaza Cruz Roja, 1, Hospital Reina Sofia, Córdoba, Spain, 32Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, 33Rheumatology, Complejo Hospitalario Universitario de La Coruña, La Coruña, Spain, 34Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 35Rheumatology, Hospital Universitario Santiago de Compostela, La Coruña, Spain, 36Rheumatology, Hospital de Cabueñes, Gijón, Spain, 37Hospital Lucus Augusti, Lugo, Spain, 38Rheumatology, Hospital San Pedro Alcántara, Cáceres, Spain, 39Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain, 40Section for Autoimmune Diseases, Rheumatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 41Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 42Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain, 43Ophthalmology., Hospital Clínico de Zaragoza, Zaragoza, Spain, 44Rheumatology, Hospital de Mérida, Mérida, Spain, 45Hospital Germans Trias i Pujol, Badalona, Spain, 46Rheumatology., Hospital de Ferrol, La Coruña, Spain, 47Ophthalmology and Rheumatology., Hospital Miguel Servet, Zaragoza, Spain, 48Ophthalmology and Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, 49Rheumatology, Hospital Infanta Sofía, Madrid, Spain, 50Rheumatology, Hospital General Universitario de Elda, Elda (Alicante), Spain, 51Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 52Rheumatology, Hospital de Palencia, Palencia, Spain, 53Rheumatology, Hospital Virgen de la Macarena, Seville, Spain, 54Department of Autoimmune Diseases, IDIBAPS, Hospital Clínic, Barcelona, Spain, 55Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 56Rheumatology, Hospital Universitario San Cecilio, Granada, Spain

    Background/Purpose: Conventional management of uveitis due to Behçet’s disease (UBD) consists on conventional immunosuppressive drugs. However, UBD is often refractory requiring more intensive therapy.Our aim was…
  • Abstract Number: 3042 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab in Refractory Uveitis Associated with Behçet’s Disease. Multicenter Study of 7 Patients. 

    Montserrat Santos-Gómez1, Vanesa Calvo-Río1, Ricardo Blanco1, Emma Beltran2, Antonio Atanes-Sandoval3, Enar Pons4, Javier Loricera1, Carmen Gonzalez-Vela5, Leyre Riancho-Zarrabeitia1, Natalia Palmou1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia, Valencia, Spain, 3Rheumatology, Complejo Hospitalario Universitario de La Coruña, La Coruña, Spain, 4Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 5Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: Treatment recommended in severe and/or refractory uveitis of Behçet disease is anti-TNF-α therapy, usually infliximab (IFX) or adalimumab (ADA) (Levy-Clarke et al Ophthalmology 2014;121:785-796).…
  • Abstract Number: 3043 • 2015 ACR/ARHP Annual Meeting

    IL-17 Expression By Lymphocytes Is Higher in Behcet’s Disease Compared to Takayasu Arteritis

    Ali Ugur Unal1, Rabia Deniz2, Aysin Tulunay Virlan3, Filiz Ture Ozdemir3, Imren Aydin Tatli3, Gulsen Ozen1, Fatma Alibaz-Oner4, Gonca Mumcu5, Tulin Ergun6 and Haner Direskeneli1, 1Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Immunology, Marmara University Faculty of Medicine, Istanbul, Turkey, 4Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 5Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 6Dermatology, Marmara University Faculty of Medicine, Dermatology, Istanbul, Turkey

    Background/Purpose: Interleukin-17 (IL-17) has been associated with the pathogenesis of  various inflammatory diseases. The aim of our study was to investigate the expression of Th17-related…
  • Abstract Number: 3044 • 2015 ACR/ARHP Annual Meeting

    Microparticles (MPs) Derived from Cell Plasma Membranes Are Increased in Behcet’s Syndrome (BS) and a Low Ratio of Tissue Factor Pathway Inhibitor Positive Mps to Tissue Factor Positive Mps (TFPI/TF) Is Associated with Thrombosis

    Emon Khan1, Nicola Ambrose1, Miles Stanford2, Michael A. Laffan3 and Dorian O. Haskard4, 1Department of Vascular Sciences, National Heart and Lung Institute, Imperial College, London, United Kingdom, 2Ophthalmology, Guy's and St. Thomas' Hospital, London, United Kingdom, 3Department of Haemostasis and Thrombosis, Imperial College, London, United Kingdom, 4Rheumatology, Imperial College, London, United Kingdom

    Background/Purpose: Thrombosis occurs in around 20% of Behçet's Syndrome (BS) patients and causes substantial morbidity.  There is a clear need for better biomarkers of thrombotic…
  • Abstract Number: 3045 • 2015 ACR/ARHP Annual Meeting

    Anti-Alpha-Enolase Antibodies in Behçet’s Disease: A Marker of Articular Disease Activity?

    Leandro L. Prado, Celio R. Gonçalves, Vilma S. T. Viana, Eloisa Bonfá and Carla G.S. Saad, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Diagnosis of Behçet´s disease (BD) is challenging because is based solely on clinical features. Articular involvement in this disease may mimic other diagnosis such…
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