Abstracts Archive - Page 1645 of 2425 - ACR Meeting Abstracts

Abstract Number: 2594 • 2015 ACR/ARHP Annual Meeting
Multi-Biomarker Disease Activity Score As a Predictor of Flare in Patients with Rheumatoid Arthritis Who Stop TNF-Alpha-Inhibitor Therapy
Femke Lamers-Karnebeek¹, Marjan Ghiti Moghadam², Harald E. Vonkeman³, Janneke Tekstra⁴, Annemarie Schilder⁵, Henk Visser⁶, Peter M. ten Klooster⁷, Eric H. Sasso⁸, David Chernoff⁹, Willem Lems¹⁰, Dirkjan van Schaardenburg¹¹, Robert Landewé¹², Iet Van Albada¹³, T.R.D.J. Radstake¹⁴, Piet van Riel¹⁵, Mart A.F.J. van de Laar¹⁶ and Tim Jansen¹⁷, ¹Rheumatology, Radboudumc, Nijmegen, Netherlands, ²rheumatology, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, ³Ariensplein 1, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, ⁴Dept. Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rheumatology, Medisch Centrum Leeuwarden, Leeuwarden, Netherlands, ⁶Rheumatology, Alysis Care Group, Arnhem, Netherlands, ⁷Pcgr, University of Twente, Enschede, Netherlands, ⁸Crescendo Bioscience Inc., South San Francisco, CA, ⁹Crescendo Bioscience, Inc., South San Francisco, CA, ¹⁰Amsterdam Rheumatology and immunology Center, location VU University Medical Center, Department of Rheumatology, Amsterdam, Netherlands, ¹¹Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center, Amsterdam, Netherlands, ¹²Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ¹³Meander MC, Amersfoort, Netherlands, ¹⁴Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁵Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁶Rheumatology, Medisch Spectrum Twente - Arthritis Center Twente, Enschede, Netherlands, ¹⁷VieCuri Medical Center, Venlo, Netherlands
Background/Purpose: Prediction which rheumatoid arthritis (RA) patients in low disease activity (LDA) can successfully discontinue TNF inhibition (TNFi) may improve the cost-effectiveness of RA management.…
Abstract Number: 2595 • 2015 ACR/ARHP Annual Meeting
Autoantibodies to Citrullinated Fibrinogen, Anti-CCP2 and Anti-MCV Antibodies in Early Rheumatoid Arthritis Patients with Rapid Radiographic Progression at 1-Year
Yannick Degboé¹, Arnaud Constantin², Delphine Nigon³, Gabriel Tobon⁴, Martin Cornillet⁵, Thierry Schaeverbeke⁶, Gilles Chiocchia⁷, Pascale Nicaise-Roland⁸, Leonor Nogueira⁹, Guy Serre^5,10,11, Alain G. Cantagrel¹² and Adeline Ruyssen Witrand^13,14, ¹Rheumatology, Rheumatology Center, Purpan University Hospital, Toulouse, France, ²Inserm U558, Rheumatology Center, Purpan University Hospital, Toulouse, France, ³CHU Purpan, Toulouse, France, ⁴Rheumatology Department, la Cavale Blanche Hospital, Brest, France, ⁵Service de Biologie Cellulaire, C.H.U. Purpan, Toulouse, France, ⁶CHU Bordeaux, Bordeaux, France, ⁷Immunology-Rheumatology, INSERM U1173, paris, France, ⁸Immunology Department, Bichat Claude-bernard, Universitary Hospital, APHP, Paris, France, ⁹Immunology, UMR CNRS 5165, INSERM 1056, Toulouse, France, ¹⁰Cell Biology, Purpan University Hospital, Toulouse, France, ¹¹Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM,Toulouse, France, Toulouse, France, ¹²Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, ¹³Rheumatolgy, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ¹⁴UMR 1027, Inserm, Toulouse, France
Background/Purpose: We compared the ability of anti-CCP2, anti-mutated citrullinated vimentin (anti-MCV) and anti-citrullinated fibrinogen (AhFibA) antibodies to predict 1-year rapid radiographic progression (RRP; total Sharp…
Abstract Number: 2596 • 2015 ACR/ARHP Annual Meeting
Less Musculoskeletal Ultrasound Power Doppler Activity Seen in Obese Rheumatoid Arthritis
Erin Bauer¹, Ami Ben-Artzi², Erin Duffy¹, David Elashoff¹, Cesar Olmos³ and Veena K. Ranganath³, ¹Medicine, David Geffen School of Medicine, Los Angeles, CA, ²David Geffen School of Medicine, Los Angeles, CA, ³Medicine, Division of Rheumatology, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Studies report that obese and overweight patients with rheumatoid arthritis (RA) are less likely to attain remission and more likely to have limited therapeutic…
Abstract Number: 2597 • 2015 ACR/ARHP Annual Meeting
Fine Specificity of Anti-Citrullinated Peptide Antibodies Is Associated with Left Ventricular Mass Index in Rheumatoid Arthritis Patients without Cardiovascular Disease
Laura Geraldino-Pardilla¹, Jon T. Giles², Jeremy Sokolove³, Afshin Zartoshti⁴, WH Robinson⁵ and Joan M. Bathon⁶, ¹Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ⁴Rheumatology, Columbia University Medical Center, NY, NY, ⁵Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁶Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Heart failure (HF) is a leading cause of excess deaths in RA. We previously found an association between left ventricular mass index (LVMI) and…
Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis
Paul Hasler¹, Stavros Giaglis¹, Ulrich A. Walker², Erik Deman¹, Christoph Hemmeler¹, Christina Ryser¹, Samuel Kretzschmar¹, Guenther Schaefer³, Juliane Franz¹ and Sinuhe Hahn⁴, ¹Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Rheumatology, University Hospital, Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ⁴Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
Abstract Number: 2599 • 2015 ACR/ARHP Annual Meeting
The Effect of Daily Low Dose Prednisone (divided daily versus single daily dose) in the Treatment of African Americans (AA) with Early Rheumatoid Arthritis (RA)
Athan Tiliakos¹, Kirk Easley², Gaobin Bao³, Shuling Liu⁴, S. Louis Bridges Jr.⁵, Leigh F. Callahan⁶, Larry W. Moreland⁷ and Doyt L. Conn¹, ¹Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ²Biostatistics, Emory University, Atlanta, GA, ³Medicine, Emory University, Atlanta, GA, ⁴Biostatistics and Bioinformatics, Emory University School of Medicine, Atlanta, GA, ⁵Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To describe the longitudinal changes in the number of swollen and tender joints and HAQ scores in 345 African Americans with early RA and…
Abstract Number: 2600 • 2015 ACR/ARHP Annual Meeting
Signs of Immune Activation and Local Inflammation Are Present in the Bronchial Tissue of Patients with Untreated Early Rheumatoid Arthritis
Gudrun Reynisdottir^1,2, Helga Olsen³, Vijay Joshua⁴, Marianne Engström², Magnus Skold³, Anders Eklund⁵, Johan Grunewald³ and Anca I Catrina², ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ³Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Events in the lungs might contribute to generation of anti citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). We investigated if signs of immune…
Abstract Number: 2601 • 2015 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Score in a TNF Inhibitor Tapering Study in Rheumatoid Arthritis Patients: Predictive Value for Successful Tapering, Flaring and Radiographic Progression
Chantal A.M. Bouman¹, Aatke van der Maas¹, Noortje van Herwaarden¹, Eric H. Sasso², Frank H.J. van den Hoogen¹ and Alfons A. den Broeder¹, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: We evaluated the predictive value of the multi-biomarker disease activity (MBDA) score for clinical outcomes and radiographic progression in a TNFi tapering study in…
Abstract Number: 2602 • 2015 ACR/ARHP Annual Meeting
CCP Antibody Negativity Is Associated with Higher Fatigue in Rheumatoid Arthritis
Laura Cappelli¹, Susan J. Bartlett^2,3, Michelle Jones⁴ and Clifton Bingham⁴, ¹Ste 4500, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, ³Medicine , Divisions of Clinical Epidemiology, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁴Johns Hopkins University, Baltimore, MD
Background/Purpose: Fatigue in rheumatoid arthritis (RA) is common and highly debilitating. Emerging evidence suggests that seronegative RA patients differ from their seropositive peers in…
Abstract Number: 2603 • 2015 ACR/ARHP Annual Meeting
What Is the Variability of HAQ over Time in Patients with Rheumatoid Arthritis Treated with Anti-TNF?
Regan Arendse¹, Boulos Haraoui², Denis Choquette³, John Kelsall⁴, Philip Baer⁵, Dalton Sholter⁶, William G. Bensen⁷, Mary J. Bell⁸, Michelle Teo⁹, Emmanouil Rampakakis¹⁰, Eliofotisti Psaradellis¹¹, Brendan Osborne¹², Cathy Tkaczyk¹², Karina Maslova¹³, Francois Nantel¹⁴ and Allen J Lehman¹³, ¹University of Saskatchewan, Saskatoon, SK, Canada, ²Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ³Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ⁴Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, ⁵Section on Rheumatology, Ontario Medical Association/Journal of the Canadian Rheumatology Association, Toronto, ON, Canada, ⁶Rheumatology Associates, Edmonton, AB, Canada, ⁷St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁸Rheum Div, Sunnybrook Health Sciences Centre/University of Toronto, Toronto, ON, Canada, ⁹Rheumatology, Penticton Regional Hospital, Penticton, BC, Canada, ¹⁰JSS Medical Research, St-Laurent, QC, Canada, ¹¹JSS Medical Research, Montreal, QC, Canada, ¹²Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹³Janssen Inc., Toronto, ON, Canada, ¹⁴19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose : The Health Assessment Questionnaire (HAQ) remains the gold standard for measuring patient-reported functional status in rheumatoid arthritis (RA) and is included among the…
Abstract Number: 2604 • 2015 ACR/ARHP Annual Meeting
Evaluation of Serum Undercarboxylated Osteocalcin in Premenopausal Rheumatoid Arthritis Patients; Its Correlation with Disease Activity and Bone Mineral Density
Heba Esaily¹, Abd El Samad Al Hewala², Samar Soliman³, Eman Galbat⁴ and Dalia Abo Al- Ela⁵, ¹Physical Medicine and Rehabilitation,, Faculty of Medicine, Menoufia University, Menofia, Egypt, ²Department of Rheumatology, Faculty of Medecine, Zagazigue University, Al Sharquia, Egypt, ³Physical Medicine and Rehabilitation, Faculty of Medicine, Menoufia University, Menoufia,, Egypt, ⁴Physical Medicine and Rehabilitation, Faculty of Medicine, Menoufia University, Menoufia, Egypt, ⁵Clinical Pathology, Faculty of Medicine, Menoufia University, Menofia, Egypt
Background/Purpose: The role of vitamin K and undercarboxylated osteocalcin (ucOC) on BMD in RA is present. Up to our knowledge no other works have discussed…
Abstract Number: 2605 • 2015 ACR/ARHP Annual Meeting
14-3-3η Positive Status and Higher Titres Are Associated with More Severe RA
Shintaro Hirata¹, Kentaro Hanami², Anthony Marotta³ and Yoshiya Tanaka⁴, ¹The First Department of Internal Medicine, University of Occupational & Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³Augurex Life Sciences Corp., Vancouver, BC, Canada, ⁴The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: Serum 14-3-3η is an RA diagnostic marker that is associated with radiographic progression risk. In vitro studies describe 14-3-3η's potent, dose-dependent up-regulation of factors…
Abstract Number: 2606 • 2015 ACR/ARHP Annual Meeting
Serum Myeloid Related Protein 8/14 Levels in Rheumatoid Arthritis: Marker of Disease Activity and Response to Methotrexate in DMARD Naïve Patients
Pradeepta Sekhar Patro, Ankita Singh, Ramnath Misra and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: MRP8/14 are calcium binding proteins produced by myeloid cells. Recently baseline serum levels of MRP8/14 have been shown to predict response to biologicals in…
Abstract Number: 2607 • 2015 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Rheumatoid Arthritis Hispanics Exposed to Biomass Smoke
Raymundo Vera-Pineda¹, Alberto Cardenas-de La Garza², Jorge Esquivel-Valerio³, Dionicio A. Galarza-Delgado², Jose Ramon Azpiri-Lopez⁴, Iris J. Colunga-Pedraza², Mario Alberto Garza-Elizondo² and Jesus Zacarias Villarreal-Pérez⁵, ¹Cardiology., Hospital Universitario, UANL., Monterrey, Mexico, ²Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, ³Rheumatology, Hospital Universitario.UANL, Monterrey, Mexico, ⁴Cardiology, Hospital Universitario, UANL., Monterrey, Mexico, ⁵Endocrinology, Hospital Universitario, UANL., Monterrey, Mexico
Background/Purpose: Tobacco smoke has been associated to anti-cyclic citrullinated peptide (anti-CCP) antibodies positivity. Recently, in wood-smoke-induced chronic obstructive pulmonary disease (COPD) patients without rheumatoid arthritis…
Abstract Number: 2608 • 2015 ACR/ARHP Annual Meeting
The “Rheumatoid Arthritis Impact of Disease”� Score Correlates with Other Patient Reported Outcomes and with Disease Activity Scores in Patients with RA and Its Patient Acceptable Symptom State Is More Stringent Than DAS28-Remission
Ricardo J.O. Ferreira^1,2, Cátia Duarte^1,3, Sylvie Batista³, Catarina Medeiros³, J.P. Sousa³, Gisela Eugénio¹, Carlos Costa¹, Pedro Carvalho¹, Joana F. Ferreira¹, Margarida Coutinho^1,4, Maria J. Salvador^1,4, Laure Gossec⁵ and J.A.P. da Silva^3,6, ¹Rheumatology, Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal, ²Health Sciences Research Unit: Nursing (UICISA: E), Coimbra, Portugal, ³Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal, ⁴Clínica Universitária de Reumatologia, Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal, ⁵Rheumatology, Pitié Salpetriere Hospital, Paris, France, ⁶Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal
Background/Purpose: The "Rheumatoid Arthritis Impact of Disease" (RAID) score is a Patient Reported Outcome (PRO) that comprises seven domains of disease[1], that may reflect the…

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