Abstract Number: 668 • 2016 ACR/ARHP Annual Meeting
The TNFAIP3 F127C Coding Variation in Sjogren’s Syndrome: Results from a Greek Cohort
Background/Purpose: TNFAIP3 gene encodes the A20 protein which is an important negative feedback regulator of the NF-κB pathway. A coding TNFAIP3 polymorphism, namely rs2230926, has…Abstract Number: 669 • 2016 ACR/ARHP Annual Meeting
RNA-Sequencing Reveals Sjogren’s Syndrome Anti-Ro Negative Patients Share Similar Pathways to Multiple Sclerosis Patients
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by autoantibodies to Ro and/or La proteins and lymphocytic infiltration into exocrine glands. Multiple sclerosis (MS)…Abstract Number: 670 • 2016 ACR/ARHP Annual Meeting
Identification and Characterization of Sjogren’s Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune-mediated disease with hallmark features of dry eyes/mouth and autoantibodies. Genetic susceptibility to SS involves many loci, including the…Abstract Number: 671 • 2016 ACR/ARHP Annual Meeting
Steered Screening for Sjögren Syndrome in Patients with Sicca Syndrome. Role of Salival Beta-2 Microglogulin
Background/Purpose: Sicca Syndrome patients represent a diagnostic challenge for the wide variety of etiologies that can afford it. Beta-2 Microglogulin (B2MG) is a non-glycosylated protein,…Abstract Number: 672 • 2016 ACR/ARHP Annual Meeting
Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)
Background/Purpose: To analyse the influence of geolocation (North-to-South gradient) on the clinical presentation of primary Sjögren syndrome (SjS) at diagnosis. Methods: The Big Data Sjögren…Abstract Number: 673 • 2016 ACR/ARHP Annual Meeting
Sjögren’s Syndrome (SS): The Role of Traditional (SS-A/SS-B) and Novel Antibodies in Diagnosis
Background/Purpose: Diagnosing SS is often challenging, particularly distinguishing patients with primary SS from xerostomia and xerophthalmia (sicca). Recently, an IL-14 transgenic murine model led to…Abstract Number: 674 • 2016 ACR/ARHP Annual Meeting
Targeting Glandular IL-21-Production in Primary Sjogren′s Syndrome Patients By Immunomodulatory Treatment
Background/Purpose: Interleukin-21 plays a central role in plasma cell differentiation and germinal center (GC) formation and is likely involved in the pathogenesis of primary Sjögren’s…Abstract Number: 675 • 2016 ACR/ARHP Annual Meeting
Association Between Structural Lesions in the Sacroiliac Joints and Spinal Inflammatory Lesions in Patients with Non-Radiographic Axial Spondyloarthritis
Background/Purpose: The relevance of structural lesions in non-radiographic axial SpA (nr-axSpA) is unclear, particularly without signs of MRI inflammation. In a post hoc analysis we…Abstract Number: 676 • 2016 ACR/ARHP Annual Meeting
Syndesmophytes in the Thoracic Spine in Ankylosing Spondylitis As Detected By Computed Tomography and Association with Lumbar Radiographic Involvement
Background/Purpose: Because the thoracic spine has traditionally been excluded from radiographic examinations of spinal damage in ankylosing spondylitis (AS) due to poor visualization, little is…Abstract Number: 677 • 2016 ACR/ARHP Annual Meeting
Low Functional Relevance of Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis
Background/Purpose: It has been shown in the past that radiographic spinal progression is an important determinant of the functional outcome in patients with advanced axial…Abstract Number: 678 • 2016 ACR/ARHP Annual Meeting
Additional Information from CT or MRI Imaging Can Increase Rheumatologists’ Consensus on Grading Sacroiliitis By Radiography: Results of the Trimage Project
Background/Purpose: The diagnosis of ankylosing spondylitis (AS) is anchored on definitive changes of sacroiliits by radiography. This is relevant not only to clinical diagnosis, but…Abstract Number: 679 • 2016 ACR/ARHP Annual Meeting
Diagnostic Value of MR Enterography As a Complementary Intervention to Colonoscopy in Axial Spondylarthritis Patients with Chronic Non-Bloody Diarrhea
Background/Purpose: Chronic intermittent diarrhea (CID) is a common clinical problem in axial spondylarthritis (axSpA) patients and eventually up to 13% of these are diagnosed with…Abstract Number: 680 • 2016 ACR/ARHP Annual Meeting
Development and Preliminary Validation of the Computed Tomography Sacroiliac Structural Score for Assessment of Structural Lesions in Axial Spondyloarthritis
Background/Purpose: Computed tomography (CT) is considered the imaging benchmark for the assessment of certain structural lesions in the sacroiliac joints (SIJ) of patients with axial…Abstract Number: 681 • 2016 ACR/ARHP Annual Meeting
Can Bridging Syndesmophytes Independantly Affect Spinal Mobility?
Background/Purpose: One of the hallmark characteristics of the disease is new bone formation that manifests as syndesmophytes and spinal fusion. Spinal fusion results from bridging…Abstract Number: 682 • 2016 ACR/ARHP Annual Meeting
Which Is the Most Reliable Imaging Method for Detection of Structural Changes in the Sacroiliac Joints of Patients with Ankylosing Spondylitis? a Cross-Sectional Study Comparing MRI, CT and Conventional Radiographs
Background/Purpose: Magnetic resonance imaging (MRI) is the gold standard for detection of inflammation and fat metaplasia in the sacroiliac joints (SIJ) and the spine of…
