Abstract Number: 2564 • 2015 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Selectively Upregulated in the Human TNF-Alpha Transgenic Model of Rheumatoid Arthritis
Background/Purpose: The orphan nuclear receptor 4A2 (NR4A2 / NURR1) is emerging as a critical transcription factor in chronic inflammatory joint diseases. We have demonstrated elevated…Abstract Number: 2565 • 2015 ACR/ARHP Annual Meeting
ACPA Specific IVIG Attenuate Collagen Induced Arthritis in Mice
Background/Purpose: Administration of intravenous-immunoglobulin (IVIg) is a recognized safe and efficient immunomodulatore therapy for many autoimmune diseases. Anti-idiotypic antibody binding to pathogenic autoantibodies was proposed…Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…Abstract Number: 2567 • 2015 ACR/ARHP Annual Meeting
SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis
Background/Purpose: SPACIA1/SAAL1 is a gene associated with abnormal synovial proliferation. We previously showed that SPACIA1/SAAL1 small interfering RNA inhibited the proliferation of rheumatoid arthritis synovial…Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting
Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis
Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Collagen-Antibody Induced Arthritis and the Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago
Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…Abstract Number: 2571 • 2015 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Loss of Bone Strength in a Mouse Model of Collagen-Induced Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting
Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis
Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis. Although the growth hormone [GH]/insulin-like growth factor 1…Abstract Number: 2573 • 2015 ACR/ARHP Annual Meeting
Confirmatory Analysis of Methylome Signatures in Rheumatoid Arthritis Using an Independent Dataset
Background/Purpose: Epigenetics can contribute to the pathogenesis of rheumatoid arthritis (RA). A DNA methylation signature that distinguishes RA fibroblast-like synoviocytes (FLS) from osteoarthritis (OA) FLS…Abstract Number: 2574 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Leads to Altered Gene Expression in the Brain and Behavioral Changes in Mice
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by joint inflammation and destruction. Pain is the major symptom in RA, which often persists despite…Abstract Number: 2575 • 2015 ACR/ARHP Annual Meeting
The Effect of mPGES-1 Deletion on Platelet Function in Mice
Background/Purpose: Microsomal prostaglandin E synthase-1 (mPGES-1) is an essential player in inflammation and has an indispensible role in the generation and maintenance of autoimmune disease…Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting
Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction
Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…Abstract Number: 2577 • 2015 ACR/ARHP Annual Meeting
Ablation of Fc Gamma Receptors Leads to a Decreased Bone Erosion in Experimental Arthritis Not By Altering Osteoclast Numbers within the Inflamed Joint but By Inhibiting Osteoclast Activation
Background/Purpose: Rheumatoid arthritis is characterized by immune complex dependent chronic joint inflammation and severe cartilage and bone destruction. In earlier studies we showed that Fcγ…Abstract Number: 2578 • 2015 ACR/ARHP Annual Meeting
Cardiovascular Effects of Etanercept in an Animal Model of Rheumatoid Arthritis: Mechanisms Involved
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality secondary to endothelial dysfunction (ED). Growing evidence suggests that TNFα-inhibitors may reduce…