ACR Meeting Abstracts

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  • Abstract Number: 2564 • 2015 ACR/ARHP Annual Meeting

    Nuclear Receptor 4A2 Is Selectively Upregulated in the Human TNF-Alpha Transgenic Model of Rheumatoid Arthritis

    Jackeline Araujo, Cullen Lilley and Kimberlee Mix, Biological Sciences, Loyola University New Orleans, New Orleans, LA

    Background/Purpose: The orphan nuclear receptor 4A2 (NR4A2 / NURR1) is emerging as a critical transcription factor in chronic inflammatory joint diseases. We have demonstrated elevated…
  • Abstract Number: 2565 • 2015 ACR/ARHP Annual Meeting

    ACPA Specific IVIG Attenuate Collagen Induced Arthritis in Mice

    Shaye Kivity1, Nina Svetliscky1, Qusim Odeh1, Smadar Gertel1, Howard Amital1, Omer Gendelman1, Iris Barshack2, Alexander Volkov2, Eran Bar-Meir3, Miri Blank1 and Yehuda Shoenfeld4, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 3Plastic surgeon Poria Medical Center affiliated to Faculty of medicine in the Galilee Bar-Ilan university, Poria, Israel, 4Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel

    Background/Purpose: Administration of intravenous-immunoglobulin (IVIg) is a recognized safe and efficient immunomodulatore therapy for many autoimmune diseases. Anti-idiotypic antibody binding to pathogenic autoantibodies was proposed…
  • Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting

    Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis

    Tomer Bashi1, Miri Blank1, Jasna Omersel2, Alexander Volkov3, Iris Barshack3 and Yehuda Shoenfeld1, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, 3Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel

    Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
  • Abstract Number: 2567 • 2015 ACR/ARHP Annual Meeting

    SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis

    Ryoji Fujii1, Iwao Seki2, Rie Komatsu1, Tomomi Kohara2, Miwa Takai2, Tomoo Sato3, Koji Konomi2, Hiroyuki Aono2, Kazuo Yudoh1, Kusuki Nishioka4 and Toshihiro Nakajima5, 1Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, 2Santen Pharmaceutical Co. Ltd., Nara, Japan, 3Molecular Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, 4Institute of Medical Science, Tokyo Medical University, Tokyo, Japan, 5Department of Locomotor Science/Future Medical Science, Institute of Medical Science, integrated Gene Editing Section (iGES), Tokyo Medical University, Tokyo, Japan

    Background/Purpose: SPACIA1/SAAL1 is a gene associated with abnormal synovial proliferation. We previously showed that SPACIA1/SAAL1 small interfering RNA inhibited the proliferation of rheumatoid arthritis synovial…
  • Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting

    The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis

    Lisa Deloch1, Anja Derer1, Axel J. Hueber2, Barbara Happich3, Rainer Fietkau1, Benjamin Frey1 and Udo S. Gaipl1, 1Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
  • Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting

    Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis

    Sang-Yeob Lee1, Sung Won Lee2, Won Tae Chung2, Jae Ho Bae3, So Youn Park4 and Chi Dae Kim4, 1Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, 2Rheumatology, Dong-A University Hospital, Busan, South Korea, 3Biochemistry, Pusan national university, Yong -San, South Korea, 4Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea

    Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…
  • Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting

    Comparative Analysis of Collagen-Antibody Induced Arthritis and the  Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago

    Christina Grimm1, Bianka Marklein1, Zoltan Konthur2, Gerd Burmester1 and Karl Skriner1, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…
  • Abstract Number: 2571 • 2015 ACR/ARHP Annual Meeting

    Anti-IL-6 Receptor Antibody Prevents Loss of Bone Strength in a Mouse Model of Collagen-Induced Arthritis

    Hiroto Yoshida, Yuanyuan Bi, Miho Suzuki, Keisuke Tanaka and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
  • Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting

    Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis

    Ricardo J. Villares1, Gabriel Criado2, Rosa P Gomariz3, Yasmina Juarranz3, Javier Leceta3, Graciela Cascio4, Jose L. Pablos5 and Mario Mellado6, 1Immunology & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, 2Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 3Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, 4Immunoloy & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, 5Instituto de Investigacion Hospital, Madrid, Spain, 6Immunology and Oncology, Centro Nacional de Biotecnología. CNIC, Madrid, Spain

    Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis.  Although the growth hormone [GH]/insulin-like growth factor 1…
  • Abstract Number: 2573 • 2015 ACR/ARHP Annual Meeting

    Confirmatory Analysis of Methylome Signatures in Rheumatoid Arthritis Using an Independent Dataset

    Rizi Ai1, Deepa Hammaker2, Wei Wang3 and Gary S. Firestein4, 1University of California San Diego, La Jolla, CA, 2Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 3Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 4Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Epigenetics can contribute to the pathogenesis of rheumatoid arthritis (RA). A DNA methylation signature that distinguishes RA fibroblast-like synoviocytes (FLS) from osteoarthritis (OA) FLS…
  • Abstract Number: 2574 • 2015 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Leads to Altered Gene Expression in the Brain and Behavioral Changes in Mice

    Karin ME Andersson1, Lovisa Leifsdottir2, Malin Erlandsson1, Marcela Pekna3, Milos Pekny3, Kjell Olmarker4 and Maria Bokarewa5, 1Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 3Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 4Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, 5Rheumatology and Inflammation Research, Göteborgs University, Göteborg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by joint inflammation and destruction. Pain is the major symptom in RA, which often persists despite…
  • Abstract Number: 2575 • 2015 ACR/ARHP Annual Meeting

    The Effect of mPGES-1 Deletion on Platelet Function in Mice

    Joan Raouf1, Fariborz Mobarrez2, Karin Larsson1, Per Johan Jakobsson1 and Marina Korotkova1, 1Medicine, Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet S-171 76, Stockholm, Sweden, Stockholm, Sweden, 2Department of Medicine, Karolinska Institutet, Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Microsomal prostaglandin E synthase-1 (mPGES-1) is an essential player in inflammation and has an indispensible role in the generation and maintenance of autoimmune disease…
  • Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting

    Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction

    Nancy E. Lane1, Wei Yao2 and Maripat Corr3, 1Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, 2University California, Davis Medical Center, Internal Medicine, Sacramento, CA, 3Medicine, University of California, San Diego, La Jolla, CA

    Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…
  • Abstract Number: 2577 • 2015 ACR/ARHP Annual Meeting

    Ablation of Fc Gamma Receptors Leads to a Decreased Bone Erosion in Experimental Arthritis Not By Altering Osteoclast Numbers within the Inflamed Joint but By Inhibiting Osteoclast Activation

    Irene Di Ceglie1, Sjef Verbeek2, Peter van der Kraan1, Wim van den Berg1 and Peter van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Human Genetic, Human Genetic, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis is characterized by immune complex dependent chronic joint inflammation and severe cartilage and bone destruction. In earlier studies we showed that Fcγ…
  • Abstract Number: 2578 • 2015 ACR/ARHP Annual Meeting

    Cardiovascular Effects of Etanercept in an Animal Model of Rheumatoid Arthritis: Mechanisms Involved

    Perle Totoson1, Katy Maguin-Gaté1, Alice Monnier2, Anne Tessier2, Christine Marie2, Frank Verhoeven3, Clément Prati3, Daniel Wendling4 and Céline Demougeot1, 1EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, 2INSERM U1093, Université de Bourgogne Franche-Comté, Dijon, France, 3Service de Rhumatologie, CHRU J Minjoz, Besançon, France, 4Université de Franche-Comté, Besançon, France

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality secondary to endothelial dysfunction (ED). Growing evidence suggests that TNFα-inhibitors may reduce…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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