Abstracts Archive - Page 1628 of 2425 - ACR Meeting Abstracts

Abstract Number: 3166 • 2016 ACR/ARHP Annual Meeting
HLA-B27 and Ankylosing Spondylitis Have Shared Effects on the Gut Microbiome
Mary-Ellen Costello¹, Mark Asquith², Kim-Anh Lê Cao³, Tammy Martin⁴, Sarah Diamond², Michelle Beaumont⁵, Timothy D. Spector⁵, James T. Rosenbaum² and Matthew A. Brown¹, ¹Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ²Oregon Health & Science University, Portland, OR, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Ophthalmology, Oregon Health & Science Univ, Portland, OR, ⁵Dept of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Background/Purpose: Evidence for a discrete intestinal microbiome signature in the terminal ileum (TI) of ankylosing spondylitis (AS) patients, compared to healthy controls, has recently been…
Abstract Number: 3167 • 2016 ACR/ARHP Annual Meeting
Total and Glucocorticoid-Related Damage Accrual in the Systemic Lupus International Collaborating Clinics Inception Cohort
Jayne Little^1,2, Mark Lunt³, Benjamin Parker^1,2, Ian N. Bruce^2,4 and The Systemic Lupus International Collaborating Clinics (SLICC) Group, ¹Centre for Musculoskeletal Research, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁴Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Total and Glucocorticoid-Related Damage Accrual in The Systemic Lupus International Collaborating Clinics Inception Cohort. Jayne Little1, Mark Lunt1, Ben Parker1, Ian N. Bruce1 and The…
Abstract Number: 3168 • 2016 ACR/ARHP Annual Meeting
Economic Evaluation of Damage Accrual in an International SLE Inception Cohort
Megan Barber¹, Ian N. Bruce², Murray Urowitz³, John G. Hanly⁴, Li Su⁵, Juanita Romero-Diaz⁶, Caroline Gordon⁷, Sang-Cheol Bae⁸, Sasha Bernatsky⁹, Daniel J Wallace¹⁰, Joan T. Merrill¹¹, David A. Isenberg¹², Anisur Rahman¹³, Ellen M. Ginzler¹⁴, Michelle Petri¹⁵, Mary Anne Dooley¹⁶, Paul R. Fortin¹⁷, Dafna D. Gladman¹⁸, Jorge Sanchez-Guerrero¹⁹, Kristján Steinsson²⁰, Rosalind Ramsey-Goldman²¹, M Khamashta²², Cynthia Aranow²³, Graciela S. Alarcon²⁴, Barri J. Fessler²⁵, Susan Manzi²⁶, Ola Nived²⁷, Andreas Jönsen²⁸, Asad Zoma²⁹, Ronald F. van Vollenhoven³⁰, Manuel Ramos-Casals³¹, Guillermo Ruiz-Irastorza³², S. Sam Lim³³, Kenneth C. Kalunian³⁴, Murat Inanc³⁵, Diane L. Kamen³⁶, Christine A. Peschken³⁷, Søren Jacobsen³⁸, Anca Askanase³⁹, Jill P. Buyon⁴⁰, Chris Theriault⁴¹, Vernon Farewell⁴² and Ann E. Clarke⁴³, ¹Division of Rheumatology, University of Calgary, Caglary, AB, Canada, ²Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ³Medicine, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁵Nova Scotia Rehab Site, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁶Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ⁷NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of, ⁹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ¹⁰Cedars-Sinai Medical Center, West Hollywood, CA, ¹¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ¹³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ¹⁴Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, ¹⁵Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁶Dooley Rheumatology, Chapel Hill Doctors, Chapel Hill, NC, ¹⁷Rheumatology, University of Laval, Quebec, QC, Canada, ¹⁸Rheumatology, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ¹⁹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²⁰Rheumatology, Univ. Hospital, Reykjavik, Iceland, ²¹FSM, Northwestern University, Chicago, IL, ²²Lupus Research Unit, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom, ²³Molecular Medicine and Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, ²⁴Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²⁵Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²⁶Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, ²⁷Department of Rheumatology, University Hospital, Lund, Sweden, ²⁸Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ²⁹Rheumatology, Hairmyres Hospital, East Kilbride, Great Britain, ³⁰Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ³¹Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ³²Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, ³³Medicine, Emory University School of Medicine, Atlanta, GA, ³⁴Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, ³⁵Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³⁶Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³⁷RR 149G, Univ of Manitoba, Winnipeg, MB, Canada, ³⁸Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ³⁹Rheumatology, Columbia University Medical Center, New York, NY, ⁴⁰Medicine, New York University School of Medicine, New York, NY, ⁴¹Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, ⁴²Medicine, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ⁴³Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Little is known about the association of healthcare costs with damage accrual in SLE. We describe the costs associated with damage states across the disease…
Abstract Number: 3169 • 2016 ACR/ARHP Annual Meeting
Mortality Trends in Systemic Lupus Erythematosus: A General Population-Based Cohort Study
April Jorge¹, Na Lu^1,2, Sharan K. Rai³ and Hyon Choi¹, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Arthritis Research Canada, Vancouver, BC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with an increased risk of mortality. Despite improvements in the recognition and treatment of SLE, it remains a challenging…
Abstract Number: 3170 • 2016 ACR/ARHP Annual Meeting
Association Between Insulin Resistance, Subclinical Artheriosclerosis and Activity/Damage Status in Systemic Lupus Erythematosus Patients
Hiurma Sanchez-Perez¹, Beatriz Tejera² and Ivan Ferraz-Amaro³, ¹Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ²Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ³Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain
Background/Purpose: Insulin resistance (IR) may contribute to an increase in cardiovascular risk. The aim of this study was to examine the association between IR and…
Abstract Number: 3171 • 2016 ACR/ARHP Annual Meeting
The Impact of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases
April Jorge, Na Lu and Hyon K. Choi, Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Individuals with systemic autoimmune rheumatic diseases (SARDs)—such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc)—have been found to have an increased risk of…
Abstract Number: 3172 • 2016 ACR/ARHP Annual Meeting
Temporal Trends in SLE Mortality According to Sex, Race, Ethnicity, and Geographic Region in the United States over the Past Five Decades
Eric Yen¹, Magda Shaheen², Jennifer MP Woo¹, Neil Mercer¹, Lewei Duan¹, Ning Li¹, Arun Karlamangla¹, Deborah K. McCurdy¹ and Ram R. Singh¹, ¹UCLA, Los Angeles, CA, ²Charles R. Drew University of Medicine and Science, Los Angeles, CO
Background/Purpose: Over the past half-century, diagnostic and therapeutic developments for SLE have led to dramatic improvements in the 5- and 10-year survival. Whether these achievements…
Abstract Number: 3173 • 2016 ACR/ARHP Annual Meeting
Pan-PPAR Agonist IVA337 Is Effective in the Prevention of Experimental Lung Fibrosis and Related Pulmonary Hypertension
Jerome Avouac¹, Irena Konstantinova², Christophe Guignabert³, Sonia Pezet⁴, Anne Cauvet⁵, Jeremy Sadoine⁶, Thomas Guilbert⁴, Jean-Michel Luccarini⁷, Jean-Louis Junien⁷, Pierre Broqua⁷ and Yannick Allanore⁸, ¹Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Inventiva, Daix, France, ³Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France, ⁴Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ⁶Equipe d’Accueil (EA) 2496 Pathologie, Imagerie et Biothérapies Orofaciales, Faculty of Odontology, Paris Descartes University, Montrouge, France, ⁷Inventiva, DAIX, France, ⁸Rheumatology, Paris Descartes University, Paris, France
Background/Purpose: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors known to modulate fibrosis. The pan-PPAR agonist IVA337 recently demonstrated efficacy in prevention and treatment of experimental…
Abstract Number: 3174 • 2016 ACR/ARHP Annual Meeting
Apremilast Attenuates the Fibrogenic Phenotype of Dermal Fibroblasts from Patients with Systemic Sclerosis, Contributing to the Prevention of the Progression of Experimental Dermal Fibrosis
Tomoaki Higuchi¹, Yasushi Kawaguchi², Kae Takagi³, Akiko Tochimoto², Yuki Ichimura², Yasuhiro Katsumata², Hisae Ichida², Hidenaga Kawasumi², Hirokazu Nishina², Mari Tochihara², Akira Nishino², Shinya Hirahara², Rina Moriyama² and Hisashi Yamanaka⁴, ¹Institute Of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Medicine, Tokyo Women's Medical University medical Center East, Tokyo, Japan, ⁴Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrosing disorder that affects the skin and other internal organs. Inflammation, vasculopathy and fibrosis at the affected area…
Abstract Number: 3175 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of MMF Clinical, Molecular, and Immunohistochemistry (IHC) Responses Shows SSc Patients Lose Their Inflammatory Signature and Rebound upon Treatment Cessation
Diana Toledo¹, Monique Hinchcliff², Jaclyn Taroni¹, Tammara A. Wood³, Jennifer Franks³, Sanjiv Shah⁴, Rishi Agrawal⁴, Lauren Beussink-Nelson⁴, Mary A. Carns⁵, Sofia Podlusky⁶, Patricia Pioli⁷ and Michael Whitfield³, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, IL, ⁵Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Rheumatology Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁷Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: We previously showed patients in the inflammatory subset were most likely to demonstrate improvement in modified Rodnan Skin Score (mRSS) during mycophenolate mofetil (MMF)…
Abstract Number: 3176 • 2016 ACR/ARHP Annual Meeting
Meta-Analysis of SSc Clinical Trials with Molecular Gene Expression Data Suggests Potential Combination Therapies
Jaclyn N. Taroni¹, Viktor Martyanov² and Michael L. Whitfield², ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Clinical trials in SSc have tended to be underpowered and not meet clinical endpoints. Genome-wide gene expression measured in some studies can prove challenging…
Abstract Number: 3177 • 2016 ACR/ARHP Annual Meeting
Targeted Nuclear Imaging for the Early Detection of Lung Involvement in Systemic Sclerosis
Janine Schniering¹, Stephanie Haller², Zhongning Guo¹, Martina Benesova^2,3, Carol A. Feghali-Bostwick⁴, Roger Schibli^2,3, Oliver Distler⁵, Cristina Müller^2,3 and Britta Maurer⁵, ¹Department of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ²Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen PSI, Switzerland, ³Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland, ⁴Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Interstitial lung disease (ILD) is one of the main causes of systemic sclerosis (SSc)-related deaths. Since routine diagnostics such as high resolution computed tomography…
Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting
Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset
Mara Stellato¹, Michal Rudnik¹, Florian Renoux², Elena Pachera¹, Karl Sotlar³, Karin Klingel⁴, Joerg C. Henes⁵, Przemyslaw Blyszczuk⁶, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
Abstract Number: 3179 • 2016 ACR/ARHP Annual Meeting
Scale Structure and Measurement Properties of a Disease Specific Patient-Reported Outcome for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Joanna C. Robson^1,2,3, Jill Dawson⁴, Judy A. Shea⁵, Helen Doll⁶, Susan Ashdown⁷, Renee Borchin⁸, Ebony Easley⁹, John T. Farrar¹⁰, Don Gebhart¹¹, Katherine Kellom¹², Georgia Lanier¹³, Raashid Luqmani¹⁴, Carol A McAlear¹⁵, John Mills¹⁶, Nataliya Milman^17,18,19, Jacqueline Peck⁷, Gunnar Tomasson²⁰, Peter F. Cronholm⁹ and Peter A. Merkel²¹, ¹Faculty of Health and Applied Science, University of the West of England, Bristol, United Kingdom, ²Department of Rheumatology, University Hospitals Bristol NHS Trust, Bristol, United Kingdom, ³School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, ⁴Nuffield Department of Population Health HSRU, University of Oxford, Oxford, United Kingdom, ⁵Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, ⁶Department of Population Health, University of East Anglia, Norwich, United Kingdom, ⁷Oxford, Oxford, United Kingdom, ⁸University of South Florida, Tampa, FL, ⁹Department of Family Medicine and Community Health, The University of Pennsylvania, Philadelphia, PA, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Columbus, Columbus, OH, ¹²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, United Kingdom, ¹³NONE, Framingham, MA, ¹⁴NDORMS , Rheumathology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ¹⁵Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁶Vasculitis UK, Sheffield, United Kingdom, ¹⁷Department of Medicine, University of Ottawa, Ottawa, ON, Canada, ¹⁸The Ottawa Hospital, Ottawa, ON, Canada, ¹⁹Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ²⁰Dept of Public Health Sciences, University of Iceland, Reykjavik, IS, ²¹Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Candidate questionnaire items were produced following in-depth qualitative research in the UK, US, and Canada plus cognitive interviews, extensive piloting and independent linguistic and…
Abstract Number: 3180 • 2016 ACR/ARHP Annual Meeting
Utility of Measurements of Urinary Soluble CD163 & MCP-1 in the Identification of Subtle Renal Flares in ANCA-Associated Vasculitis
Sarah M Moran¹, Michelle Ryan¹, Paul A. Monach², David Cuthbertson³, Simon Carette⁴, Jean Dunne⁵, Gary S. Hoffman⁶, Nader A. Khalidi⁷, Curry L. Koening⁸, Carol A. Langford⁹, Carol A. McAlear¹⁰, Larry W. Moreland¹¹, Christian Pagnoux⁴, Philip Seo¹², Ulrich Specks¹³, Antoine G. Sreih¹⁴, Steven R. Ytterberg¹⁵, Lina Zgaga¹⁶, Peter A. Merkel¹⁷, Mark A. Little¹⁸ and the Vasculitis Clinical Research Consortium, ¹Clinical Medicine, Trinity Health Kidney Centre, Dublin, Ireland, ²Rheumatology, Boston University School of Medicine, Boston, MA, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Immunology Department, St James's Hospital, Dublin, Ireland, ⁶Rheumatology, Cleveland Clinic, Cleveland, OH, ⁷McMaster University, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁸Rheumatology, University of Utah, Salt Lake City, UT, ⁹Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹²Medicine, Johns Hopkins University, Baltimore, MD, ¹³Mayo Clinic, Rochester, MN, ¹⁴Rheumatology, The University of Pennsylvania, Philadelphia, PA, ¹⁵Rheumatology, Mayo Clinic, Rochester, MN, ¹⁶Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland, ¹⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁸Clinical Medicine, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Prior work has shown that urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis using samples from patients with…

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